A citation-based method for searching scientific literature

H Rao, F Uhlmann, K Nasmyth, A Varshavsky. Nature 2001
Times Cited: 220







List of co-cited articles
992 articles co-cited >1



Times Cited
  Times     Co-cited
Similarity



N-terminal acetylation of cellular proteins creates specific degradation signals.
Cheol-Sang Hwang, Anna Shemorry, Alexander Varshavsky. Science 2010
442
46

The N-end rule pathway and regulation by proteolysis.
Alexander Varshavsky. Protein Sci 2011
456
45

The N-end rule pathway counteracts cell death by destroying proapoptotic protein fragments.
Konstantin I Piatkov, Christopher S Brower, Alexander Varshavsky. Proc Natl Acad Sci U S A 2012
102
36

The N-end rule pathway.
Takafumi Tasaki, Shashikanth M Sriram, Kyong Soo Park, Yong Tae Kwon. Annu Rev Biochem 2012
254
36

The N-end rule pathway as a nitric oxide sensor controlling the levels of multiple regulators.
Rong-Gui Hu, Jun Sheng, Xin Qi, Zhenming Xu, Terry T Takahashi, Alexander Varshavsky. Nature 2005
226
35

An essential role of N-terminal arginylation in cardiovascular development.
Yong Tae Kwon, Anna S Kashina, Ilia V Davydov, Rong-Gui Hu, Jee Young An, Jai Wha Seo, Fangyong Du, Alexander Varshavsky. Science 2002
248
34

Structural basis for the recognition of N-end rule substrates by the UBR box of ubiquitin ligases.
Woo Suk Choi, Byung-Cheon Jeong, Yoo Jin Joo, Myeong-Ryeol Lee, Joon Kim, Michael J Eck, Hyun Kyu Song. Nat Struct Mol Biol 2010
101
33


Degradation of DIAP1 by the N-end rule pathway is essential for regulating apoptosis.
Mark Ditzel, Rebecca Wilson, Tencho Tenev, Anna Zachariou, Angela Paul, Emma Deas, Pascal Meier. Nat Cell Biol 2003
200
30

The substrate recognition domains of the N-end rule pathway.
Takafumi Tasaki, Adriana Zakrzewska, Drew D Dudgeon, Yonghua Jiang, John S Lazo, Yong Tae Kwon. J Biol Chem 2009
93
32

RGS4 and RGS5 are in vivo substrates of the N-end rule pathway.
Min Jae Lee, Takafumi Tasaki, Kayoko Moroi, Jee Young An, Sadao Kimura, Ilia V Davydov, Yong Tae Kwon. Proc Natl Acad Sci U S A 2005
186
29

Control of protein quality and stoichiometries by N-terminal acetylation and the N-end rule pathway.
Anna Shemorry, Cheol-Sang Hwang, Alexander Varshavsky. Mol Cell 2013
200
29

Deficiency of UBR1, a ubiquitin ligase of the N-end rule pathway, causes pancreatic dysfunction, malformations and mental retardation (Johanson-Blizzard syndrome).
Martin Zenker, Julia Mayerle, Markus M Lerch, Andreas Tagariello, Klaus Zerres, Peter R Durie, Matthias Beier, Georg Hülskamp, Celina Guzman, Helga Rehder,[...]. Nat Genet 2005
175
28

The N-terminal methionine of cellular proteins as a degradation signal.
Heon-Ki Kim, Ryu-Ryun Kim, Jang-Hyun Oh, Hanna Cho, Alexander Varshavsky, Cheol-Sang Hwang. Cell 2014
121
28

The degradation signal in a short-lived protein.
A Bachmair, A Varshavsky. Cell 1989
358
27

The N-end rule in bacteria.
J W Tobias, T E Shrader, G Rocap, A Varshavsky. Science 1991
422
27

Neurodegeneration-associated protein fragments as short-lived substrates of the N-end rule pathway.
Christopher S Brower, Konstantin I Piatkov, Alexander Varshavsky. Mol Cell 2013
79
34

A family of mammalian E3 ubiquitin ligases that contain the UBR box motif and recognize N-degrons.
Takafumi Tasaki, Lubbertus C F Mulder, Akihiro Iwamatsu, Min Jae Lee, Ilia V Davydov, Alexander Varshavsky, Mark Muesing, Yong Tae Kwon. Mol Cell Biol 2005
232
26

Structural basis of substrate recognition and specificity in the N-end rule pathway.
Edna Matta-Camacho, Guennadi Kozlov, Flora F Li, Kalle Gehring. Nat Struct Mol Biol 2010
75
34

Glutamine-specific N-terminal amidase, a component of the N-end rule pathway.
Haiqing Wang, Konstantin I Piatkov, Christopher S Brower, Alexander Varshavsky. Mol Cell 2009
68
36

Pairs of dipeptides synergistically activate the binding of substrate by ubiquitin ligase through dissociation of its autoinhibitory domain.
Fangyong Du, Federico Navarro-Garcia, Zanxian Xia, Takafumi Tasaki, Alexander Varshavsky. Proc Natl Acad Sci U S A 2002
85
28

The N-end rule pathway is a sensor of heme.
Rong-Gui Hu, Haiqing Wang, Zanxian Xia, Alexander Varshavsky. Proc Natl Acad Sci U S A 2008
87
26

The recognition component of the N-end rule pathway.
B Bartel, I Wünning, A Varshavsky. EMBO J 1990
331
23

Substrate-binding sites of UBR1, the ubiquitin ligase of the N-end rule pathway.
Zanxian Xia, Ailsa Webster, Fangyong Du, Konstantin Piatkov, Michel Ghislain, Alexander Varshavsky. J Biol Chem 2008
81
27


Cytoplasmic protein quality control degradation mediated by parallel actions of the E3 ubiquitin ligases Ubr1 and San1.
Jarrod W Heck, Samantha K Cheung, Randolph Y Hampton. Proc Natl Acad Sci U S A 2010
206
21

Universality and structure of the N-end rule.
D K Gonda, A Bachmair, I Wünning, J W Tobias, W S Lane, A Varshavsky. J Biol Chem 1989
360
20

The N-end rule pathway for regulated proteolysis: prokaryotic and eukaryotic strategies.
Axel Mogk, Ronny Schmidt, Bernd Bukau. Trends Cell Biol 2007
193
20


The auto-generated fragment of the Usp1 deubiquitylase is a physiological substrate of the N-end rule pathway.
Konstantin I Piatkov, Luca Colnaghi, Miklos Békés, Alexander Varshavsky, Tony T Huang. Mol Cell 2012
51
37

Calpain-generated natural protein fragments as short-lived substrates of the N-end rule pathway.
Konstantin I Piatkov, Jang-Hyun Oh, Yuan Liu, Alexander Varshavsky. Proc Natl Acad Sci U S A 2014
61
31

N-degron and C-degron pathways of protein degradation.
Alexander Varshavsky. Proc Natl Acad Sci U S A 2019
221
19

The N-end rule: functions, mysteries, uses.
A Varshavsky. Proc Natl Acad Sci U S A 1996
663
18

Female lethality and apoptosis of spermatocytes in mice lacking the UBR2 ubiquitin ligase of the N-end rule pathway.
Yong Tae Kwon, Zanxian Xia, Jee Young An, Takafumi Tasaki, Ilia V Davydov, Jai Wha Seo, Jun Sheng, Youming Xie, Alexander Varshavsky. Mol Cell Biol 2003
117
18

Aminoacyl-transferases and the N-end rule pathway of prokaryotic/eukaryotic specificity in a human pathogen.
Emmanuelle Graciet, Rong-Gui Hu, Konstantin Piatkov, Joon Haeng Rhee, Erich M Schwarz, Alexander Varshavsky. Proc Natl Acad Sci U S A 2006
72
25

Two proteolytic pathways regulate DNA repair by cotargeting the Mgt1 alkylguanine transferase.
Cheol-Sang Hwang, Anna Shemorry, Alexander Varshavsky. Proc Natl Acad Sci U S A 2009
60
30

Ubiquitin fusion technique and related methods.
Alexander Varshavsky. Methods Enzymol 2005
86
20


The N-end rule pathway is mediated by a complex of the RING-type Ubr1 and HECT-type Ufd4 ubiquitin ligases.
Cheol-Sang Hwang, Anna Shemorry, Daniel Auerbach, Alexander Varshavsky. Nat Cell Biol 2010
102
18

An N-end rule pathway that recognizes proline and destroys gluconeogenic enzymes.
Shun-Jia Chen, Xia Wu, Brandon Wadas, Jang-Hyun Oh, Alexander Varshavsky. Science 2017
112
18

Impaired neurogenesis and cardiovascular development in mice lacking the E3 ubiquitin ligases UBR1 and UBR2 of the N-end rule pathway.
Jee Young An, Jai Wha Seo, Takafumi Tasaki, Min Jae Lee, Alexander Varshavsky, Yong Tae Kwon. Proc Natl Acad Sci U S A 2006
71
23

ClpS is an essential component of the N-end rule pathway in Escherichia coli.
A Erbse, R Schmidt, T Bornemann, J Schneider-Mergener, A Mogk, R Zahn, D A Dougan, B Bukau. Nature 2006
171
17

The molecular basis of N-end rule recognition.
Kevin H Wang, Giselle Roman-Hernandez, Robert A Grant, Robert T Sauer, Tania A Baker. Mol Cell 2008
73
23

The N-end rule pathway: from recognition by N-recognins, to destruction by AAA+proteases.
D A Dougan, D Micevski, K N Truscott. Biochim Biophys Acta 2012
85
20

Homeostatic response to hypoxia is regulated by the N-end rule pathway in plants.
Daniel J Gibbs, Seung Cho Lee, Nurulhikma Md Isa, Silvia Gramuglia, Takeshi Fukao, George W Bassel, Cristina Sousa Correia, Françoise Corbineau, Frederica L Theodoulou, Julia Bailey-Serres,[...]. Nature 2011
384
17

Discovery of cellular regulation by protein degradation.
Alexander Varshavsky. J Biol Chem 2008
74
21

Molecular basis of substrate selection by the N-end rule adaptor protein ClpS.
Giselle Román-Hernández, Robert A Grant, Robert T Sauer, Tania A Baker. Proc Natl Acad Sci U S A 2009
48
33

Oxygen sensing in plants is mediated by an N-end rule pathway for protein destabilization.
Francesco Licausi, Monika Kosmacz, Daan A Weits, Beatrice Giuntoli, Federico M Giorgi, Laurentius A C J Voesenek, Pierdomenico Perata, Joost T van Dongen. Nature 2011
404
16

Amino acids induce peptide uptake via accelerated degradation of CUP9, the transcriptional repressor of the PTR2 peptide transporter.
Zanxian Xia, Glenn C Turner, Cheol-Sang Hwang, Christopher Byrd, Alexander Varshavsky. J Biol Chem 2008
36
41


Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.