A citation-based method for searching scientific literature

J Parrish-Novak, S R Dillon, A Nelson, A Hammond, C Sprecher, J A Gross, J Johnston, K Madden, W Xu, J West, S Schrader, S Burkhead, M Heipel, C Brandt, J L Kuijper, J Kramer, D Conklin, S R Presnell, J Berry, F Shiota, S Bort, K Hambly, S Mudri, C Clegg, M Moore, F J Grant, C Lofton-Day, T Gilbert, F Rayond, A Ching, L Yao, D Smith, P Webster, T Whitmore, M Maurer, K Kaushansky, R D Holly, D Foster. Nature 2000
Times Cited: 924







List of co-cited articles
1001 articles co-cited >1



Times Cited
  Times     Co-cited
Similarity


Interleukin-21: basic biology and implications for cancer and autoimmunity.
Rosanne Spolski, Warren J Leonard. Annu Rev Immunol 2008
522
19

Interleukin-21: a double-edged sword with therapeutic potential.
Rosanne Spolski, Warren J Leonard. Nat Rev Drug Discov 2014
311
16

A critical role for IL-21 in regulating immunoglobulin production.
Katsutoshi Ozaki, Rosanne Spolski, Carl G Feng, Chen-Feng Qi, Jun Cheng, Alan Sher, Herbert C Morse, Chengyu Liu, Pamela L Schwartzberg, Warren J Leonard. Science 2002
745
14

IL-21 limits NK cell responses and promotes antigen-specific T cell activation: a mediator of the transition from innate to adaptive immunity.
Marion T Kasaian, Matthew J Whitters, Laura L Carter, Leslie D Lowe, Jason M Jussif, Bijia Deng, Kaley A Johnson, JoAnn S Witek, Mayra Senices, Richard F Konz,[...]. Immunity 2002
376
13

Cloning of a type I cytokine receptor most related to the IL-2 receptor beta chain.
K Ozaki, K Kikly, D Michalovich, P R Young, W J Leonard. Proc Natl Acad Sci U S A 2000
253
12

Synergy of IL-21 and IL-15 in regulating CD8+ T cell expansion and function.
Rong Zeng, Rosanne Spolski, Steven E Finkelstein, SangKon Oh, Panu E Kovanen, Christian S Hinrichs, Cynthia A Pise-Masison, Michael F Radonovich, John N Brady, Nicholas P Restifo,[...]. J Exp Med 2005
543
12

Regulation of B cell differentiation and plasma cell generation by IL-21, a novel inducer of Blimp-1 and Bcl-6.
Katsutoshi Ozaki, Rosanne Spolski, Rachel Ettinger, Hyoung-Pyo Kim, Gang Wang, Chen-Feng Qi, Patrick Hwu, Daniel J Shaffer, Shreeram Akilesh, Derry C Roopenian,[...]. J Immunol 2004
500
12

Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex.
H Asao, C Okuyama, S Kumaki, N Ishii, S Tsuchiya, D Foster, K Sugamura. J Immunol 2001
408
10

Redistribution, hyperproliferation, activation of natural killer cells and CD8 T cells, and cytokine production during first-in-human clinical trial of recombinant human interleukin-15 in patients with cancer.
Kevin C Conlon, Enrico Lugli, Hugh C Welles, Steven A Rosenberg, Antonio Tito Fojo, John C Morris, Thomas A Fleisher, Sigrid P Dubois, Liyanage P Perera, Donn M Stewart,[...]. J Clin Oncol 2015
394
10

IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells.
Thomas Korn, Estelle Bettelli, Wenda Gao, Amit Awasthi, Anneli Jäger, Terry B Strom, Mohamed Oukka, Vijay K Kuchroo. Nature 2007
10


IL-21 is produced by NKT cells and modulates NKT cell activation and cytokine production.
Jonathan M Coquet, Konstantinos Kyparissoudis, Daniel G Pellicci, Gurdyal Besra, Stuart P Berzins, Mark J Smyth, Dale I Godfrey. J Immunol 2007
295
9


Essential autocrine regulation by IL-21 in the generation of inflammatory T cells.
Roza Nurieva, Xuexian O Yang, Gustavo Martinez, Yongliang Zhang, Athanasia D Panopoulos, Li Ma, Kimberly Schluns, Qiang Tian, Stephanie S Watowich, Anton M Jetten,[...]. Nature 2007
9


Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice.
M K Kennedy, M Glaccum, S N Brown, E A Butz, J L Viney, M Embers, N Matsuki, K Charrier, L Sedger, C R Willis,[...]. J Exp Med 2000
9

IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways.
Liang Zhou, Ivaylo I Ivanov, Rosanne Spolski, Roy Min, Kevin Shenderov, Takeshi Egawa, David E Levy, Warren J Leonard, Dan R Littman. Nat Immunol 2007
9



Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages.
Roza I Nurieva, Yeonseok Chung, Daehee Hwang, Xuexian O Yang, Hong Soon Kang, Li Ma, Yi-hong Wang, Stephanie S Watowich, Anton M Jetten, Qiang Tian,[...]. Immunity 2008
898
8

Interleukin-21 and the IL-21 receptor: novel effectors of NK and T cell responses.
Julia Parrish-Novak, Donald C Foster, Richard D Holly, Christopher H Clegg. J Leukoc Biol 2002
193
7

Interleukin-21 inhibits dendritic cell activation and maturation.
Katja Brandt, Silvia Bulfone-Paus, Donald C Foster, René Rückert. Blood 2003
201
7

IL-21 induces differentiation of human naive and memory B cells into antibody-secreting plasma cells.
Rachel Ettinger, Gary P Sims, Anna-Marie Fairhurst, Rachel Robbins, Yong Sing da Silva, Rosanne Spolski, Warren J Leonard, Peter E Lipsky. J Immunol 2005
479
7

IL-21 regulates germinal center B cell differentiation and proliferation through a B cell-intrinsic mechanism.
Dimitra Zotos, Jonathan M Coquet, Yang Zhang, Amanda Light, Kathy D'Costa, Axel Kallies, Lynn M Corcoran, Dale I Godfrey, Kai-Michael Toellner, Mark J Smyth,[...]. J Exp Med 2010
537
7

Follicular helper CD4 T cells (TFH).
Shane Crotty. Annu Rev Immunol 2011
7

Cutting edge: IL-21 is a switch factor for the production of IgG1 and IgG3 by human B cells.
Jérôme Pène, Jean-François Gauchat, Sandrine Lécart, Elodie Drouet, Paul Guglielmi, Vera Boulay, Adriana Delwail, Don Foster, Jean-Claude Lecron, Hans Yssel. J Immunol 2004
227
7

Sustained effector function of IL-12/15/18-preactivated NK cells against established tumors.
Jing Ni, Matthias Miller, Ana Stojanovic, Natalio Garbi, Adelheid Cerwenka. J Exp Med 2012
243
7


IL-21 and T Cell Differentiation: Consider the Context.
Yuan Tian, Allan J Zajac. Trends Immunol 2016
79
8

Blockade of the interleukin-21/interleukin-21 receptor pathway ameliorates disease in animal models of rheumatoid arthritis.
Deborah A Young, Martin Hegen, Hak Ling Margery Ma, Matthew J Whitters, Leo M Albert, Leslie Lowe, Mayra Senices, Paul W Wu, Barbara Sibley, Yelena Leathurby,[...]. Arthritis Rheum 2007
224
6

IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation.
J P Lodolce, D L Boone, S Chai, R E Swain, T Dassopoulos, S Trettin, A Ma. Immunity 1998
6

High-dose recombinant interleukin 2 therapy for patients with metastatic melanoma: analysis of 270 patients treated between 1985 and 1993.
M B Atkins, M T Lotze, J P Dutcher, R I Fisher, G Weiss, K Margolin, J Abrams, M Sznol, D Parkinson, M Hawkins,[...]. J Clin Oncol 1999
6

Cytokine-mediated regulation of human B cell differentiation into Ig-secreting cells: predominant role of IL-21 produced by CXCR5+ T follicular helper cells.
Vanessa L Bryant, Cindy S Ma, Danielle T Avery, Ying Li, Kim L Good, Lynn M Corcoran, Rene de Waal Malefyt, Stuart G Tangye. J Immunol 2007
369
6

Successful adoptive transfer and in vivo expansion of human haploidentical NK cells in patients with cancer.
Jeffrey S Miller, Yvette Soignier, Angela Panoskaltsis-Mortari, Sarah A McNearney, Gong H Yun, Susan K Fautsch, David McKenna, Chap Le, Todd E Defor, Linda J Burns,[...]. Blood 2005
6

Biology of IL-21 and the IL-21 receptor.
Devangi S Mehta, Andrea L Wurster, Michael J Grusby. Immunol Rev 2004
146
6

Functional characterization of a nonmammalian IL-21: rainbow trout Oncorhynchus mykiss IL-21 upregulates the expression of the Th cell signature cytokines IFN-gamma, IL-10, and IL-22.
Tiehui Wang, Patricia Diaz-Rosales, Maria M Costa, Scott Campbell, Michael Snow, Bertrand Collet, Samuel A M Martin, Christopher J Secombes. J Immunol 2011
118
6

IL-21 is required to control chronic viral infection.
Heidi Elsaesser, Karsten Sauer, David G Brooks. Science 2009
414
6

The molecular basis of IL-21-mediated proliferation.
Rong Zeng, Rosanne Spolski, Esther Casas, Wei Zhu, David E Levy, Warren J Leonard. Blood 2007
210
6

Clinical significance and immunobiology of IL-21 in autoimmunity.
Di Long, Yongjian Chen, Haijing Wu, Ming Zhao, Qianjin Lu. J Autoimmun 2019
60
10

IL-21 Signaling in Immunity.
Warren J Leonard, Chi-Keung Wan. F1000Res 2016
78
7


IL-21 is produced by Th17 cells and drives IL-17 production in a STAT3-dependent manner.
Lai Wei, Arian Laurence, Kevin M Elias, John J O'Shea. J Biol Chem 2007
471
6

Analysis of interleukin-21-induced Prdm1 gene regulation reveals functional cooperation of STAT3 and IRF4 transcription factors.
Hyokjoon Kwon, Danielle Thierry-Mieg, Jean Thierry-Mieg, Hyoung-Pyo Kim, Jangsuk Oh, Chainarong Tunyaplin, Sebastian Carotta, Colleen E Donovan, Matthew L Goldman, Prafullakumar Tailor,[...]. Immunity 2009
264
6

Essential role of IL-21 in B cell activation, expansion, and plasma cell generation during CD4+ T cell-B cell collaboration.
Stefan Kuchen, Rachel Robbins, Gary P Sims, Chen Sheng, Terence M Phillips, Peter E Lipsky, Rachel Ettinger. J Immunol 2007
225
5

IL-21 in synergy with IL-15 or IL-18 enhances IFN-gamma production in human NK and T cells.
Mari Strengell, Sampsa Matikainen, Jukka Sirén, Anne Lehtonen, Don Foster, Ilkka Julkunen, Timo Sareneva. J Immunol 2003
288
5

IL-21: a pleiotropic cytokine with potential applications in oncology.
Michela Croce, Valentina Rigo, Silvano Ferrini. J Immunol Res 2015
52
9

Membrane-bound IL-21 promotes sustained ex vivo proliferation of human natural killer cells.
Cecele J Denman, Vladimir V Senyukov, Srinivas S Somanchi, Prasad V Phatarpekar, Lisa M Kopp, Jennifer L Johnson, Harjeet Singh, Lenka Hurton, Sourindra N Maiti, M Helen Huls,[...]. PLoS One 2012
344
5

Phase 1 clinical trial using mbIL21 ex vivo-expanded donor-derived NK cells after haploidentical transplantation.
Stefan O Ciurea, Jolie R Schafer, Roland Bassett, Cecele J Denman, Kai Cao, Dana Willis, Gabriela Rondon, Julianne Chen, Doris Soebbing, Indreshpal Kaur,[...]. Blood 2017
170
5

Interleukin-21 activates human natural killer cells and modulates their surface receptor expression.
Kresten Skak, Klaus Stensgaard Frederiksen, Dorthe Lundsgaard. Immunology 2008
76
6

IL-15Ralpha recycles and presents IL-15 In trans to neighboring cells.
Sigrid Dubois, Jennifer Mariner, Thomas A Waldmann, Yutaka Tagaya. Immunity 2002
683
5


Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.