A citation-based method for searching scientific literature

Recent advances in the applications of radioisotopes in drug metabolism, toxicology and pharmacokinetics.
D Dalvie. Curr. Pharm. Des. 2000
Times Cited: 20






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List of co-cited articles
67 articles co-cited >1



Times Cited
  Times     Co-cited
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The use of radiolabeled compounds for ADME studies in discovery and exploratory development.
P H Marathe, W C Shyu, W G Humphreys. Curr. Pharm. Des. 2004
30
8
40

Drug-protein adducts: an industry perspective on minimizing the potential for drug bioactivation in drug discovery and development.
David C Evans, Alan P Watt, Deborah A Nicoll-Griffith, Thomas A Baillie. Chem. Res. Toxicol. 2004
349
5
25

Drug metabolites in safety testing.
Thomas A Baillie, Mitchell N Cayen, Hassan Fouda, Ronald J Gerson, James D Green, Scott J Grossman, Lewis J Klunk, Bernard LeBlanc, Darcy G Perkins, Lisa A Shipley. Toxicol. Appl. Pharmacol. 2002
149
4
20

Cytochrome p450 and chemical toxicology.
F Peter Guengerich. Chem. Res. Toxicol. 2008
725
4
20

A regulatory and industrial perspective of the use of carbon-14 and tritium isotopes in human ADME studies.
J G Dain, J M Collins, W T Robinson. Pharm. Res. 1994
12
3
25

Accelerator mass spectrometry in pharmaceutical research and development--a new ultrasensitive analytical method for isotope measurement.
R C Garner. Curr. Drug Metab. 2000
43
3
15

Evaluation of accelerator mass spectrometry in a human mass balance and pharmacokinetic study-experience with 14C-labeled (R)-6-[amino(4- chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1- methyl-2(1H)-quinolinone (R115777), a farnesyl transferase inhibitor.
R C Garner, I Goris, A A E Laenen, E Vanhoutte, W Meuldermans, S Gregory, J V Garner, D Leong, M Whattam, A Calam,[...]. Drug Metab. Dispos. 2002
45
3
15

Seeing through the mist: abundance versus percentage. Commentary on metabolites in safety testing.
Dennis A Smith, R Scott Obach. Drug Metab. Dispos. 2005
65
3
15

On-line liquid chromatography-accurate radioisotope counting coupled with a radioactivity detector and mass spectrometer for metabolite identification in drug discovery and development.
A E F Nassar, S M Bjorge, D Y Lee. Anal. Chem. 2003
26
3
15

Functional expression of sinusoidal drug transporters in primary human and rat hepatocytes.
Emilie Jigorel, Marc Le Vee, Claire Boursier-Neyret, Marc Bertrand, Olivier Fardel. Drug Metab. Dispos. 2005
80
3
15

Novel approach to performing metabolite identification in drug metabolism.
A-E F Nassar, D Y Lee. J Chromatogr Sci 2007
8
3
37

What is the objective of the mass balance study? A retrospective analysis of data in animal and human excretion studies employing radiolabeled drugs.
Sarah J Roffey, R Scott Obach, Jenny I Gedge, Dennis A Smith. Drug Metab. Rev. 2007
115
3
15

Bioanalytical applications of accelerator mass spectrometry for pharmaceutical research.
K W Turteltaub, J S Vogel. Curr. Pharm. Des. 2000
45
2
10

Current perspectives of 14C-isotope measurement in biomedical accelerator mass spectrometry.
Graham Lappin, R Colin Garner. Anal Bioanal Chem 2004
50
2
10

Mass balance and metabolism of [(3)H]Formoterol in healthy men after combined i.v. and oral administration-mimicking inhalation.
J Rosenborg, P Larsson, K Tegnér, G Hallström. Drug Metab. Dispos. 1999
25
2
10

Biomedical applications of accelerator mass spectrometry-isotope measurements at the level of the atom.
J Barker, R C Garner. Rapid Commun. Mass Spectrom. 1999
35
2
10

Big physics, small doses: the use of AMS and PET in human microdosing of development drugs.
Graham Lappin, R Colin Garner. Nat Rev Drug Discov 2003
124
2
10

Metabolism and excretion of a new antipsychotic drug, ziprasidone, in humans.
C Prakash, A Kamel, J Gummerus, K Wilner. Drug Metab. Dispos. 1997
64
2
10

Recent developments in tritium incorporation for radiotracer studies.
M Saljoughian, P G Williams. Curr. Pharm. Des. 2000
13
2
15

An introduction to drug disposition: the basic principles of absorption, distribution, metabolism, and excretion.
J Caldwell, I Gardner, N Swales. Toxicol Pathol 1995
40
2
10

An interface for direct analysis of (14)c in nonvolatile samples by accelerator mass spectrometry.
Rosa G Liberman, Steven R Tannenbaum, Barbara J Hughey, Ruth E Shefer, Robert E Klinkowstein, Chandra Prakash, Shawn P Harriman, Paul L Skipper. Anal. Chem. 2004
31
2
10

Liquid chromatography/atmospheric pressure ionization-mass spectrometry in drug metabolism studies.
R Kostiainen, T Kotiaho, T Kuuranne, S Auriola. J Mass Spectrom 2003
187
2
10

HPLC assay for bupropion and its major metabolites in human plasma.
Katarzyna K Loboz, Annette S Gross, John Ray, Andrew J McLachlan. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2005
33
2
10

Metabolite identification in drug discovery.
Alan P Watt, Russell J Mortishire-Smith, Ute Gerhard, Steven R Thomas. Curr Opin Drug Discov Devel 2003
44
2
10

Biotransformation of a GABAA receptor partial agonist in sprague-dawley rats and cynomolgus monkeys: identification of two unique N-carbamoyl metabolites.
Christopher L Shaffer, Mithat Gunduz, Thomas N O'Connell, R Scott Obach, Shiyin Yee. Drug Metab. Dispos. 2005
17
2
11

Bridging cheminformatic metabolite prediction and tandem mass spectrometry.
M Reza Anari, Thomas A Baillie. Drug Discov. Today 2005
24
2
10

Quantitation of niflumic acid in human plasma by high-performance liquid chromatography with ultraviolet absorbance detection and its application to a bioequivalence study of talniflumate tablets.
H W Lee, K J Won, S H Cho, Y H Ha, W S Park, H T Yim, M Baek, J H Rew, S H Yoon, S V Yim,[...]. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2005
7
2
28

Selective reduction of N-oxides to amines: application to drug metabolism.
Palaniappan Kulanthaivel, Robert J Barbuch, Rita S Davidson, Ping Yi, Gregory A Rener, Edward L Mattiuz, Chad E Hadden, Lawrence A Goodwin, William J Ehlhardt. Drug Metab. Dispos. 2004
28
2
10

Accelerator mass spectrometry (AMS): recent experience of its use in a clinical study and the potential future of the technique.
G Young, W Ellis, J Ayrton, E Hussey, B Adamkiewicz. Xenobiotica 2001
38
2
10

The price of innovation: new estimates of drug development costs.
Joseph A DiMasi, Ronald W Hansen, Henry G Grabowski. J Health Econ 2003
1365
2
10

The use of 96-well Scintiplates to facilitate definitive metabolism studies for drug candidates.
Angus N R Nedderman, Mark E Savage, Katharine L White, Donald K Walker. J Pharm Biomed Anal 2004
13
2
15

Triple quadrupole linear ion trap mass spectrometer for the analysis of small molecules and macromolecules.
Gérard Hopfgartner, Emmanuel Varesio, Viviane Tschäppät, Chantal Grivet, Emmanuel Bourgogne, Luc Alexis Leuthold. J Mass Spectrom 2004
118
2
10

A software filter to remove interference ions from drug metabolites in accurate mass liquid chromatography/mass spectrometric analyses.
Haiying Zhang, Donglu Zhang, Kenneth Ray. J Mass Spectrom 2003
88
2
10

The use of Qtrap technology in drug metabolism.
Richard King, Carmen Fernandez-Metzler. Curr. Drug Metab. 2006
27
2
10

Use of a quadrupole linear ion trap mass spectrometer in metabolite identification and bioanalysis.
Yuan-Qing Xia, Jeffrey D Miller, Ray Bakhtiar, Ronald B Franklin, David Q Liu. Rapid Commun. Mass Spectrom. 2003
69
2
10

Systematic LC/MS metabolite identification in drug discovery.
N J Clarke, D Rindgen, W A Korfmacher, K A Cox. Anal. Chem. 2001
63
2
10

Use of on-line hydrogen/deuterium exchange to facilitate metabolite identification.
D Q Liu, C E Hop, M G Beconi, A Mao, S H Chiu. Rapid Commun. Mass Spectrom. 2001
45
2
10

Increasing throughput and information content for in vitro drug metabolism experiments using ultra-performance liquid chromatography coupled to a quadrupole time-of-flight mass spectrometer.
Jose Castro-Perez, Robert Plumb, Jennifer H Granger, Iain Beattie, Karine Joncour, Andrew Wright. Rapid Commun. Mass Spectrom. 2005
117
2
10

Strategies for characterization of drug metabolites using liquid chromatography-tandem mass spectrometry in conjunction with chemical derivatization and on-line H/D exchange approaches.
David Q Liu, Cornelis E C A Hop. J Pharm Biomed Anal 2005
98
2
10

Preparation of (99m)Tc-C(60)(OH)(x) and its biodistribution studies.
Li Qingnuan, Xiu yan, Zhang Xiaodong, Liu Ruili, Du qieqie, Shun Xiaoguang, Chen Shaoliang, Li Wenxin. Nucl. Med. Biol. 2002
41
2
10

Tissue biodistribution and blood clearance rates of intravenously administered carbon nanotube radiotracers.
Ravi Singh, Davide Pantarotto, Lara Lacerda, Giorgia Pastorin, Cédric Klumpp, Maurizio Prato, Alberto Bianco, Kostas Kostarelos. Proc. Natl. Acad. Sci. U.S.A. 2006
459
2
10

Disposition of [14C]ruboxistaurin in humans.
Jennifer L Burkey, Kristina M Campanale, Robert Barbuch, Douglas O'Bannon, James Rash, Charles Benson, David Small. Drug Metab. Dispos. 2006
4
2
50

Metabolism and disposition of a potent group II metabotropic glutamate receptor agonist, in rats, dogs, and monkeys.
Joyce K James, Masato Nakamura, Atsuro Nakazato, Kanyin E Zhang, Merryl Cramer, Janice Brunner, Jacquelynn Cook, Weichao G Chen. Drug Metab. Dispos. 2005
4
2
50

Development and evaluation of an electrochemical method for studying reactive phase-I metabolites: correlation to in vitro drug metabolism.
Kim G Madsen, Jørgen Olsen, Christian Skonberg, Steen H Hansen, Ulrik Jurva. Chem. Res. Toxicol. 2007
56
2
10

Biomimetic modeling of oxidative drug metabolism : Strategies, advantages and limitations.
Wiebke Lohmann, Uwe Karst. Anal Bioanal Chem 2008
61
2
10

Prediction of drug metabolism and interactions on the basis of in vitro investigations.
Olavi Pelkonen, Miia Turpeinen, Jouko Uusitalo, Arja Rautio, Hannu Raunio. Basic Clin. Pharmacol. Toxicol. 2005
76
2
10

Safety assessment of drug metabolites: Characterization of chemically stable metabolites.
W Griffith Humphreys, Steve E Unger. Chem. Res. Toxicol. 2006
29
2
10

Simulation of the detoxification of paracetamol using on-line electrochemistry/liquid chromatography/mass spectrometry.
Wiebke Lohmann, Uwe Karst. Anal Bioanal Chem 2006
45
2
10

Bioactivation of diclofenac in vitro and in vivo: correlation to electrochemical studies.
Kim G Madsen, Christian Skonberg, Ulrik Jurva, Claus Cornett, Steen H Hansen, Tommy N Johansen, Jørgen Olsen. Chem. Res. Toxicol. 2008
39
2
10

Mimicry of phase I drug metabolism--novel methods for metabolite characterization and synthesis.
Tove Johansson, Lars Weidolf, Ulrik Jurva. Rapid Commun. Mass Spectrom. 2007
62
2
10


Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.

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