Fas preassociation required for apoptosis signaling and dominant inhibition by pathogenic mutations.
R M Siegel, J K Frederiksen, D A Zacharias, F K Chan, M Johnson, D Lynch, R Y Tsien, M J Lenardo. Science 2000
Times Cited: 499
Times Cited: 499
Times Cited
Times Co-cited
Similarity
A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling.
F K Chan, H J Chun, L Zheng, R M Siegel, K L Bui, M J Lenardo. Science 2000
F K Chan, H J Chun, L Zheng, R M Siegel, K L Bui, M J Lenardo. Science 2000
44
Identification and characterization of a ligand-independent oligomerization domain in the extracellular region of the CD95 death receptor.
G Papoff, P Hausler, A Eramo, M G Pagano, G Di Leve, A Signore, G Ruberti. J Biol Chem 1999
G Papoff, P Hausler, A Eramo, M G Pagano, G Di Leve, A Signore, G Ruberti. J Biol Chem 1999
24
Membrane-bound Fas ligand only is essential for Fas-induced apoptosis.
Lorraine A O' Reilly, Lin Tai, Lily Lee, Elizabeth A Kruse, Stephanie Grabow, W Douglas Fairlie, Nicole M Haynes, David M Tarlinton, Jian-Guo Zhang, Gabrielle T Belz,[...]. Nature 2009
Lorraine A O' Reilly, Lin Tai, Lily Lee, Elizabeth A Kruse, Stephanie Grabow, W Douglas Fairlie, Nicole M Haynes, David M Tarlinton, Jian-Guo Zhang, Gabrielle T Belz,[...]. Nature 2009
21
Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor.
F C Kischkel, S Hellbardt, I Behrmann, M Germer, M Pawlita, P H Krammer, M E Peter. EMBO J 1995
F C Kischkel, S Hellbardt, I Behrmann, M Germer, M Pawlita, P H Krammer, M E Peter. EMBO J 1995
20
Preligand assembly domain-mediated ligand-independent association between TRAIL receptor 4 (TR4) and TR2 regulates TRAIL-induced apoptosis.
Lauren Clancy, Karen Mruk, Kristina Archer, Melissa Woelfel, Juthathip Mongkolsapaya, Gavin Screaton, Michael J Lenardo, Francis Ka-Ming Chan. Proc Natl Acad Sci U S A 2005
Lauren Clancy, Karen Mruk, Kristina Archer, Melissa Woelfel, Juthathip Mongkolsapaya, Gavin Screaton, Michael J Lenardo, Francis Ka-Ming Chan. Proc Natl Acad Sci U S A 2005
20
The Fas-FADD death domain complex structure unravels signalling by receptor clustering.
Fiona L Scott, Boguslaw Stec, Cristina Pop, Małgorzata K Dobaczewska, JeongEun J Lee, Edward Monosov, Howard Robinson, Guy S Salvesen, Robert Schwarzenbacher, Stefan J Riedl. Nature 2009
Fiona L Scott, Boguslaw Stec, Cristina Pop, Małgorzata K Dobaczewska, JeongEun J Lee, Edward Monosov, Howard Robinson, Guy S Salvesen, Robert Schwarzenbacher, Stefan J Riedl. Nature 2009
20
Conversion of membrane-bound Fas(CD95) ligand to its soluble form is associated with downregulation of its proapoptotic activity and loss of liver toxicity.
P Schneider, N Holler, J L Bodmer, M Hahne, K Frei, A Fontana, J Tschopp. J Exp Med 1998
P Schneider, N Holler, J L Bodmer, M Hahne, K Frei, A Fontana, J Tschopp. J Exp Med 1998
19
Yes and PI3K bind CD95 to signal invasion of glioblastoma.
Susanne Kleber, Ignacio Sancho-Martinez, Benedict Wiestler, Alexandra Beisel, Christian Gieffers, Oliver Hill, Meinolf Thiemann, Wolf Mueller, Jaromir Sykora, Andreas Kuhn,[...]. Cancer Cell 2008
Susanne Kleber, Ignacio Sancho-Martinez, Benedict Wiestler, Alexandra Beisel, Christian Gieffers, Oliver Hill, Meinolf Thiemann, Wolf Mueller, Jaromir Sykora, Andreas Kuhn,[...]. Cancer Cell 2008
18
The Fas-FADD death domain complex structure reveals the basis of DISC assembly and disease mutations.
Liwei Wang, Jin Kuk Yang, Venkataraman Kabaleeswaran, Amanda J Rice, Anthony C Cruz, Ah Young Park, Qian Yin, Ermelinda Damko, Se Bok Jang, Stefan Raunser,[...]. Nat Struct Mol Biol 2010
Liwei Wang, Jin Kuk Yang, Venkataraman Kabaleeswaran, Amanda J Rice, Anthony C Cruz, Ah Young Park, Qian Yin, Ermelinda Damko, Se Bok Jang, Stefan Raunser,[...]. Nat Struct Mol Biol 2010
17
Structural Basis and Functional Role of Intramembrane Trimerization of the Fas/CD95 Death Receptor.
Qingshan Fu, Tian-Min Fu, Anthony C Cruz, Prabuddha Sengupta, Stacy K Thomas, Shuqing Wang, Richard M Siegel, Hao Wu, James J Chou. Mol Cell 2016
Qingshan Fu, Tian-Min Fu, Anthony C Cruz, Prabuddha Sengupta, Stacy K Thomas, Shuqing Wang, Richard M Siegel, Hao Wu, James J Chou. Mol Cell 2016
17
The TNF and TNF receptor superfamilies: integrating mammalian biology.
R M Locksley, N Killeen, M J Lenardo. Cell 2001
R M Locksley, N Killeen, M J Lenardo. Cell 2001
16
Mutations in Fas associated with human lymphoproliferative syndrome and autoimmunity.
F Rieux-Laucat, F Le Deist, C Hivroz, I A Roberts, K M Debatin, A Fischer, J P de Villartay. Science 1995
F Rieux-Laucat, F Le Deist, C Hivroz, I A Roberts, K M Debatin, A Fischer, J P de Villartay. Science 1995
16
Dominant interfering Fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome.
G H Fisher, F J Rosenberg, S E Straus, J K Dale, L A Middleton, A Y Lin, W Strober, M J Lenardo, J M Puck. Cell 1995
G H Fisher, F J Rosenberg, S E Straus, J K Dale, L A Middleton, A Y Lin, W Strober, M J Lenardo, J M Puck. Cell 1995
15
A death effector domain chain DISC model reveals a crucial role for caspase-8 chain assembly in mediating apoptotic cell death.
Laura S Dickens, Robert S Boyd, Rebekah Jukes-Jones, Michelle A Hughes, Gemma L Robinson, Louise Fairall, John W R Schwabe, Kelvin Cain, Marion Macfarlane. Mol Cell 2012
Laura S Dickens, Robert S Boyd, Rebekah Jukes-Jones, Michelle A Hughes, Gemma L Robinson, Louise Fairall, John W R Schwabe, Kelvin Cain, Marion Macfarlane. Mol Cell 2012
15
Crystallographic evidence for dimerization of unliganded tumor necrosis factor receptor.
J H Naismith, T Q Devine, B J Brandhuber, S R Sprang. J Biol Chem 1995
J H Naismith, T Q Devine, B J Brandhuber, S R Sprang. J Biol Chem 1995
15
The naturally processed CD95L elicits a c-yes/calcium/PI3K-driven cell migration pathway.
Sébastien Tauzin, Benjamin Chaigne-Delalande, Eric Selva, Nadine Khadra, Sophie Daburon, Cécile Contin-Bordes, Patrick Blanco, Jacques Le Seyec, Thomas Ducret, Laurent Counillon,[...]. PLoS Biol 2011
Sébastien Tauzin, Benjamin Chaigne-Delalande, Eric Selva, Nadine Khadra, Sophie Daburon, Cécile Contin-Bordes, Patrick Blanco, Jacques Le Seyec, Thomas Ducret, Laurent Counillon,[...]. PLoS Biol 2011
19
The many roles of FAS receptor signaling in the immune system.
Andreas Strasser, Philipp J Jost, Shigekazu Nagata. Immunity 2009
Andreas Strasser, Philipp J Jost, Shigekazu Nagata. Immunity 2009
14
Stoichiometry of the CD95 death-inducing signaling complex: experimental and modeling evidence for a death effector domain chain model.
Kolja Schleich, Uwe Warnken, Nicolai Fricker, Selcen Oztürk, Petra Richter, Kerstin Kammerer, Martina Schnölzer, Peter H Krammer, Inna N Lavrik. Mol Cell 2012
Kolja Schleich, Uwe Warnken, Nicolai Fricker, Selcen Oztürk, Petra Richter, Kerstin Kammerer, Martina Schnölzer, Peter H Krammer, Inna N Lavrik. Mol Cell 2012
13
The transmembrane form of tumor necrosis factor is the prime activating ligand of the 80 kDa tumor necrosis factor receptor.
M Grell, E Douni, H Wajant, M Löhden, M Clauss, B Maxeiner, S Georgopoulos, W Lesslauer, G Kollias, K Pfizenmaier,[...]. Cell 1995
M Grell, E Douni, H Wajant, M Löhden, M Clauss, B Maxeiner, S Georgopoulos, W Lesslauer, G Kollias, K Pfizenmaier,[...]. Cell 1995
13
Triggering cell death: the crystal structure of Apo2L/TRAIL in a complex with death receptor 5.
S G Hymowitz, H W Christinger, G Fuh, M Ultsch, M O'Connell, R F Kelley, A Ashkenazi, A M de Vos. Mol Cell 1999
S G Hymowitz, H W Christinger, G Fuh, M Ultsch, M O'Connell, R F Kelley, A Ashkenazi, A M de Vos. Mol Cell 1999
13
Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes.
Olivier Micheau, Jürg Tschopp. Cell 2003
Olivier Micheau, Jürg Tschopp. Cell 2003
13
The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis.
N Itoh, S Yonehara, A Ishii, M Yonehara, S Mizushima, M Sameshima, A Hase, Y Seto, S Nagata. Cell 1991
N Itoh, S Yonehara, A Ishii, M Yonehara, S Mizushima, M Sameshima, A Hase, Y Seto, S Nagata. Cell 1991
13
Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation.
D W Banner, A D'Arcy, W Janes, R Gentz, H J Schoenfeld, C Broger, H Loetscher, W Lesslauer. Cell 1993
D W Banner, A D'Arcy, W Janes, R Gentz, H J Schoenfeld, C Broger, H Loetscher, W Lesslauer. Cell 1993
13
Solution of the structure of the TNF-TNFR2 complex.
Yohei Mukai, Teruya Nakamura, Mai Yoshikawa, Yasuo Yoshioka, Shin-ichi Tsunoda, Shinsaku Nakagawa, Yuriko Yamagata, Yasuo Tsutsumi. Sci Signal 2010
Yohei Mukai, Teruya Nakamura, Mai Yoshikawa, Yasuo Yoshioka, Shin-ichi Tsunoda, Shinsaku Nakagawa, Yuriko Yamagata, Yasuo Tsutsumi. Sci Signal 2010
13
Autoimmune lymphoproliferative syndrome with somatic Fas mutations.
Eliska Holzelova, Cédric Vonarbourg, Marie-Claude Stolzenberg, Peter D Arkwright, Françoise Selz, Anne-Marie Prieur, Stéphane Blanche, Jirina Bartunkova, Etienne Vilmer, Alain Fischer,[...]. N Engl J Med 2004
Eliska Holzelova, Cédric Vonarbourg, Marie-Claude Stolzenberg, Peter D Arkwright, Françoise Selz, Anne-Marie Prieur, Stéphane Blanche, Jirina Bartunkova, Etienne Vilmer, Alain Fischer,[...]. N Engl J Med 2004
12
Revised diagnostic criteria and classification for the autoimmune lymphoproliferative syndrome (ALPS): report from the 2009 NIH International Workshop.
Joao B Oliveira, Jack J Bleesing, Umberto Dianzani, Thomas A Fleisher, Elaine S Jaffe, Michael J Lenardo, Frederic Rieux-Laucat, Richard M Siegel, Helen C Su, David T Teachey,[...]. Blood 2010
Joao B Oliveira, Jack J Bleesing, Umberto Dianzani, Thomas A Fleisher, Elaine S Jaffe, Michael J Lenardo, Frederic Rieux-Laucat, Richard M Siegel, Helen C Su, David T Teachey,[...]. Blood 2010
12
The development of lymphomas in families with autoimmune lymphoproliferative syndrome with germline Fas mutations and defective lymphocyte apoptosis.
S E Straus, E S Jaffe, J M Puck, J K Dale, K B Elkon, A Rösen-Wolff, A M Peters, M C Sneller, C W Hallahan, J Wang,[...]. Blood 2001
S E Straus, E S Jaffe, J M Puck, J K Dale, K B Elkon, A Rösen-Wolff, A M Peters, M C Sneller, C W Hallahan, J Wang,[...]. Blood 2001
12
CD95 promotes tumour growth.
Lina Chen, Sun-Mi Park, Alexei V Tumanov, Annika Hau, Kenjiro Sawada, Christine Feig, Jerrold R Turner, Yang-Xin Fu, Iris L Romero, Ernst Lengyel,[...]. Nature 2010
Lina Chen, Sun-Mi Park, Alexei V Tumanov, Annika Hau, Kenjiro Sawada, Christine Feig, Jerrold R Turner, Yang-Xin Fu, Iris L Romero, Ernst Lengyel,[...]. Nature 2010
12
The molecular architecture of the TNF superfamily.
Jean-Luc Bodmer, Pascal Schneider, Jürg Tschopp. Trends Biochem Sci 2002
Jean-Luc Bodmer, Pascal Schneider, Jürg Tschopp. Trends Biochem Sci 2002
12
Two adjacent trimeric Fas ligands are required for Fas signaling and formation of a death-inducing signaling complex.
Nils Holler, Aubry Tardivel, Magdalena Kovacsovics-Bankowski, Sylvie Hertig, Olivier Gaide, Fabio Martinon, Antoine Tinel, David Deperthes, Silvio Calderara, Therese Schulthess,[...]. Mol Cell Biol 2003
Nils Holler, Aubry Tardivel, Magdalena Kovacsovics-Bankowski, Sylvie Hertig, Olivier Gaide, Fabio Martinon, Antoine Tinel, David Deperthes, Silvio Calderara, Therese Schulthess,[...]. Mol Cell Biol 2003
12
Palmitoylation of CD95 facilitates formation of SDS-stable receptor aggregates that initiate apoptosis signaling.
Christine Feig, Vladimir Tchikov, Stefan Schütze, Marcus E Peter. EMBO J 2007
Christine Feig, Vladimir Tchikov, Stefan Schütze, Marcus E Peter. EMBO J 2007
12
Natural history of autoimmune lymphoproliferative syndrome associated with FAS gene mutations.
Susan Price, Pamela A Shaw, Amy Seitz, Gyan Joshi, Joie Davis, Julie E Niemela, Katie Perkins, Ronald L Hornung, Les Folio, Philip S Rosenberg,[...]. Blood 2014
Susan Price, Pamela A Shaw, Amy Seitz, Gyan Joshi, Joie Davis, Julie E Niemela, Katie Perkins, Ronald L Hornung, Les Folio, Philip S Rosenberg,[...]. Blood 2014
12
NMR structure and mutagenesis of the Fas (APO-1/CD95) death domain.
B Huang, M Eberstadt, E T Olejniczak, R P Meadows, S W Fesik. Nature 1996
B Huang, M Eberstadt, E T Olejniczak, R P Meadows, S W Fesik. Nature 1996
11
Solution NMR investigation of the CD95/FADD homotypic death domain complex suggests lack of engagement of the CD95 C terminus.
Diego Esposito, Andrew Sankar, Nina Morgner, Carol V Robinson, Katrin Rittinger, Paul C Driscoll. Structure 2010
Diego Esposito, Andrew Sankar, Nina Morgner, Carol V Robinson, Katrin Rittinger, Paul C Driscoll. Structure 2010
27
Membrane Fas ligand kills human peripheral blood T lymphocytes, and soluble Fas ligand blocks the killing.
T Suda, H Hashimoto, M Tanaka, T Ochi, S Nagata. J Exp Med 1997
T Suda, H Hashimoto, M Tanaka, T Ochi, S Nagata. J Exp Med 1997
11
Defective CD95/APO-1/Fas signal complex formation in the human autoimmune lymphoproliferative syndrome, type Ia.
D A Martin, L Zheng, R M Siegel, B Huang, G H Fisher, J Wang, C E Jackson, J M Puck, J Dale, S E Straus,[...]. Proc Natl Acad Sci U S A 1999
D A Martin, L Zheng, R M Siegel, B Huang, G H Fisher, J Wang, C E Jackson, J M Puck, J Dale, S E Straus,[...]. Proc Natl Acad Sci U S A 1999
10
FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex.
M Muzio, A M Chinnaiyan, F C Kischkel, K O'Rourke, A Shevchenko, J Ni, C Scaffidi, J D Bretz, M Zhang, R Gentz,[...]. Cell 1996
M Muzio, A M Chinnaiyan, F C Kischkel, K O'Rourke, A Shevchenko, J Ni, C Scaffidi, J D Bretz, M Zhang, R Gentz,[...]. Cell 1996
10
Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis.
Andrew Oberst, Christopher P Dillon, Ricardo Weinlich, Laura L McCormick, Patrick Fitzgerald, Cristina Pop, Razq Hakem, Guy S Salvesen, Douglas R Green. Nature 2011
Andrew Oberst, Christopher P Dillon, Ricardo Weinlich, Laura L McCormick, Patrick Fitzgerald, Cristina Pop, Razq Hakem, Guy S Salvesen, Douglas R Green. Nature 2011
10
CD95-ligand on peripheral myeloid cells activates Syk kinase to trigger their recruitment to the inflammatory site.
Elisabeth Letellier, Sachin Kumar, Ignacio Sancho-Martinez, Stefanie Krauth, Anne Funke-Kaiser, Sabrina Laudenklos, Katrin Konecki, Stefan Klussmann, Nina S Corsini, Susanne Kleber,[...]. Immunity 2010
Elisabeth Letellier, Sachin Kumar, Ignacio Sancho-Martinez, Stefanie Krauth, Anne Funke-Kaiser, Sabrina Laudenklos, Katrin Konecki, Stefan Klussmann, Nina S Corsini, Susanne Kleber,[...]. Immunity 2010
10
CD95L cell surface cleavage triggers a prometastatic signaling pathway in triple-negative breast cancer.
Marine Malleter, Sébastien Tauzin, Alban Bessede, Rémy Castellano, Armelle Goubard, Florence Godey, Jean Levêque, Pascal Jézéquel, Loic Campion, Mario Campone,[...]. Cancer Res 2013
Marine Malleter, Sébastien Tauzin, Alban Bessede, Rémy Castellano, Armelle Goubard, Florence Godey, Jean Levêque, Pascal Jézéquel, Loic Campion, Mario Campone,[...]. Cancer Res 2013
16
Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis.
R Watanabe-Fukunaga, C I Brannan, N G Copeland, N A Jenkins, S Nagata. Nature 1992
R Watanabe-Fukunaga, C I Brannan, N G Copeland, N A Jenkins, S Nagata. Nature 1992
10
FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis.
A M Chinnaiyan, K O'Rourke, M Tewari, V M Dixit. Cell 1995
A M Chinnaiyan, K O'Rourke, M Tewari, V M Dixit. Cell 1995
10
Three is better than one: pre-ligand receptor assembly in the regulation of TNF receptor signaling.
Francis Ka-Ming Chan. Cytokine 2007
Francis Ka-Ming Chan. Cytokine 2007
10
Dominant negative effects of tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) receptor 4 on TRAIL receptor 1 signaling by formation of heteromeric complexes.
Simon Neumann, Jan Hasenauer, Nadine Pollak, Peter Scheurich. J Biol Chem 2014
Simon Neumann, Jan Hasenauer, Nadine Pollak, Peter Scheurich. J Biol Chem 2014
29
Co-operative and Hierarchical Binding of c-FLIP and Caspase-8: A Unified Model Defines How c-FLIP Isoforms Differentially Control Cell Fate.
Michelle A Hughes, Ian R Powley, Rebekah Jukes-Jones, Sebastian Horn, Maria Feoktistova, Louise Fairall, John W R Schwabe, Martin Leverkus, Kelvin Cain, Marion MacFarlane. Mol Cell 2016
Michelle A Hughes, Ian R Powley, Rebekah Jukes-Jones, Sebastian Horn, Maria Feoktistova, Louise Fairall, John W R Schwabe, Martin Leverkus, Kelvin Cain, Marion MacFarlane. Mol Cell 2016
10
Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death.
M P Boldin, T M Goncharov, Y V Goltsev, D Wallach. Cell 1996
M P Boldin, T M Goncharov, Y V Goltsev, D Wallach. Cell 1996
9
Signalling pathways of the TNF superfamily: a double-edged sword.
Bharat B Aggarwal. Nat Rev Immunol 2003
Bharat B Aggarwal. Nat Rev Immunol 2003
9
Structure of the TRAIL-DR5 complex reveals mechanisms conferring specificity in apoptotic initiation.
J Mongkolsapaya, J M Grimes, N Chen, X N Xu, D I Stuart, E Y Jones, G R Screaton. Nat Struct Biol 1999
J Mongkolsapaya, J M Grimes, N Chen, X N Xu, D I Stuart, E Y Jones, G R Screaton. Nat Struct Biol 1999
9
Fas transduces activation signals in normal human T lymphocytes.
M R Alderson, R J Armitage, E Maraskovsky, T W Tough, E Roux, K Schooley, F Ramsdell, D H Lynch. J Exp Med 1993
M R Alderson, R J Armitage, E Maraskovsky, T W Tough, E Roux, K Schooley, F Ramsdell, D H Lynch. J Exp Med 1993
9
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.