P Fernandez-Funez, M L Nino-Rosales, B de Gouyon, W C She, J M Luchak, P Martinez, E Turiegano, J Benito, M Capovilla, P J Skinner, A McCall, I Canal, H T Orr, H Y Zoghbi, J Botas. Nature 2000
Times Cited: 483
Times Cited: 483
Times Cited
Times Co-cited
Similarity
Targeted gene expression as a means of altering cell fates and generating dominant phenotypes.
A H Brand, N Perrimon. Development 1993
A H Brand, N Perrimon. Development 1993
19
Genetic suppression of polyglutamine toxicity in Drosophila.
P Kazemi-Esfarjani, S Benzer. Science 2000
P Kazemi-Esfarjani, S Benzer. Science 2000
18
Genome-wide screen for modifiers of ataxin-3 neurodegeneration in Drosophila.
Julide Bilen, Nancy M Bonini. PLoS Genet 2007
Julide Bilen, Nancy M Bonini. PLoS Genet 2007
18
Expansion of an unstable trinucleotide CAG repeat in spinocerebellar ataxia type 1.
H T Orr, M Y Chung, S Banfi, T J Kwiatkowski, A Servadio, A L Beaudet, A E McCall, L A Duvick, L P Ranum, H Y Zoghbi. Nat Genet 1993
H T Orr, M Y Chung, S Banfi, T J Kwiatkowski, A Servadio, A L Beaudet, A E McCall, L A Duvick, L P Ranum, H Y Zoghbi. Nat Genet 1993
18
RAS-MAPK-MSK1 pathway modulates ataxin 1 protein levels and toxicity in SCA1.
Jeehye Park, Ismael Al-Ramahi, Qiumin Tan, Nissa Mollema, Javier R Diaz-Garcia, Tatiana Gallego-Flores, Hsiang-Chih Lu, Sarita Lagalwar, Lisa Duvick, Hyojin Kang,[...]. Nature 2013
Jeehye Park, Ismael Al-Ramahi, Qiumin Tan, Nissa Mollema, Javier R Diaz-Garcia, Tatiana Gallego-Flores, Hsiang-Chih Lu, Sarita Lagalwar, Lisa Duvick, Hyojin Kang,[...]. Nature 2013
19
Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70.
J M Warrick, H Y Chan, G L Gray-Board, Y Chai, H L Paulson, N M Bonini. Nat Genet 1999
J M Warrick, H Y Chan, G L Gray-Board, Y Chai, H L Paulson, N M Bonini. Nat Genet 1999
17
Expanded polyglutamine protein forms nuclear inclusions and causes neural degeneration in Drosophila.
J M Warrick, H L Paulson, G L Gray-Board, Q T Bui, K H Fischbeck, R N Pittman, N M Bonini. Cell 1998
J M Warrick, H L Paulson, G L Gray-Board, Q T Bui, K H Fischbeck, R N Pittman, N M Bonini. Cell 1998
17
ATAXIN-1 interacts with the repressor Capicua in its native complex to cause SCA1 neuropathology.
Yung C Lam, Aaron B Bowman, Paymaan Jafar-Nejad, Janghoo Lim, Ronald Richman, John D Fryer, Eric D Hyun, Lisa A Duvick, Harry T Orr, Juan Botas,[...]. Cell 2006
Yung C Lam, Aaron B Bowman, Paymaan Jafar-Nejad, Janghoo Lim, Ronald Richman, John D Fryer, Eric D Hyun, Lisa A Duvick, Harry T Orr, Juan Botas,[...]. Cell 2006
16
Ataxin-1 nuclear localization and aggregation: role in polyglutamine-induced disease in SCA1 transgenic mice.
I A Klement, P J Skinner, M D Kaytor, H Yi, S M Hersch, H B Clark, H Y Zoghbi, H T Orr. Cell 1998
I A Klement, P J Skinner, M D Kaytor, H Yi, S M Hersch, H B Clark, H Y Zoghbi, H T Orr. Cell 1998
16
A long CAG repeat in the mouse Sca1 locus replicates SCA1 features and reveals the impact of protein solubility on selective neurodegeneration.
Kei Watase, Edwin J Weeber, Bisong Xu, Barbara Antalffy, Lisa Yuva-Paylor, Kouichi Hashimoto, Masanobu Kano, Richard Atkinson, Yaling Sun, Dawna L Armstrong,[...]. Neuron 2002
Kei Watase, Edwin J Weeber, Bisong Xu, Barbara Antalffy, Lisa Yuva-Paylor, Kouichi Hashimoto, Masanobu Kano, Richard Atkinson, Yaling Sun, Dawna L Armstrong,[...]. Neuron 2002
15
Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila.
J S Steffan, L Bodai, J Pallos, M Poelman, A McCampbell, B L Apostol, A Kazantsev, E Schmidt, Y Z Zhu, M Greenwald,[...]. Nature 2001
J S Steffan, L Bodai, J Pallos, M Poelman, A McCampbell, B L Apostol, A Kazantsev, E Schmidt, Y Z Zhu, M Greenwald,[...]. Nature 2001
15
Chaperone suppression of aggregation and altered subcellular proteasome localization imply protein misfolding in SCA1.
C J Cummings, M A Mancini, B Antalffy, D B DeFranco, H T Orr, H Y Zoghbi. Nat Genet 1998
C J Cummings, M A Mancini, B Antalffy, D B DeFranco, H T Orr, H Y Zoghbi. Nat Genet 1998
14
Polyglutamine-expanded human huntingtin transgenes induce degeneration of Drosophila photoreceptor neurons.
G R Jackson, I Salecker, X Dong, X Yao, N Arnheim, P W Faber, M E MacDonald, S L Zipursky. Neuron 1998
G R Jackson, I Salecker, X Dong, X Yao, N Arnheim, P W Faber, M E MacDonald, S L Zipursky. Neuron 1998
14
Serine 776 of ataxin-1 is critical for polyglutamine-induced disease in SCA1 transgenic mice.
Effat S Emamian, Michael D Kaytor, Lisa A Duvick, Tao Zu, Susan K Tousey, Huda Y Zoghbi, H Brent Clark, Harry T Orr. Neuron 2003
Effat S Emamian, Michael D Kaytor, Lisa A Duvick, Tao Zu, Susan K Tousey, Huda Y Zoghbi, H Brent Clark, Harry T Orr. Neuron 2003
13
SCA1 transgenic mice: a model for neurodegeneration caused by an expanded CAG trinucleotide repeat.
E N Burright, H B Clark, A Servadio, T Matilla, R M Feddersen, W S Yunis, L A Duvick, H Y Zoghbi, H T Orr. Cell 1995
E N Burright, H B Clark, A Servadio, T Matilla, R M Feddersen, W S Yunis, L A Duvick, H Y Zoghbi, H T Orr. Cell 1995
13
Opposing effects of polyglutamine expansion on native protein complexes contribute to SCA1.
Janghoo Lim, Juan Crespo-Barreto, Paymaan Jafar-Nejad, Aaron B Bowman, Ronald Richman, David E Hill, Harry T Orr, Huda Y Zoghbi. Nature 2008
Janghoo Lim, Juan Crespo-Barreto, Paymaan Jafar-Nejad, Aaron B Bowman, Ronald Richman, David E Hill, Harry T Orr, Huda Y Zoghbi. Nature 2008
12
Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain.
M DiFiglia, E Sapp, K O Chase, S W Davies, G P Bates, J P Vonsattel, N Aronin. Science 1997
M DiFiglia, E Sapp, K O Chase, S W Davies, G P Bates, J P Vonsattel, N Aronin. Science 1997
12
The AXH domain of Ataxin-1 mediates neurodegeneration through its interaction with Gfi-1/Senseless proteins.
Hiroshi Tsuda, Hamed Jafar-Nejad, Akash J Patel, Yaling Sun, Hung-Kai Chen, Matthew F Rose, Koen J T Venken, Juan Botas, Harry T Orr, Hugo J Bellen,[...]. Cell 2005
Hiroshi Tsuda, Hamed Jafar-Nejad, Akash J Patel, Yaling Sun, Hung-Kai Chen, Matthew F Rose, Koen J T Venken, Juan Botas, Harry T Orr, Hugo J Bellen,[...]. Cell 2005
12
HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS.
Udai Bhan Pandey, Zhiping Nie, Yakup Batlevi, Brett A McCray, Gillian P Ritson, Natalia B Nedelsky, Stephanie L Schwartz, Nicholas A DiProspero, Melanie A Knight, Oren Schuldiner,[...]. Nature 2007
Udai Bhan Pandey, Zhiping Nie, Yakup Batlevi, Brett A McCray, Gillian P Ritson, Natalia B Nedelsky, Stephanie L Schwartz, Nicholas A DiProspero, Melanie A Knight, Oren Schuldiner,[...]. Nature 2007
12
Pathogenic mechanisms of a polyglutamine-mediated neurodegenerative disease, spinocerebellar ataxia type 1.
Huda Y Zoghbi, Harry T Orr. J Biol Chem 2009
Huda Y Zoghbi, Harry T Orr. J Biol Chem 2009
11
Pumilio1 haploinsufficiency leads to SCA1-like neurodegeneration by increasing wild-type Ataxin1 levels.
Vincenzo A Gennarino, Ravi K Singh, Joshua J White, Antonia De Maio, Kihoon Han, Ji-Yoen Kim, Paymaan Jafar-Nejad, Alberto di Ronza, Hyojin Kang, Layal S Sayegh,[...]. Cell 2015
Vincenzo A Gennarino, Ravi K Singh, Joshua J White, Antonia De Maio, Kihoon Han, Ji-Yoen Kim, Paymaan Jafar-Nejad, Alberto di Ronza, Hyojin Kang, Layal S Sayegh,[...]. Cell 2015
11
Interaction of Akt-phosphorylated ataxin-1 with 14-3-3 mediates neurodegeneration in spinocerebellar ataxia type 1.
Hung-Kai Chen, Pedro Fernandez-Funez, Summer F Acevedo, Yung C Lam, Michael D Kaytor, Michael H Fernandez, Alastair Aitken, Efthimios M C Skoulakis, Harry T Orr, Juan Botas,[...]. Cell 2003
Hung-Kai Chen, Pedro Fernandez-Funez, Summer F Acevedo, Yung C Lam, Michael D Kaytor, Michael H Fernandez, Alastair Aitken, Efthimios M C Skoulakis, Harry T Orr, Juan Botas,[...]. Cell 2003
10
Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS.
Andrew C Elden, Hyung-Jun Kim, Michael P Hart, Alice S Chen-Plotkin, Brian S Johnson, Xiaodong Fang, Maria Armakola, Felix Geser, Robert Greene, Min Min Lu,[...]. Nature 2010
Andrew C Elden, Hyung-Jun Kim, Michael P Hart, Alice S Chen-Plotkin, Brian S Johnson, Xiaodong Fang, Maria Armakola, Felix Geser, Robert Greene, Min Min Lu,[...]. Nature 2010
10
Suppression of neurodegeneration and increased neurotransmission caused by expanded full-length huntingtin accumulating in the cytoplasm.
Eliana Romero, Guang-Ho Cha, Patrik Verstreken, Cindy V Ly, Robert E Hughes, Hugo J Bellen, Juan Botas. Neuron 2008
Eliana Romero, Guang-Ho Cha, Patrik Verstreken, Cindy V Ly, Robert E Hughes, Hugo J Bellen, Juan Botas. Neuron 2008
10
Huntingtin interacting proteins are genetic modifiers of neurodegeneration.
Linda S Kaltenbach, Eliana Romero, Robert R Becklin, Rakesh Chettier, Russell Bell, Amit Phansalkar, Andrew Strand, Cameron Torcassi, Justin Savage, Anthony Hurlburt,[...]. PLoS Genet 2007
Linda S Kaltenbach, Eliana Romero, Robert R Becklin, Rakesh Chettier, Russell Bell, Amit Phansalkar, Andrew Strand, Cameron Torcassi, Justin Savage, Anthony Hurlburt,[...]. PLoS Genet 2007
9
SCA17, a novel autosomal dominant cerebellar ataxia caused by an expanded polyglutamine in TATA-binding protein.
K Nakamura, S Y Jeong, T Uchihara, M Anno, K Nagashima, T Nagashima, S Ikeda, S Tsuji, I Kanazawa. Hum Mol Genet 2001
K Nakamura, S Y Jeong, T Uchihara, M Anno, K Nagashima, T Nagashima, S Ikeda, S Tsuji, I Kanazawa. Hum Mol Genet 2001
9
CAG expansions in a novel gene for Machado-Joseph disease at chromosome 14q32.1.
Y Kawaguchi, T Okamoto, M Taniwaki, M Aizawa, M Inoue, S Katayama, H Kawakami, S Nakamura, M Nishimura, I Akiguchi. Nat Genet 1994
Y Kawaguchi, T Okamoto, M Taniwaki, M Aizawa, M Inoue, S Katayama, H Kawakami, S Nakamura, M Nishimura, I Akiguchi. Nat Genet 1994
9
Mechanisms of chaperone suppression of polyglutamine disease: selectivity, synergy and modulation of protein solubility in Drosophila.
H Y Chan, J M Warrick, G L Gray-Board, H L Paulson, N M Bonini. Hum Mol Genet 2000
H Y Chan, J M Warrick, G L Gray-Board, H L Paulson, N M Bonini. Hum Mol Genet 2000
9
Over-expression of inducible HSP70 chaperone suppresses neuropathology and improves motor function in SCA1 mice.
C J Cummings, Y Sun, P Opal, B Antalffy, R Mestril, H T Orr, W H Dillmann, H Y Zoghbi. Hum Mol Genet 2001
C J Cummings, Y Sun, P Opal, B Antalffy, R Mestril, H T Orr, W H Dillmann, H Y Zoghbi. Hum Mol Genet 2001
9
Autosomal dominant cerebellar ataxia (SCA6) associated with small polyglutamine expansions in the alpha 1A-voltage-dependent calcium channel.
O Zhuchenko, J Bailey, P Bonnen, T Ashizawa, D W Stockton, C Amos, W B Dobyns, S H Subramony, H Y Zoghbi, C C Lee. Nat Genet 1997
O Zhuchenko, J Bailey, P Bonnen, T Ashizawa, D W Stockton, C Amos, W B Dobyns, S H Subramony, H Y Zoghbi, C C Lee. Nat Genet 1997
9
Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease.
Pavan K Auluck, H Y Edwin Chan, John Q Trojanowski, Virginia M Y Lee, Nancy M Bonini. Science 2002
Pavan K Auluck, H Y Edwin Chan, John Q Trojanowski, Virginia M Y Lee, Nancy M Bonini. Science 2002
9
100 years of Drosophila research and its impact on vertebrate neuroscience: a history lesson for the future.
Hugo J Bellen, Chao Tong, Hiroshi Tsuda. Nat Rev Neurosci 2010
Hugo J Bellen, Chao Tong, Hiroshi Tsuda. Nat Rev Neurosci 2010
9
Native functions of the androgen receptor are essential to pathogenesis in a Drosophila model of spinobulbar muscular atrophy.
Natalia B Nedelsky, Maria Pennuto, Rebecca B Smith, Isabella Palazzolo, Jennifer Moore, Zhiping Nie, Geoffrey Neale, J Paul Taylor. Neuron 2010
Natalia B Nedelsky, Maria Pennuto, Rebecca B Smith, Isabella Palazzolo, Jennifer Moore, Zhiping Nie, Geoffrey Neale, J Paul Taylor. Neuron 2010
9
Polyglutamine-expanded androgen receptors form aggregates that sequester heat shock proteins, proteasome components and SRC-1, and are suppressed by the HDJ-2 chaperone.
D L Stenoien, C J Cummings, H P Adams, M G Mancini, K Patel, G N DeMartino, M Marcelli, N L Weigel, M A Mancini. Hum Mol Genet 1999
D L Stenoien, C J Cummings, H P Adams, M G Mancini, K Patel, G N DeMartino, M Marcelli, N L Weigel, M A Mancini. Hum Mol Genet 1999
8
RORalpha-mediated Purkinje cell development determines disease severity in adult SCA1 mice.
Heliane G Serra, Lisa Duvick, Tao Zu, Kerri Carlson, Sam Stevens, Nathan Jorgensen, Alana Lysholm, Eric Burright, Huda Y Zoghbi, H Brent Clark,[...]. Cell 2006
Heliane G Serra, Lisa Duvick, Tao Zu, Kerri Carlson, Sam Stevens, Nathan Jorgensen, Alana Lysholm, Eric Burright, Huda Y Zoghbi, H Brent Clark,[...]. Cell 2006
8
Cloning of the SCA7 gene reveals a highly unstable CAG repeat expansion.
G David, N Abbas, G Stevanin, A Dürr, G Yvert, G Cancel, C Weber, G Imbert, F Saudou, E Antoniou,[...]. Nat Genet 1997
G David, N Abbas, G Stevanin, A Dürr, G Yvert, G Cancel, C Weber, G Imbert, F Saudou, E Antoniou,[...]. Nat Genet 1997
8
Intranuclear inclusions of expanded polyglutamine protein in spinocerebellar ataxia type 3.
H L Paulson, M K Perez, Y Trottier, J Q Trojanowski, S H Subramony, S S Das, P Vig, J L Mandel, K H Fischbeck, R N Pittman. Neuron 1997
H L Paulson, M K Perez, Y Trottier, J Q Trojanowski, S H Subramony, S S Das, P Vig, J L Mandel, K H Fischbeck, R N Pittman. Neuron 1997
8
A conditional pan-neuronal Drosophila model of spinocerebellar ataxia 7 with a reversible adult phenotype suitable for identifying modifier genes.
Morwena Latouche, Christelle Lasbleiz, Elodie Martin, Véronique Monnier, Thomas Debeir, Annick Mouatt-Prigent, Marie-Paule Muriel, Lydie Morel, Merle Ruberg, Alexis Brice,[...]. J Neurosci 2007
Morwena Latouche, Christelle Lasbleiz, Elodie Martin, Véronique Monnier, Thomas Debeir, Annick Mouatt-Prigent, Marie-Paule Muriel, Lydie Morel, Merle Ruberg, Alexis Brice,[...]. J Neurosci 2007
13
Moderate expansion of a normally biallelic trinucleotide repeat in spinocerebellar ataxia type 2.
S M Pulst, A Nechiporuk, T Nechiporuk, S Gispert, X N Chen, I Lopes-Cendes, S Pearlman, S Starkman, G Orozco-Diaz, A Lunkes,[...]. Nat Genet 1996
S M Pulst, A Nechiporuk, T Nechiporuk, S Gispert, X N Chen, I Lopes-Cendes, S Pearlman, S Starkman, G Orozco-Diaz, A Lunkes,[...]. Nat Genet 1996
8
A neurological disease caused by an expanded CAG trinucleotide repeat in the TATA-binding protein gene: a new polyglutamine disease?
R Koide, S Kobayashi, T Shimohata, T Ikeuchi, M Maruyama, M Saito, M Yamada, H Takahashi, S Tsuji. Hum Mol Genet 1999
R Koide, S Kobayashi, T Shimohata, T Ikeuchi, M Maruyama, M Saito, M Yamada, H Takahashi, S Tsuji. Hum Mol Genet 1999
8
A Drosophila model of FUS-related neurodegeneration reveals genetic interaction between FUS and TDP-43.
Nicholas A Lanson, Astha Maltare, Hanna King, Rebecca Smith, Ji Han Kim, J Paul Taylor, Thomas E Lloyd, Udai Bhan Pandey. Hum Mol Genet 2011
Nicholas A Lanson, Astha Maltare, Hanna King, Rebecca Smith, Ji Han Kim, J Paul Taylor, Thomas E Lloyd, Udai Bhan Pandey. Hum Mol Genet 2011
8
Probing mechanisms that underlie human neurodegenerative diseases in Drosophila.
M Jaiswal, H Sandoval, K Zhang, V Bayat, H J Bellen. Annu Rev Genet 2012
M Jaiswal, H Sandoval, K Zhang, V Bayat, H J Bellen. Annu Rev Genet 2012
10
Ataxin-3 suppresses polyglutamine neurodegeneration in Drosophila by a ubiquitin-associated mechanism.
John M Warrick, Lance M Morabito, Julide Bilen, Beth Gordesky-Gold, Lynn Z Faust, Henry L Paulson, Nancy M Bonini. Mol Cell 2005
John M Warrick, Lance M Morabito, Julide Bilen, Beth Gordesky-Gold, Lynn Z Faust, Henry L Paulson, Nancy M Bonini. Mol Cell 2005
8
Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death.
Montserrat Arrasate, Siddhartha Mitra, Erik S Schweitzer, Mark R Segal, Steven Finkbeiner. Nature 2004
Montserrat Arrasate, Siddhartha Mitra, Erik S Schweitzer, Mark R Segal, Steven Finkbeiner. Nature 2004
8
8
A systematic analysis of human disease-associated gene sequences in Drosophila melanogaster.
L T Reiter, L Potocki, S Chien, M Gribskov, E Bier. Genome Res 2001
L T Reiter, L Potocki, S Chien, M Gribskov, E Bier. Genome Res 2001
8
Cytoplasmic aggregates trap polyglutamine-containing proteins and block axonal transport in a Drosophila model of Huntington's disease.
Wyan-Ching Mimi Lee, Motojiro Yoshihara, J Troy Littleton. Proc Natl Acad Sci U S A 2004
Wyan-Ching Mimi Lee, Motojiro Yoshihara, J Troy Littleton. Proc Natl Acad Sci U S A 2004
8
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.