P F Shelbourne, N Killeen, R F Hevner, H M Johnston, L Tecott, M Lewandoski, M Ennis, L Ramirez, Z Li, C Iannicola, D R Littman, R M Myers. Hum Mol Genet 1999
Times Cited: 193
Times Cited: 193
Times Cited
Times Co-cited
Similarity
Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice.
L Mangiarini, K Sathasivam, M Seller, B Cozens, A Harper, C Hetherington, M Lawton, Y Trottier, H Lehrach, S W Davies,[...]. Cell 1996
L Mangiarini, K Sathasivam, M Seller, B Cozens, A Harper, C Hetherington, M Lawton, Y Trottier, H Lehrach, S W Davies,[...]. Cell 1996
74
Neurological abnormalities in a knock-in mouse model of Huntington's disease.
C H Lin, S Tallaksen-Greene, W M Chien, J A Cearley, W S Jackson, A B Crouse, S Ren, X J Li, R L Albin, P J Detloff. Hum Mol Genet 2001
C H Lin, S Tallaksen-Greene, W M Chien, J A Cearley, W S Jackson, A B Crouse, S Ren, X J Li, R L Albin, P J Detloff. Hum Mol Genet 2001
66
60
A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration.
J G Hodgson, N Agopyan, C A Gutekunst, B R Leavitt, F LePiane, R Singaraja, D J Smith, N Bissada, K McCutcheon, J Nasir,[...]. Neuron 1999
J G Hodgson, N Agopyan, C A Gutekunst, B R Leavitt, F LePiane, R Singaraja, D J Smith, N Bissada, K McCutcheon, J Nasir,[...]. Neuron 1999
58
Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease.
Elizabeth J Slow, Jeremy van Raamsdonk, Daniel Rogers, Sarah H Coleman, Rona K Graham, Yu Deng, Rosemary Oh, Nagat Bissada, Sazzad M Hossain, Yu-Zhou Yang,[...]. Hum Mol Genet 2003
Elizabeth J Slow, Jeremy van Raamsdonk, Daniel Rogers, Sarah H Coleman, Rona K Graham, Yu Deng, Rosemary Oh, Nagat Bissada, Sazzad M Hossain, Yu-Zhou Yang,[...]. Hum Mol Genet 2003
58
Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin.
G Schilling, M W Becher, A H Sharp, H A Jinnah, K Duan, J A Kotzuk, H H Slunt, T Ratovitski, J K Cooper, N A Jenkins,[...]. Hum Mol Genet 1999
G Schilling, M W Becher, A H Sharp, H A Jinnah, K Duan, J A Kotzuk, H H Slunt, T Ratovitski, J K Cooper, N A Jenkins,[...]. Hum Mol Genet 1999
54
Long glutamine tracts cause nuclear localization of a novel form of huntingtin in medium spiny striatal neurons in HdhQ92 and HdhQ111 knock-in mice.
V C Wheeler, J K White, C A Gutekunst, V Vrbanac, M Weaver, X J Li, S H Li, H Yi, J P Vonsattel, J F Gusella,[...]. Hum Mol Genet 2000
V C Wheeler, J K White, C A Gutekunst, V Vrbanac, M Weaver, X J Li, S H Li, H Yi, J P Vonsattel, J F Gusella,[...]. Hum Mol Genet 2000
53
Full-length human mutant huntingtin with a stable polyglutamine repeat can elicit progressive and selective neuropathogenesis in BACHD mice.
Michelle Gray, Dyna I Shirasaki, Carlos Cepeda, Véronique M André, Brian Wilburn, Xiao-Hong Lu, Jifang Tao, Irene Yamazaki, Shi-Hua Li, Yi E Sun,[...]. J Neurosci 2008
Michelle Gray, Dyna I Shirasaki, Carlos Cepeda, Véronique M André, Brian Wilburn, Xiao-Hong Lu, Jifang Tao, Irene Yamazaki, Shi-Hua Li, Yi E Sun,[...]. J Neurosci 2008
52
Time course of early motor and neuropathological anomalies in a knock-in mouse model of Huntington's disease with 140 CAG repeats.
Liliana B Menalled, Jessica D Sison, Ioannis Dragatsis, Scott Zeitlin, Marie-Françoise Chesselet. J Comp Neurol 2003
Liliana B Menalled, Jessica D Sison, Ioannis Dragatsis, Scott Zeitlin, Marie-Françoise Chesselet. J Comp Neurol 2003
43
Length-dependent gametic CAG repeat instability in the Huntington's disease knock-in mouse.
V C Wheeler, W Auerbach, J K White, J Srinidhi, A Auerbach, A Ryan, M P Duyao, V Vrbanac, M Weaver, J F Gusella,[...]. Hum Mol Genet 1999
V C Wheeler, W Auerbach, J K White, J Srinidhi, A Auerbach, A Ryan, M P Duyao, V Vrbanac, M Weaver, J F Gusella,[...]. Hum Mol Genet 1999
41
Early motor dysfunction and striosomal distribution of huntingtin microaggregates in Huntington's disease knock-in mice.
Liliana B Menalled, Jessica D Sison, Ying Wu, Melisa Olivieri, Xiao-Jiang Li, He Li, Scott Zeitlin, Marie-Françoise Chesselet. J Neurosci 2002
Liliana B Menalled, Jessica D Sison, Ying Wu, Melisa Olivieri, Xiao-Jiang Li, He Li, Scott Zeitlin, Marie-Françoise Chesselet. J Neurosci 2002
39
Huntingtin is required for neurogenesis and is not impaired by the Huntington's disease CAG expansion.
J K White, W Auerbach, M P Duyao, J P Vonsattel, J F Gusella, A L Joyner, M E MacDonald. Nat Genet 1997
J K White, W Auerbach, M P Duyao, J P Vonsattel, J F Gusella, A L Joyner, M E MacDonald. Nat Genet 1997
35
Neuropathological classification of Huntington's disease.
J P Vonsattel, R H Myers, T J Stevens, R J Ferrante, E D Bird, E P Richardson. J Neuropathol Exp Neurol 1985
J P Vonsattel, R H Myers, T J Stevens, R J Ferrante, E D Bird, E P Richardson. J Neuropathol Exp Neurol 1985
34
Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation.
S W Davies, M Turmaine, B A Cozens, M DiFiglia, A H Sharp, C A Ross, E Scherzinger, E E Wanker, L Mangiarini, G P Bates. Cell 1997
S W Davies, M Turmaine, B A Cozens, M DiFiglia, A H Sharp, C A Ross, E Scherzinger, E E Wanker, L Mangiarini, G P Bates. Cell 1997
34
Behavioural abnormalities and selective neuronal loss in HD transgenic mice expressing mutated full-length HD cDNA.
P H Reddy, M Williams, V Charles, L Garrett, L Pike-Buchanan, W O Whetsell, G Miller, D A Tagle. Nat Genet 1998
P H Reddy, M Williams, V Charles, L Garrett, L Pike-Buchanan, W O Whetsell, G Miller, D A Tagle. Nat Genet 1998
34
Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain.
M DiFiglia, E Sapp, K O Chase, S W Davies, G P Bates, J P Vonsattel, N Aronin. Science 1997
M DiFiglia, E Sapp, K O Chase, S W Davies, G P Bates, J P Vonsattel, N Aronin. Science 1997
33
Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease.
A Yamamoto, J J Lucas, R Hen. Cell 2000
A Yamamoto, J J Lucas, R Hen. Cell 2000
32
Characterization of progressive motor deficits in mice transgenic for the human Huntington's disease mutation.
R J Carter, L A Lione, T Humby, L Mangiarini, A Mahal, G P Bates, S B Dunnett, A J Morton. J Neurosci 1999
R J Carter, L A Lione, T Humby, L Mangiarini, A Mahal, G P Bates, S B Dunnett, A J Morton. J Neurosci 1999
30
Transgenic rat model of Huntington's disease.
Stephan von Hörsten, Ina Schmitt, Huu Phuc Nguyen, Carsten Holzmann, Thorsten Schmidt, Thomas Walther, Michael Bader, Reinhard Pabst, Philipp Kobbe, Jana Krotova,[...]. Hum Mol Genet 2003
Stephan von Hörsten, Ina Schmitt, Huu Phuc Nguyen, Carsten Holzmann, Thorsten Schmidt, Thomas Walther, Michael Bader, Reinhard Pabst, Philipp Kobbe, Jana Krotova,[...]. Hum Mol Genet 2003
28
Changes in cortical and striatal neurons predict behavioral and electrophysiological abnormalities in a transgenic murine model of Huntington's disease.
G A Laforet, E Sapp, K Chase, C McIntyre, F M Boyce, M Campbell, B A Cadigan, L Warzecki, D A Tagle, P H Reddy,[...]. J Neurosci 2001
G A Laforet, E Sapp, K Chase, C McIntyre, F M Boyce, M Campbell, B A Cadigan, L Warzecki, D A Tagle, P H Reddy,[...]. J Neurosci 2001
27
Enhanced sensitivity to N-methyl-D-aspartate receptor activation in transgenic and knockin mouse models of Huntington's disease.
M S Levine, G J Klapstein, A Koppel, E Gruen, C Cepeda, M E Vargas, E S Jokel, E M Carpenter, H Zanjani, R S Hurst,[...]. J Neurosci Res 1999
M S Levine, G J Klapstein, A Koppel, E Gruen, C Cepeda, M E Vargas, E S Jokel, E M Carpenter, H Zanjani, R S Hurst,[...]. J Neurosci Res 1999
27
Selective discrimination learning impairments in mice expressing the human Huntington's disease mutation.
L A Lione, R J Carter, M J Hunt, G P Bates, A J Morton, S B Dunnett. J Neurosci 1999
L A Lione, R J Carter, M J Hunt, G P Bates, A J Morton, S B Dunnett. J Neurosci 1999
26
Longitudinal evaluation of the Hdh(CAG)150 knock-in murine model of Huntington's disease.
Mary Y Heng, Sara J Tallaksen-Greene, Peter J Detloff, Roger L Albin. J Neurosci 2007
Mary Y Heng, Sara J Tallaksen-Greene, Peter J Detloff, Roger L Albin. J Neurosci 2007
26
Cognitive dysfunction precedes neuropathology and motor abnormalities in the YAC128 mouse model of Huntington's disease.
Jeremy M Van Raamsdonk, Jacqueline Pearson, Elizabeth J Slow, Sazzad M Hossain, Blair R Leavitt, Michael R Hayden. J Neurosci 2005
Jeremy M Van Raamsdonk, Jacqueline Pearson, Elizabeth J Slow, Sazzad M Hossain, Blair R Leavitt, Michael R Hayden. J Neurosci 2005
25
Extensive early motor and non-motor behavioral deficits are followed by striatal neuronal loss in knock-in Huntington's disease mice.
M A Hickey, A Kosmalska, J Enayati, R Cohen, S Zeitlin, M S Levine, M-F Chesselet. Neuroscience 2008
M A Hickey, A Kosmalska, J Enayati, R Cohen, S Zeitlin, M S Levine, M-F Chesselet. Neuroscience 2008
22
Decreased expression of striatal signaling genes in a mouse model of Huntington's disease.
R Luthi-Carter, A Strand, N L Peters, S M Solano, Z R Hollingsworth, A S Menon, A S Frey, B S Spektor, E B Penney, G Schilling,[...]. Hum Mol Genet 2000
R Luthi-Carter, A Strand, N L Peters, S M Solano, Z R Hollingsworth, A S Menon, A S Frey, B S Spektor, E B Penney, G Schilling,[...]. Hum Mol Genet 2000
21
Absence of behavioral abnormalities and neurodegeneration in vivo despite widespread neuronal huntingtin inclusions.
Elizabeth J Slow, Rona K Graham, Alexander P Osmand, Rebecca S Devon, Ge Lu, Yu Deng, Jacqui Pearson, Kuljeet Vaid, Nagat Bissada, Ronald Wetzel,[...]. Proc Natl Acad Sci U S A 2005
Elizabeth J Slow, Rona K Graham, Alexander P Osmand, Rebecca S Devon, Ge Lu, Yu Deng, Jacqui Pearson, Kuljeet Vaid, Nagat Bissada, Ronald Wetzel,[...]. Proc Natl Acad Sci U S A 2005
20
Chronology of behavioral symptoms and neuropathological sequela in R6/2 Huntington's disease transgenic mice.
Edward C Stack, James K Kubilus, Karen Smith, Kerry Cormier, Steven J Del Signore, Emmanuel Guelin, Hoon Ryu, Steven M Hersch, Robert J Ferrante. J Comp Neurol 2005
Edward C Stack, James K Kubilus, Karen Smith, Kerry Cormier, Steven J Del Signore, Emmanuel Guelin, Hoon Ryu, Steven M Hersch, Robert J Ferrante. J Comp Neurol 2005
20
Systematic behavioral evaluation of Huntington's disease transgenic and knock-in mouse models.
Liliana Menalled, Bassem F El-Khodor, Monica Patry, Mayte Suárez-Fariñas, Samantha J Orenstein, Benjamin Zahasky, Christina Leahy, Vanessa Wheeler, X William Yang, Marcy MacDonald,[...]. Neurobiol Dis 2009
Liliana Menalled, Bassem F El-Khodor, Monica Patry, Mayte Suárez-Fariñas, Samantha J Orenstein, Benjamin Zahasky, Christina Leahy, Vanessa Wheeler, X William Yang, Marcy MacDonald,[...]. Neurobiol Dis 2009
19
Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin.
Rona K Graham, Yu Deng, Elizabeth J Slow, Brendan Haigh, Nagat Bissada, Ge Lu, Jacqueline Pearson, Jacqueline Shehadeh, Lisa Bertram, Zoe Murphy,[...]. Cell 2006
Rona K Graham, Yu Deng, Elizabeth J Slow, Brendan Haigh, Nagat Bissada, Ge Lu, Jacqueline Pearson, Jacqueline Shehadeh, Lisa Bertram, Zoe Murphy,[...]. Cell 2006
18
Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.
F Saudou, S Finkbeiner, D Devys, M E Greenberg. Cell 1998
F Saudou, S Finkbeiner, D Devys, M E Greenberg. Cell 1998
18
Early phenotypes that presage late-onset neurodegenerative disease allow testing of modifiers in Hdh CAG knock-in mice.
Vanessa C Wheeler, Claire-Anne Gutekunst, Vladimir Vrbanac, Lori-Anne Lebel, Gabriele Schilling, Steven Hersch, Robert M Friedlander, James F Gusella, Jean-Paul Vonsattel, David R Borchelt,[...]. Hum Mol Genet 2002
Vanessa C Wheeler, Claire-Anne Gutekunst, Vladimir Vrbanac, Lori-Anne Lebel, Gabriele Schilling, Steven Hersch, Robert M Friedlander, James F Gusella, Jean-Paul Vonsattel, David R Borchelt,[...]. Hum Mol Genet 2002
18
Mutant huntingtin causes context-dependent neurodegeneration in mice with Huntington's disease.
Zhao-Xue Yu, Shi-Hua Li, Joy Evans, Ajay Pillarisetti, He Li, Xiao-Jiang Li. J Neurosci 2003
Zhao-Xue Yu, Shi-Hua Li, Joy Evans, Ajay Pillarisetti, He Li, Xiao-Jiang Li. J Neurosci 2003
17
Towards a transgenic model of Huntington's disease in a non-human primate.
Shang-Hsun Yang, Pei-Hsun Cheng, Heather Banta, Karolina Piotrowska-Nitsche, Jin-Jing Yang, Eric C H Cheng, Brooke Snyder, Katherine Larkin, Jun Liu, Jack Orkin,[...]. Nature 2008
Shang-Hsun Yang, Pei-Hsun Cheng, Heather Banta, Karolina Piotrowska-Nitsche, Jin-Jing Yang, Eric C H Cheng, Brooke Snyder, Katherine Larkin, Jun Liu, Jack Orkin,[...]. Nature 2008
17
Comprehensive behavioral and molecular characterization of a new knock-in mouse model of Huntington's disease: zQ175.
Liliana B Menalled, Andrea E Kudwa, Sam Miller, Jon Fitzpatrick, Judy Watson-Johnson, Nicole Keating, Melinda Ruiz, Richard Mushlin, William Alosio, Kristi McConnell,[...]. PLoS One 2012
Liliana B Menalled, Andrea E Kudwa, Sam Miller, Jon Fitzpatrick, Judy Watson-Johnson, Nicole Keating, Melinda Ruiz, Richard Mushlin, William Alosio, Kristi McConnell,[...]. PLoS One 2012
17
Altered brain neurotransmitter receptors in transgenic mice expressing a portion of an abnormal human huntington disease gene.
J H Cha, C M Kosinski, J A Kerner, S A Alsdorf, L Mangiarini, S W Davies, J B Penney, G P Bates, A B Young. Proc Natl Acad Sci U S A 1998
J H Cha, C M Kosinski, J A Kerner, S A Alsdorf, L Mangiarini, S W Davies, J B Penney, G P Bates, A B Young. Proc Natl Acad Sci U S A 1998
16
Nuclear and neuropil aggregates in Huntington's disease: relationship to neuropathology.
C A Gutekunst, S H Li, H Yi, J S Mulroy, S Kuemmerle, R Jones, D Rye, R J Ferrante, S M Hersch, X J Li. J Neurosci 1999
C A Gutekunst, S H Li, H Yi, J S Mulroy, S Kuemmerle, R Jones, D Rye, R J Ferrante, S M Hersch, X J Li. J Neurosci 1999
16
Nonapoptotic neurodegeneration in a transgenic mouse model of Huntington's disease.
M Turmaine, A Raza, A Mahal, L Mangiarini, G P Bates, S W Davies. Proc Natl Acad Sci U S A 2000
M Turmaine, A Raza, A Mahal, L Mangiarini, G P Bates, S W Davies. Proc Natl Acad Sci U S A 2000
16
Environmental enrichment slows disease progression in R6/2 Huntington's disease mice.
Emma Hockly, Patricia M Cordery, Benjamin Woodman, Amarbirpal Mahal, Anton van Dellen, Colin Blakemore, Cathryn M Lewis, Anthony J Hannan, Gillian P Bates. Ann Neurol 2002
Emma Hockly, Patricia M Cordery, Benjamin Woodman, Amarbirpal Mahal, Anton van Dellen, Colin Blakemore, Cathryn M Lewis, Anthony J Hannan, Gillian P Bates. Ann Neurol 2002
16
Mouse models of Huntington's disease.
Liliana B Menalled, Marie-Françoise Chesselet. Trends Pharmacol Sci 2002
Liliana B Menalled, Marie-Françoise Chesselet. Trends Pharmacol Sci 2002
16
Lesion of striatal neurones with kainic acid provides a model for Huntington's chorea.
J T Coyle, R Schwarcz. Nature 1976
J T Coyle, R Schwarcz. Nature 1976
16
Executive and mnemonic functions in early Huntington's disease.
A D Lawrence, B J Sahakian, J R Hodges, A E Rosser, K W Lange, T W Robbins. Brain 1996
A D Lawrence, B J Sahakian, J R Hodges, A E Rosser, K W Lange, T W Robbins. Brain 1996
16
Mutant huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosage.
Alexandre Kuhn, Darlene R Goldstein, Angela Hodges, Andrew D Strand, Thierry Sengstag, Charles Kooperberg, Kristina Becanovic, Mahmoud A Pouladi, Kirupa Sathasivam, Jang-Ho J Cha,[...]. Hum Mol Genet 2007
Alexandre Kuhn, Darlene R Goldstein, Angela Hodges, Andrew D Strand, Thierry Sengstag, Charles Kooperberg, Kristina Becanovic, Mahmoud A Pouladi, Kirupa Sathasivam, Jang-Ho J Cha,[...]. Hum Mol Genet 2007
16
Electrophysiological and morphological changes in striatal spiny neurons in R6/2 Huntington's disease transgenic mice.
G J Klapstein, R S Fisher, H Zanjani, C Cepeda, E S Jokel, M F Chesselet, M S Levine. J Neurophysiol 2001
G J Klapstein, R S Fisher, H Zanjani, C Cepeda, E S Jokel, M F Chesselet, M S Levine. J Neurophysiol 2001
15
Replication of the neurochemical characteristics of Huntington's disease by quinolinic acid.
M F Beal, N W Kowall, D W Ellison, M F Mazurek, K J Swartz, J B Martin. Nature 1986
M F Beal, N W Kowall, D W Ellison, M F Mazurek, K J Swartz, J B Martin. Nature 1986
15
Age-dependent and tissue-specific CAG repeat instability occurs in mouse knock-in for a mutant Huntington's disease gene.
H Ishiguro, K Yamada, H Sawada, K Nishii, N Ichino, M Sawada, Y Kurosawa, N Matsushita, K Kobayashi, J Goto,[...]. J Neurosci Res 2001
H Ishiguro, K Yamada, H Sawada, K Nishii, N Ichino, M Sawada, Y Kurosawa, N Matsushita, K Kobayashi, J Goto,[...]. J Neurosci Res 2001
27
Phenotypic abnormalities in the YAC128 mouse model of Huntington disease are penetrant on multiple genetic backgrounds and modulated by strain.
Jeremy M Van Raamsdonk, Martina Metzler, Elizabeth Slow, Jacqueline Pearson, Claudia Schwab, Jeffrey Carroll, Rona K Graham, Blair R Leavitt, Michael R Hayden. Neurobiol Dis 2007
Jeremy M Van Raamsdonk, Martina Metzler, Elizabeth Slow, Jacqueline Pearson, Claudia Schwab, Jeffrey Carroll, Rona K Graham, Blair R Leavitt, Michael R Hayden. Neurobiol Dis 2007
20
Amino-terminal fragments of mutant huntingtin show selective accumulation in striatal neurons and synaptic toxicity.
H Li, S H Li, H Johnston, P F Shelbourne, X J Li. Nat Genet 2000
H Li, S H Li, H Johnston, P F Shelbourne, X J Li. Nat Genet 2000
14
Differential loss of striatal projection neurons in Huntington disease.
A Reiner, R L Albin, K D Anderson, C J D'Amato, J B Penney, A B Young. Proc Natl Acad Sci U S A 1988
A Reiner, R L Albin, K D Anderson, C J D'Amato, J B Penney, A B Young. Proc Natl Acad Sci U S A 1988
14
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.