B Li, S Oestreich, T de Lange. Cell 2000
Times Cited: 430
Times Cited: 430
Times Cited
Times Co-cited
Similarity
Shelterin: the protein complex that shapes and safeguards human telomeres.
Titia de Lange. Genes Dev 2005
Titia de Lange. Genes Dev 2005
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Mammalian telomeres end in a large duplex loop.
J D Griffith, L Comeau, S Rosenfield, R M Stansel, A Bianchi, H Moss, T de Lange. Cell 1999
J D Griffith, L Comeau, S Rosenfield, R M Stansel, A Bianchi, H Moss, T de Lange. Cell 1999
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Loss of Rap1 induces telomere recombination in the absence of NHEJ or a DNA damage signal.
Agnel Sfeir, Shaheen Kabir, Megan van Overbeek, Giulia B Celli, Titia de Lange. Science 2010
Agnel Sfeir, Shaheen Kabir, Megan van Overbeek, Giulia B Celli, Titia de Lange. Science 2010
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Mammalian Rap1 controls telomere function and gene expression through binding to telomeric and extratelomeric sites.
Paula Martinez, Maria Thanasoula, Ana R Carlos, Gonzalo Gómez-López, Agueda M Tejera, Stefan Schoeftner, Orlando Dominguez, David G Pisano, Madalena Tarsounas, Maria A Blasco. Nat Cell Biol 2010
Paula Martinez, Maria Thanasoula, Ana R Carlos, Gonzalo Gómez-López, Agueda M Tejera, Stefan Schoeftner, Orlando Dominguez, David G Pisano, Madalena Tarsounas, Maria A Blasco. Nat Cell Biol 2010
41
Pot1, the putative telomere end-binding protein in fission yeast and humans.
P Baumann, T R Cech. Science 2001
P Baumann, T R Cech. Science 2001
41
Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2.
D Broccoli, A Smogorzewska, L Chong, T de Lange. Nat Genet 1997
D Broccoli, A Smogorzewska, L Chong, T de Lange. Nat Genet 1997
40
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TIN2, a new regulator of telomere length in human cells.
S H Kim, P Kaminker, J Campisi. Nat Genet 1999
S H Kim, P Kaminker, J Campisi. Nat Genet 1999
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PTOP interacts with POT1 and regulates its localization to telomeres.
Dan Liu, Amin Safari, Matthew S O'Connor, Doug W Chan, Andrew Laegeler, Jun Qin, Zhou Songyang. Nat Cell Biol 2004
Dan Liu, Amin Safari, Matthew S O'Connor, Doug W Chan, Andrew Laegeler, Jun Qin, Zhou Songyang. Nat Cell Biol 2004
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POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex.
Jeffrey Zheng-Sheng Ye, Dirk Hockemeyer, Andrew N Krutchinsky, Diego Loayza, Sarah M Hooper, Brian T Chait, Titia de Lange. Genes Dev 2004
Jeffrey Zheng-Sheng Ye, Dirk Hockemeyer, Andrew N Krutchinsky, Diego Loayza, Sarah M Hooper, Brian T Chait, Titia de Lange. Genes Dev 2004
31
TRF2 protects human telomeres from end-to-end fusions.
B van Steensel, A Smogorzewska, T de Lange. Cell 1998
B van Steensel, A Smogorzewska, T de Lange. Cell 1998
30
A dynamic molecular link between the telomere length regulator TRF1 and the chromosome end protector TRF2.
Benjamin R Houghtaling, Leanora Cuttonaro, William Chang, Susan Smith. Curr Biol 2004
Benjamin R Houghtaling, Leanora Cuttonaro, William Chang, Susan Smith. Curr Biol 2004
29
Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1.
Eros Lazzerini Denchi, Titia de Lange. Nature 2007
Eros Lazzerini Denchi, Titia de Lange. Nature 2007
29
Telomere-independent Rap1 is an IKK adaptor and regulates NF-kappaB-dependent gene expression.
Hsiangling Teo, Sourav Ghosh, Hendrik Luesch, Arkasubhra Ghosh, Ee Tsin Wong, Najib Malik, Anthony Orth, Paul de Jesus, Anthony S Perry, Jeffrey D Oliver,[...]. Nat Cell Biol 2010
Hsiangling Teo, Sourav Ghosh, Hendrik Luesch, Arkasubhra Ghosh, Ee Tsin Wong, Najib Malik, Anthony Orth, Paul de Jesus, Anthony S Perry, Jeffrey D Oliver,[...]. Nat Cell Biol 2010
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Identification of a specific telomere terminal transferase activity in Tetrahymena extracts.
C W Greider, E H Blackburn. Cell 1985
C W Greider, E H Blackburn. Cell 1985
26
POT1 as a terminal transducer of TRF1 telomere length control.
Diego Loayza, Titia De Lange. Nature 2003
Diego Loayza, Titia De Lange. Nature 2003
25
Control of telomere length by the human telomeric protein TRF1.
B van Steensel, T de Lange. Nature 1997
B van Steensel, T de Lange. Nature 1997
25
Mammalian telomeres resemble fragile sites and require TRF1 for efficient replication.
Agnel Sfeir, Settapong T Kosiyatrakul, Dirk Hockemeyer, Sheila L MacRae, Jan Karlseder, Carl L Schildkraut, Titia de Lange. Cell 2009
Agnel Sfeir, Settapong T Kosiyatrakul, Dirk Hockemeyer, Sheila L MacRae, Jan Karlseder, Carl L Schildkraut, Titia de Lange. Cell 2009
25
Super-resolution fluorescence imaging of telomeres reveals TRF2-dependent T-loop formation.
Ylli Doksani, John Y Wu, Titia de Lange, Xiaowei Zhuang. Cell 2013
Ylli Doksani, John Y Wu, Titia de Lange, Xiaowei Zhuang. Cell 2013
25
DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion.
Giulia B Celli, Titia de Lange. Nat Cell Biol 2005
Giulia B Celli, Titia de Lange. Nat Cell Biol 2005
25
Telomeric localization of TRF2, a novel human telobox protein.
T Bilaud, C Brun, K Ancelin, C E Koering, T Laroche, E Gilson. Nat Genet 1997
T Bilaud, C Brun, K Ancelin, C E Koering, T Laroche, E Gilson. Nat Genet 1997
25
The POT1-TPP1 telomere complex is a telomerase processivity factor.
Feng Wang, Elaine R Podell, Arthur J Zaug, Yuting Yang, Paul Baciu, Thomas R Cech, Ming Lei. Nature 2007
Feng Wang, Elaine R Podell, Arthur J Zaug, Yuting Yang, Paul Baciu, Thomas R Cech, Ming Lei. Nature 2007
24
A human telomeric protein.
L Chong, B van Steensel, D Broccoli, H Erdjument-Bromage, J Hanish, P Tempst, T de Lange. Science 1995
L Chong, B van Steensel, D Broccoli, H Erdjument-Bromage, J Hanish, P Tempst, T de Lange. Science 1995
23
TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres.
Jeffrey Zheng-Sheng Ye, Jill R Donigian, Megan van Overbeek, Diego Loayza, Yan Luo, Andrew N Krutchinsky, Brian T Chait, Titia de Lange. J Biol Chem 2004
Jeffrey Zheng-Sheng Ye, Jill R Donigian, Megan van Overbeek, Diego Loayza, Yan Luo, Andrew N Krutchinsky, Brian T Chait, Titia de Lange. J Biol Chem 2004
23
Telomere protection by TPP1/POT1 requires tethering to TIN2.
Kaori K Takai, Tatsuya Kibe, Jill R Donigian, David Frescas, Titia de Lange. Mol Cell 2011
Kaori K Takai, Tatsuya Kibe, Jill R Donigian, David Frescas, Titia de Lange. Mol Cell 2011
22
Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins.
Dan Liu, Matthew S O'Connor, Jun Qin, Zhou Songyang. J Biol Chem 2004
Dan Liu, Matthew S O'Connor, Jun Qin, Zhou Songyang. J Biol Chem 2004
22
A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins.
Yong Chen, Yuting Yang, Megan van Overbeek, Jill R Donigian, Paul Baciu, Titia de Lange, Ming Lei. Science 2008
Yong Chen, Yuting Yang, Megan van Overbeek, Jill R Donigian, Paul Baciu, Titia de Lange, Ming Lei. Science 2008
22
Telomeric repeat containing RNA and RNA surveillance factors at mammalian chromosome ends.
Claus M Azzalin, Patrick Reichenbach, Lela Khoriauli, Elena Giulotto, Joachim Lingner. Science 2007
Claus M Azzalin, Patrick Reichenbach, Lela Khoriauli, Elena Giulotto, Joachim Lingner. Science 2007
21
The human Rap1 protein complex and modulation of telomere length.
Matthew S O'Connor, Amin Safari, Dan Liu, Jun Qin, Zhou Songyang. J Biol Chem 2004
Matthew S O'Connor, Amin Safari, Dan Liu, Jun Qin, Zhou Songyang. J Biol Chem 2004
20
TALEN gene knockouts reveal no requirement for the conserved human shelterin protein Rap1 in telomere protection and length regulation.
Shaheen Kabir, Dirk Hockemeyer, Titia de Lange. Cell Rep 2014
Shaheen Kabir, Dirk Hockemeyer, Titia de Lange. Cell Rep 2014
46
A conserved motif within RAP1 has diversified roles in telomere protection and regulation in different organisms.
Yong Chen, Rekha Rai, Zi-Ren Zhou, Junko Kanoh, Cyril Ribeyre, Yuting Yang, Hong Zheng, Pascal Damay, Feng Wang, Hisayo Tsujii,[...]. Nat Struct Mol Biol 2011
Yong Chen, Rekha Rai, Zi-Ren Zhou, Junko Kanoh, Cyril Ribeyre, Yuting Yang, Hong Zheng, Pascal Damay, Feng Wang, Hisayo Tsujii,[...]. Nat Struct Mol Biol 2011
30
TPP1 is a homologue of ciliate TEBP-beta and interacts with POT1 to recruit telomerase.
Huawei Xin, Dan Liu, Ma Wan, Amin Safari, Hyeung Kim, Wen Sun, Matthew S O'Connor, Zhou Songyang. Nature 2007
Huawei Xin, Dan Liu, Ma Wan, Amin Safari, Hyeung Kim, Wen Sun, Matthew S O'Connor, Zhou Songyang. Nature 2007
20
RAP1 protects from obesity through its extratelomeric role regulating gene expression.
Paula Martínez, Gonzalo Gómez-López, Fernando García, Evi Mercken, Sarah Mitchell, Juana M Flores, Rafael de Cabo, Maria A Blasco. Cell Rep 2013
Paula Martínez, Gonzalo Gómez-López, Fernando García, Evi Mercken, Sarah Mitchell, Juana M Flores, Rafael de Cabo, Maria A Blasco. Cell Rep 2013
28
Structure of human POT1 bound to telomeric single-stranded DNA provides a model for chromosome end-protection.
Ming Lei, Elaine R Podell, Thomas R Cech. Nat Struct Mol Biol 2004
Ming Lei, Elaine R Podell, Thomas R Cech. Nat Struct Mol Biol 2004
20
Human RAP1 inhibits non-homologous end joining at telomeres.
Jay Sarthy, Nancy S Bae, Jonathan Scrafford, Peter Baumann. EMBO J 2009
Jay Sarthy, Nancy S Bae, Jonathan Scrafford, Peter Baumann. EMBO J 2009
23
A RAP1/TRF2 complex inhibits nonhomologous end-joining at human telomeric DNA ends.
Nancy S Bae, Peter Baumann. Mol Cell 2007
Nancy S Bae, Peter Baumann. Mol Cell 2007
19
Nontelomeric role for Rap1 in regulating metabolism and protecting against obesity.
Frank Yeung, Cristina M Ramírez, Pedro A Mateos-Gomez, Alexandra Pinzaru, Giovanni Ceccarini, Shaheen Kabir, Carlos Fernández-Hernando, Agnel Sfeir. Cell Rep 2013
Frank Yeung, Cristina M Ramírez, Pedro A Mateos-Gomez, Alexandra Pinzaru, Giovanni Ceccarini, Shaheen Kabir, Carlos Fernández-Hernando, Agnel Sfeir. Cell Rep 2013
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Specific association of human telomerase activity with immortal cells and cancer.
N W Kim, M A Piatyszek, K R Prowse, C B Harley, M D West, P L Ho, G M Coviello, W E Wright, S L Weinrich, J W Shay. Science 1994
N W Kim, M A Piatyszek, K R Prowse, C B Harley, M D West, P L Ho, G M Coviello, W E Wright, S L Weinrich, J W Shay. Science 1994
19
TRF2-RAP1 is required to protect telomeres from engaging in homologous recombination-mediated deletions and fusions.
Rekha Rai, Yong Chen, Ming Lei, Sandy Chang. Nat Commun 2016
Rekha Rai, Yong Chen, Ming Lei, Sandy Chang. Nat Commun 2016
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TIN2-tethered TPP1 recruits human telomerase to telomeres in vivo.
Eladio Abreu, Elena Aritonovska, Patrick Reichenbach, Gaël Cristofari, Brad Culp, Rebecca M Terns, Joachim Lingner, Michael P Terns. Mol Cell Biol 2010
Eladio Abreu, Elena Aritonovska, Patrick Reichenbach, Gaël Cristofari, Brad Culp, Rebecca M Terns, Joachim Lingner, Michael P Terns. Mol Cell Biol 2010
18
Removal of shelterin reveals the telomere end-protection problem.
Agnel Sfeir, Titia de Lange. Science 2012
Agnel Sfeir, Titia de Lange. Science 2012
18
Rap1 affects the length and heterogeneity of human telomeres.
Bibo Li, Titia de Lange. Mol Biol Cell 2003
Bibo Li, Titia de Lange. Mol Biol Cell 2003
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A critical role for TPP1 and TIN2 interaction in high-order telomeric complex assembly.
Matthew S O'Connor, Amin Safari, Huawei Xin, Dan Liu, Zhou Songyang. Proc Natl Acad Sci U S A 2006
Matthew S O'Connor, Amin Safari, Huawei Xin, Dan Liu, Zhou Songyang. Proc Natl Acad Sci U S A 2006
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In vivo stoichiometry of shelterin components.
Kaori K Takai, Sarah Hooper, Stephanie Blackwood, Rita Gandhi, Titia de Lange. J Biol Chem 2010
Kaori K Takai, Sarah Hooper, Stephanie Blackwood, Rita Gandhi, Titia de Lange. J Biol Chem 2010
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A mammalian factor that binds telomeric TTAGGG repeats in vitro.
Z Zhong, L Shiue, S Kaplan, T de Lange. Mol Cell Biol 1992
Z Zhong, L Shiue, S Kaplan, T de Lange. Mol Cell Biol 1992
17
Pot1 deficiency initiates DNA damage checkpoint activation and aberrant homologous recombination at telomeres.
Ling Wu, Asha S Multani, Hua He, Wilfredo Cosme-Blanco, Yu Deng, Jian Min Deng, Olga Bachilo, Sen Pathak, Hedioshi Tahara, Susan M Bailey,[...]. Cell 2006
Ling Wu, Asha S Multani, Hua He, Wilfredo Cosme-Blanco, Yu Deng, Jian Min Deng, Olga Bachilo, Sen Pathak, Hedioshi Tahara, Susan M Bailey,[...]. Cell 2006
16
Human Rap1 interacts directly with telomeric DNA and regulates TRF2 localization at the telomere.
N Özlem Arat, Jack D Griffith. J Biol Chem 2012
N Özlem Arat, Jack D Griffith. J Biol Chem 2012
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The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity.
Jayakrishnan Nandakumar, Caitlin F Bell, Ina Weidenfeld, Arthur J Zaug, Leslie A Leinwand, Thomas R Cech. Nature 2012
Jayakrishnan Nandakumar, Caitlin F Bell, Ina Weidenfeld, Arthur J Zaug, Leslie A Leinwand, Thomas R Cech. Nature 2012
16
Human telomeric proteins occupy selective interstitial sites.
Dong Yang, Yuanyan Xiong, Hyeung Kim, Quanyuan He, Yumei Li, Rui Chen, Zhou Songyang. Cell Res 2011
Dong Yang, Yuanyan Xiong, Hyeung Kim, Quanyuan He, Yumei Li, Rui Chen, Zhou Songyang. Cell Res 2011
17
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.