P Baumann, T R Cech. Science 2001
Times Cited: 737
Times Cited: 737
Times Cited
Times Co-cited
Similarity
Shelterin: the protein complex that shapes and safeguards human telomeres.
Titia de Lange. Genes Dev 2005
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Mammalian telomeres end in a large duplex loop.
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The POT1-TPP1 telomere complex is a telomerase processivity factor.
Feng Wang, Elaine R Podell, Arthur J Zaug, Yuting Yang, Paul Baciu, Thomas R Cech, Ming Lei. Nature 2007
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Structure of human POT1 bound to telomeric single-stranded DNA provides a model for chromosome end-protection.
Ming Lei, Elaine R Podell, Thomas R Cech. Nat Struct Mol Biol 2004
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Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2.
D Broccoli, A Smogorzewska, L Chong, T de Lange. Nat Genet 1997
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Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1.
Eros Lazzerini Denchi, Titia de Lange. Nature 2007
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PTOP interacts with POT1 and regulates its localization to telomeres.
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POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex.
Jeffrey Zheng-Sheng Ye, Dirk Hockemeyer, Andrew N Krutchinsky, Diego Loayza, Sarah M Hooper, Brian T Chait, Titia de Lange. Genes Dev 2004
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Super-resolution fluorescence imaging of telomeres reveals TRF2-dependent T-loop formation.
Ylli Doksani, John Y Wu, Titia de Lange, Xiaowei Zhuang. Cell 2013
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POT1 as a terminal transducer of TRF1 telomere length control.
Diego Loayza, Titia De Lange. Nature 2003
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A dynamic molecular link between the telomere length regulator TRF1 and the chromosome end protector TRF2.
Benjamin R Houghtaling, Leanora Cuttonaro, William Chang, Susan Smith. Curr Biol 2004
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Specific association of human telomerase activity with immortal cells and cancer.
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The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity.
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Telomere protection by TPP1/POT1 requires tethering to TIN2.
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Mammalian telomeres resemble fragile sites and require TRF1 for efficient replication.
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TPP1 is a homologue of ciliate TEBP-beta and interacts with POT1 to recruit telomerase.
Huawei Xin, Dan Liu, Ma Wan, Amin Safari, Hyeung Kim, Wen Sun, Matthew S O'Connor, Zhou Songyang. Nature 2007
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Identification of human Rap1: implications for telomere evolution.
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Pot1 deficiency initiates DNA damage checkpoint activation and aberrant homologous recombination at telomeres.
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Recent expansion of the telomeric complex in rodents: Two distinct POT1 proteins protect mouse telomeres.
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Telomeric repeat containing RNA and RNA surveillance factors at mammalian chromosome ends.
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Long G tails at both ends of human chromosomes suggest a C strand degradation mechanism for telomere shortening.
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Identification of a specific telomere terminal transferase activity in Tetrahymena extracts.
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TRF2 protects human telomeres from end-to-end fusions.
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TPP1 OB-fold domain controls telomere maintenance by recruiting telomerase to chromosome ends.
Franklin L Zhong, Luis F Z Batista, Adam Freund, Matthew F Pech, Andrew S Venteicher, Steven E Artandi. Cell 2012
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Telomeric localization of TRF2, a novel human telobox protein.
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TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres.
Jeffrey Zheng-Sheng Ye, Jill R Donigian, Megan van Overbeek, Diego Loayza, Yan Luo, Andrew N Krutchinsky, Brian T Chait, Titia de Lange. J Biol Chem 2004
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Control of telomere length by the human telomeric protein TRF1.
B van Steensel, T de Lange. Nature 1997
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DNA damage foci at dysfunctional telomeres.
Hiroyuki Takai, Agata Smogorzewska, Titia de Lange. Curr Biol 2003
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TIN2-tethered TPP1 recruits human telomerase to telomeres in vivo.
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A critical role for TPP1 and TIN2 interaction in high-order telomeric complex assembly.
Matthew S O'Connor, Amin Safari, Huawei Xin, Dan Liu, Zhou Songyang. Proc Natl Acad Sci U S A 2006
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A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes.
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A human telomeric protein.
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POT1 loss-of-function variants predispose to familial melanoma.
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Structural insights into POT1-TPP1 interaction and POT1 C-terminal mutations in human cancer.
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Telomeres shorten during ageing of human fibroblasts.
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Removal of shelterin reveals the telomere end-protection problem.
Agnel Sfeir, Titia de Lange. Science 2012
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A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis.
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The human CST complex is a terminator of telomerase activity.
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T-loop assembly in vitro involves binding of TRF2 near the 3' telomeric overhang.
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Telomere Replication Stress Induced by POT1 Inactivation Accelerates Tumorigenesis.
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Telomeric 3' overhangs derive from resection by Exo1 and Apollo and fill-in by POT1b-associated CST.
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Human POT1 disrupts telomeric G-quadruplexes allowing telomerase extension in vitro.
Arthur J Zaug, Elaine R Podell, Thomas R Cech. Proc Natl Acad Sci U S A 2005
Arthur J Zaug, Elaine R Podell, Thomas R Cech. Proc Natl Acad Sci U S A 2005
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Structural and functional analysis of the human POT1-TPP1 telomeric complex.
Cory Rice, Prashanth Krishna Shastrula, Andrew V Kossenkov, Robert Hills, Duncan M Baird, Louise C Showe, Tzanko Doukov, Susan Janicki, Emmanuel Skordalakes. Nat Commun 2017
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Telomere protection by mammalian Pot1 requires interaction with Tpp1.
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Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins.
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p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2.
J Karlseder, D Broccoli, Y Dai, S Hardy, T de Lange. Science 1999
J Karlseder, D Broccoli, Y Dai, S Hardy, T de Lange. Science 1999
14
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.