G M Pitari, M D Di Guglielmo, J Park, S Schulz, S A Waldman. Proc Natl Acad Sci U S A 2001
Times Cited: 125
Times Cited: 125
Times Cited
Times Co-cited
Similarity
Uroguanylin treatment suppresses polyp formation in the Apc(Min/+) mouse and induces apoptosis in human colon adenocarcinoma cells via cyclic GMP.
K Shailubhai, H H Yu, K Karunanandaa, J Y Wang, S L Eber, Y Wang, N S Joo, H D Kim, B W Miedema, S Z Abbas,[...]. Cancer Res 2000
K Shailubhai, H H Yu, K Karunanandaa, J Y Wang, S L Eber, Y Wang, N S Joo, H D Kim, B W Miedema, S Z Abbas,[...]. Cancer Res 2000
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Bacterial enterotoxins are associated with resistance to colon cancer.
G M Pitari, L V Zingman, D M Hodgson, A E Alekseev, S Kazerounian, M Bienengraeber, G Hajnóczky, A Terzic, S A Waldman. Proc Natl Acad Sci U S A 2003
G M Pitari, L V Zingman, D M Hodgson, A E Alekseev, S Kazerounian, M Bienengraeber, G Hajnóczky, A Terzic, S A Waldman. Proc Natl Acad Sci U S A 2003
58
Targeted inactivation of the mouse guanylin gene results in altered dynamics of colonic epithelial proliferation.
Kris A Steinbrecher, Steve A Wowk, Jeffrey A Rudolph, David P Witte, Mitchell B Cohen. Am J Pathol 2002
Kris A Steinbrecher, Steve A Wowk, Jeffrey A Rudolph, David P Witte, Mitchell B Cohen. Am J Pathol 2002
57
Homeostatic control of the crypt-villus axis by the bacterial enterotoxin receptor guanylyl cyclase C restricts the proliferating compartment in intestine.
Peng Li, Jieru E Lin, Inna Chervoneva, Stephanie Schulz, Scott A Waldman, Giovanni M Pitari. Am J Pathol 2007
Peng Li, Jieru E Lin, Inna Chervoneva, Stephanie Schulz, Scott A Waldman, Giovanni M Pitari. Am J Pathol 2007
56
Guanylyl cyclase C suppresses intestinal tumorigenesis by restricting proliferation and maintaining genomic integrity.
Peng Li, Stephanie Schulz, Alessandro Bombonati, Juan P Palazzo, Terry M Hyslop, Yihuan Xu, Amy A Baran, Linda D Siracusa, Giovanni M Pitari, Scott A Waldman. Gastroenterology 2007
Peng Li, Stephanie Schulz, Alessandro Bombonati, Juan P Palazzo, Terry M Hyslop, Yihuan Xu, Amy A Baran, Linda D Siracusa, Giovanni M Pitari, Scott A Waldman. Gastroenterology 2007
45
Guanylyl cyclases and signaling by cyclic GMP.
K A Lucas, G M Pitari, S Kazerounian, I Ruiz-Stewart, J Park, S Schulz, K P Chepenik, S A Waldman. Pharmacol Rev 2000
K A Lucas, G M Pitari, S Kazerounian, I Ruiz-Stewart, J Park, S Schulz, K P Chepenik, S A Waldman. Pharmacol Rev 2000
43
Guanylyl cyclase is a heat-stable enterotoxin receptor.
S Schulz, C K Green, P S Yuen, D L Garbers. Cell 1990
S Schulz, C K Green, P S Yuen, D L Garbers. Cell 1990
38
Expression of guanylin is downregulated in mouse and human intestinal adenomas.
K A Steinbrecher, T M Tuohy, K Heppner Goss, M C Scott, D P Witte, J Groden, M B Cohen. Biochem Biophys Res Commun 2000
K A Steinbrecher, T M Tuohy, K Heppner Goss, M C Scott, D P Witte, J Groden, M B Cohen. Biochem Biophys Res Commun 2000
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Guanylyl cyclase C is a selective marker for metastatic colorectal tumors in human extraintestinal tissues.
S L Carrithers, M T Barber, S Biswas, S J Parkinson, P K Park, S D Goldstein, S A Waldman. Proc Natl Acad Sci U S A 1996
S L Carrithers, M T Barber, S Biswas, S J Parkinson, P K Park, S D Goldstein, S A Waldman. Proc Natl Acad Sci U S A 1996
35
Uroguanylin: structure and activity of a second endogenous peptide that stimulates intestinal guanylate cyclase.
F K Hamra, L R Forte, S L Eber, N V Pidhorodeckyj, W J Krause, R H Freeman, D T Chin, J A Tompkins, K F Fok, C E Smith. Proc Natl Acad Sci U S A 1993
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Transcriptional gene expression profiles of colorectal adenoma, adenocarcinoma, and normal tissue examined by oligonucleotide arrays.
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Guanylin: an endogenous activator of intestinal guanylate cyclase.
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30
Interruption of homologous desensitization in cyclic guanosine 3',5'-monophosphate signaling restores colon cancer cytostasis by bacterial enterotoxins.
Giovanni M Pitari, Ronnie I Baksh, David M Harris, Peng Li, Shiva Kazerounian, Scott A Waldman. Cancer Res 2005
Giovanni M Pitari, Ronnie I Baksh, David M Harris, Peng Li, Shiva Kazerounian, Scott A Waldman. Cancer Res 2005
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The hormone receptor GUCY2C suppresses intestinal tumor formation by inhibiting AKT signaling.
Jieru Egeria Lin, Peng Li, Adam Eugene Snook, Stephanie Schulz, Abhijit Dasgupta, Terry Marie Hyslop, Ahmara Vivian Gibbons, Glen Marszlowicz, Giovanni Mario Pitari, Scott Arthur Waldman. Gastroenterology 2010
Jieru Egeria Lin, Peng Li, Adam Eugene Snook, Stephanie Schulz, Abhijit Dasgupta, Terry Marie Hyslop, Ahmara Vivian Gibbons, Glen Marszlowicz, Giovanni Mario Pitari, Scott Arthur Waldman. Gastroenterology 2010
37
Disruption of the guanylyl cyclase-C gene leads to a paradoxical phenotype of viable but heat-stable enterotoxin-resistant mice.
S Schulz, M J Lopez, M Kuhn, D L Garbers. J Clin Invest 1997
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29
Guanylyl cyclase C is a marker of intestinal metaplasia, dysplasia, and adenocarcinoma of the gastrointestinal tract.
Ruth Birbe, Juan P Palazzo, Rhonda Walters, David Weinberg, Stephanie Schulz, Scott A Waldman. Hum Pathol 2005
Ruth Birbe, Juan P Palazzo, Rhonda Walters, David Weinberg, Stephanie Schulz, Scott A Waldman. Hum Pathol 2005
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Guanylin mRNA expression in human intestine and colorectal adenocarcinoma.
M B Cohen, J A Hawkins, D P Witte. Lab Invest 1998
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Exisulind induction of apoptosis involves guanosine 3',5'-cyclic monophosphate phosphodiesterase inhibition, protein kinase G activation, and attenuated beta-catenin.
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Escherichia coli heat-stable toxin receptors in human colonic tumors.
S L Carrithers, S J Parkinson, S Goldstein, P Park, D C Robertson, S A Waldman. Gastroenterology 1994
S L Carrithers, S J Parkinson, S Goldstein, P Park, D C Robertson, S A Waldman. Gastroenterology 1994
28
A validated quantitative assay to detect occult micrometastases by reverse transcriptase-polymerase chain reaction of guanylyl cyclase C in patients with colorectal cancer.
Stephanie Schulz, Terry Hyslop, Janis Haaf, Christine Bonaccorso, Karl Nielsen, Matthew E Witek, Ruth Birbe, Juan Palazzo, David Weinberg, Scott A Waldman. Clin Cancer Res 2006
Stephanie Schulz, Terry Hyslop, Janis Haaf, Christine Bonaccorso, Karl Nielsen, Matthew E Witek, Ruth Birbe, Juan Palazzo, David Weinberg, Scott A Waldman. Clin Cancer Res 2006
34
Guanylyl cyclase C messenger RNA is a biomarker for recurrent stage II colorectal cancer.
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The paracrine hormone hypothesis of colorectal cancer.
G M Pitari, P Li, J E Lin, D Zuzga, A V Gibbons, A E Snook, S Schulz, S A Waldman. Clin Pharmacol Ther 2007
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Guanylin and uroguanylin induce natriuresis in mice lacking guanylyl cyclase-C receptor.
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Heat-stable enterotoxin of Escherichia coli: in vitro effects on guanylate cyclase activity, cyclic GMP concentration, and ion transport in small intestine.
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Gene expression in colorectal cancer.
Karin Birkenkamp-Demtroder, Lise Lotte Christensen, Sanne Harder Olesen, Casper M Frederiksen, Päivi Laiho, Lauri A Aaltonen, Søren Laurberg, Flemming B Sørensen, Rikke Hagemann, Torben F ØRntoft. Cancer Res 2002
Karin Birkenkamp-Demtroder, Lise Lotte Christensen, Sanne Harder Olesen, Casper M Frederiksen, Päivi Laiho, Lauri A Aaltonen, Søren Laurberg, Flemming B Sørensen, Rikke Hagemann, Torben F ØRntoft. Cancer Res 2002
17
Mice lacking the guanylyl cyclase C receptor are resistant to STa-induced intestinal secretion.
E A Mann, M L Jump, J Wu, E Yee, R A Giannella. Biochem Biophys Res Commun 1997
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17
Association of GUCY2C expression in lymph nodes with time to recurrence and disease-free survival in pN0 colorectal cancer.
Scott A Waldman, Terry Hyslop, Stephanie Schulz, Alan Barkun, Karl Nielsen, Janis Haaf, Christine Bonaccorso, Yanyan Li, David S Weinberg. JAMA 2009
Scott A Waldman, Terry Hyslop, Stephanie Schulz, Alan Barkun, Karl Nielsen, Janis Haaf, Christine Bonaccorso, Yanyan Li, David S Weinberg. JAMA 2009
20
Cyclic GMP-dependent protein kinase activation and induction by exisulind and CP461 in colon tumor cells.
L Liu, H Li, T Underwood, M Lloyd, M David, G Sperl, R Pamukcu, W J Thompson. J Pharmacol Exp Ther 2001
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Uroguanylin and guanylin peptides: pharmacology and experimental therapeutics.
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16
Activation of protein kinase G is sufficient to induce apoptosis and inhibit cell migration in colon cancer cells.
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Gene expression profiles in normal and cancer cells.
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Loss of guanylyl cyclase C (GCC) signaling leads to dysfunctional intestinal barrier.
Xiaonan Han, Elizabeth Mann, Shila Gilbert, Yanfang Guan, Kris A Steinbrecher, Marshall H Montrose, Mitchell B Cohen. PLoS One 2011
Xiaonan Han, Elizabeth Mann, Shila Gilbert, Yanfang Guan, Kris A Steinbrecher, Marshall H Montrose, Mitchell B Cohen. PLoS One 2011
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Meconium ileus caused by mutations in GUCY2C, encoding the CFTR-activating guanylate cyclase 2C.
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26
Familial diarrhea syndrome caused by an activating GUCY2C mutation.
Torunn Fiskerstrand, Najla Arshad, Bjørn Ivar Haukanes, Rune Rose Tronstad, Khanh Do-Cong Pham, Stefan Johansson, Bjarte Håvik, Siv L Tønder, Shawn E Levy, Damien Brackman,[...]. N Engl J Med 2012
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15
GUCY2C opposes systemic genotoxic tumorigenesis by regulating AKT-dependent intestinal barrier integrity.
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Regulation of intestinal uroguanylin/guanylin receptor-mediated responses by mucosal acidity.
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In vivo imaging of human colon cancer xenografts in immunodeficient mice using a guanylyl cyclase C--specific ligand.
Henry R Wolfe, Marivi Mendizabal, Elinor Lleong, Alan Cuthbertson, Vinay Desai, Shirley Pullan, Dennis K Fujii, Matthew Morrison, Richard Pither, Scott A Waldman. J Nucl Med 2002
Henry R Wolfe, Marivi Mendizabal, Elinor Lleong, Alan Cuthbertson, Vinay Desai, Shirley Pullan, Dennis K Fujii, Matthew Morrison, Richard Pither, Scott A Waldman. J Nucl Med 2002
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The putative tumor suppressor Cdx2 is overexpressed by human colorectal adenocarcinomas.
Matthew E Witek, Karl Nielsen, Rhonda Walters, Terry Hyslop, Juan Palazzo, Stephanie Schulz, Scott A Waldman. Clin Cancer Res 2005
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Colorectal cancer is a paracrine deficiency syndrome amenable to oral hormone replacement therapy.
P Li, J E Lin, A E Snook, A V Gibbons, D S Zuzga, S Schulz, G M Pitari, S A Waldman. Clin Transl Sci 2008
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A uroguanylin-GUCY2C endocrine axis regulates feeding in mice.
Michael A Valentino, Jieru E Lin, Adam E Snook, Peng Li, Gilbert W Kim, Glen Marszalowicz, Michael S Magee, Terry Hyslop, Stephanie Schulz, Scott A Waldman. J Clin Invest 2011
Michael A Valentino, Jieru E Lin, Adam E Snook, Peng Li, Gilbert W Kim, Glen Marszalowicz, Michael S Magee, Terry Hyslop, Stephanie Schulz, Scott A Waldman. J Clin Invest 2011
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Cyclic GMP mediates apoptosis induced by sulindac derivatives via activation of c-Jun NH2-terminal kinase 1.
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Use of guanylyl cyclase C for detecting micrometastases in lymph nodes of patients with colon cancer.
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The paracrine hormone for the GUCY2C tumor suppressor, guanylin, is universally lost in colorectal cancer.
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Activation of intestinal CFTR Cl- channel by heat-stable enterotoxin and guanylin via cAMP-dependent protein kinase.
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Guanylyl cyclase C in colorectal cancer: susceptibility gene and potential therapeutic target.
Jieru E Lin, Peng Li, Giovanni M Pitari, Stephanie Schulz, Scott A Waldman. Future Oncol 2009
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Enterotoxin preconditioning restores calcium-sensing receptor-mediated cytostasis in colon cancer cells.
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Receptor guanylyl cyclase C (GC-C): regulation and signal transduction.
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Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.