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Times Cited: 2779
Times Cited: 2779
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Molecular mechanisms of epithelial-mesenchymal transition.
Samy Lamouille, Jian Xu, Rik Derynck. Nat Rev Mol Cell Biol 2014
Samy Lamouille, Jian Xu, Rik Derynck. Nat Rev Mol Cell Biol 2014
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The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells.
E Batlle, E Sancho, C Francí, D Domínguez, M Monfar, J Baulida, A García De Herreros. Nat Cell Biol 2000
E Batlle, E Sancho, C Francí, D Domínguez, M Monfar, J Baulida, A García De Herreros. Nat Cell Biol 2000
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New insights into the mechanisms of epithelial-mesenchymal transition and implications for cancer.
Anushka Dongre, Robert A Weinberg. Nat Rev Mol Cell Biol 2019
Anushka Dongre, Robert A Weinberg. Nat Rev Mol Cell Biol 2019
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20
Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis.
Jing Yang, Sendurai A Mani, Joana Liu Donaher, Sridhar Ramaswamy, Raphael A Itzykson, Christophe Come, Pierre Savagner, Inna Gitelman, Andrea Richardson, Robert A Weinberg. Cell 2004
Jing Yang, Sendurai A Mani, Joana Liu Donaher, Sridhar Ramaswamy, Raphael A Itzykson, Christophe Come, Pierre Savagner, Inna Gitelman, Andrea Richardson, Robert A Weinberg. Cell 2004
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The epithelial-mesenchymal transition generates cells with properties of stem cells.
Sendurai A Mani, Wenjun Guo, Mai-Jing Liao, Elinor Ng Eaton, Ayyakkannu Ayyanan, Alicia Y Zhou, Mary Brooks, Ferenc Reinhard, Cheng Cheng Zhang, Michail Shipitsin,[...]. Cell 2008
Sendurai A Mani, Wenjun Guo, Mai-Jing Liao, Elinor Ng Eaton, Ayyakkannu Ayyanan, Alicia Y Zhou, Mary Brooks, Ferenc Reinhard, Cheng Cheng Zhang, Michail Shipitsin,[...]. Cell 2008
14
Epithelial-mesenchymal transitions in development and disease.
Jean Paul Thiery, Hervé Acloque, Ruby Y J Huang, M Angela Nieto. Cell 2009
Jean Paul Thiery, Hervé Acloque, Ruby Y J Huang, M Angela Nieto. Cell 2009
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The basics of epithelial-mesenchymal transition.
Raghu Kalluri, Robert A Weinberg. J Clin Invest 2009
Raghu Kalluri, Robert A Weinberg. J Clin Invest 2009
13
The transcription factor Slug represses E-cadherin expression and induces epithelial to mesenchymal transitions: a comparison with Snail and E47 repressors.
Victoria Bolós, Hector Peinado, Mirna A Pérez-Moreno, Mario F Fraga, Manel Esteller, Amparo Cano. J Cell Sci 2003
Victoria Bolós, Hector Peinado, Mirna A Pérez-Moreno, Mario F Fraga, Manel Esteller, Amparo Cano. J Cell Sci 2003
13
Guidelines and definitions for research on epithelial-mesenchymal transition.
Jing Yang, Parker Antin, Geert Berx, Cédric Blanpain, Thomas Brabletz, Marianne Bronner, Kyra Campbell, Amparo Cano, Jordi Casanova, Gerhard Christofori,[...]. Nat Rev Mol Cell Biol 2020
Jing Yang, Parker Antin, Geert Berx, Cédric Blanpain, Thomas Brabletz, Marianne Bronner, Kyra Campbell, Amparo Cano, Jordi Casanova, Gerhard Christofori,[...]. Nat Rev Mol Cell Biol 2020
12
The EMT-activator Zeb1 is a key factor for cell plasticity and promotes metastasis in pancreatic cancer.
Angela M Krebs, Julia Mitschke, María Lasierra Losada, Otto Schmalhofer, Melanie Boerries, Hauke Busch, Martin Boettcher, Dimitrios Mougiakakos, Wilfried Reichardt, Peter Bronsert,[...]. Nat Cell Biol 2017
Angela M Krebs, Julia Mitschke, María Lasierra Losada, Otto Schmalhofer, Melanie Boerries, Hauke Busch, Martin Boettcher, Dimitrios Mougiakakos, Wilfried Reichardt, Peter Bronsert,[...]. Nat Cell Biol 2017
11
The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion.
J Comijn, G Berx, P Vermassen, K Verschueren, L van Grunsven, E Bruyneel, M Mareel, D Huylebroeck, F van Roy. Mol Cell 2001
J Comijn, G Berx, P Vermassen, K Verschueren, L van Grunsven, E Bruyneel, M Mareel, D Huylebroeck, F van Roy. Mol Cell 2001
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Identification of the tumour transition states occurring during EMT.
Ievgenia Pastushenko, Audrey Brisebarre, Alejandro Sifrim, Marco Fioramonti, Tatiana Revenco, Soufiane Boumahdi, Alexandra Van Keymeulen, Daniel Brown, Virginie Moers, Sophie Lemaire,[...]. Nature 2018
Ievgenia Pastushenko, Audrey Brisebarre, Alejandro Sifrim, Marco Fioramonti, Tatiana Revenco, Soufiane Boumahdi, Alexandra Van Keymeulen, Daniel Brown, Virginie Moers, Sophie Lemaire,[...]. Nature 2018
10
Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer.
Xiaofeng Zheng, Julienne L Carstens, Jiha Kim, Matthew Scheible, Judith Kaye, Hikaru Sugimoto, Chia-Chin Wu, Valerie S LeBleu, Raghu Kalluri. Nature 2015
Xiaofeng Zheng, Julienne L Carstens, Jiha Kim, Matthew Scheible, Judith Kaye, Hikaru Sugimoto, Chia-Chin Wu, Valerie S LeBleu, Raghu Kalluri. Nature 2015
10
Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?
Héctor Peinado, David Olmeda, Amparo Cano. Nat Rev Cancer 2007
Héctor Peinado, David Olmeda, Amparo Cano. Nat Rev Cancer 2007
10
DeltaEF1 is a transcriptional repressor of E-cadherin and regulates epithelial plasticity in breast cancer cells.
Andreas Eger, Kirsten Aigner, Stefan Sonderegger, Brigitta Dampier, Susanne Oehler, Martin Schreiber, Geert Berx, Amparo Cano, Hartmut Beug, Roland Foisner. Oncogene 2005
Andreas Eger, Kirsten Aigner, Stefan Sonderegger, Brigitta Dampier, Susanne Oehler, Martin Schreiber, Geert Berx, Amparo Cano, Hartmut Beug, Roland Foisner. Oncogene 2005
10
EMT in cancer.
Thomas Brabletz, Raghu Kalluri, M Angela Nieto, Robert A Weinberg. Nat Rev Cancer 2018
Thomas Brabletz, Raghu Kalluri, M Angela Nieto, Robert A Weinberg. Nat Rev Cancer 2018
10
Metastatic colonization requires the repression of the epithelial-mesenchymal transition inducer Prrx1.
Oscar H Ocaña, Rebeca Córcoles, Angels Fabra, Gema Moreno-Bueno, Hervé Acloque, Sonia Vega, Alejandro Barrallo-Gimeno, Amparo Cano, M Angela Nieto. Cancer Cell 2012
Oscar H Ocaña, Rebeca Córcoles, Angels Fabra, Gema Moreno-Bueno, Hervé Acloque, Sonia Vega, Alejandro Barrallo-Gimeno, Amparo Cano, M Angela Nieto. Cancer Cell 2012
9
Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries.
Hyuna Sung, Jacques Ferlay, Rebecca L Siegel, Mathieu Laversanne, Isabelle Soerjomataram, Ahmedin Jemal, Freddie Bray. CA Cancer J Clin 2021
Hyuna Sung, Jacques Ferlay, Rebecca L Siegel, Mathieu Laversanne, Isabelle Soerjomataram, Ahmedin Jemal, Freddie Bray. CA Cancer J Clin 2021
9
Epithelial-Mesenchymal Plasticity in Cancer Progression and Metastasis.
Wei Lu, Yibin Kang. Dev Cell 2019
Wei Lu, Yibin Kang. Dev Cell 2019
9
Linking EMT programmes to normal and neoplastic epithelial stem cells.
Arthur W Lambert, Robert A Weinberg. Nat Rev Cancer 2021
Arthur W Lambert, Robert A Weinberg. Nat Rev Cancer 2021
8
ZEB1 represses E-cadherin and induces an EMT by recruiting the SWI/SNF chromatin-remodeling protein BRG1.
E Sánchez-Tilló, A Lázaro, R Torrent, M Cuatrecasas, E C Vaquero, A Castells, P Engel, A Postigo. Oncogene 2010
E Sánchez-Tilló, A Lázaro, R Torrent, M Cuatrecasas, E C Vaquero, A Castells, P Engel, A Postigo. Oncogene 2010
8
TGF-beta-induced epithelial to mesenchymal transition.
Jian Xu, Samy Lamouille, Rik Derynck. Cell Res 2009
Jian Xu, Samy Lamouille, Rik Derynck. Cell Res 2009
8
The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1.
Philip A Gregory, Andrew G Bert, Emily L Paterson, Simon C Barry, Anna Tsykin, Gelareh Farshid, Mathew A Vadas, Yeesim Khew-Goodall, Gregory J Goodall. Nat Cell Biol 2008
Philip A Gregory, Andrew G Bert, Emily L Paterson, Simon C Barry, Anna Tsykin, Gelareh Farshid, Mathew A Vadas, Yeesim Khew-Goodall, Gregory J Goodall. Nat Cell Biol 2008
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EMT Transition States during Tumor Progression and Metastasis.
Ievgenia Pastushenko, Cédric Blanpain. Trends Cell Biol 2019
Ievgenia Pastushenko, Cédric Blanpain. Trends Cell Biol 2019
8
Circulating breast tumor cells exhibit dynamic changes in epithelial and mesenchymal composition.
Min Yu, Aditya Bardia, Ben S Wittner, Shannon L Stott, Malgorzata E Smas, David T Ting, Steven J Isakoff, Jordan C Ciciliano, Marissa N Wells, Ajay M Shah,[...]. Science 2013
Min Yu, Aditya Bardia, Ben S Wittner, Shannon L Stott, Malgorzata E Smas, David T Ting, Steven J Isakoff, Jordan C Ciciliano, Marissa N Wells, Ajay M Shah,[...]. Science 2013
7
Non-redundant functions of EMT transcription factors.
Marc P Stemmler, Rebecca L Eccles, Simone Brabletz, Thomas Brabletz. Nat Cell Biol 2019
Marc P Stemmler, Rebecca L Eccles, Simone Brabletz, Thomas Brabletz. Nat Cell Biol 2019
7
7
G9a interacts with Snail and is critical for Snail-mediated E-cadherin repression in human breast cancer.
Chenfang Dong, Yadi Wu, Jun Yao, Yifan Wang, Yinhua Yu, Piotr G Rychahou, B Mark Evers, Binhua P Zhou. J Clin Invest 2012
Chenfang Dong, Yadi Wu, Jun Yao, Yifan Wang, Yinhua Yu, Piotr G Rychahou, B Mark Evers, Binhua P Zhou. J Clin Invest 2012
7
The SLUG zinc-finger protein represses E-cadherin in breast cancer.
Karen M Hajra, David Y-S Chen, Eric R Fearon. Cancer Res 2002
Karen M Hajra, David Y-S Chen, Eric R Fearon. Cancer Res 2002
7
The E-Cadherin and N-Cadherin Switch in Epithelial-to-Mesenchymal Transition: Signaling, Therapeutic Implications, and Challenges.
Chin-Yap Loh, Jian Yi Chai, Ting Fang Tang, Won Fen Wong, Gautam Sethi, Muthu Kumaraswamy Shanmugam, Pei Pei Chong, Chung Yeng Looi. Cells 2019
Chin-Yap Loh, Jian Yi Chai, Ting Fang Tang, Won Fen Wong, Gautam Sethi, Muthu Kumaraswamy Shanmugam, Pei Pei Chong, Chung Yeng Looi. Cells 2019
7
EMT Subtype Influences Epithelial Plasticity and Mode of Cell Migration.
Nicole M Aiello, Ravikanth Maddipati, Robert J Norgard, David Balli, Jinyang Li, Salina Yuan, Taiji Yamazoe, Taylor Black, Amine Sahmoud, Emma E Furth,[...]. Dev Cell 2018
Nicole M Aiello, Ravikanth Maddipati, Robert J Norgard, David Balli, Jinyang Li, Salina Yuan, Taiji Yamazoe, Taylor Black, Amine Sahmoud, Emma E Furth,[...]. Dev Cell 2018
6
Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance.
Kari R Fischer, Anna Durrans, Sharrell Lee, Jianting Sheng, Fuhai Li, Stephen T C Wong, Hyejin Choi, Tina El Rayes, Seongho Ryu, Juliane Troeger,[...]. Nature 2015
Kari R Fischer, Anna Durrans, Sharrell Lee, Jianting Sheng, Fuhai Li, Stephen T C Wong, Hyejin Choi, Tina El Rayes, Seongho Ryu, Juliane Troeger,[...]. Nature 2015
6
6
Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition.
Binhua P Zhou, Jiong Deng, Weiya Xia, Jihong Xu, Yan M Li, Mehmet Gunduz, Mien-Chie Hung. Nat Cell Biol 2004
Binhua P Zhou, Jiong Deng, Weiya Xia, Jihong Xu, Yan M Li, Mehmet Gunduz, Mien-Chie Hung. Nat Cell Biol 2004
6
Direct regulation of TWIST by HIF-1alpha promotes metastasis.
Muh-Hwa Yang, Min-Zu Wu, Shih-Hwa Chiou, Po-Min Chen, Shyue-Yih Chang, Chung-Ji Liu, Shu-Chun Teng, Kou-Juey Wu. Nat Cell Biol 2008
Muh-Hwa Yang, Min-Zu Wu, Shih-Hwa Chiou, Po-Min Chen, Shyue-Yih Chang, Chung-Ji Liu, Shu-Chun Teng, Kou-Juey Wu. Nat Cell Biol 2008
6
Functional cooperation between Snail1 and twist in the regulation of ZEB1 expression during epithelial to mesenchymal transition.
Natàlia Dave, Sandra Guaita-Esteruelas, Susana Gutarra, Àlex Frias, Manuel Beltran, Sandra Peiró, Antonio García de Herreros. J Biol Chem 2011
Natàlia Dave, Sandra Guaita-Esteruelas, Susana Gutarra, Àlex Frias, Manuel Beltran, Sandra Peiró, Antonio García de Herreros. J Biol Chem 2011
6
Signaling mechanisms of the epithelial-mesenchymal transition.
David M Gonzalez, Damian Medici. Sci Signal 2014
David M Gonzalez, Damian Medici. Sci Signal 2014
6
Epithelial-to-mesenchymal transition induces cell cycle arrest and parenchymal damage in renal fibrosis.
Sara Lovisa, Valerie S LeBleu, Björn Tampe, Hikaru Sugimoto, Komal Vadnagara, Julienne L Carstens, Chia-Chin Wu, Yohannes Hagos, Birgitta C Burckhardt, Tsvetelina Pentcheva-Hoang,[...]. Nat Med 2015
Sara Lovisa, Valerie S LeBleu, Björn Tampe, Hikaru Sugimoto, Komal Vadnagara, Julienne L Carstens, Chia-Chin Wu, Yohannes Hagos, Birgitta C Burckhardt, Tsvetelina Pentcheva-Hoang,[...]. Nat Med 2015
6
6
Distinct EMT programs control normal mammary stem cells and tumour-initiating cells.
Xin Ye, Wai Leong Tam, Tsukasa Shibue, Yasemin Kaygusuz, Ferenc Reinhardt, Elinor Ng Eaton, Robert A Weinberg. Nature 2015
Xin Ye, Wai Leong Tam, Tsukasa Shibue, Yasemin Kaygusuz, Ferenc Reinhardt, Elinor Ng Eaton, Robert A Weinberg. Nature 2015
6
Spatiotemporal regulation of epithelial-mesenchymal transition is essential for squamous cell carcinoma metastasis.
Jeff H Tsai, Joana Liu Donaher, Danielle A Murphy, Sandra Chau, Jing Yang. Cancer Cell 2012
Jeff H Tsai, Joana Liu Donaher, Danielle A Murphy, Sandra Chau, Jing Yang. Cancer Cell 2012
6
Cancer metastasis is accelerated through immunosuppression during Snail-induced EMT of cancer cells.
Chie Kudo-Saito, Hiromi Shirako, Tadashi Takeuchi, Yutaka Kawakami. Cancer Cell 2009
Chie Kudo-Saito, Hiromi Shirako, Tadashi Takeuchi, Yutaka Kawakami. Cancer Cell 2009
6
Single-Cell Transcriptomic Analysis of Primary and Metastatic Tumor Ecosystems in Head and Neck Cancer.
Sidharth V Puram, Itay Tirosh, Anuraag S Parikh, Anoop P Patel, Keren Yizhak, Shawn Gillespie, Christopher Rodman, Christina L Luo, Edmund A Mroz, Kevin S Emerick,[...]. Cell 2017
Sidharth V Puram, Itay Tirosh, Anuraag S Parikh, Anoop P Patel, Keren Yizhak, Shawn Gillespie, Christopher Rodman, Christina L Luo, Edmund A Mroz, Kevin S Emerick,[...]. Cell 2017
6
EMT, the cytoskeleton, and cancer cell invasion.
Mahmut Yilmaz, Gerhard Christofori. Cancer Metastasis Rev 2009
Mahmut Yilmaz, Gerhard Christofori. Cancer Metastasis Rev 2009
6
Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries.
Freddie Bray, Jacques Ferlay, Isabelle Soerjomataram, Rebecca L Siegel, Lindsey A Torre, Ahmedin Jemal. CA Cancer J Clin 2018
Freddie Bray, Jacques Ferlay, Isabelle Soerjomataram, Rebecca L Siegel, Lindsey A Torre, Ahmedin Jemal. CA Cancer J Clin 2018
6
Controversies around epithelial-mesenchymal plasticity in cancer metastasis.
Elizabeth D Williams, Dingcheng Gao, Andrew Redfern, Erik W Thompson. Nat Rev Cancer 2019
Elizabeth D Williams, Dingcheng Gao, Andrew Redfern, Erik W Thompson. Nat Rev Cancer 2019
5
Epithelial-to-Mesenchymal Transition Contributes to Immunosuppression in Breast Carcinomas.
Anushka Dongre, Mohammad Rashidian, Ferenc Reinhardt, Aaron Bagnato, Zuzana Keckesova, Hidde L Ploegh, Robert A Weinberg. Cancer Res 2017
Anushka Dongre, Mohammad Rashidian, Ferenc Reinhardt, Aaron Bagnato, Zuzana Keckesova, Hidde L Ploegh, Robert A Weinberg. Cancer Res 2017
5
The epithelial-mesenchymal transition: new insights in signaling, development, and disease.
Jonathan M Lee, Shoukat Dedhar, Raghu Kalluri, Erik W Thompson. J Cell Biol 2006
Jonathan M Lee, Shoukat Dedhar, Raghu Kalluri, Erik W Thompson. J Cell Biol 2006
5
Twist is a transcriptional repressor of E-cadherin gene expression in breast cancer.
Farhad Vesuna, Paul van Diest, Ji Hshiung Chen, Venu Raman. Biochem Biophys Res Commun 2008
Farhad Vesuna, Paul van Diest, Ji Hshiung Chen, Venu Raman. Biochem Biophys Res Commun 2008
5
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.