A citation-based method for searching scientific literature

Haoqiang Ying, Alec C Kimmelman, Costas A Lyssiotis, Sujun Hua, Gerald C Chu, Eliot Fletcher-Sananikone, Jason W Locasale, Jaekyoung Son, Hailei Zhang, Jonathan L Coloff, Haiyan Yan, Wei Wang, Shujuan Chen, Andrea Viale, Hongwu Zheng, Ji-hye Paik, Carol Lim, Alexander R Guimaraes, Eric S Martin, Jeffery Chang, Aram F Hezel, Samuel R Perry, Jian Hu, Boyi Gan, Yonghong Xiao, John M Asara, Ralph Weissleder, Y Alan Wang, Lynda Chin, Lewis C Cantley, Ronald A DePinho. Cell 2012
Times Cited: 1034

List of co-cited articles
1250 articles co-cited >1

Times Cited
  Times     Co-cited

p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase.
Peng Jiang, Wenjing Du, Xingwu Wang, Anthony Mancuso, Xiang Gao, Mian Wu, Xiaolu Yang. Nat Cell Biol 2011

Understanding the Intersections between Metabolism and Cancer Biology.
Matthew G Vander Heiden, Ralph J DeBerardinis. Cell 2017

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries.
Freddie Bray, Jacques Ferlay, Isabelle Soerjomataram, Rebecca L Siegel, Lindsey A Torre, Ahmedin Jemal. CA Cancer J Clin 2018

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth.
Heather R Christofk, Matthew G Vander Heiden, Marian H Harris, Arvind Ramanathan, Robert E Gerszten, Ru Wei, Mark D Fleming, Stuart L Schreiber, Lewis C Cantley. Nature 2008

KRAS4A directly regulates hexokinase 1.
Caroline R Amendola, James P Mahaffey, Seth J Parker, Ian M Ahearn, Wei-Ching Chen, Mo Zhou, Helen Court, Jie Shi, Sebastian L Mendoza, Michael J Morten,[...]. Nature 2019

Pancreatic cancer.
Terumi Kamisawa, Laura D Wood, Takao Itoi, Kyoichi Takaori. Lancet 2016

Fueling the fire: emerging role of the hexosamine biosynthetic pathway in cancer.
Neha M Akella, Lorela Ciraku, Mauricio J Reginato. BMC Biol 2019

Targeting tumor-intrinsic hexosamine biosynthesis sensitizes pancreatic cancer to anti-PD1 therapy.
Nikita S Sharma, Vineet K Gupta, Vanessa T Garrido, Roey Hadad, Brittany C Durden, Kousik Kesh, Bhuwan Giri, Anthony Ferrantella, Vikas Dudeja, Ashok Saluja,[...]. J Clin Invest 2020

Targeting Metabolism for Cancer Therapy.
Alba Luengo, Dan Y Gui, Matthew G Vander Heiden. Cell Chem Biol 2017

Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer.
Daniel Öhlund, Abram Handly-Santana, Giulia Biffi, Ela Elyada, Ana S Almeida, Mariano Ponz-Sarvise, Vincenzo Corbo, Tobiloba E Oni, Stephen A Hearn, Eun Jung Lee,[...]. J Exp Med 2017

Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma.
Andrew D Rhim, Paul E Oberstein, Dafydd H Thomas, Emily T Mirek, Carmine F Palermo, Stephen A Sastra, Erin N Dekleva, Tyler Saunders, Claudia P Becerra, Ian W Tattersall,[...]. Cancer Cell 2014

MCT4 defines a glycolytic subtype of pancreatic cancer with poor prognosis and unique metabolic dependencies.
GuemHee Baek, Yan F Tse, Zeping Hu, Derek Cox, Noah Buboltz, Peter McCue, Charles J Yeo, Michael A White, Ralph J DeBerardinis, Erik S Knudsen,[...]. Cell Rep 2014

A Variant of SLC1A5 Is a Mitochondrial Glutamine Transporter for Metabolic Reprogramming in Cancer Cells.
Hee Chan Yoo, Seung Joon Park, Miso Nam, Juwon Kang, Kibum Kim, Joo Hye Yeo, Joon-Ki Kim, Yunkyung Heo, Hee Seung Lee, Myeong Youl Lee,[...]. Cell Metab 2020

Aerobic glycolysis: meeting the metabolic requirements of cell proliferation.
Sophia Y Lunt, Matthew G Vander Heiden. Annu Rev Cell Dev Biol 2011

Pancreatic cancer.
Jorg Kleeff, Murray Korc, Minoti Apte, Carlo La Vecchia, Colin D Johnson, Andrew V Biankin, Rachel E Neale, Margaret Tempero, David A Tuveson, Ralph H Hruban,[...]. Nat Rev Dis Primers 2016

Autophagy and metabolism.
Joshua D Rabinowitz, Eileen White. Science 2010

MYC Instructs and Maintains Pancreatic Adenocarcinoma Phenotype.
Nicole M Sodir, Roderik M Kortlever, Valentin J A Barthet, Tania Campos, Luca Pellegrinet, Steven Kupczak, Panayiotis Anastasiou, Lamorna Brown Swigart, Laura Soucek, Mark J Arends,[...]. Cancer Discov 2020

TIGAR, a p53-inducible regulator of glycolysis and apoptosis.
Karim Bensaad, Atsushi Tsuruta, Mary A Selak, M Nieves Calvo Vidal, Katsunori Nakano, Ramon Bartrons, Eyal Gottlieb, Karen H Vousden. Cell 2006

α-Ketoglutarate links p53 to cell fate during tumour suppression.
John P Morris, Jossie J Yashinskie, Richard Koche, Rohit Chandwani, Sha Tian, Chi-Chao Chen, Timour Baslan, Zoran S Marinkovic, Francisco J Sánchez-Rivera, Steven D Leach,[...]. Nature 2019

Autophagy and Tumor Metabolism.
Alec C Kimmelman, Eileen White. Cell Metab 2017

Deoxycytidine Release from Pancreatic Stellate Cells Promotes Gemcitabine Resistance.
Simona Dalin, Mark R Sullivan, Allison N Lau, Beatrice Grauman-Boss, Helen S Mueller, Emanuel Kreidl, Silvia Fenoglio, Alba Luengo, Jacqueline A Lees, Matthew G Vander Heiden,[...]. Cancer Res 2019

Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial.
H A Burris, M J Moore, J Andersen, M R Green, M L Rothenberg, M R Modiano, M C Cripps, R K Portenoy, A M Storniolo, P Tarassoff,[...]. J Clin Oncol 1997

Whole-exome sequencing of pancreatic cancer defines genetic diversity and therapeutic targets.
Agnieszka K Witkiewicz, Elizabeth A McMillan, Uthra Balaji, GuemHee Baek, Wan-Chi Lin, John Mansour, Mehri Mollaee, Kay-Uwe Wagner, Prasad Koduru, Adam Yopp,[...]. Nat Commun 2015

Roles for KRAS in pancreatic tumor development and progression.
Marina Pasca di Magliano, Craig D Logsdon. Gastroenterology 2013

Oncogenic Kras-induced GM-CSF production promotes the development of pancreatic neoplasia.
Yuliya Pylayeva-Gupta, Kyoung Eun Lee, Cristina H Hajdu, George Miller, Dafna Bar-Sagi. Cancer Cell 2012

The metabolic profile of tumors depends on both the responsible genetic lesion and tissue type.
Mariia O Yuneva, Teresa W M Fan, Thaddeus D Allen, Richard M Higashi, Dana V Ferraris, Takashi Tsukamoto, José M Matés, Francisco J Alonso, Chunmei Wang, Youngho Seo,[...]. Cell Metab 2012

Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions.
Orianne Olivares, Jared R Mayers, Victoire Gouirand, Margaret E Torrence, Tristan Gicquel, Laurence Borge, Sophie Lac, Julie Roques, Marie-Noëlle Lavaut, Patrice Berthezène,[...]. Nat Commun 2017

Modulating the therapeutic response of tumours to dietary serine and glycine starvation.
Oliver D K Maddocks, Dimitris Athineos, Eric C Cheung, Pearl Lee, Tong Zhang, Niels J F van den Broek, Gillian M Mackay, Christiaan F Labuschagne, David Gay, Flore Kruiswijk,[...]. Nature 2017

Vertical Pathway Inhibition Overcomes Adaptive Feedback Resistance to KRASG12C Inhibition.
Meagan B Ryan, Ferran Fece de la Cruz, Sarah Phat, David T Myers, Edmond Wong, Heather A Shahzade, Catriona B Hong, Ryan B Corcoran. Clin Cancer Res 2020

Autophagy is critical for pancreatic tumor growth and progression in tumors with p53 alterations.
Annan Yang, N V Rajeshkumar, Xiaoxu Wang, Shinichi Yabuuchi, Brian M Alexander, Gerald C Chu, Daniel D Von Hoff, Anirban Maitra, Alec C Kimmelman. Cancer Discov 2014

BI-3406, a Potent and Selective SOS1-KRAS Interaction Inhibitor, Is Effective in KRAS-Driven Cancers through Combined MEK Inhibition.
Marco H Hofmann, Michael Gmachl, Juergen Ramharter, Fabio Savarese, Daniel Gerlach, Joseph R Marszalek, Michael P Sanderson, Dirk Kessler, Francesca Trapani, Heribert Arnhof,[...]. Cancer Discov 2021

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles.
Aravind Subramanian, Pablo Tamayo, Vamsi K Mootha, Sayan Mukherjee, Benjamin L Ebert, Michael A Gillette, Amanda Paulovich, Scott L Pomeroy, Todd R Golub, Eric S Lander,[...]. Proc Natl Acad Sci U S A 2005

Oncogenic KRAS and BRAF Drive Metabolic Reprogramming in Colorectal Cancer.
Josiah E Hutton, Xiaojing Wang, Lisa J Zimmerman, Robbert J C Slebos, Irina A Trenary, Jamey D Young, Ming Li, Daniel C Liebler. Mol Cell Proteomics 2016

A small molecule that inhibits OGT activity in cells.
Rodrigo F Ortiz-Meoz, Jiaoyang Jiang, Michael B Lazarus, Marina Orman, John Janetzko, Chenguang Fan, Damien Y Duveau, Zhi-Wei Tan, Craig J Thomas, Suzanne Walker. ACS Chem Biol 2015

O-GlcNAcylation regulates cancer metabolism and survival stress signaling via regulation of the HIF-1 pathway.
Christina M Ferrer, Thomas P Lynch, Valerie L Sodi, John N Falcone, Luciana P Schwab, Danielle L Peacock, David J Vocadlo, Tiffany N Seagroves, Mauricio J Reginato. Mol Cell 2014

The O-GlcNAc transferase gene resides on the X chromosome and is essential for embryonic stem cell viability and mouse ontogeny.
R Shafi, S P Iyer, L G Ellies, N O'Donnell, K W Marek, D Chui, G W Hart, J D Marth. Proc Natl Acad Sci U S A 2000

Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS-SOS1 interaction.
Roman C Hillig, Brice Sautier, Jens Schroeder, Dieter Moosmayer, André Hilpmann, Christian M Stegmann, Nicolas D Werbeck, Hans Briem, Ulf Boemer, Joerg Weiske,[...]. Proc Natl Acad Sci U S A 2019

The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data.
Ethan Cerami, Jianjiong Gao, Ugur Dogrusoz, Benjamin E Gross, Selcuk Onur Sumer, Bülent Arman Aksoy, Anders Jacobsen, Caitlin J Byrne, Michael L Heuer, Erik Larsson,[...]. Cancer Discov 2012

Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases.
Ying-Nan P Chen, Matthew J LaMarche, Ho Man Chan, Peter Fekkes, Jorge Garcia-Fortanet, Michael G Acker, Brandon Antonakos, Christine Hiu-Tung Chen, Zhouliang Chen, Vesselina G Cooke,[...]. Nature 2016

SHP2 Inhibition Prevents Adaptive Resistance to MEK Inhibitors in Multiple Cancer Models.
Carmine Fedele, Hao Ran, Brian Diskin, Wei Wei, Jayu Jen, Mitchell J Geer, Kiyomi Araki, Ugur Ozerdem, Diane M Simeone, George Miller,[...]. Cancer Discov 2018

c-Myc transactivation of LDH-A: implications for tumor metabolism and growth.
H Shim, C Dolde, B C Lewis, C S Wu, G Dang, R A Jungmann, R Dalla-Favera, C V Dang. Proc Natl Acad Sci U S A 1997

Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice.
Pierre Sonveaux, Frédérique Végran, Thies Schroeder, Melanie C Wergin, Julien Verrax, Zahid N Rabbani, Christophe J De Saedeleer, Kelly M Kennedy, Caroline Diepart, Bénédicte F Jordan,[...]. J Clin Invest 2008

Cancer cell metabolism: Warburg and beyond.
Peggy P Hsu, David M Sabatini. Cell 2008

A central role for RAF→MEK→ERK signaling in the genesis of pancreatic ductal adenocarcinoma.
Eric A Collisson, Christy L Trejo, Jillian M Silva, Shenda Gu, James E Korkola, Laura M Heiser, Roch-Philippe Charles, Brian A Rabinovich, Byron Hann, David Dankort,[...]. Cancer Discov 2012

Physiologic Medium Rewires Cellular Metabolism and Reveals Uric Acid as an Endogenous Inhibitor of UMP Synthase.
Jason R Cantor, Monther Abu-Remaileh, Naama Kanarek, Elizaveta Freinkman, Xin Gao, Abner Louissaint, Caroline A Lewis, David M Sabatini. Cell 2017

Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.