A citation-based method for searching scientific literature

D Lee, S A Long, J H Murray, J L Adams, M E Nuttall, D P Nadeau, K Kikly, J D Winkler, C M Sung, M D Ryan, M A Levy, P M Keller, W E DeWolf. J Med Chem 2001
Times Cited: 117







List of co-cited articles
673 articles co-cited >1



Times Cited
  Times     Co-cited
Similarity


Potent and selective nonpeptide inhibitors of caspases 3 and 7 inhibit apoptosis and maintain cell functionality.
D Lee, S A Long, J L Adams, G Chan, K S Vaidya, T A Francis, K Kikly, J D Winkler, C M Sung, C Debouck,[...]. J Biol Chem 2000
181
41

N-benzylisatin sulfonamide analogues as potent caspase-3 inhibitors: synthesis, in vitro activity, and molecular modeling studies.
Wenhua Chu, Jun Zhang, Chenbo Zeng, Justin Rothfuss, Zhude Tu, Yunxiang Chu, David E Reichert, Michael J Welch, Robert H Mach. J Med Chem 2005
65
50

Synthesis, radiolabeling, and in vivo evaluation of an 18F-labeled isatin analog for imaging caspase-3 activation in apoptosis.
Dong Zhou, Wenhua Chu, Justin Rothfuss, Chenbo Zeng, Jinbin Xu, Lynne Jones, Michael J Welch, Robert H Mach. Bioorg Med Chem Lett 2006
89
25

A novel nonpeptidic caspase-3/7 inhibitor, (S)-(+)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin reduces myocardial ischemic injury.
Justin G Chapman, William P Magee, Hans A Stukenbrok, Gretchen E Beckius, Anthony J Milici, W Ross Tracey. Eur J Pharmacol 2002
57
38

5-pyrrolidinylsulfonyl isatins as a potential tool for the molecular imaging of caspases in apoptosis.
Klaus Kopka, Andreas Faust, Petra Keul, Stefan Wagner, Hans-Jörg Breyholz, Carsten Höltke, Otmar Schober, Michael Schäfers, Bodo Levkau. J Med Chem 2006
52
40

Isatin sulfonamide analogs containing a Michael addition acceptor: a new class of caspase 3/7 inhibitors.
Wenhua Chu, Justin Rothfuss, André d'Avignon, Chenbo Zeng, Dong Zhou, Richard S Hotchkiss, Robert H Mach. J Med Chem 2007
45
44

The biochemistry of apoptosis.
M O Hengartner. Nature 2000
19

Design, synthesis, and biological characterization of a caspase 3/7 selective isatin labeled with 2-[18F]fluoroethylazide.
Graham Smith, Matthias Glaser, Meg Perumal, Quang-De Nguyen, Bo Shan, Erik Arstad, Eric O Aboagye. J Med Chem 2008
95
20

Inhibition of human caspases by peptide-based and macromolecular inhibitors.
M Garcia-Calvo, E P Peterson, B Leiting, R Ruel, D W Nicholson, N A Thornberry. J Biol Chem 1998
783
18

Caspases: keys in the ignition of cell death.
Jean-Bernard Denault, Guy S Salvesen. Chem Rev 2002
235
17


Prospects for caspase inhibitors.
Tom O'Brien, Dennis Lee. Mini Rev Med Chem 2004
48
33

[18F]- and [11C]-labeled N-benzyl-isatin sulfonamide analogues as PET tracers for apoptosis: synthesis, radiolabeling mechanism, and in vivo imaging study of apoptosis in Fas-treated mice using [11C]WC-98.
Dong Zhou, Wenhua Chu, Delphine L Chen, Qi Wang, David E Reichert, Justin Rothfuss, Andre D'Avignon, Michael J Welch, Robert H Mach. Org Biomol Chem 2009
60
26

Positron emission tomography imaging of drug-induced tumor apoptosis with a caspase-3/7 specific [18F]-labeled isatin sulfonamide.
Quang-Dé Nguyen, Graham Smith, Matthias Glaser, Meg Perumal, Erik Arstad, Eric O Aboagye. Proc Natl Acad Sci U S A 2009
123
16

Apoptosis-based therapies.
John C Reed. Nat Rev Drug Discov 2002
483
15

Fluorinated isatin derivatives. Part 1: synthesis of new N-substituted (S)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatins as potent caspase-3 and -7 inhibitors.
Anil Kumar Podichetty, Andreas Faust, Klaus Kopka, Stefan Wagner, Otmar Schober, Michael Schäfers, Günter Haufe. Bioorg Med Chem 2009
37
40

Fluorinated isatin derivatives. Part 2. New N-substituted 5-pyrrolidinylsulfonyl isatins as potential tools for molecular imaging of caspases in apoptosis.
Anil K Podichetty, Stefan Wagner, Sandra Schröer, Andreas Faust, Michael Schäfers, Otmar Schober, Klaus Kopka, Günter Haufe. J Med Chem 2009
48
31

Emerging roles of caspase-3 in apoptosis.
A G Porter, R U Jänicke. Cell Death Differ 1999
14

Novel small molecule inhibitors of caspase-3 block cellular and biochemical features of apoptosis.
Clay W Scott, Cindy Sobotka-Briner, Deidre E Wilkins, Robert T Jacobs, James J Folmer, William J Frazee, Ratan V Bhat, Smita V Ghanekar, David Aharony. J Pharmacol Exp Ther 2003
44
29

A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis.
N A Thornberry, T A Rano, E P Peterson, D M Rasper, T Timkey, M Garcia-Calvo, V M Houtzager, P A Nordstrom, S Roy, J P Vaillancourt,[...]. J Biol Chem 1997
12

Mammalian caspases: structure, activation, substrates, and functions during apoptosis.
W C Earnshaw, L M Martins, S H Kaufmann. Annu Rev Biochem 1999
12

Caspases: enemies within.
N A Thornberry, Y Lazebnik. Science 1998
12

Caspases as targets for anti-inflammatory and anti-apoptotic drug discovery.
R V Talanian, K D Brady, V L Cryns. J Med Chem 2000
91
12

Synthesis and structure-activity relationship of 4-substituted 2-(2-acetyloxyethyl)-8-(morpholine-4-sulfonyl)pyrrolo[3,4-c]quinoline-1,3-diones as potent caspase-3 inhibitors.
Dmitri V Kravchenko, Yulia A Kuzovkova, Volodymyr M Kysil, Sergey E Tkachenko, Sergey Maliarchouk, Ilya M Okun, Konstantin V Balakin, Alexandre V Ivachtchenko. J Med Chem 2005
32
34

Caspases: killer proteases.
D W Nicholson, N A Thornberry. Trends Biochem Sci 1997
11

Synthesis and in vitro evaluation of sulfonamide isatin Michael acceptors as small molecule inhibitors of caspase-6.
Wenhua Chu, Justin Rothfuss, Yunxiang Chu, Dong Zhou, Robert H Mach. J Med Chem 2009
33
33

1,3-Dioxo-4-methyl-2,3-dihydro-1H-pyrrolo[3,4-c]quinolines as potent caspase-3 inhibitors.
Dmitri V Kravchenko, Vladimir V Kysil, Alexey P Ilyn, Sergey E Tkachenko, Sergey Maliarchouk, Ilya M Okun, Alexandre V Ivachtchenko. Bioorg Med Chem Lett 2005
20
50

Apoptosis-detecting radioligands: current state of the art and future perspectives.
Christophe M M Lahorte, Jean-Luc Vanderheyden, Neil Steinmetz, Christophe Van de Wiele, Rudi A Dierckx, Guido Slegers. Eur J Nucl Med Mol Imaging 2004
163
10

Comparison of radiolabeled isatin analogs for imaging apoptosis with positron emission tomography.
Delphine L Chen, Dong Zhou, Wenhua Chu, Phillip E Herrbrich, Lynne A Jones, Justin M Rothfuss, Jacquelyn T Engle, Marco Geraci, Michael J Welch, Robert H Mach. Nucl Med Biol 2009
36
27


Identification of potent and selective small-molecule inhibitors of caspase-3 through the use of extended tethering and structure-based drug design.
Ingrid C Choong, Willard Lew, Dennis Lee, Phuongly Pham, Matthew T Burdett, Joni W Lam, Christian Wiesmann, Tinh N Luong, Bruce Fahr, Warren L DeLano,[...]. J Med Chem 2002
73
12



Anticonvulsant activity of Schiff bases of isatin derivatives.
Manjusha Verma, Surendra Nath Pandeya, Krishna Nand Singh, James P Stables. Acta Pharm 2004
80
11

From the Gla domain to a novel small-molecule detector of apoptosis.
Avi Cohen, Anat Shirvan, Galit Levin, Hagit Grimberg, Ayelet Reshef, Ilan Ziv. Cell Res 2009
80
11

Docking and 3D-QSAR studies on isatin sulfonamide analogues as caspase-3 inhibitors.
Qi Wang, Robert H Mach, David E Reichert. J Chem Inf Model 2009
26
34

18F-ICMT-11, a caspase-3-specific PET tracer for apoptosis: biodistribution and radiation dosimetry.
Amarnath Challapalli, Laura M Kenny, William A Hallett, Kasia Kozlowski, Giampaolo Tomasi, Mihir Gudi, Adil Al-Nahhas, R Charles Coombes, Eric O Aboagye. J Nucl Med 2013
66
13

MX1013, a dipeptide caspase inhibitor with potent in vivo antiapoptotic activity.
Wu Yang, John Guastella, Jin-Cheng Huang, Yan Wang, Li Zhang, Dong Xue, Minhtam Tran, Richard Woodward, Shailaja Kasibhatla, Ben Tseng,[...]. Br J Pharmacol 2003
67
11

The endogenous oxindoles 5-hydroxyoxindole and isatin are antiproliferative and proapoptotic.
A Cane, M C Tournaire, D Barritault, M Crumeyrolle-Arias. Biochem Biophys Res Commun 2000
77
10

Design, synthesis, and evaluation of aza-peptide Michael acceptors as selective and potent inhibitors of caspases-2, -3, -6, -7, -8, -9, and -10.
Ozlem Dogan Ekici, Zhao Zhao Li, Amy J Campbell, Karen Ellis James, Juliana L Asgian, Jowita Mikolajczyk, Guy S Salvesen, Rajkumar Ganesan, Stjepan Jelakovic, Markus G Grütter,[...]. J Med Chem 2006
51
15

Metabolite identification of a radiotracer by electrochemistry coupled to liquid chromatography with mass spectrometric and radioactivity detection.
Anne Baumann, Andreas Faust, Marylin P Law, Michael T Kuhlmann, Klaus Kopka, Michael Schäfers, Uwe Karst. Anal Chem 2011
24
33


Isatin 1,2,3-triazoles as potent inhibitors against caspase-3.
Yang Jiang, Trond Vidar Hansen. Bioorg Med Chem Lett 2011
24
33

The three-dimensional structure of apopain/CPP32, a key mediator of apoptosis.
J Rotonda, D W Nicholson, K M Fazil, M Gallant, Y Gareau, M Labelle, E P Peterson, D M Rasper, R Ruel, J P Vaillancourt,[...]. Nat Struct Biol 1996
362
7

The structures of caspases-1, -3, -7 and -8 reveal the basis for substrate and inhibitor selectivity.
Y Wei, T Fox, S P Chambers, J Sintchak, J T Coll, J M Golec, L Swenson, K P Wilson, P S Charifson. Chem Biol 2000
166
7

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis.
D W Nicholson, A Ali, N A Thornberry, J P Vaillancourt, C K Ding, M Gallant, Y Gareau, P R Griffin, M Labelle, Y A Lazebnik. Nature 1995
7

Identification of potent and novel small-molecule inhibitors of caspase-3.
Darin A Allen, Phuongly Pham, Ingrid C Choong, Bruce Fahr, Matthew T Burdett, Willard Lew, Warren L DeLano, Eric M Gordon, Joni W Lam, Tom O'Brien,[...]. Bioorg Med Chem Lett 2003
20
35

Discovery of novel aspartyl ketone dipeptides as potent and selective caspase-3 inhibitors.
Yongxin Han, André Giroux, Erich L Grimm, Renée Aspiotis, Sébastien Francoeur, Christopher I Bayly, Daniel J Mckay, Sophie Roy, Steve Xanthoudakis, John P Vaillancourt,[...]. Bioorg Med Chem Lett 2004
25
28

Acyl dipeptides as reversible caspase inhibitors. Part 1: initial lead optimization.
Steven D Linton, Donald S Karanewsky, Robert J Ternansky, Joe C Wu, Brian Pham, Lalitha Kodandapani, Robert Smidt, Jose-Luis Diaz, Lawrence C Fritz, Kevin J Tomaselli. Bioorg Med Chem Lett 2002
24
29

Irreversible inhibitors of serine, cysteine, and threonine proteases.
James C Powers, Juliana L Asgian, Ozlem Dogan Ekici, Karen Ellis James. Chem Rev 2002
654
7


Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.