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Times Cited: 643
Times Cited: 643
Times Cited
Times Co-cited
Similarity
Shelterin: the protein complex that shapes and safeguards human telomeres.
Titia de Lange. Genes Dev 2005
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Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1.
Eros Lazzerini Denchi, Titia de Lange. Nature 2007
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Structure of human POT1 bound to telomeric single-stranded DNA provides a model for chromosome end-protection.
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Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2.
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Dan Liu, Amin Safari, Matthew S O'Connor, Doug W Chan, Andrew Laegeler, Jun Qin, Zhou Songyang. Nat Cell Biol 2004
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Super-resolution fluorescence imaging of telomeres reveals TRF2-dependent T-loop formation.
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POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex.
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Mammalian telomeres resemble fragile sites and require TRF1 for efficient replication.
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TPP1 is a homologue of ciliate TEBP-beta and interacts with POT1 to recruit telomerase.
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Pot1 deficiency initiates DNA damage checkpoint activation and aberrant homologous recombination at telomeres.
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The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity.
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TRF2 protects human telomeres from end-to-end fusions.
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Recent expansion of the telomeric complex in rodents: Two distinct POT1 proteins protect mouse telomeres.
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Telomere protection by TPP1/POT1 requires tethering to TIN2.
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Specific association of human telomerase activity with immortal cells and cancer.
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TPP1 OB-fold domain controls telomere maintenance by recruiting telomerase to chromosome ends.
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TIN2-tethered TPP1 recruits human telomerase to telomeres in vivo.
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DNA damage foci at dysfunctional telomeres.
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A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes.
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A dynamic molecular link between the telomere length regulator TRF1 and the chromosome end protector TRF2.
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TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres.
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Telomeric repeat containing RNA and RNA surveillance factors at mammalian chromosome ends.
Claus M Azzalin, Patrick Reichenbach, Lela Khoriauli, Elena Giulotto, Joachim Lingner. Science 2007
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Removal of shelterin reveals the telomere end-protection problem.
Agnel Sfeir, Titia de Lange. Science 2012
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POT1 mutations cause telomere dysfunction in chronic lymphocytic leukemia.
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POT1 loss-of-function variants predispose to familial melanoma.
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Telomere protection by mammalian Pot1 requires interaction with Tpp1.
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POT1 protects telomeres from a transient DNA damage response and determines how human chromosomes end.
Dirk Hockemeyer, Agnel J Sfeir, Jerry W Shay, Woodring E Wright, Titia de Lange. EMBO J 2005
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Telomeric localization of TRF2, a novel human telobox protein.
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Long G tails at both ends of human chromosomes suggest a C strand degradation mechanism for telomere shortening.
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A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins.
Yong Chen, Yuting Yang, Megan van Overbeek, Jill R Donigian, Paul Baciu, Titia de Lange, Ming Lei. Science 2008
Yong Chen, Yuting Yang, Megan van Overbeek, Jill R Donigian, Paul Baciu, Titia de Lange, Ming Lei. Science 2008
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Rare missense variants in POT1 predispose to familial cutaneous malignant melanoma.
Jianxin Shi, Xiaohong R Yang, Bari Ballew, Melissa Rotunno, Donato Calista, Maria Concetta Fargnoli, Paola Ghiorzo, Brigitte Bressac-de Paillerets, Eduardo Nagore, Marie Francoise Avril,[...]. Nat Genet 2014
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DNA binding features of human POT1: a nonamer 5'-TAGGGTTAG-3' minimal binding site, sequence specificity, and internal binding to multimeric sites.
Diego Loayza, Heather Parsons, Jill Donigian, Kristina Hoke, Titia de Lange. J Biol Chem 2004
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Germline mutations in shelterin complex genes are associated with familial glioma.
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