A citation-based method for searching scientific literature

S Artavanis-Tsakonas, M D Rand, R J Lake. Science 1999
Times Cited: 4410







List of co-cited articles
526 articles co-cited >1



Times Cited
  Times     Co-cited
Similarity



Notch signalling in context.
Sarah J Bray. Nat Rev Mol Cell Biol 2016
419
14

Notch signalling: a simple pathway becomes complex.
Sarah J Bray. Nat Rev Mol Cell Biol 2006
11


Notch signaling: simplicity in design, versatility in function.
Emma R Andersson, Rickard Sandberg, Urban Lendahl. Development 2011
590
10

Mechanism and significance of cis-inhibition in Notch signalling.
David del Álamo, Hervé Rouault, François Schweisguth. Curr Biol 2011
159
9

Notch signaling at a glance.
Kazuya Hori, Anindya Sen, Spyros Artavanis-Tsakonas. J Cell Sci 2013
329
9

The notch ligands Dll4 and Jagged1 have opposing effects on angiogenesis.
Rui Benedito, Cristina Roca, Inga Sörensen, Susanne Adams, Achim Gossler, Marcus Fruttiger, Ralf H Adams. Cell 2009
652
8

Therapeutic modulation of Notch signalling--are we there yet?
Emma R Andersson, Urban Lendahl. Nat Rev Drug Discov 2014
300
7

Mechanical Allostery: Evidence for a Force Requirement in the Proteolytic Activation of Notch.
Wendy R Gordon, Brandon Zimmerman, Li He, Laura J Miles, Jiuhong Huang, Kittichoat Tiyanont, Debbie G McArthur, Jon C Aster, Norbert Perrimon, Joseph J Loparo,[...]. Dev Cell 2015
152
7

Notch Signaling in Development, Tissue Homeostasis, and Disease.
Chris Siebel, Urban Lendahl. Physiol Rev 2017
295
7

Cis-activation in the Notch signaling pathway.
Nagarajan Nandagopal, Leah A Santat, Michael B Elowitz. Elife 2019
25
24

Mechanisms of Notch signaling: a simple logic deployed in time and space.
Domingos Henrique, François Schweisguth. Development 2019
57
10

Dynamic Ligand Discrimination in the Notch Signaling Pathway.
Nagarajan Nandagopal, Leah A Santat, Lauren LeBon, David Sprinzak, Marianne E Bronner, Michael B Elowitz. Cell 2018
122
6

Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells.
Johan H van Es, Marielle E van Gijn, Orbicia Riccio, Maaike van den Born, Marc Vooijs, Harry Begthel, Miranda Cozijnsen, Sylvie Robine, Doug J Winton, Freddy Radtke,[...]. Nature 2005
5

A Phase I, dose-finding study in patients with advanced solid malignancies of the oral γ-secretase inhibitor PF-03084014.
Wells A Messersmith, Geoffrey I Shapiro, James M Cleary, Antonio Jimeno, Arvind Dasari, Bo Huang, M Naveed Shaik, Rossano Cesari, Xianxian Zheng, Jennifer M Reynolds,[...]. Clin Cancer Res 2015
116
5


Activation of the Notch Signaling Pathway In Vivo Elicits Changes in CSL Nuclear Dynamics.
Maria J Gomez-Lamarca, Julia Falo-Sanjuan, Robert Stojnic, Sohaib Abdul Rehman, Leila Muresan, Matthew L Jones, Zoe Pillidge, Gustavo Cerda-Moya, Zhenyu Yuan, Sarah Baloul,[...]. Dev Cell 2018
31
16

Cis-interactions between Notch and Delta generate mutually exclusive signalling states.
David Sprinzak, Amit Lakhanpal, Lauren Lebon, Leah A Santat, Michelle E Fontes, Graham A Anderson, Jordi Garcia-Ojalvo, Michael B Elowitz. Nature 2010
365
5

The Varied Roles of Notch in Cancer.
Jon C Aster, Warren S Pear, Stephen C Blacklow. Annu Rev Pathol 2017
238
5


Enhancer Priming Enables Fast and Sustained Transcriptional Responses to Notch Signaling.
Julia Falo-Sanjuan, Nicholas C Lammers, Hernan G Garcia, Sarah J Bray. Dev Cell 2019
36
13

HES and HERP families: multiple effectors of the Notch signaling pathway.
Tatsuya Iso, Larry Kedes, Yasuo Hamamori. J Cell Physiol 2003
921
5

Notch ligand endocytosis generates mechanical pulling force dependent on dynamin, epsins, and actin.
Laurence Meloty-Kapella, Bhupinder Shergill, Jane Kuon, Elliot Botvinick, Gerry Weinmaster. Dev Cell 2012
137
5

The divergent DSL ligand Dll3 does not activate Notch signaling but cell autonomously attenuates signaling induced by other DSL ligands.
Ena Ladi, James T Nichols, Weihong Ge, Alison Miyamoto, Christine Yao, Liang-Tung Yang, Jim Boulter, Yi E Sun, Chris Kintner, Gerry Weinmaster. J Cell Biol 2005
195
5

Endocytic regulation of Notch signaling.
Mark E Fortini, David Bilder. Curr Opin Genet Dev 2009
120
5


The many facets of Notch ligands.
B D'Souza, A Miyamoto, G Weinmaster. Oncogene 2008
300
5

Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis.
John Ridgway, Gu Zhang, Yan Wu, Scott Stawicki, Wei-Ching Liang, Yvan Chanthery, Joe Kowalski, Ryan J Watts, Christopher Callahan, Ian Kasman,[...]. Nature 2006
724
4

Signalling downstream of activated mammalian Notch.
S Jarriault, C Brou, F Logeat, E H Schroeter, R Kopan, A Israel. Nature 1995
4

Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia.
Xose S Puente, Magda Pinyol, Víctor Quesada, Laura Conde, Gonzalo R Ordóñez, Neus Villamor, Georgia Escaramis, Pedro Jares, Sílvia Beà, Marcos González-Díaz,[...]. Nature 2011
4

First-in-human study of LY3039478, an oral Notch signaling inhibitor in advanced or metastatic cancer.
C Massard, A Azaro, J-C Soria, U Lassen, C Le Tourneau, D Sarker, C Smith, U Ohnmacht, G Oakley, B K R Patel,[...]. Ann Oncol 2018
53
7

A first-in-human phase I study of the oral Notch inhibitor, LY900009, in patients with advanced cancer.
Shubham Pant, Suzanne F Jones, Carla D Kurkjian, Jeffrey R Infante, Kathleen N Moore, Howard A Burris, Donald S McMeekin, Karim A Benhadji, Bharvin K R Patel, Martin J Frenzel,[...]. Eur J Cancer 2016
40
10

The role of Notch in tumorigenesis: oncogene or tumour suppressor?
Freddy Radtke, Kenneth Raj. Nat Rev Cancer 2003
619
4


Endosomal entry regulates Notch receptor activation in Drosophila melanogaster.
Thomas Vaccari, Han Lu, Ritu Kanwar, Mark E Fortini, David Bilder. J Cell Biol 2008
201
4

The molecular logic of Notch signaling--a structural and biochemical perspective.
Wendy R Gordon, Kelly L Arnett, Stephen C Blacklow. J Cell Sci 2008
171
4

Structural biology. Structural basis for Notch1 engagement of Delta-like 4.
Vincent C Luca, Kevin M Jude, Nathan W Pierce, Maxence V Nachury, Suzanne Fischer, K Christopher Garcia. Science 2015
140
4

Notch-Jagged complex structure implicates a catch bond in tuning ligand sensitivity.
Vincent C Luca, Byoung Choul Kim, Chenghao Ge, Shinako Kakuda, Di Wu, Mehdi Roein-Peikar, Robert S Haltiwanger, Cheng Zhu, Taekjip Ha, K Christopher Garcia. Science 2017
125
4

The Notch signalling system: recent insights into the complexity of a conserved pathway.
K G Guruharsha, Mark W Kankel, Spyros Artavanis-Tsakonas. Nat Rev Genet 2012
445
4

Notch signaling.
Raphael Kopan. Cold Spring Harb Perspect Biol 2012
144
4

Origin and evolution of the Notch signalling pathway: an overview from eukaryotic genomes.
Eve Gazave, Pascal Lapébie, Gemma S Richards, Frédéric Brunet, Alexander V Ereskovsky, Bernard M Degnan, Carole Borchiellini, Michel Vervoort, Emmanuelle Renard. BMC Evol Biol 2009
136
4

Notch1 functions as a tumor suppressor in mouse skin.
Michael Nicolas, Anita Wolfer, Kenneth Raj, J Alain Kummer, Pleasantine Mill, Mascha van Noort, Chi-chung Hui, Hans Clevers, G Paolo Dotto, Freddy Radtke. Nat Genet 2003
746
4



Optical tweezers studies on Notch: single-molecule interaction strength is independent of ligand endocytosis.
Bhupinder Shergill, Laurence Meloty-Kapella, Abdiwahab A Musse, Gerry Weinmaster, Elliot Botvinick. Dev Cell 2012
46
8


A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE.
C Brou, F Logeat, N Gupta, C Bessia, O LeBail, J R Doedens, A Cumano, P Roux, R A Black, A Israël. Mol Cell 2000
826
4

Notch3 is required for arterial identity and maturation of vascular smooth muscle cells.
Valérie Domenga, Peggy Fardoux, Pierre Lacombe, Marie Monet, Jacqueline Maciazek, Luke T Krebs, Bernard Klonjkowski, Eliane Berrou, Matthias Mericskay, Zhen Li,[...]. Genes Dev 2004
346
4

Role of conserved intracellular motifs in Serrate signalling, cis-inhibition and endocytosis.
Marcus Glittenberg, Chrysoula Pitsouli, Clare Garvey, Christos Delidakis, Sarah Bray. EMBO J 2006
90
4


Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.