A citation-based method for searching scientific literature

H Hemmi, O Takeuchi, T Kawai, T Kaisho, S Sato, H Sanjo, M Matsumoto, K Hoshino, H Wagner, K Takeda, S Akira. Nature 2000
Times Cited: 4729







List of co-cited articles
863 articles co-cited >1



Times Cited
  Times     Co-cited
Similarity


Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3.
L Alexopoulou, A C Holt, R Medzhitov, R A Flavell. Nature 2001
23

Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8.
Florian Heil, Hiroaki Hemmi, Hubertus Hochrein, Franziska Ampenberger, Carsten Kirschning, Shizuo Akira, Grayson Lipford, Hermann Wagner, Stefan Bauer. Science 2004
18

Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway.
Lijun Sun, Jiaxi Wu, Fenghe Du, Xiang Chen, Zhijian J Chen. Science 2013
13

Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene.
A Poltorak, X He, I Smirnova, M Y Liu, C Van Huffel, X Du, D Birdwell, E Alejos, M Silva, C Galanos,[...]. Science 1998
12

Pathogen recognition and innate immunity.
Shizuo Akira, Satoshi Uematsu, Osamu Takeuchi. Cell 2006
11


Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA.
Jiaxi Wu, Lijun Sun, Xiang Chen, Fenghe Du, Heping Shi, Chuo Chen, Zhijian J Chen. Science 2013
10

CpG motifs in bacterial DNA and their immune effects.
Arthur M Krieg. Annu Rev Immunol 2002
10

Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides.
Veit Hornung, Simon Rothenfusser, Stefanie Britsch, Anne Krug, Bernd Jahrsdörfer, Thomas Giese, Stefan Endres, Gunther Hartmann. J Immunol 2002
10

Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA.
Sandra S Diebold, Tsuneyasu Kaisho, Hiroaki Hemmi, Shizuo Akira, Caetano Reis e Sousa. Science 2004
10

AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA.
Teresa Fernandes-Alnemri, Je-Wook Yu, Pinaki Datta, Jianghong Wu, Emad S Alnemri. Nature 2009
9

IFI16 is an innate immune sensor for intracellular DNA.
Leonie Unterholzner, Sinead E Keating, Marcin Baran, Kristy A Horan, Søren B Jensen, Shruti Sharma, Cherilyn M Sirois, Tengchuan Jin, Eicke Latz, T Sam Xiao,[...]. Nat Immunol 2010
9

Innate immune pattern recognition: a cell biological perspective.
Sky W Brubaker, Kevin S Bonham, Ivan Zanoni, Jonathan C Kagan. Annu Rev Immunol 2015
680
9

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC.
Veit Hornung, Andrea Ablasser, Marie Charrel-Dennis, Franz Bauernfeind, Gabor Horvath, Daniel R Caffrey, Eicke Latz, Katherine A Fitzgerald. Nature 2009
8

The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5.
F Hayashi, K D Smith, A Ozinsky, T R Hawn, E C Yi, D R Goodlett, J K Eng, S Akira, D M Underhill, A Aderem. Nature 2001
8

Circulating mitochondrial DAMPs cause inflammatory responses to injury.
Qin Zhang, Mustafa Raoof, Yu Chen, Yuka Sumi, Tolga Sursal, Wolfgang Junger, Karim Brohi, Kiyoshi Itagaki, Carl J Hauser. Nature 2010
8


Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5.
Hiroki Kato, Osamu Takeuchi, Eriko Mikamo-Satoh, Reiko Hirai, Tomoji Kawai, Kazufumi Matsushita, Akane Hiiragi, Terence S Dermody, Takashi Fujita, Shizuo Akira. J Exp Med 2008
7

Toll-like receptor signalling.
Shizuo Akira, Kiyoshi Takeda. Nat Rev Immunol 2004
7

TLR9 signals after translocating from the ER to CpG DNA in the lysosome.
Eicke Latz, Annett Schoenemeyer, Alberto Visintin, Katherine A Fitzgerald, Brian G Monks, Cathrine F Knetter, Egil Lien, Nadra J Nilsen, Terje Espevik, Douglas T Golenbock. Nat Immunol 2004
991
7

CpG motifs in bacterial DNA trigger direct B-cell activation.
A M Krieg, A K Yi, S Matson, T J Waldschmidt, G A Bishop, R Teasdale, G A Koretzky, D M Klinman. Nature 1995
7

Pattern recognition receptors and inflammation.
Osamu Takeuchi, Shizuo Akira. Cell 2010
7


5'-Triphosphate RNA is the ligand for RIG-I.
Veit Hornung, Jana Ellegast, Sarah Kim, Krzysztof Brzózka, Andreas Jung, Hiroki Kato, Hendrik Poeck, Shizuo Akira, Karl-Klaus Conzelmann, Martin Schlee,[...]. Science 2006
6

The structural biology of Toll-like receptors.
Istvan Botos, David M Segal, David R Davies. Structure 2011
356
6

Structural basis of CpG and inhibitory DNA recognition by Toll-like receptor 9.
Umeharu Ohto, Takuma Shibata, Hiromi Tanji, Hanako Ishida, Elena Krayukhina, Susumu Uchiyama, Kensuke Miyake, Toshiyuki Shimizu. Nature 2015
182
6



Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway.
Hiroaki Hemmi, Tsuneyasu Kaisho, Osamu Takeuchi, Shintaro Sato, Hideki Sanjo, Katsuaki Hoshino, Takao Horiuchi, Hideyuki Tomizawa, Kiyoshi Takeda, Shizuo Akira. Nat Immunol 2002
6

Toll-like receptor signaling pathways.
Takumi Kawasaki, Taro Kawai. Front Immunol 2014
6

A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity.
Martin Jinek, Krzysztof Chylinski, Ines Fonfara, Michael Hauer, Jennifer A Doudna, Emmanuelle Charpentier. Science 2012
5

Multiplex genome engineering using CRISPR/Cas systems.
Le Cong, F Ann Ran, David Cox, Shuailiang Lin, Robert Barretto, Naomi Habib, Patrick D Hsu, Xuebing Wu, Wenyan Jiang, Luciano A Marraffini,[...]. Science 2013
5

Highly efficient RNA-guided genome editing in human cells via delivery of purified Cas9 ribonucleoproteins.
Sojung Kim, Daesik Kim, Seung Woo Cho, Jungeun Kim, Jin-Soo Kim. Genome Res 2014
890
5

Toll-like receptor 8 senses degradation products of single-stranded RNA.
Hiromi Tanji, Umeharu Ohto, Takuma Shibata, Masato Taoka, Yoshio Yamauchi, Toshiaki Isobe, Kensuke Miyake, Toshiyuki Shimizu. Nat Struct Mol Biol 2015
174
5

Toll-like Receptor 9 Contains Two DNA Binding Sites that Function Cooperatively to Promote Receptor Dimerization and Activation.
Umeharu Ohto, Hanako Ishida, Takuma Shibata, Ryota Sato, Kensuke Miyake, Toshiyuki Shimizu. Immunity 2018
50
10

TLR8 Is a Sensor of RNase T2 Degradation Products.
Wilhelm Greulich, Mirko Wagner, Moritz M Gaidt, Che Stafford, Yiming Cheng, Andreas Linder, Thomas Carell, Veit Hornung. Cell 2019
34
14

cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING.
Andrea Ablasser, Marion Goldeck, Taner Cavlar, Tobias Deimling, Gregor Witte, Ingo Röhl, Karl-Peter Hopfner, Janos Ludwig, Veit Hornung. Nature 2013
713
5

Tight nuclear tethering of cGAS is essential for preventing autoreactivity.
Hannah E Volkman, Stephanie Cambier, Elizabeth E Gray, Daniel B Stetson. Elife 2019
78
6

Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retroviruses.
Daxing Gao, Jiaxi Wu, You-Tong Wu, Fenghe Du, Chukwuemika Aroh, Nan Yan, Lijun Sun, Zhijian J Chen. Science 2013
606
5

Nuclear cGAS suppresses DNA repair and promotes tumorigenesis.
Haipeng Liu, Haiping Zhang, Xiangyang Wu, Dapeng Ma, Juehui Wu, Lin Wang, Yan Jiang, Yiyan Fei, Chenggang Zhu, Rong Tan,[...]. Nature 2018
199
5

The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses.
Mitsutoshi Yoneyama, Mika Kikuchi, Takashi Natsukawa, Noriaki Shinobu, Tadaatsu Imaizumi, Makoto Miyagishi, Kazunari Taira, Shizuo Akira, Takashi Fujita. Nat Immunol 2004
5


Peptidoglycan- and lipoteichoic acid-induced cell activation is mediated by toll-like receptor 2.
R Schwandner, R Dziarski, H Wesche, M Rothe, C J Kirschning. J Biol Chem 1999
5

The history of Toll-like receptors - redefining innate immunity.
Luke A J O'Neill, Douglas Golenbock, Andrew G Bowie. Nat Rev Immunol 2013
923
5

Therapeutic potential of Toll-like receptor 9 activation.
Arthur M Krieg. Nat Rev Drug Discov 2006
887
5

Development of TLR9 agonists for cancer therapy.
Arthur M Krieg. J Clin Invest 2007
307
5


Immunotherapeutic uses of CpG oligodeoxynucleotides.
Dennis M Klinman. Nat Rev Immunol 2004
629
5

Role of Mitochondrial DNA in Septic AKI via Toll-Like Receptor 9.
Naoko Tsuji, Takayuki Tsuji, Naro Ohashi, Akihiko Kato, Yoshihide Fujigaki, Hideo Yasuda. J Am Soc Nephrol 2016
72
6

Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE.
Jane Tian, Ana Maria Avalos, Su-Yau Mao, Bo Chen, Kannaki Senthil, Herren Wu, Peggy Parroche, Stacey Drabic, Douglas Golenbock, Cherilyn Sirois,[...]. Nat Immunol 2007
996
5


Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.