J B Davis, J Gray, M J Gunthorpe, J P Hatcher, P T Davey, P Overend, M H Harries, J Latcham, C Clapham, K Atkinson, S A Hughes, K Rance, E Grau, A J Harper, P L Pugh, D C Rogers, S Bingham, A Randall, S A Sheardown. Nature 2000
Times Cited: 1295
Times Cited: 1295
Times Cited
Times Co-cited
Similarity
Impaired nociception and pain sensation in mice lacking the capsaicin receptor.
M J Caterina, A Leffler, A B Malmberg, W J Martin, J Trafton, K R Petersen-Zeitz, M Koltzenburg, A I Basbaum, D Julius. Science 2000
M J Caterina, A Leffler, A B Malmberg, W J Martin, J Trafton, K R Petersen-Zeitz, M Koltzenburg, A I Basbaum, D Julius. Science 2000
66
The capsaicin receptor: a heat-activated ion channel in the pain pathway.
M J Caterina, M A Schumacher, M Tominaga, T A Rosen, J D Levine, D Julius. Nature 1997
M J Caterina, M A Schumacher, M Tominaga, T A Rosen, J D Levine, D Julius. Nature 1997
57
The cloned capsaicin receptor integrates multiple pain-producing stimuli.
M Tominaga, M J Caterina, A B Malmberg, T A Rosen, H Gilbert, K Skinner, B E Raumann, A I Basbaum, D Julius. Neuron 1998
M Tominaga, M J Caterina, A B Malmberg, T A Rosen, H Gilbert, K Skinner, B E Raumann, A I Basbaum, D Julius. Neuron 1998
24
A TRP channel trio mediates acute noxious heat sensing.
Ine Vandewauw, Katrien De Clercq, Marie Mulier, Katharina Held, Silvia Pinto, Nele Van Ranst, Andrei Segal, Thierry Voet, Rudi Vennekens, Katharina Zimmermann,[...]. Nature 2018
Ine Vandewauw, Katrien De Clercq, Marie Mulier, Katharina Held, Silvia Pinto, Nele Van Ranst, Andrei Segal, Thierry Voet, Rudi Vennekens, Katharina Zimmermann,[...]. Nature 2018
19
Cellular and molecular mechanisms of pain.
Allan I Basbaum, Diana M Bautista, Grégory Scherrer, David Julius. Cell 2009
Allan I Basbaum, Diana M Bautista, Grégory Scherrer, David Julius. Cell 2009
14
Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin.
Michael Bandell, Gina M Story, Sun Wook Hwang, Veena Viswanath, Samer R Eid, Matt J Petrus, Taryn J Earley, Ardem Patapoutian. Neuron 2004
Michael Bandell, Gina M Story, Sun Wook Hwang, Veena Viswanath, Samer R Eid, Matt J Petrus, Taryn J Earley, Ardem Patapoutian. Neuron 2004
14
NGF rapidly increases membrane expression of TRPV1 heat-gated ion channels.
Xuming Zhang, Jiehong Huang, Peter A McNaughton. EMBO J 2005
Xuming Zhang, Jiehong Huang, Peter A McNaughton. EMBO J 2005
13
TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents.
Diana M Bautista, Sven-Eric Jordt, Tetsuro Nikai, Pamela R Tsuruda, Andrew J Read, Jeannie Poblete, Ebenezer N Yamoah, Allan I Basbaum, David Julius. Cell 2006
Diana M Bautista, Sven-Eric Jordt, Tetsuro Nikai, Pamela R Tsuruda, Andrew J Read, Jeannie Poblete, Ebenezer N Yamoah, Allan I Basbaum, David Julius. Cell 2006
13
ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures.
Gina M Story, Andrea M Peier, Alison J Reeve, Samer R Eid, Johannes Mosbacher, Todd R Hricik, Taryn J Earley, Anne C Hergarden, David A Andersson, Sun Wook Hwang,[...]. Cell 2003
Gina M Story, Andrea M Peier, Alison J Reeve, Samer R Eid, Johannes Mosbacher, Todd R Hricik, Taryn J Earley, Anne C Hergarden, David A Andersson, Sun Wook Hwang,[...]. Cell 2003
12
Structure of the TRPV1 ion channel determined by electron cryo-microscopy.
Maofu Liao, Erhu Cao, David Julius, Yifan Cheng. Nature 2013
Maofu Liao, Erhu Cao, David Julius, Yifan Cheng. Nature 2013
12
TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction.
Kelvin Y Kwan, Andrew J Allchorne, Melissa A Vollrath, Adam P Christensen, Duan-Sun Zhang, Clifford J Woolf, David P Corey. Neuron 2006
Kelvin Y Kwan, Andrew J Allchorne, Melissa A Vollrath, Adam P Christensen, Duan-Sun Zhang, Clifford J Woolf, David P Corey. Neuron 2006
12
TRPM3 is a nociceptor channel involved in the detection of noxious heat.
Joris Vriens, Grzegorz Owsianik, Thomas Hofmann, Stephan E Philipp, Julia Stab, Xiaodi Chen, Melissa Benoit, Fenqin Xue, Annelies Janssens, Sara Kerselaers,[...]. Neuron 2011
Joris Vriens, Grzegorz Owsianik, Thomas Hofmann, Stephan E Philipp, Julia Stab, Xiaodi Chen, Melissa Benoit, Fenqin Xue, Annelies Janssens, Sara Kerselaers,[...]. Neuron 2011
11
Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1.
Sven-Eric Jordt, Diana M Bautista, Huai-Hu Chuang, David D McKemy, Peter M Zygmunt, Edward D Högestätt, Ian D Meng, David Julius. Nature 2004
Sven-Eric Jordt, Diana M Bautista, Huai-Hu Chuang, David D McKemy, Peter M Zygmunt, Edward D Högestätt, Ian D Meng, David Julius. Nature 2004
11
Identification of a cold receptor reveals a general role for TRP channels in thermosensation.
David D McKemy, Werner M Neuhausser, David Julius. Nature 2002
David D McKemy, Werner M Neuhausser, David Julius. Nature 2002
11
TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action.
Yuan Gao, Erhu Cao, David Julius, Yifan Cheng. Nature 2016
Yuan Gao, Erhu Cao, David Julius, Yifan Cheng. Nature 2016
11
p38 MAPK activation by NGF in primary sensory neurons after inflammation increases TRPV1 levels and maintains heat hyperalgesia.
Ru-Rong Ji, Tarek A Samad, Shan-Xue Jin, Raymond Schmoll, Clifford J Woolf. Neuron 2002
Ru-Rong Ji, Tarek A Samad, Shan-Xue Jin, Raymond Schmoll, Clifford J Woolf. Neuron 2002
10
Transient receptor potential channels: targeting pain at the source.
Ardem Patapoutian, Simon Tate, Clifford J Woolf. Nat Rev Drug Discov 2009
Ardem Patapoutian, Simon Tate, Clifford J Woolf. Nat Rev Drug Discov 2009
10
Pharmacological blockade of the vanilloid receptor TRPV1 elicits marked hyperthermia in humans.
Narender R Gavva, James J S Treanor, Andras Garami, Liang Fang, Sekhar Surapaneni, Anna Akrami, Francisco Alvarez, Annette Bak, Mary Darling, Anu Gore,[...]. Pain 2008
Narender R Gavva, James J S Treanor, Andras Garami, Liang Fang, Sekhar Surapaneni, Anna Akrami, Francisco Alvarez, Annette Bak, Mary Darling, Anu Gore,[...]. Pain 2008
9
A TRP channel that senses cold stimuli and menthol.
Andrea M Peier, Aziz Moqrich, Anne C Hergarden, Alison J Reeve, David A Andersson, Gina M Story, Taryn J Earley, Ilaria Dragoni, Peter McIntyre, Stuart Bevan,[...]. Cell 2002
Andrea M Peier, Aziz Moqrich, Anne C Hergarden, Alison J Reeve, David A Andersson, Gina M Story, Taryn J Earley, Ilaria Dragoni, Peter McIntyre, Stuart Bevan,[...]. Cell 2002
9
The vanilloid receptor: a molecular gateway to the pain pathway.
M J Caterina, D Julius. Annu Rev Neurosci 2001
M J Caterina, D Julius. Annu Rev Neurosci 2001
9
TRPA1 acts as a cold sensor in vitro and in vivo.
Yuji Karashima, Karel Talavera, Wouter Everaerts, Annelies Janssens, Kelvin Y Kwan, Rudi Vennekens, Bernd Nilius, Thomas Voets. Proc Natl Acad Sci U S A 2009
Yuji Karashima, Karel Talavera, Wouter Everaerts, Annelies Janssens, Kelvin Y Kwan, Rudi Vennekens, Bernd Nilius, Thomas Voets. Proc Natl Acad Sci U S A 2009
8
A gain-of-function mutation in TRPA1 causes familial episodic pain syndrome.
Barbara Kremeyer, Francisco Lopera, James J Cox, Aliakmal Momin, Francois Rugiero, Steve Marsh, C Geoffrey Woods, Nicholas G Jones, Kathryn J Paterson, Florence R Fricker,[...]. Neuron 2010
Barbara Kremeyer, Francisco Lopera, James J Cox, Aliakmal Momin, Francois Rugiero, Steve Marsh, C Geoffrey Woods, Nicholas G Jones, Kathryn J Paterson, Florence R Fricker,[...]. Neuron 2010
8
Investigation of the role of TRPV1 receptors in acute and chronic nociceptive processes using gene-deficient mice.
Kata Bölcskei, Zsuzsanna Helyes, Árpád Szabó, Katalin Sándor, Krisztián Elekes, József Németh, Róbert Almási, Erika Pintér, Gábor Pethő, János Szolcsányi. Pain 2005
Kata Bölcskei, Zsuzsanna Helyes, Árpád Szabó, Katalin Sándor, Krisztián Elekes, József Németh, Róbert Almási, Erika Pintér, Gábor Pethő, János Szolcsányi. Pain 2005
8
Trpv1 reporter mice reveal highly restricted brain distribution and functional expression in arteriolar smooth muscle cells.
Daniel J Cavanaugh, Alexander T Chesler, Alexander C Jackson, Yaron M Sigal, Hiroki Yamanaka, Rebecca Grant, Dajan O'Donnell, Roger A Nicoll, Nirao M Shah, David Julius,[...]. J Neurosci 2011
Daniel J Cavanaugh, Alexander T Chesler, Alexander C Jackson, Yaron M Sigal, Hiroki Yamanaka, Rebecca Grant, Dajan O'Donnell, Roger A Nicoll, Nirao M Shah, David Julius,[...]. J Neurosci 2011
8
Transient receptor potential channels as drug targets: from the science of basic research to the art of medicine.
Bernd Nilius, Arpad Szallasi. Pharmacol Rev 2014
Bernd Nilius, Arpad Szallasi. Pharmacol Rev 2014
8
TRPV1 structures in distinct conformations reveal activation mechanisms.
Erhu Cao, Maofu Liao, Yifan Cheng, David Julius. Nature 2013
Erhu Cao, Maofu Liao, Yifan Cheng, David Julius. Nature 2013
8
Protein kinase C phosphorylation sensitizes but does not activate the capsaicin receptor transient receptor potential vanilloid 1 (TRPV1).
Gautam Bhave, Hui-Juan Hu, Kathi S Glauner, Weiguo Zhu, Haibin Wang, D J Brasier, Gerry S Oxford, Robert W Gereau. Proc Natl Acad Sci U S A 2003
Gautam Bhave, Hui-Juan Hu, Kathi S Glauner, Weiguo Zhu, Haibin Wang, D J Brasier, Gerry S Oxford, Robert W Gereau. Proc Natl Acad Sci U S A 2003
8
Quantitative assessment of tactile allodynia in the rat paw.
S R Chaplan, F W Bach, J W Pogrel, J M Chung, T L Yaksh. J Neurosci Methods 1994
S R Chaplan, F W Bach, J W Pogrel, J M Chung, T L Yaksh. J Neurosci Methods 1994
7
A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia.
K Hargreaves, R Dubner, F Brown, C Flores, J Joris. Pain 1988
K Hargreaves, R Dubner, F Brown, C Flores, J Joris. Pain 1988
7
Regulated exocytosis contributes to protein kinase C potentiation of vanilloid receptor activity.
Cruz Morenilla-Palao, Rosa Planells-Cases, Nuria García-Sanz, Antonio Ferrer-Montiel. J Biol Chem 2004
Cruz Morenilla-Palao, Rosa Planells-Cases, Nuria García-Sanz, Antonio Ferrer-Montiel. J Biol Chem 2004
7
Spider toxins activate the capsaicin receptor to produce inflammatory pain.
Jan Siemens, Sharleen Zhou, Rebecca Piskorowski, Tetsuro Nikai, Ellen A Lumpkin, Allan I Basbaum, David King, David Julius. Nature 2006
Jan Siemens, Sharleen Zhou, Rebecca Piskorowski, Tetsuro Nikai, Ellen A Lumpkin, Allan I Basbaum, David King, David Julius. Nature 2006
7
Peripheral thermosensation in mammals.
Joris Vriens, Bernd Nilius, Thomas Voets. Nat Rev Neurosci 2014
Joris Vriens, Bernd Nilius, Thomas Voets. Nat Rev Neurosci 2014
7
A capsaicin-receptor homologue with a high threshold for noxious heat.
M J Caterina, T A Rosen, M Tominaga, A J Brake, D Julius. Nature 1999
M J Caterina, T A Rosen, M Tominaga, A J Brake, D Julius. Nature 1999
7
Methylglyoxal activates nociceptors through transient receptor potential channel A1 (TRPA1): a possible mechanism of metabolic neuropathies.
Mirjam J Eberhardt, Milos R Filipovic, Andreas Leffler, Jeanne de la Roche, Katrin Kistner, Michael J Fischer, Thomas Fleming, Katharina Zimmermann, Ivana Ivanovic-Burmazovic, Peter P Nawroth,[...]. J Biol Chem 2012
Mirjam J Eberhardt, Milos R Filipovic, Andreas Leffler, Jeanne de la Roche, Katrin Kistner, Michael J Fischer, Thomas Fleming, Katharina Zimmermann, Ivana Ivanovic-Burmazovic, Peter P Nawroth,[...]. J Biol Chem 2012
7
Transient receptor potential A1 is a sensory receptor for multiple products of oxidative stress.
David A Andersson, Clive Gentry, Sian Moss, Stuart Bevan. J Neurosci 2008
David A Andersson, Clive Gentry, Sian Moss, Stuart Bevan. J Neurosci 2008
7
TRPV1 channels are critical brain inflammation detectors and neuropathic pain biomarkers in mice.
Maria Cristina Marrone, Annunziato Morabito, Michela Giustizieri, Valerio Chiurchiù, Alessandro Leuti, Marzia Mattioli, Sara Marinelli, Loredana Riganti, Marta Lombardi, Emanuele Murana,[...]. Nat Commun 2017
Maria Cristina Marrone, Annunziato Morabito, Michela Giustizieri, Valerio Chiurchiù, Alessandro Leuti, Marzia Mattioli, Sara Marinelli, Loredana Riganti, Marta Lombardi, Emanuele Murana,[...]. Nat Commun 2017
7
Proteinase-activated receptor 2 sensitizes transient receptor potential vanilloid 1, transient receptor potential vanilloid 4, and transient receptor potential ankyrin 1 in paclitaxel-induced neuropathic pain.
Y Chen, C Yang, Z J Wang. Neuroscience 2011
Y Chen, C Yang, Z J Wang. Neuroscience 2011
7
The vanilloid receptor TRPV1: 10 years from channel cloning to antagonist proof-of-concept.
Arpad Szallasi, Daniel N Cortright, Charles A Blum, Samer R Eid. Nat Rev Drug Discov 2007
Arpad Szallasi, Daniel N Cortright, Charles A Blum, Samer R Eid. Nat Rev Drug Discov 2007
7
The menthol receptor TRPM8 is the principal detector of environmental cold.
Diana M Bautista, Jan Siemens, Joshua M Glazer, Pamela R Tsuruda, Allan I Basbaum, Cheryl L Stucky, Sven-Eric Jordt, David Julius. Nature 2007
Diana M Bautista, Jan Siemens, Joshua M Glazer, Pamela R Tsuruda, Allan I Basbaum, Cheryl L Stucky, Sven-Eric Jordt, David Julius. Nature 2007
7
Molecular basis for species-specific sensitivity to "hot" chili peppers.
Sven-Eric Jordt, David Julius. Cell 2002
Sven-Eric Jordt, David Julius. Cell 2002
7
Acid potentiation of the capsaicin receptor determined by a key extracellular site.
S E Jordt, M Tominaga, D Julius. Proc Natl Acad Sci U S A 2000
S E Jordt, M Tominaga, D Julius. Proc Natl Acad Sci U S A 2000
7
Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide.
P M Zygmunt, J Petersson, D A Andersson, H Chuang, M Sørgård, V Di Marzo, D Julius, E D Högestätt. Nature 1999
P M Zygmunt, J Petersson, D A Andersson, H Chuang, M Sørgård, V Di Marzo, D Julius, E D Högestätt. Nature 1999
7
cAMP-dependent protein kinase regulates desensitization of the capsaicin receptor (VR1) by direct phosphorylation.
Gautam Bhave, Weiguo Zhu, Haibin Wang, D J Brasier, Gerry S Oxford, Robert W Gereau. Neuron 2002
Gautam Bhave, Weiguo Zhu, Haibin Wang, D J Brasier, Gerry S Oxford, Robert W Gereau. Neuron 2002
6
TRPV1 channels are intrinsically heat sensitive and negatively regulated by phosphoinositide lipids.
Erhu Cao, Julio F Cordero-Morales, Beiying Liu, Feng Qin, David Julius. Neuron 2013
Erhu Cao, Julio F Cordero-Morales, Beiying Liu, Feng Qin, David Julius. Neuron 2013
6
Protein kinase C activation potentiates gating of the vanilloid receptor VR1 by capsaicin, protons, heat and anandamide.
V Vellani, S Mapplebeck, A Moriondo, J B Davis, P A McNaughton. J Physiol 2001
V Vellani, S Mapplebeck, A Moriondo, J B Davis, P A McNaughton. J Physiol 2001
6
Direct phosphorylation of capsaicin receptor VR1 by protein kinase Cepsilon and identification of two target serine residues.
Mitsuko Numazaki, Tomoko Tominaga, Hidenori Toyooka, Makoto Tominaga. J Biol Chem 2002
Mitsuko Numazaki, Tomoko Tominaga, Hidenori Toyooka, Makoto Tominaga. J Biol Chem 2002
6
VR1 protein expression increases in undamaged DRG neurons after partial nerve injury.
L J Hudson, S Bevan, G Wotherspoon, C Gentry, A Fox, J Winter. Eur J Neurosci 2001
L J Hudson, S Bevan, G Wotherspoon, C Gentry, A Fox, J Winter. Eur J Neurosci 2001
6
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.