A citation-based method for searching scientific literature

E Roessler, E Belloni, K Gaudenz, P Jay, P Berta, S W Scherer, L C Tsui, M Muenke. Nat Genet 1996
Times Cited: 841







List of co-cited articles
1109 articles co-cited >1



Times Cited
  Times     Co-cited
Similarity


GDC-0449-a potent inhibitor of the hedgehog pathway.
Kirk D Robarge, Shirley A Brunton, Georgette M Castanedo, Yong Cui, Michael S Dina, Richard Goldsmith, Stephen E Gould, Oivin Guichert, Janet L Gunzner, Jason Halladay,[...]. Bioorg Med Chem Lett 2009
274
6

Small molecule modulation of Smoothened activity.
James K Chen, Jussi Taipale, Keith E Young, Tapan Maiti, Philip A Beachy. Proc Natl Acad Sci U S A 2002
740
6


Pathogenic mutations in GLI2 cause a specific phenotype that is distinct from holoprosencephaly.
Kelly A Bear, Benjamin D Solomon, Sonir Antonini, Ivo J P Arnhold, Marcela M França, Erica H Gerkes, Dorothy K Grange, Donald W Hadley, Jarmo Jääskeläinen, Sabrina S Paulo,[...]. J Med Genet 2014
37
16

Point mutations in human GLI3 cause Greig syndrome.
A Wild, M Kalff-Suske, A Vortkamp, D Bornholdt, R König, K H Grzeschik. Hum Mol Genet 1997
138
6

Novel mutation in sonic hedgehog in non-syndromic colobomatous microphthalmia.
Lisa A Schimmenti, June de la Cruz, Richard Alan Lewis, J D Karkera, Glenda S Manligas, Erich Roessler, Maximilian Muenke. Am J Med Genet A 2003
111
6



Gli2 gene-environment interactions contribute to the etiological complexity of holoprosencephaly: evidence from a mouse model.
Galen W Heyne, Joshua L Everson, Lydia J Ansen-Wilson, Cal G Melberg, Dustin M Fink, Kia F Parins, Padydeh Doroodchi, Caden M Ulschmid, Robert J Lipinski. Dis Model Mech 2016
25
24

Dose-dependent functions of Fgf8 in regulating telencephalic patterning centers.
Elaine E Storm, Sonia Garel, Ugo Borello, Jean M Hebert, Salvador Martinez, Susan K McConnell, Gail R Martin, John L R Rubenstein. Development 2006
263
6

Hedgehog receptor function during craniofacial development.
Guilherme M Xavier, Maisa Seppala, William Barrell, Anahid A Birjandi, Finn Geoghegan, Martyn T Cobourne. Dev Biol 2016
64
9

Reduced cholesterol levels impair Smoothened activation in Smith-Lemli-Opitz syndrome.
Robert Blassberg, James I Macrae, James Briscoe, John Jacob. Hum Mol Genet 2016
54
11

Structural basis of Smoothened regulation by its extracellular domains.
Eamon F X Byrne, Ria Sircar, Paul S Miller, George Hedger, Giovanni Luchetti, Sigrid Nachtergaele, Mark D Tully, Laurel Mydock-McGrane, Douglas F Covey, Robert P Rambo,[...]. Nature 2016
190
6

Ethanol itself is a holoprosencephaly-inducing teratogen.
Mingi Hong, Robert S Krauss. PLoS One 2017
21
28

Dominant-negative kinase domain mutations in FGFR1 can explain the clinical severity of Hartsfield syndrome.
Sungkook Hong, Ping Hu, Juliana Marino, Sophia B Hufnagel, Robert J Hopkin, Alma Toromanović, Antonio Richieri-Costa, Lucilene A Ribeiro-Bicudo, Paul Kruszka, Erich Roessler,[...]. Hum Mol Genet 2016
29
20


The mutational spectrum of holoprosencephaly-associated changes within the SHH gene in humans predicts loss-of-function through either key structural alterations of the ligand or its altered synthesis.
Erich Roessler, Kenia B El-Jaick, Christèle Dubourg, Jorge I Vélez, Benjamin D Solomon, Daniel E Pineda-Alvarez, Felicitas Lacbawan, Nan Zhou, Maia Ouspenskaia, Aimée Paulussen,[...]. Hum Mutat 2009
62
9


STIL mutation causes autosomal recessive microcephalic lobar holoprosencephaly.
Naseebullah Kakar, Jamil Ahmad, Deborah J Morris-Rosendahl, Janine Altmüller, Katrin Friedrich, Gotthold Barbi, Peter Nürnberg, Christian Kubisch, William B Dobyns, Guntram Borck. Hum Genet 2015
21
23

Novel FGF8 mutations associated with recessive holoprosencephaly, craniofacial defects, and hypothalamo-pituitary dysfunction.
Mark J McCabe, Carles Gaston-Massuet, Vaitsa Tziaferi, Louise C Gregory, Kyriaki S Alatzoglou, Massimo Signore, Eduardo Puelles, Dianne Gerrelli, I Sadaf Farooqi, Jamal Raza,[...]. J Clin Endocrinol Metab 2011
74
6

Functional analysis of mutations in TGIF associated with holoprosencephaly.
Kenia B El-Jaick, Shannon E Powers, Laurent Bartholin, Kenneth R Myers, Jin Hahn, Ieda M Orioli, Maia Ouspenskaia, Felicitas Lacbawan, Erich Roessler, David Wotton,[...]. Mol Genet Metab 2007
54
9




Receptor-mediated endocytosis of soluble and membrane-tethered Sonic hedgehog by Patched-1.
J P Incardona, J H Lee, C P Robertson, K Enga, R P Kapur, H Roelink. Proc Natl Acad Sci U S A 2000
142
5


The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins.
Eric W Humke, Karolin V Dorn, Ljiljana Milenkovic, Matthew P Scott, Rajat Rohatgi. Genes Dev 2010
303
5

Altered neural cell fates and medulloblastoma in mouse patched mutants.
L V Goodrich, L Milenković, K M Higgins, M P Scott. Science 1997
5

Sonic Hedgehog dependent phosphorylation by CK1α and GRK2 is required for ciliary accumulation and activation of smoothened.
Yongbin Chen, Noriaki Sasai, Guoqiang Ma, Tao Yue, Jianhang Jia, James Briscoe, Jin Jiang. PLoS Biol 2011
136
5


Cleft lip and palate results from Hedgehog signaling antagonism in the mouse: Phenotypic characterization and clinical implications.
Robert J Lipinski, Chihwa Song, Kathleen K Sulik, Joshua L Everson, Jerry J Gipp, Dong Yan, Wade Bushman, Ian J Rowland. Birth Defects Res A Clin Mol Teratol 2010
60
8

Mutations in Hedgehog acyltransferase (Hhat) perturb Hedgehog signaling, resulting in severe acrania-holoprosencephaly-agnathia craniofacial defects.
Jennifer F Dennis, Hiroshi Kurosaka, Angelo Iulianella, Jennifer Pace, Nancy Thomas, Sharon Beckham, Trevor Williams, Paul A Trainor. PLoS Genet 2012
40
12

Regulation of a remote Shh forebrain enhancer by the Six3 homeoprotein.
Yongsu Jeong, Federico Coluccio Leskow, Kenia El-Jaick, Erich Roessler, Maximilian Muenke, Anastasia Yocum, Christele Dubourg, Xue Li, Xin Geng, Guillermo Oliver,[...]. Nat Genet 2008
128
5

The crosstalk of mTOR/S6K1 and Hedgehog pathways.
Yan Wang, Qingqing Ding, Chia-Jui Yen, Weiya Xia, Julie G Izzo, Jing-Yu Lang, Chia-Wei Li, Jennifer L Hsu, Stephanie A Miller, Xuemei Wang,[...]. Cancer Cell 2012
254
5

Gene-Environment Interactions and the Etiology of Birth Defects.
Robert S Krauss, Mingi Hong. Curr Top Dev Biol 2016
37
13

FGFR1 mutations cause Hartsfield syndrome, the unique association of holoprosencephaly and ectrodactyly.
Nicolas Simonis, Isabelle Migeotte, Nelle Lambert, Camille Perazzolo, Deepthi C de Silva, Boyan Dimitrov, Claudine Heinrichs, Sandra Janssens, Bronwyn Kerr, Geert Mortier,[...]. J Med Genet 2013
50
10

Loss of Tgif function causes holoprosencephaly by disrupting the SHH signaling pathway.
Kenichiro Taniguchi, Anoush E Anderson, Ann E Sutherland, David Wotton. PLoS Genet 2012
56
8

The primary cilium as a Hedgehog signal transduction machine.
Sarah C Goetz, Polloneal J R Ocbina, Kathryn V Anderson. Methods Cell Biol 2009
102
5


The Zic2 gene directs the formation and function of node cilia to control cardiac situs.
Kristen S Barratt, Hannah C Glanville-Jones, Ruth M Arkell. Genesis 2014
19
26

Murine models of holoprosencephaly.
Karen A Schachter, Robert S Krauss. Curr Top Dev Biol 2008
36
13


The unfolding clinical spectrum of holoprosencephaly due to mutations in SHH, ZIC2, SIX3 and TGIF genes.
Aimée D C Paulussen, Constance T Schrander-Stumpel, Demis C J Tserpelis, Matteus K M Spee, Alexander P A Stegmann, Grazia M Mancini, Alice S Brooks, Margriet Collée, Anneke Maat-Kievit, Marleen E H Simon,[...]. Eur J Hum Genet 2010
32
15

Beta-arrestin-mediated localization of smoothened to the primary cilium.
Jeffrey J Kovacs, Erin J Whalen, Renshui Liu, Kunhong Xiao, Jihee Kim, Minyong Chen, Jiangbo Wang, Wei Chen, Robert J Lefkowitz. Science 2008
196
5

Cholesterol Modification of Smoothened Is Required for Hedgehog Signaling.
Xu Xiao, Jing-Jie Tang, Chao Peng, Yan Wang, Lin Fu, Zhi-Ping Qiu, Yue Xiong, Lian-Fang Yang, Hai-Wei Cui, Xiao-Long He,[...]. Mol Cell 2017
93
5

Septopreoptic holoprosencephaly: a mild subtype associated with midline craniofacial anomalies.
J S Hahn, P D Barnes, N J Clegg, E E Stashinko. AJNR Am J Neuroradiol 2010
33
15

Loss-of-function mutations in FGF8 can be independent risk factors for holoprosencephaly.
Sungkook Hong, Ping Hu, Erich Roessler, Tommy Hu, Maximilian Muenke. Hum Mol Genet 2018
11
45

Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology.
Sue Richards, Nazneen Aziz, Sherri Bale, David Bick, Soma Das, Julie Gastier-Foster, Wayne W Grody, Madhuri Hegde, Elaine Lyon, Elaine Spector,[...]. Genet Med 2015
5

Structures of human Patched and its complex with native palmitoylated sonic hedgehog.
Xiaofeng Qi, Philip Schmiege, Elias Coutavas, Jiawei Wang, Xiaochun Li. Nature 2018
89
5



Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.