A citation-based method for searching scientific literature

Alejandro Martin-Montalvo, Evi M Mercken, Sarah J Mitchell, Hector H Palacios, Patricia L Mote, Morten Scheibye-Knudsen, Ana P Gomes, Theresa M Ward, Robin K Minor, Marie-José Blouin, Matthias Schwab, Michael Pollak, Yongqing Zhang, Yinbing Yu, Kevin G Becker, Vilhelm A Bohr, Donald K Ingram, David A Sinclair, Norman S Wolf, Stephen R Spindler, Michel Bernier, Rafael de Cabo. Nat Commun 2013
Times Cited: 670







List of co-cited articles
1094 articles co-cited >1



Times Cited
  Times     Co-cited
Similarity


Anti-Inflammatory Effects of Metformin Irrespective of Diabetes Status.
Amy R Cameron, Vicky L Morrison, Daniel Levin, Mohapradeep Mohan, Calum Forteath, Craig Beall, Alison D McNeilly, David J K Balfour, Terhi Savinko, Aaron K F Wong,[...]. Circ Res 2016
251
6

mTOR inhibition improves immune function in the elderly.
Joan B Mannick, Giuseppe Del Giudice, Maria Lattanzi, Nicholas M Valiante, Jens Praestgaard, Baisong Huang, Michael A Lonetto, Holden T Maecker, John Kovarik, Simon Carson,[...]. Sci Transl Med 2014
353
6

Metformin alleviates human cellular aging by upregulating the endoplasmic reticulum glutathione peroxidase 7.
Jingqi Fang, Jiping Yang, Xun Wu, Gangming Zhang, Tao Li, Xi'e Wang, Hong Zhang, Chih-Chen Wang, Guang-Hui Liu, Lei Wang. Aging Cell 2018
55
10

Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds.
Michael S Bonkowski, David A Sinclair. Nat Rev Mol Cell Biol 2016
318
6

Rapamycin extends murine lifespan but has limited effects on aging.
Frauke Neff, Diana Flores-Dominguez, Devon P Ryan, Marion Horsch, Susanne Schröder, Thure Adler, Luciana Caminha Afonso, Juan Antonio Aguilar-Pimentel, Lore Becker, Lillian Garrett,[...]. J Clin Invest 2013
231
6

Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan.
Darren J Baker, Bennett G Childs, Matej Durik, Melinde E Wijers, Cynthia J Sieben, Jian Zhong, Rachel A Saltness, Karthik B Jeganathan, Grace Casaclang Verzosa, Abdulmohammad Pezeshki,[...]. Nature 2016
6

Caloric restriction delays disease onset and mortality in rhesus monkeys.
Ricki J Colman, Rozalyn M Anderson, Sterling C Johnson, Erik K Kastman, Kristopher J Kosmatka, T Mark Beasley, David B Allison, Christina Cruzen, Heather A Simmons, Joseph W Kemnitz,[...]. Science 2009
6

Long-term metformin usage and cognitive function among older adults with diabetes.
Tze Pin Ng, Liang Feng, Keng Bee Yap, Tih Shih Lee, Chay Hoon Tan, Bengt Winblad. J Alzheimers Dis 2014
164
6

Caloric restriction.
John R Speakman, Sharon E Mitchell. Mol Aspects Med 2011
434
6

Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy.
E Morselli, M C Maiuri, M Markaki, E Megalou, A Pasparaki, K Palikaras, A Criollo, L Galluzzi, S A Malik, I Vitale,[...]. Cell Death Dis 2010
404
6

Sirtuin activators mimic caloric restriction and delay ageing in metazoans.
Jason G Wood, Blanka Rogina, Siva Lavu, Konrad Howitz, Stephen L Helfand, Marc Tatar, David Sinclair. Nature 2004
6


Ketogenic Diet Reduces Midlife Mortality and Improves Memory in Aging Mice.
John C Newman, Anthony J Covarrubias, Minghao Zhao, Xinxing Yu, Philipp Gut, Che-Ping Ng, Yu Huang, Saptarsi Haldar, Eric Verdin. Cell Metab 2017
154
6

AMPK: a nutrient and energy sensor that maintains energy homeostasis.
D Grahame Hardie, Fiona A Ross, Simon A Hawley. Nat Rev Mol Cell Biol 2012
6

Disruption of the beclin 1-BCL2 autophagy regulatory complex promotes longevity in mice.
Álvaro F Fernández, Salwa Sebti, Yongjie Wei, Zhongju Zou, Mingjun Shi, Kathryn L McMillan, Congcong He, Tabitha Ting, Yang Liu, Wei-Chung Chiang,[...]. Nature 2018
227
6

Fat tissue, aging, and cellular senescence.
Tamara Tchkonia, Dean E Morbeck, Thomas Von Zglinicki, Jan Van Deursen, Joseph Lustgarten, Heidi Scrable, Sundeep Khosla, Michael D Jensen, James L Kirkland. Aging Cell 2010
554
6

The serial cultivation of human diploid cell strains.
L HAYFLICK, P S MOORHEAD. Exp Cell Res 1961
6

The biologic clock: the mitochondria?
D Harman. J Am Geriatr Soc 1972
6

Metformin: from mechanisms of action to therapies.
Marc Foretz, Bruno Guigas, Luc Bertrand, Michael Pollak, Benoit Viollet. Cell Metab 2014
605
6


Metabolic effects of metformin in non-insulin-dependent diabetes mellitus.
M Stumvoll, N Nurjhan, G Perriello, G Dailey, J E Gerich. N Engl J Med 1995
820
6

Caloric restriction improves health and survival of rhesus monkeys.
Julie A Mattison, Ricki J Colman, T Mark Beasley, David B Allison, Joseph W Kemnitz, George S Roth, Donald K Ingram, Richard Weindruch, Rafael de Cabo, Rozalyn M Anderson. Nat Commun 2017
341
6

Senolytic drugs: from discovery to translation.
J L Kirkland, T Tchkonia. J Intern Med 2020
91
6

MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation.
Remi-Martin Laberge, Yu Sun, Arturo V Orjalo, Christopher K Patil, Adam Freund, Lili Zhou, Samuel C Curran, Albert R Davalos, Kathleen A Wilson-Edell, Su Liu,[...]. Nat Cell Biol 2015
484
6

Reversal of epigenetic aging and immunosenescent trends in humans.
Gregory M Fahy, Robert T Brooke, James P Watson, Zinaida Good, Shreyas S Vasanawala, Holden Maecker, Michael D Leipold, David T S Lin, Michael S Kobor, Steve Horvath. Aging Cell 2019
108
6

Health benefits of late-onset metformin treatment every other week in mice.
Irene Alfaras, Sarah J Mitchell, Hector Mora, Darisbeth Rosario Lugo, Alessandra Warren, Ignacio Navas-Enamorado, Vickie Hoffmann, Christopher Hine, James R Mitchell, David G Le Couteur,[...]. NPJ Aging Mech Dis 2017
27
22

Cellular and molecular mechanisms of metformin: an overview.
Benoit Viollet, Bruno Guigas, Nieves Sanz Garcia, Jocelyne Leclerc, Marc Foretz, Fabrizio Andreelli. Clin Sci (Lond) 2012
955
6

Geroscience: linking aging to chronic disease.
Brian K Kennedy, Shelley L Berger, Anne Brunet, Judith Campisi, Ana Maria Cuervo, Elissa S Epel, Claudio Franceschi, Gordon J Lithgow, Richard I Morimoto, Jeffrey E Pessin,[...]. Cell 2014
813
5

Metformin Is a Direct SIRT1-Activating Compound: Computational Modeling and Experimental Validation.
Elisabet Cuyàs, Sara Verdura, Laura Llorach-Parés, Salvador Fernández-Arroyo, Jorge Joven, Begoña Martin-Castillo, Joaquim Bosch-Barrera, Joan Brunet, Alfons Nonell-Canals, Melchor Sanchez-Martinez,[...]. Front Endocrinol (Lausanne) 2018
53
9

Metformin Improves Mitochondrial Respiratory Activity through Activation of AMPK.
Yu Wang, Hongying An, Ting Liu, Caolitao Qin, Hiromi Sesaki, Shaodong Guo, Sally Radovick, Mehboob Hussain, Akhil Maheshwari, Fredric E Wondisford,[...]. Cell Rep 2019
75
6

Metformin Inhibits Hepatic mTORC1 Signaling via Dose-Dependent Mechanisms Involving AMPK and the TSC Complex.
Jessica J Howell, Kristina Hellberg, Marc Turner, George Talbott, Matthew J Kolar, Debbie S Ross, Gerta Hoxhaj, Alan Saghatelian, Reuben J Shaw, Brendan D Manning. Cell Metab 2017
164
5

Metformin reduces endogenous reactive oxygen species and associated DNA damage.
Carolyn Algire, Olga Moiseeva, Xavier Deschênes-Simard, Lilian Amrein, Luca Petruccelli, Elena Birman, Benoit Viollet, Gerardo Ferbeyre, Michael N Pollak. Cancer Prev Res (Phila) 2012
201
5

Fisetin is a senotherapeutic that extends health and lifespan.
Matthew J Yousefzadeh, Yi Zhu, Sara J McGowan, Luise Angelini, Heike Fuhrmann-Stroissnigg, Ming Xu, Yuan Yuan Ling, Kendra I Melos, Tamar Pirtskhalava, Christina L Inman,[...]. EBioMedicine 2018
193
5

Metformin inhibits monocyte-to-macrophage differentiation via AMPK-mediated inhibition of STAT3 activation: potential role in atherosclerosis.
Sathish Babu Vasamsetti, Santosh Karnewar, Anantha Koteswararao Kanugula, Avinash Raj Thatipalli, Jerald Mahesh Kumar, Srigiridhar Kotamraju. Diabetes 2015
194
5

Metformin Acts on Two Different Molecular Pathways to Enhance Adult Neural Precursor Proliferation/Self-Renewal and Differentiation.
Michael Fatt, Karolynn Hsu, Ling He, Fredric Wondisford, Freda D Miller, David R Kaplan, Jing Wang. Stem Cell Reports 2015
60
8

The critical role of metabolic pathways in aging.
Nir Barzilai, Derek M Huffman, Radhika H Muzumdar, Andrzej Bartke. Diabetes 2012
398
5

Overview of caloric restriction and ageing.
Edward J Masoro. Mech Ageing Dev 2005
671
5

Long live FOXO: unraveling the role of FOXO proteins in aging and longevity.
Rute Martins, Gordon J Lithgow, Wolfgang Link. Aging Cell 2016
307
5

Effect of metformin on life span and on the development of spontaneous mammary tumors in HER-2/neu transgenic mice.
Vladimir N Anisimov, Lev M Berstein, Peter A Egormin, Tatiana S Piskunova, Irina G Popovich, Mark A Zabezhinski, Irina G Kovalenko, Tatiana E Poroshina, Anna V Semenchenko, Mauro Provinciali,[...]. Exp Gerontol 2005
294
5

Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study.
Jamie N Justice, Anoop M Nambiar, Tamar Tchkonia, Nathan K LeBrasseur, Rodolfo Pascual, Shahrukh K Hashmi, Larissa Prata, Michal M Masternak, Stephen B Kritchevsky, Nicolas Musi,[...]. EBioMedicine 2019
309
5

An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA.
Marco Demaria, Naoko Ohtani, Sameh A Youssef, Francis Rodier, Wendy Toussaint, James R Mitchell, Remi-Martin Laberge, Jan Vijg, Harry Van Steeg, Martijn E T Dollé,[...]. Dev Cell 2014
755
5

Senescent intimal foam cells are deleterious at all stages of atherosclerosis.
Bennett G Childs, Darren J Baker, Tobias Wijshake, Cheryl A Conover, Judith Campisi, Jan M van Deursen. Science 2016
444
5

Metformin extends life span of HER-2/neu transgenic mice and in combination with melatonin inhibits growth of transplantable tumors in vivo.
Vladimir N Anisimov, Peter A Egormin, Tatiana S Piskunova, Irina G Popovich, Margarita L Tyndyk, Maria N Yurova, Mark A Zabezhinski, Ivan V Anikin, Arseniy S Karkach, Alexey A Romanyukha. Cell Cycle 2010
131
5

Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study.
Julie A Mattison, George S Roth, T Mark Beasley, Edward M Tilmont, April M Handy, Richard L Herbert, Dan L Longo, David B Allison, Jennifer E Young, Mark Bryant,[...]. Nature 2012
636
5

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1.
Joungmok Kim, Mondira Kundu, Benoit Viollet, Kun-Liang Guan. Nat Cell Biol 2011
5

Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster.
Ivana Bjedov, Janne M Toivonen, Fiona Kerr, Cathy Slack, Jake Jacobson, Andrea Foley, Linda Partridge. Cell Metab 2010
609
5

A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice.
Jamie L Barger, Tsuyoshi Kayo, James M Vann, Edward B Arias, Jelai Wang, Timothy A Hacker, Ying Wang, Daniel Raederstorff, Jason D Morrow, Christiaan Leeuwenburgh,[...]. PLoS One 2008
407
5

Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha.
Marie Lagouge, Carmen Argmann, Zachary Gerhart-Hines, Hamid Meziane, Carles Lerin, Frederic Daussin, Nadia Messadeq, Jill Milne, Philip Lambert, Peter Elliott,[...]. Cell 2006
5

Sirt1 extends life span and delays aging in mice through the regulation of Nk2 homeobox 1 in the DMH and LH.
Akiko Satoh, Cynthia S Brace, Nick Rensing, Paul Cliften, David F Wozniak, Erik D Herzog, Kelvin A Yamada, Shin-Ichiro Imai. Cell Metab 2013
390
5

Clinical pharmacokinetics of metformin.
Garry G Graham, Jeroen Punt, Manit Arora, Richard O Day, Matthew P Doogue, Janna K Duong, Timothy J Furlong, Jerry R Greenfield, Louise C Greenup, Carl M Kirkpatrick,[...]. Clin Pharmacokinet 2011
601
5


Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.