F Radtke, A Wilson, G Stark, M Bauer, J van Meerwijk, H R MacDonald, M Aguet. Immunity 1999
Times Cited: 1080
Times Cited: 1080
Times Cited
Times Co-cited
Similarity
Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia.
Andrew P Weng, Adolfo A Ferrando, Woojoong Lee, John P Morris, Lewis B Silverman, Cheryll Sanchez-Irizarry, Stephen C Blacklow, A Thomas Look, Jon C Aster. Science 2004
Andrew P Weng, Adolfo A Ferrando, Woojoong Lee, John P Morris, Lewis B Silverman, Cheryll Sanchez-Irizarry, Stephen C Blacklow, A Thomas Look, Jon C Aster. Science 2004
28
Delta-like 4 is indispensable in thymic environment specific for T cell development.
Katsuto Hozumi, Carolina Mailhos, Naoko Negishi, Ken-ichi Hirano, Takashi Yahata, Kiyoshi Ando, Saulius Zuklys, Georg A Holländer, David T Shima, Sonoko Habu. J Exp Med 2008
Katsuto Hozumi, Carolina Mailhos, Naoko Negishi, Ken-ichi Hirano, Takashi Yahata, Kiyoshi Ando, Saulius Zuklys, Georg A Holländer, David T Shima, Sonoko Habu. J Exp Med 2008
26
The canonical Notch signaling pathway: unfolding the activation mechanism.
Raphael Kopan, Maria Xenia G Ilagan. Cell 2009
Raphael Kopan, Maria Xenia G Ilagan. Cell 2009
24
Notch1 expression in early lymphopoiesis influences B versus T lineage determination.
J C Pui, D Allman, L Xu, S DeRocco, F G Karnell, S Bakkour, J Y Lee, T Kadesch, R R Hardy, J C Aster,[...]. Immunity 1999
J C Pui, D Allman, L Xu, S DeRocco, F G Karnell, S Bakkour, J Y Lee, T Kadesch, R R Hardy, J C Aster,[...]. Immunity 1999
23
Delta-like 4 is the essential, nonredundant ligand for Notch1 during thymic T cell lineage commitment.
Ute Koch, Emma Fiorini, Rui Benedito, Valerie Besseyrias, Karin Schuster-Gossler, Michel Pierres, Nancy R Manley, Antonio Duarte, H Robson Macdonald, Freddy Radtke. J Exp Med 2008
Ute Koch, Emma Fiorini, Rui Benedito, Valerie Besseyrias, Karin Schuster-Gossler, Michel Pierres, Nancy R Manley, Antonio Duarte, H Robson Macdonald, Freddy Radtke. J Exp Med 2008
20
A critical role for TCF-1 in T-lineage specification and differentiation.
Brittany Nicole Weber, Anthony Wei-Shine Chi, Alejandro Chavez, Yumi Yashiro-Ohtani, Qi Yang, Olga Shestova, Avinash Bhandoola. Nature 2011
Brittany Nicole Weber, Anthony Wei-Shine Chi, Alejandro Chavez, Yumi Yashiro-Ohtani, Qi Yang, Olga Shestova, Avinash Bhandoola. Nature 2011
17
Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage development.
Toshiki Saito, Shigeru Chiba, Motoshi Ichikawa, Atsushi Kunisato, Takashi Asai, Kiyoshi Shimizu, Tomoyuki Yamaguchi, Go Yamamoto, Sachiko Seo, Keiki Kumano,[...]. Immunity 2003
Toshiki Saito, Shigeru Chiba, Motoshi Ichikawa, Atsushi Kunisato, Takashi Asai, Kiyoshi Shimizu, Tomoyuki Yamaguchi, Go Yamamoto, Sachiko Seo, Keiki Kumano,[...]. Immunity 2003
16
Notch 1-deficient common lymphoid precursors adopt a B cell fate in the thymus.
A Wilson, H R MacDonald, F Radtke. J Exp Med 2001
A Wilson, H R MacDonald, F Radtke. J Exp Med 2001
15
Developmental gene networks: a triathlon on the course to T cell identity.
Mary A Yui, Ellen V Rothenberg. Nat Rev Immunol 2014
Mary A Yui, Ellen V Rothenberg. Nat Rev Immunol 2014
14
Induction of T cell development from hematopoietic progenitor cells by delta-like-1 in vitro.
Thomas M Schmitt, Juan Carlos Zúñiga-Pflücker. Immunity 2002
Thomas M Schmitt, Juan Carlos Zúñiga-Pflücker. Immunity 2002
14
14
TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms.
L W Ellisen, J Bird, D C West, A L Soreng, T C Reynolds, S D Smith, J Sklar. Cell 1991
L W Ellisen, J Bird, D C West, A L Soreng, T C Reynolds, S D Smith, J Sklar. Cell 1991
13
Inducible gene knockout of transcription factor recombination signal binding protein-J reveals its essential role in T versus B lineage decision.
Hua Han, Kenji Tanigaki, Norio Yamamoto, Kazuki Kuroda, Momoko Yoshimoto, Tatsutoshi Nakahata, Koichi Ikuta, Tasuku Honjo. Int Immunol 2002
Hua Han, Kenji Tanigaki, Norio Yamamoto, Kazuki Kuroda, Momoko Yoshimoto, Tatsutoshi Nakahata, Koichi Ikuta, Tasuku Honjo. Int Immunol 2002
12
An early T cell lineage commitment checkpoint dependent on the transcription factor Bcl11b.
Long Li, Mark Leid, Ellen V Rothenberg. Science 2010
Long Li, Mark Leid, Ellen V Rothenberg. Science 2010
12
T-cell factor 1 is a gatekeeper for T-cell specification in response to Notch signaling.
Kristine Germar, Marei Dose, Tassos Konstantinou, Jiangwen Zhang, Hongfang Wang, Camille Lobry, Kelly L Arnett, Stephen C Blacklow, Iannis Aifantis, Jon C Aster,[...]. Proc Natl Acad Sci U S A 2011
Kristine Germar, Marei Dose, Tassos Konstantinou, Jiangwen Zhang, Hongfang Wang, Camille Lobry, Kelly L Arnett, Stephen C Blacklow, Iannis Aifantis, Jon C Aster,[...]. Proc Natl Acad Sci U S A 2011
12
Therapeutic antibody targeting of individual Notch receptors.
Yan Wu, Carol Cain-Hom, Lisa Choy, Thijs J Hagenbeek, Gladys P de Leon, Yongmei Chen, David Finkle, Rayna Venook, Xiumin Wu, John Ridgway,[...]. Nature 2010
Yan Wu, Carol Cain-Hom, Lisa Choy, Thijs J Hagenbeek, Gladys P de Leon, Yongmei Chen, David Finkle, Rayna Venook, Xiumin Wu, John Ridgway,[...]. Nature 2010
12
RBPJ-dependent Notch signaling initiates the T cell program in a subset of thymus-seeding progenitors.
Edward L Y Chen, Patrycja K Thompson, Juan Carlos Zúñiga-Pflücker. Nat Immunol 2019
Edward L Y Chen, Patrycja K Thompson, Juan Carlos Zúñiga-Pflücker. Nat Immunol 2019
38
Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia.
Teresa Palomero, Maria Luisa Sulis, Maria Cortina, Pedro J Real, Kelly Barnes, Maria Ciofani, Esther Caparros, Jean Buteau, Kristy Brown, Sherrie L Perkins,[...]. Nat Med 2007
Teresa Palomero, Maria Luisa Sulis, Maria Cortina, Pedro J Real, Kelly Barnes, Maria Ciofani, Esther Caparros, Jean Buteau, Kristy Brown, Sherrie L Perkins,[...]. Nat Med 2007
11
NOTCH1-RBPJ complexes drive target gene expression through dynamic interactions with superenhancers.
Hongfang Wang, Chongzhi Zang, Len Taing, Kelly L Arnett, Yinling Joey Wong, Warren S Pear, Stephen C Blacklow, X Shirley Liu, Jon C Aster. Proc Natl Acad Sci U S A 2014
Hongfang Wang, Chongzhi Zang, Len Taing, Kelly L Arnett, Yinling Joey Wong, Warren S Pear, Stephen C Blacklow, X Shirley Liu, Jon C Aster. Proc Natl Acad Sci U S A 2014
11
Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles.
W S Pear, J C Aster, M L Scott, R P Hasserjian, B Soffer, J Sklar, D Baltimore. J Exp Med 1996
W S Pear, J C Aster, M L Scott, R P Hasserjian, B Soffer, J Sklar, D Baltimore. J Exp Med 1996
11
Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells.
Derk Amsen, J Magarian Blander, Gap Ryol Lee, Kenji Tanigaki, Tasuku Honjo, Richard A Flavell. Cell 2004
Derk Amsen, J Magarian Blander, Gap Ryol Lee, Kenji Tanigaki, Tasuku Honjo, Richard A Flavell. Cell 2004
11
Notch promotes survival of pre-T cells at the beta-selection checkpoint by regulating cellular metabolism.
Maria Ciofani, Juan Carlos Zúñiga-Pflücker. Nat Immunol 2005
Maria Ciofani, Juan Carlos Zúñiga-Pflücker. Nat Immunol 2005
10
Notch signaling: cell fate control and signal integration in development.
S Artavanis-Tsakonas, M D Rand, R J Lake. Science 1999
S Artavanis-Tsakonas, M D Rand, R J Lake. Science 1999
10
FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors.
Jennifer O'Neil, Jonathan Grim, Peter Strack, Sudhir Rao, Deanne Tibbitts, Christopher Winter, James Hardwick, Markus Welcker, Jules P Meijerink, Rob Pieters,[...]. J Exp Med 2007
Jennifer O'Neil, Jonathan Grim, Peter Strack, Sudhir Rao, Deanne Tibbitts, Christopher Winter, James Hardwick, Markus Welcker, Jules P Meijerink, Rob Pieters,[...]. J Exp Med 2007
10
Deletion of Notch1 converts pro-T cells to dendritic cells and promotes thymic B cells by cell-extrinsic and cell-intrinsic mechanisms.
Thorsten B Feyerabend, Grzegorz Terszowski, Annette Tietz, Carmen Blum, Hervé Luche, Achim Gossler, Nicholas W Gale, Freddy Radtke, Hans Jörg Fehling, Hans-Reimer Rodewald. Immunity 2009
Thorsten B Feyerabend, Grzegorz Terszowski, Annette Tietz, Carmen Blum, Hervé Luche, Achim Gossler, Nicholas W Gale, Freddy Radtke, Hans Jörg Fehling, Hans-Reimer Rodewald. Immunity 2009
10
A NOTCH1-driven MYC enhancer promotes T cell development, transformation and acute lymphoblastic leukemia.
Daniel Herranz, Alberto Ambesi-Impiombato, Teresa Palomero, Stephanie A Schnell, Laura Belver, Agnieszka A Wendorff, Luyao Xu, Mireia Castillo-Martin, David Llobet-Navás, Carlos Cordon-Cardo,[...]. Nat Med 2014
Daniel Herranz, Alberto Ambesi-Impiombato, Teresa Palomero, Stephanie A Schnell, Laura Belver, Agnieszka A Wendorff, Luyao Xu, Mireia Castillo-Martin, David Llobet-Navás, Carlos Cordon-Cardo,[...]. Nat Med 2014
10
Regulation of innate and adaptive immunity by Notch.
Freddy Radtke, H Robson MacDonald, Fabienne Tacchini-Cottier. Nat Rev Immunol 2013
Freddy Radtke, H Robson MacDonald, Fabienne Tacchini-Cottier. Nat Rev Immunol 2013
10
Notch simultaneously orchestrates multiple helper T cell programs independently of cytokine signals.
Will Bailis, Yumi Yashiro-Ohtani, Terry C Fang, Robin D Hatton, Casey T Weaver, David Artis, Warren S Pear. Immunity 2013
Will Bailis, Yumi Yashiro-Ohtani, Terry C Fang, Robin D Hatton, Casey T Weaver, David Artis, Warren S Pear. Immunity 2013
10
Lineage-Determining Transcription Factor TCF-1 Initiates the Epigenetic Identity of T Cells.
John L Johnson, Georgios Georgakilas, Jelena Petrovic, Makoto Kurachi, Stanley Cai, Christelle Harly, Warren S Pear, Avinash Bhandoola, E John Wherry, Golnaz Vahedi. Immunity 2018
John L Johnson, Georgios Georgakilas, Jelena Petrovic, Makoto Kurachi, Stanley Cai, Christelle Harly, Warren S Pear, Avinash Bhandoola, E John Wherry, Golnaz Vahedi. Immunity 2018
10
Delta-like 1 is necessary for the generation of marginal zone B cells but not T cells in vivo.
Katsuto Hozumi, Naoko Negishi, Daisuke Suzuki, Natsumi Abe, Yusuke Sotomaru, Norikazu Tamaoki, Carolina Mailhos, David Ish-Horowicz, Sonoko Habu, Michael J Owen. Nat Immunol 2004
Katsuto Hozumi, Naoko Negishi, Daisuke Suzuki, Natsumi Abe, Yusuke Sotomaru, Norikazu Tamaoki, Carolina Mailhos, David Ish-Horowicz, Sonoko Habu, Michael J Owen. Nat Immunol 2004
10
The Varied Roles of Notch in Cancer.
Jon C Aster, Warren S Pear, Stephen C Blacklow. Annu Rev Pathol 2017
Jon C Aster, Warren S Pear, Stephen C Blacklow. Annu Rev Pathol 2017
10
Notch1 but not Notch2 is essential for generating hematopoietic stem cells from endothelial cells.
Keiki Kumano, Shigeru Chiba, Atsushi Kunisato, Masataka Sata, Toshiki Saito, Etsuko Nakagami-Yamaguchi, Tomoyuki Yamaguchi, Shigeo Masuda, Kiyoshi Shimizu, Tokiharu Takahashi,[...]. Immunity 2003
Keiki Kumano, Shigeru Chiba, Atsushi Kunisato, Masataka Sata, Toshiki Saito, Etsuko Nakagami-Yamaguchi, Tomoyuki Yamaguchi, Shigeo Masuda, Kiyoshi Shimizu, Tokiharu Takahashi,[...]. Immunity 2003
9
Notch-RBP-J signaling is involved in cell fate determination of marginal zone B cells.
Kenji Tanigaki, Hua Han, Norio Yamamoto, Kei Tashiro, Masaya Ikegawa, Kazuki Kuroda, Akira Suzuki, Toru Nakano, Tasuku Honjo. Nat Immunol 2002
Kenji Tanigaki, Hua Han, Norio Yamamoto, Kei Tashiro, Masaya Ikegawa, Kazuki Kuroda, Akira Suzuki, Toru Nakano, Tasuku Honjo. Nat Immunol 2002
9
Inactivation of Notch1 impairs VDJbeta rearrangement and allows pre-TCR-independent survival of early alpha beta Lineage Thymocytes.
Anita Wolfer, Anne Wilson, Mohamed Nemir, H Robson MacDonald, Freddy Radtke. Immunity 2002
Anita Wolfer, Anne Wilson, Mohamed Nemir, H Robson MacDonald, Freddy Radtke. Immunity 2002
9
An essential developmental checkpoint for production of the T cell lineage.
Tomokatsu Ikawa, Satoshi Hirose, Kyoko Masuda, Kiyokazu Kakugawa, Rumi Satoh, Asako Shibano-Satoh, Ryo Kominami, Yoshimoto Katsura, Hiroshi Kawamoto. Science 2010
Tomokatsu Ikawa, Satoshi Hirose, Kyoko Masuda, Kiyokazu Kakugawa, Rumi Satoh, Asako Shibano-Satoh, Ryo Kominami, Yoshimoto Katsura, Hiroshi Kawamoto. Science 2010
9
NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth.
Teresa Palomero, Wei Keat Lim, Duncan T Odom, Maria Luisa Sulis, Pedro J Real, Adam Margolin, Kelly C Barnes, Jennifer O'Neil, Donna Neuberg, Andrew P Weng,[...]. Proc Natl Acad Sci U S A 2006
Teresa Palomero, Wei Keat Lim, Duncan T Odom, Maria Luisa Sulis, Pedro J Real, Adam Margolin, Kelly C Barnes, Jennifer O'Neil, Donna Neuberg, Andrew P Weng,[...]. Proc Natl Acad Sci U S A 2006
9
c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma.
Andrew P Weng, John M Millholland, Yumi Yashiro-Ohtani, Marie Laure Arcangeli, Arthur Lau, Carol Wai, Cristina Del Bianco, Carlos G Rodriguez, Hong Sai, John Tobias,[...]. Genes Dev 2006
Andrew P Weng, John M Millholland, Yumi Yashiro-Ohtani, Marie Laure Arcangeli, Arthur Lau, Carol Wai, Cristina Del Bianco, Carlos G Rodriguez, Hong Sai, John Tobias,[...]. Genes Dev 2006
9
Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells.
Johan H van Es, Marielle E van Gijn, Orbicia Riccio, Maaike van den Born, Marc Vooijs, Harry Begthel, Miranda Cozijnsen, Sylvie Robine, Doug J Winton, Freddy Radtke,[...]. Nature 2005
Johan H van Es, Marielle E van Gijn, Orbicia Riccio, Maaike van den Born, Marc Vooijs, Harry Begthel, Miranda Cozijnsen, Sylvie Robine, Doug J Winton, Freddy Radtke,[...]. Nature 2005
9
Specific fibroblastic niches in secondary lymphoid organs orchestrate distinct Notch-regulated immune responses.
Nicolas Fasnacht, Hsin-Ying Huang, Ute Koch, Stéphanie Favre, Floriane Auderset, Qian Chai, Lucas Onder, Sandra Kallert, Daniel D Pinschewer, H Robson MacDonald,[...]. J Exp Med 2014
Nicolas Fasnacht, Hsin-Ying Huang, Ute Koch, Stéphanie Favre, Floriane Auderset, Qian Chai, Lucas Onder, Sandra Kallert, Daniel D Pinschewer, H Robson MacDonald,[...]. J Exp Med 2014
9
Asynchronous combinatorial action of four regulatory factors activates Bcl11b for T cell commitment.
Hao Yuan Kueh, Mary A Yui, Kenneth K H Ng, Shirley S Pease, Jingli A Zhang, Sagar S Damle, George Freedman, Sharmayne Siu, Irwin D Bernstein, Michael B Elowitz,[...]. Nat Immunol 2016
Hao Yuan Kueh, Mary A Yui, Kenneth K H Ng, Shirley S Pease, Jingli A Zhang, Sagar S Damle, George Freedman, Sharmayne Siu, Irwin D Bernstein, Michael B Elowitz,[...]. Nat Immunol 2016
10
Notch signaling: simplicity in design, versatility in function.
Emma R Andersson, Rickard Sandberg, Urban Lendahl. Development 2011
Emma R Andersson, Rickard Sandberg, Urban Lendahl. Development 2011
8
Genome-wide analysis reveals conserved and divergent features of Notch1/RBPJ binding in human and murine T-lymphoblastic leukemia cells.
Hongfang Wang, James Zou, Bo Zhao, Eric Johannsen, Todd Ashworth, Hoifung Wong, Warren S Pear, Jonathan Schug, Stephen C Blacklow, Kelly L Arnett,[...]. Proc Natl Acad Sci U S A 2011
Hongfang Wang, James Zou, Bo Zhao, Eric Johannsen, Todd Ashworth, Hoifung Wong, Warren S Pear, Jonathan Schug, Stephen C Blacklow, Kelly L Arnett,[...]. Proc Natl Acad Sci U S A 2011
8
Canonical notch signaling is dispensable for the maintenance of adult hematopoietic stem cells.
Ivan Maillard, Ute Koch, Alexis Dumortier, Olga Shestova, Lanwei Xu, Hong Sai, Seth E Pross, Jon C Aster, Avinash Bhandoola, Freddy Radtke,[...]. Cell Stem Cell 2008
Ivan Maillard, Ute Koch, Alexis Dumortier, Olga Shestova, Lanwei Xu, Hong Sai, Seth E Pross, Jon C Aster, Avinash Bhandoola, Freddy Radtke,[...]. Cell Stem Cell 2008
8
Jagged1-dependent Notch signaling is dispensable for hematopoietic stem cell self-renewal and differentiation.
Stéphane J C Mancini, Ned Mantei, Alexis Dumortier, Ueli Suter, H Robson MacDonald, Freddy Radtke. Blood 2005
Stéphane J C Mancini, Ned Mantei, Alexis Dumortier, Ueli Suter, H Robson MacDonald, Freddy Radtke. Blood 2005
8
Mastermind critically regulates Notch-mediated lymphoid cell fate decisions.
Ivan Maillard, Andrew P Weng, Andrea C Carpenter, Carlos G Rodriguez, Hong Sai, Lanwei Xu, David Allman, Jon C Aster, Warren S Pear. Blood 2004
Ivan Maillard, Andrew P Weng, Andrea C Carpenter, Carlos G Rodriguez, Hong Sai, Lanwei Xu, David Allman, Jon C Aster, Warren S Pear. Blood 2004
8
Control of peripheral tolerance by regulatory T cell-intrinsic Notch signaling.
Louis-Marie Charbonnier, Sen Wang, Peter Georgiev, Esen Sefik, Talal A Chatila. Nat Immunol 2015
Louis-Marie Charbonnier, Sen Wang, Peter Georgiev, Esen Sefik, Talal A Chatila. Nat Immunol 2015
10
A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia.
Apostolos Klinakis, Camille Lobry, Omar Abdel-Wahab, Philmo Oh, Hiroshi Haeno, Silvia Buonamici, Inge van De Walle, Severine Cathelin, Thomas Trimarchi, Elisa Araldi,[...]. Nature 2011
Apostolos Klinakis, Camille Lobry, Omar Abdel-Wahab, Philmo Oh, Hiroshi Haeno, Silvia Buonamici, Inge van De Walle, Severine Cathelin, Thomas Trimarchi, Elisa Araldi,[...]. Nature 2011
8
Direct comparison of Dll1- and Dll4-mediated Notch activation levels shows differential lymphomyeloid lineage commitment outcomes.
Mahmood Mohtashami, Divya K Shah, Hiroshi Nakase, Korosh Kianizad, Howard T Petrie, Juan Carlos Zúñiga-Pflücker. J Immunol 2010
Mahmood Mohtashami, Divya K Shah, Hiroshi Nakase, Korosh Kianizad, Howard T Petrie, Juan Carlos Zúñiga-Pflücker. J Immunol 2010
8
The cis-Regulatory Atlas of the Mouse Immune System.
Hideyuki Yoshida, Caleb A Lareau, Ricardo N Ramirez, Samuel A Rose, Barbara Maier, Aleksandra Wroblewska, Fiona Desland, Aleksey Chudnovskiy, Arthur Mortha, Claudia Dominguez,[...]. Cell 2019
Hideyuki Yoshida, Caleb A Lareau, Ricardo N Ramirez, Samuel A Rose, Barbara Maier, Aleksandra Wroblewska, Fiona Desland, Aleksey Chudnovskiy, Arthur Mortha, Claudia Dominguez,[...]. Cell 2019
8
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.