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Times Cited: 385
Times Cited: 385
Times Cited
Times Co-cited
Similarity
Variants of the melanocyte-stimulating hormone receptor gene are associated with red hair and fair skin in humans.
P Valverde, E Healy, I Jackson, J L Rees, A J Thody. Nat Genet 1995
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Melanocortin 1 receptor (MC1R) gene variants are associated with an increased risk for cutaneous melanoma which is largely independent of skin type and hair color.
C Kennedy, J ter Huurne, M Berkhout, N Gruis, M Bastiaens, W Bergman, R Willemze, J N Bavinck. J Invest Dermatol 2001
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Characterization of melanocyte stimulating hormone receptor variant alleles in twins with red hair.
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MC1R variants, melanoma and red hair color phenotype: a meta-analysis.
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An ultraviolet-radiation-independent pathway to melanoma carcinogenesis in the red hair/fair skin background.
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alpha-Melanocortin and endothelin-1 activate antiapoptotic pathways and reduce DNA damage in human melanocytes.
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The Asp84Glu variant of the melanocortin 1 receptor (MC1R) is associated with melanoma.
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Melanocortin-1 receptor structure and functional regulation.
José C García-Borrón, Berta L Sánchez-Laorden, Celia Jiménez-Cervantes. Pigment Cell Res 2005
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Topical drug rescue strategy and skin protection based on the role of Mc1r in UV-induced tanning.
John A D'Orazio, Tetsuji Nobuhisa, Rutao Cui, Michelle Arya, Malinda Spry, Kazumasa Wakamatsu, Vivien Igras, Takahiro Kunisada, Scott R Granter, Emi K Nishimura,[...]. Nature 2006
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Interactive effects of MC1R and OCA2 on melanoma risk phenotypes.
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Melanocortin 1 receptor genotype: an important determinant of the damage response of melanocytes to ultraviolet radiation.
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Melanocortin 1 receptor variants in an Irish population.
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MC1R, ASIP, and DNA repair in sporadic and familial melanoma in a Mediterranean population.
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alpha-Melanocyte-stimulating hormone protects from ultraviolet radiation-induced apoptosis and DNA damage.
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Does MC1R genotype convey information about melanoma risk beyond risk phenotypes?
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MC1R genotype modifies risk of melanoma in families segregating CDKN2A mutations.
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Alpha-melanocyte-stimulating hormone suppresses oxidative stress through a p53-mediated signaling pathway in human melanocytes.
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alpha-MSH activates immediate defense responses to UV-induced oxidative stress in human melanocytes.
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Melanocortin 1 receptor and risk of cutaneous melanoma: a meta-analysis and estimates of population burden.
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Human melanocortin 1 receptor variants, receptor function and melanocyte response to UV radiation.
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Comprehensive evaluation of allele frequency differences of MC1R variants across populations.
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Population-based study of natural variation in the melanocortin-1 receptor gene and melanoma.
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A novel recurrent mutation in MITF predisposes to familial and sporadic melanoma.
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A SUMOylation-defective MITF germline mutation predisposes to melanoma and renal carcinoma.
Corine Bertolotto, Fabienne Lesueur, Sandy Giuliano, Thomas Strub, Mahaut de Lichy, Karine Bille, Philippe Dessen, Benoit d'Hayer, Hamida Mohamdi, Audrey Remenieras,[...]. Nature 2011
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Melanocortin-1 receptor gene variants determine the risk of nonmelanoma skin cancer independently of fair skin and red hair.
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Central role of p53 in the suntan response and pathologic hyperpigmentation.
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alpha-MSH tripeptide analogs activate the melanocortin 1 receptor and reduce UV-induced DNA damage in human melanocytes.
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Germline MC1R status influences somatic mutation burden in melanoma.
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MC1R germline variants confer risk for BRAF-mutant melanoma.
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Melanin content and MC1R function independently affect UVR-induced DNA damage in cultured human melanocytes.
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Altered cell surface expression of human MC1R variant receptor alleles associated with red hair and skin cancer risk.
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A landscape of driver mutations in melanoma.
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MC1R variants increased the risk of sporadic cutaneous melanoma in darker-pigmented Caucasians: a pooled-analysis from the M-SKIP project.
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Multiple pigmentation gene polymorphisms account for a substantial proportion of risk of cutaneous malignant melanoma.
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Receptor function, dominant negative activity and phenotype correlations for MC1R variant alleles.
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Evidence for variable selective pressures at MC1R.
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The cloning of a family of genes that encode the melanocortin receptors.
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Significance of the melanocortin 1 receptor in the DNA damage response of human melanocytes to ultraviolet radiation.
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Germline mutations in the p16INK4a binding domain of CDK4 in familial melanoma.
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Binding of melanotropic hormones to the melanocortin receptor MC1R on human melanocytes stimulates proliferation and melanogenesis.
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MC1R is a potent regulator of PTEN after UV exposure in melanocytes.
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Genome-wide association study identifies three loci associated with melanoma risk.
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Loss of function mutations of the human melanocortin 1 receptor are common and are associated with red hair.
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Genome-wide association study identifies novel loci predisposing to cutaneous melanoma.
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MC1R, the cAMP pathway, and the response to solar UV: extending the horizon beyond pigmentation.
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POT1 loss-of-function variants predispose to familial melanoma.
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Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.