S Imai, C M Armstrong, M Kaeberlein, L Guarente. Nature 2000
Times Cited: 2575
Times Cited: 2575
Times Cited
Times Co-cited
Similarity
The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases.
J Landry, A Sutton, S T Tafrov, R C Heller, J Stebbins, L Pillus, R Sternglanz. Proc Natl Acad Sci U S A 2000
J Landry, A Sutton, S T Tafrov, R C Heller, J Stebbins, L Pillus, R Sternglanz. Proc Natl Acad Sci U S A 2000
18
The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms.
M Kaeberlein, M McVey, L Guarente. Genes Dev 1999
M Kaeberlein, M McVey, L Guarente. Genes Dev 1999
16
Sirtuins as regulators of metabolism and healthspan.
Riekelt H Houtkooper, Eija Pirinen, Johan Auwerx. Nat Rev Mol Cell Biol 2012
Riekelt H Houtkooper, Eija Pirinen, Johan Auwerx. Nat Rev Mol Cell Biol 2012
15
Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase.
Jintang Du, Yeyun Zhou, Xiaoyang Su, Jiu Jiu Yu, Saba Khan, Hong Jiang, Jungwoo Kim, Jimin Woo, Jun Huyn Kim, Brian Hyun Choi,[...]. Science 2011
Jintang Du, Yeyun Zhou, Xiaoyang Su, Jiu Jiu Yu, Saba Khan, Hong Jiang, Jungwoo Kim, Jimin Woo, Jun Huyn Kim, Brian Hyun Choi,[...]. Science 2011
12
Mammalian sirtuins: biological insights and disease relevance.
Marcia C Haigis, David A Sinclair. Annu Rev Pathol 2010
Marcia C Haigis, David A Sinclair. Annu Rev Pathol 2010
11
Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase.
Anne Brunet, Lora B Sweeney, J Fitzhugh Sturgill, Katrin F Chua, Paul L Greer, Yingxi Lin, Hien Tran, Sarah E Ross, Raul Mostoslavsky, Haim Y Cohen,[...]. Science 2004
Anne Brunet, Lora B Sweeney, J Fitzhugh Sturgill, Katrin F Chua, Paul L Greer, Yingxi Lin, Hien Tran, Sarah E Ross, Raul Mostoslavsky, Haim Y Cohen,[...]. Science 2004
11
SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation.
Matthew D Hirschey, Tadahiro Shimazu, Eric Goetzman, Enxuan Jing, Bjoern Schwer, David B Lombard, Carrie A Grueter, Charles Harris, Sudha Biddinger, Olga R Ilkayeva,[...]. Nature 2010
Matthew D Hirschey, Tadahiro Shimazu, Eric Goetzman, Enxuan Jing, Bjoern Schwer, David B Lombard, Carrie A Grueter, Charles Harris, Sudha Biddinger, Olga R Ilkayeva,[...]. Nature 2010
11
The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase.
Brian J North, Brett L Marshall, Margie T Borra, John M Denu, Eric Verdin. Mol Cell 2003
Brian J North, Brett L Marshall, Margie T Borra, John M Denu, Eric Verdin. Mol Cell 2003
11
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan.
Konrad T Howitz, Kevin J Bitterman, Haim Y Cohen, Dudley W Lamming, Siva Lavu, Jason G Wood, Robert E Zipkin, Phuong Chung, Anne Kisielewski, Li-Li Zhang,[...]. Nature 2003
Konrad T Howitz, Kevin J Bitterman, Haim Y Cohen, Dudley W Lamming, Siva Lavu, Jason G Wood, Robert E Zipkin, Phuong Chung, Anne Kisielewski, Li-Li Zhang,[...]. Nature 2003
10
Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds.
Michael S Bonkowski, David A Sinclair. Nat Rev Mol Cell Biol 2016
Michael S Bonkowski, David A Sinclair. Nat Rev Mol Cell Biol 2016
10
Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation.
David B Lombard, Frederick W Alt, Hwei-Ling Cheng, Jakob Bunkenborg, Ryan S Streeper, Raul Mostoslavsky, Jennifer Kim, George Yancopoulos, David Valenzuela, Andrew Murphy,[...]. Mol Cell Biol 2007
David B Lombard, Frederick W Alt, Hwei-Ling Cheng, Jakob Bunkenborg, Ryan S Streeper, Raul Mostoslavsky, Jennifer Kim, George Yancopoulos, David Valenzuela, Andrew Murphy,[...]. Mol Cell Biol 2007
10
A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis.
Bong-Hyun Ahn, Hyun-Seok Kim, Shiwei Song, In Hye Lee, Jie Liu, Athanassios Vassilopoulos, Chu-Xia Deng, Toren Finkel. Proc Natl Acad Sci U S A 2008
Bong-Hyun Ahn, Hyun-Seok Kim, Shiwei Song, In Hye Lee, Jie Liu, Athanassios Vassilopoulos, Chu-Xia Deng, Toren Finkel. Proc Natl Acad Sci U S A 2008
10
Mammalian Sir2 homolog SIRT7 is an activator of RNA polymerase I transcription.
Ethan Ford, Renate Voit, Gregory Liszt, Cornelia Magin, Ingrid Grummt, Leonard Guarente. Genes Dev 2006
Ethan Ford, Renate Voit, Gregory Liszt, Cornelia Magin, Ingrid Grummt, Leonard Guarente. Genes Dev 2006
9
Sirtuins in mammals: insights into their biological function.
Shaday Michan, David Sinclair. Biochem J 2007
Shaday Michan, David Sinclair. Biochem J 2007
9
Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha.
Marie Lagouge, Carmen Argmann, Zachary Gerhart-Hines, Hamid Meziane, Carles Lerin, Frederic Daussin, Nadia Messadeq, Jill Milne, Philip Lambert, Peter Elliott,[...]. Cell 2006
Marie Lagouge, Carmen Argmann, Zachary Gerhart-Hines, Hamid Meziane, Carles Lerin, Frederic Daussin, Nadia Messadeq, Jill Milne, Philip Lambert, Peter Elliott,[...]. Cell 2006
9
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity.
Carles Cantó, Zachary Gerhart-Hines, Jerome N Feige, Marie Lagouge, Lilia Noriega, Jill C Milne, Peter J Elliott, Pere Puigserver, Johan Auwerx. Nature 2009
Carles Cantó, Zachary Gerhart-Hines, Jerome N Feige, Marie Lagouge, Lilia Noriega, Jill C Milne, Peter J Elliott, Pere Puigserver, Johan Auwerx. Nature 2009
9
SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells.
Marcia C Haigis, Raul Mostoslavsky, Kevin M Haigis, Kamau Fahie, Danos C Christodoulou, Andrew J Murphy, David M Valenzuela, George D Yancopoulos, Margaret Karow, Gil Blander,[...]. Cell 2006
Marcia C Haigis, Raul Mostoslavsky, Kevin M Haigis, Kamau Fahie, Danos C Christodoulou, Andrew J Murphy, David M Valenzuela, George D Yancopoulos, Margaret Karow, Gil Blander,[...]. Cell 2006
9
Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma.
Frédéric Picard, Martin Kurtev, Namjin Chung, Acharawan Topark-Ngarm, Thanaset Senawong, Rita Machado De Oliveira, Mark Leid, Michael W McBurney, Leonard Guarente. Nature 2004
Frédéric Picard, Martin Kurtev, Namjin Chung, Acharawan Topark-Ngarm, Thanaset Senawong, Rita Machado De Oliveira, Mark Leid, Michael W McBurney, Leonard Guarente. Nature 2004
9
Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity.
R A Frye. Biochem Biophys Res Commun 1999
R A Frye. Biochem Biophys Res Commun 1999
8
Sirtuins: Sir2-related NAD-dependent protein deacetylases.
Brian J North, Eric Verdin. Genome Biol 2004
Brian J North, Eric Verdin. Genome Biol 2004
8
The hallmarks of aging.
Carlos López-Otín, Maria A Blasco, Linda Partridge, Manuel Serrano, Guido Kroemer. Cell 2013
Carlos López-Otín, Maria A Blasco, Linda Partridge, Manuel Serrano, Guido Kroemer. Cell 2013
8
Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase.
Haim Y Cohen, Christine Miller, Kevin J Bitterman, Nathan R Wall, Brian Hekking, Benedikt Kessler, Konrad T Howitz, Myriam Gorospe, Rafael de Cabo, David A Sinclair. Science 2004
Haim Y Cohen, Christine Miller, Kevin J Bitterman, Nathan R Wall, Brian Hekking, Benedikt Kessler, Konrad T Howitz, Myriam Gorospe, Rafael de Cabo, David A Sinclair. Science 2004
8
8
Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation.
Xiaolei Qiu, Katharine Brown, Matthew D Hirschey, Eric Verdin, Danica Chen. Cell Metab 2010
Xiaolei Qiu, Katharine Brown, Matthew D Hirschey, Eric Verdin, Danica Chen. Cell Metab 2010
8
Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction.
Shinichi Someya, Wei Yu, William C Hallows, Jinze Xu, James M Vann, Christiaan Leeuwenburgh, Masaru Tanokura, John M Denu, Tomas A Prolla. Cell 2010
Shinichi Someya, Wei Yu, William C Hallows, Jinze Xu, James M Vann, Christiaan Leeuwenburgh, Masaru Tanokura, John M Denu, Tomas A Prolla. Cell 2010
8
Resveratrol improves health and survival of mice on a high-calorie diet.
Joseph A Baur, Kevin J Pearson, Nathan L Price, Hamish A Jamieson, Carles Lerin, Avash Kalra, Vinayakumar V Prabhu, Joanne S Allard, Guillermo Lopez-Lluch, Kaitlyn Lewis,[...]. Nature 2006
Joseph A Baur, Kevin J Pearson, Nathan L Price, Hamish A Jamieson, Carles Lerin, Avash Kalra, Vinayakumar V Prabhu, Joanne S Allard, Guillermo Lopez-Lluch, Kaitlyn Lewis,[...]. Nature 2006
8
Mammalian SIRT1 represses forkhead transcription factors.
Maria Carla Motta, Nullin Divecha, Madeleine Lemieux, Christopher Kamel, Delin Chen, Wei Gu, Yvette Bultsma, Michael McBurney, Leonard Guarente. Cell 2004
Maria Carla Motta, Nullin Divecha, Madeleine Lemieux, Christopher Kamel, Delin Chen, Wei Gu, Yvette Bultsma, Michael McBurney, Leonard Guarente. Cell 2004
8
Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase.
Fan Yeung, Jamie E Hoberg, Catherine S Ramsey, Michael D Keller, David R Jones, Roy A Frye, Marty W Mayo. EMBO J 2004
Fan Yeung, Jamie E Hoberg, Catherine S Ramsey, Michael D Keller, David R Jones, Roy A Frye, Marty W Mayo. EMBO J 2004
8
Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1.
Kevin J Bitterman, Rozalyn M Anderson, Haim Y Cohen, Magda Latorre-Esteves, David A Sinclair. J Biol Chem 2002
Kevin J Bitterman, Rozalyn M Anderson, Haim Y Cohen, Magda Latorre-Esteves, David A Sinclair. J Biol Chem 2002
7
CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism.
Juliana Camacho-Pereira, Mariana G Tarragó, Claudia C S Chini, Veronica Nin, Carlos Escande, Gina M Warner, Amrutesh S Puranik, Renee A Schoon, Joel M Reid, Antonio Galina,[...]. Cell Metab 2016
Juliana Camacho-Pereira, Mariana G Tarragó, Claudia C S Chini, Veronica Nin, Carlos Escande, Gina M Warner, Amrutesh S Puranik, Renee A Schoon, Joel M Reid, Antonio Galina,[...]. Cell Metab 2016
7
The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity.
Carles Cantó, Riekelt H Houtkooper, Eija Pirinen, Dou Y Youn, Maaike H Oosterveer, Yana Cen, Pablo J Fernandez-Marcos, Hiroyasu Yamamoto, Pénélope A Andreux, Philippe Cettour-Rose,[...]. Cell Metab 2012
Carles Cantó, Riekelt H Houtkooper, Eija Pirinen, Dou Y Youn, Maaike H Oosterveer, Yana Cen, Pablo J Fernandez-Marcos, Hiroyasu Yamamoto, Pénélope A Andreux, Philippe Cettour-Rose,[...]. Cell Metab 2012
7
Nicotinamide riboside promotes Sir2 silencing and extends lifespan via Nrk and Urh1/Pnp1/Meu1 pathways to NAD+.
Peter Belenky, Frances G Racette, Katrina L Bogan, Julie M McClure, Jeffrey S Smith, Charles Brenner. Cell 2007
Peter Belenky, Frances G Racette, Katrina L Bogan, Julie M McClure, Jeffrey S Smith, Charles Brenner. Cell 2007
7
A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family.
J S Smith, C B Brachmann, I Celic, M A Kenna, S Muhammad, V J Starai, J L Avalos, J C Escalante-Semerena, C Grubmeyer, C Wolberger,[...]. Proc Natl Acad Sci U S A 2000
J S Smith, C B Brachmann, I Celic, M A Kenna, S Muhammad, V J Starai, J L Avalos, J C Escalante-Semerena, C Grubmeyer, C Wolberger,[...]. Proc Natl Acad Sci U S A 2000
7
ACETYLATION AND METHYLATION OF HISTONES AND THEIR POSSIBLE ROLE IN THE REGULATION OF RNA SYNTHESIS.
V G ALLFREY, R FAULKNER, A E MIRSKY. Proc Natl Acad Sci U S A 1964
V G ALLFREY, R FAULKNER, A E MIRSKY. Proc Natl Acad Sci U S A 1964
7
Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice.
Nagalingam R Sundaresan, Madhu Gupta, Gene Kim, Senthilkumar B Rajamohan, Ayman Isbatan, Mahesh P Gupta. J Clin Invest 2009
Nagalingam R Sundaresan, Madhu Gupta, Gene Kim, Senthilkumar B Rajamohan, Ayman Isbatan, Mahesh P Gupta. J Clin Invest 2009
7
NAD+ metabolism and its roles in cellular processes during ageing.
Anthony J Covarrubias, Rosalba Perrone, Alessia Grozio, Eric Verdin. Nat Rev Mol Cell Biol 2021
Anthony J Covarrubias, Rosalba Perrone, Alessia Grozio, Eric Verdin. Nat Rev Mol Cell Biol 2021
7
SIRT3, a human SIR2 homologue, is an NAD-dependent deacetylase localized to mitochondria.
Patrick Onyango, Ivana Celic, J Michael McCaffery, Jef D Boeke, Andrew P Feinberg. Proc Natl Acad Sci U S A 2002
Patrick Onyango, Ivana Celic, J Michael McCaffery, Jef D Boeke, Andrew P Feinberg. Proc Natl Acad Sci U S A 2002
7
SirT2 is a histone deacetylase with preference for histone H4 Lys 16 during mitosis.
Alejandro Vaquero, Michael B Scher, Dong Hoon Lee, Ann Sutton, Hwei-Ling Cheng, Frederick W Alt, Lourdes Serrano, Rolf Sternglanz, Danny Reinberg. Genes Dev 2006
Alejandro Vaquero, Michael B Scher, Dong Hoon Lee, Ann Sutton, Hwei-Ling Cheng, Frederick W Alt, Lourdes Serrano, Rolf Sternglanz, Danny Reinberg. Genes Dev 2006
7
Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice.
Rui-Hong Wang, Kundan Sengupta, Cuiling Li, Hyun-Seok Kim, Liu Cao, Cuiying Xiao, Sangsoo Kim, Xiaoling Xu, Yin Zheng, Beverly Chilton,[...]. Cancer Cell 2008
Rui-Hong Wang, Kundan Sengupta, Cuiling Li, Hyun-Seok Kim, Liu Cao, Cuiying Xiao, Sangsoo Kim, Xiaoling Xu, Yin Zheng, Beverly Chilton,[...]. Cancer Cell 2008
7
SIRT7 is a histone desuccinylase that functionally links to chromatin compaction and genome stability.
Lei Li, Lan Shi, Shangda Yang, Ruorong Yan, Di Zhang, Jianguo Yang, Lin He, Wanjin Li, Xia Yi, Luyang Sun,[...]. Nat Commun 2016
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7
Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice.
Jun Yoshino, Kathryn F Mills, Myeong Jin Yoon, Shin-ichiro Imai. Cell Metab 2011
Jun Yoshino, Kathryn F Mills, Myeong Jin Yoon, Shin-ichiro Imai. Cell Metab 2011
6
An overview of Sirtuins as potential therapeutic target: Structure, function and modulators.
Yijie Wang, Jun He, Mengya Liao, Mingxing Hu, Wenzhen Li, Hongling Ouyang, Xin Wang, Tinghong Ye, Yiwen Zhang, Liang Ouyang. Eur J Med Chem 2019
Yijie Wang, Jun He, Mengya Liao, Mingxing Hu, Wenzhen Li, Hongling Ouyang, Xin Wang, Tinghong Ye, Yiwen Zhang, Liang Ouyang. Eur J Med Chem 2019
6
Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity.
Hiroaki Daitoku, Mitsutoki Hatta, Hitomi Matsuzaki, Satoko Aratani, Takayuki Ohshima, Makoto Miyagishi, Toshihiro Nakajima, Akiyoshi Fukamizu. Proc Natl Acad Sci U S A 2004
Hiroaki Daitoku, Mitsutoki Hatta, Hitomi Matsuzaki, Satoko Aratani, Takayuki Ohshima, Makoto Miyagishi, Toshihiro Nakajima, Akiyoshi Fukamizu. Proc Natl Acad Sci U S A 2004
6
Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging.
Ana P Gomes, Nathan L Price, Alvin J Y Ling, Javid J Moslehi, Magdalene K Montgomery, Luis Rajman, James P White, João S Teodoro, Christiane D Wrann, Basil P Hubbard,[...]. Cell 2013
Ana P Gomes, Nathan L Price, Alvin J Y Ling, Javid J Moslehi, Magdalene K Montgomery, Luis Rajman, James P White, João S Teodoro, Christiane D Wrann, Basil P Hubbard,[...]. Cell 2013
6
It takes two to tango: NAD+ and sirtuins in aging/longevity control.
Shin-Ichiro Imai, Leonard Guarente. NPJ Aging Mech Dis 2016
Shin-Ichiro Imai, Leonard Guarente. NPJ Aging Mech Dis 2016
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Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae.
S J Lin, P A Defossez, L Guarente. Science 2000
S J Lin, P A Defossez, L Guarente. Science 2000
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SIRT1 and aging related signaling pathways.
Cui Chen, Min Zhou, Yuchen Ge, Xiaobo Wang. Mech Ageing Dev 2020
Cui Chen, Min Zhou, Yuchen Ge, Xiaobo Wang. Mech Ageing Dev 2020
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SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin.
Eriko Michishita, Ronald A McCord, Elisabeth Berber, Mitomu Kioi, Hesed Padilla-Nash, Mara Damian, Peggie Cheung, Rika Kusumoto, Tiara L A Kawahara, J Carl Barrett,[...]. Nature 2008
Eriko Michishita, Ronald A McCord, Elisabeth Berber, Mitomu Kioi, Hesed Padilla-Nash, Mara Damian, Peggie Cheung, Rika Kusumoto, Tiara L A Kawahara, J Carl Barrett,[...]. Nature 2008
6
Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1.
Joseph T Rodgers, Carlos Lerin, Wilhelm Haas, Steven P Gygi, Bruce M Spiegelman, Pere Puigserver. Nature 2005
Joseph T Rodgers, Carlos Lerin, Wilhelm Haas, Steven P Gygi, Bruce M Spiegelman, Pere Puigserver. Nature 2005
6
hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase.
H Vaziri, S K Dessain, E Ng Eaton, S I Imai, R A Frye, T K Pandita, L Guarente, R A Weinberg. Cell 2001
H Vaziri, S K Dessain, E Ng Eaton, S I Imai, R A Frye, T K Pandita, L Guarente, R A Weinberg. Cell 2001
6
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.