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Times Cited: 717
Times Cited: 717
Times Cited
Times Co-cited
Similarity
Shelterin: the protein complex that shapes and safeguards human telomeres.
Titia de Lange. Genes Dev 2005
Titia de Lange. Genes Dev 2005
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Mammalian telomeres end in a large duplex loop.
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Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1.
Eros Lazzerini Denchi, Titia de Lange. Nature 2007
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The POT1-TPP1 telomere complex is a telomerase processivity factor.
Feng Wang, Elaine R Podell, Arthur J Zaug, Yuting Yang, Paul Baciu, Thomas R Cech, Ming Lei. Nature 2007
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Structure of human POT1 bound to telomeric single-stranded DNA provides a model for chromosome end-protection.
Ming Lei, Elaine R Podell, Thomas R Cech. Nat Struct Mol Biol 2004
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Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2.
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PTOP interacts with POT1 and regulates its localization to telomeres.
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POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex.
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Super-resolution fluorescence imaging of telomeres reveals TRF2-dependent T-loop formation.
Ylli Doksani, John Y Wu, Titia de Lange, Xiaowei Zhuang. Cell 2013
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POT1 as a terminal transducer of TRF1 telomere length control.
Diego Loayza, Titia De Lange. Nature 2003
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Mammalian telomeres resemble fragile sites and require TRF1 for efficient replication.
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Pot1 deficiency initiates DNA damage checkpoint activation and aberrant homologous recombination at telomeres.
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TPP1 is a homologue of ciliate TEBP-beta and interacts with POT1 to recruit telomerase.
Huawei Xin, Dan Liu, Ma Wan, Amin Safari, Hyeung Kim, Wen Sun, Matthew S O'Connor, Zhou Songyang. Nature 2007
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The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity.
Jayakrishnan Nandakumar, Caitlin F Bell, Ina Weidenfeld, Arthur J Zaug, Leslie A Leinwand, Thomas R Cech. Nature 2012
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Specific association of human telomerase activity with immortal cells and cancer.
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Telomere protection by TPP1/POT1 requires tethering to TIN2.
Kaori K Takai, Tatsuya Kibe, Jill R Donigian, David Frescas, Titia de Lange. Mol Cell 2011
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Recent expansion of the telomeric complex in rodents: Two distinct POT1 proteins protect mouse telomeres.
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Identification of a specific telomere terminal transferase activity in Tetrahymena extracts.
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A dynamic molecular link between the telomere length regulator TRF1 and the chromosome end protector TRF2.
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TRF2 protects human telomeres from end-to-end fusions.
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TIN2-tethered TPP1 recruits human telomerase to telomeres in vivo.
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TPP1 OB-fold domain controls telomere maintenance by recruiting telomerase to chromosome ends.
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TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres.
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Control of telomere length by the human telomeric protein TRF1.
B van Steensel, T de Lange. Nature 1997
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Telomeric localization of TRF2, a novel human telobox protein.
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Telomeric repeat containing RNA and RNA surveillance factors at mammalian chromosome ends.
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The human CST complex is a terminator of telomerase activity.
Liuh-Yow Chen, Sophie Redon, Joachim Lingner. Nature 2012
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Long G tails at both ends of human chromosomes suggest a C strand degradation mechanism for telomere shortening.
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Telomeres shorten during ageing of human fibroblasts.
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DNA damage foci at dysfunctional telomeres.
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A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes.
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Removal of shelterin reveals the telomere end-protection problem.
Agnel Sfeir, Titia de Lange. Science 2012
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POT1 mutations cause telomere dysfunction in chronic lymphocytic leukemia.
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A critical role for TPP1 and TIN2 interaction in high-order telomeric complex assembly.
Matthew S O'Connor, Amin Safari, Huawei Xin, Dan Liu, Zhou Songyang. Proc Natl Acad Sci U S A 2006
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A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins.
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Telomere protection by mammalian Pot1 requires interaction with Tpp1.
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DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion.
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Telomere Replication Stress Induced by POT1 Inactivation Accelerates Tumorigenesis.
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POT1 loss-of-function variants predispose to familial melanoma.
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Regulation of telomere length and function by a Myb-domain protein in fission yeast.
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POT1 protects telomeres from a transient DNA damage response and determines how human chromosomes end.
Dirk Hockemeyer, Agnel J Sfeir, Jerry W Shay, Woodring E Wright, Titia de Lange. EMBO J 2005
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Extension of life-span by introduction of telomerase into normal human cells.
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Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.