G Mannaioni, M J Marino, O Valenti, S F Traynelis, P J Conn. J Neurosci 2001
Times Cited: 335
Times Cited: 335
Times Cited
Times Co-cited
Similarity
Metabotropic glutamate receptors: physiology, pharmacology, and disease.
Colleen M Niswender, P Jeffrey Conn. Annu Rev Pharmacol Toxicol 2010
Colleen M Niswender, P Jeffrey Conn. Annu Rev Pharmacol Toxicol 2010
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Activation of metabotropic glutamate receptor 5 has direct excitatory effects and potentiates NMDA receptor currents in neurons of the subthalamic nucleus.
H Awad, G W Hubert, Y Smith, A I Levey, P J Conn. J Neurosci 2000
H Awad, G W Hubert, Y Smith, A I Levey, P J Conn. J Neurosci 2000
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Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins.
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Selective abolition of the NMDA component of long-term potentiation in mice lacking mGluR5.
Z Jia, Y Lu, J Henderson, F Taverna, C Romano, W Abramow-Newerly, J M Wojtowicz, J Roder. Learn Mem 1998
Z Jia, Y Lu, J Henderson, F Taverna, C Romano, W Abramow-Newerly, J M Wojtowicz, J Roder. Learn Mem 1998
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mGluR5 positive allosteric modulators facilitate both hippocampal LTP and LTD and enhance spatial learning.
Jennifer E Ayala, Yelin Chen, Jessica L Banko, Douglas J Sheffler, Richard Williams, Alexandra N Telk, Noreen L Watson, Zixiu Xiang, Yongqin Zhang, Paulianda J Jones,[...]. Neuropsychopharmacology 2009
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(RS)-2-chloro-5-hydroxyphenylglycine (CHPG) activates mGlu5, but no mGlu1, receptors expressed in CHO cells and potentiates NMDA responses in the hippocampus.
A J Doherty, M J Palmer, J M Henley, G L Collingridge, D E Jane. Neuropharmacology 1997
A J Doherty, M J Palmer, J M Henley, G L Collingridge, D E Jane. Neuropharmacology 1997
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Perisynaptic location of metabotropic glutamate receptors mGluR1 and mGluR5 on dendrites and dendritic spines in the rat hippocampus.
R Lujan, Z Nusser, J D Roberts, R Shigemoto, P Somogyi. Eur J Neurosci 1996
R Lujan, Z Nusser, J D Roberts, R Shigemoto, P Somogyi. Eur J Neurosci 1996
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The metabotropic glutamate receptor, mGluR5, is a key determinant of good and bad spatial learning performance and hippocampal synaptic plasticity.
Denise Manahan-Vaughan, Karl-Heinz Braunewell. Cereb Cortex 2005
Denise Manahan-Vaughan, Karl-Heinz Braunewell. Cereb Cortex 2005
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Pharmacology and functions of metabotropic glutamate receptors.
P J Conn, J P Pin. Annu Rev Pharmacol Toxicol 1997
P J Conn, J P Pin. Annu Rev Pharmacol Toxicol 1997
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Metabotropic glutamate receptors: from the workbench to the bedside.
F Nicoletti, J Bockaert, G L Collingridge, P J Conn, F Ferraguti, D D Schoepp, J T Wroblewski, J P Pin. Neuropharmacology 2011
F Nicoletti, J Bockaert, G L Collingridge, P J Conn, F Ferraguti, D D Schoepp, J T Wroblewski, J P Pin. Neuropharmacology 2011
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Activation of type 5 metabotropic glutamate receptors enhances NMDA responses in mice cortical wedges.
S Attucci, V Carlà, G Mannaioni, F Moroni. Br J Pharmacol 2001
S Attucci, V Carlà, G Mannaioni, F Moroni. Br J Pharmacol 2001
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Mice lacking metabotropic glutamate receptor 5 show impaired learning and reduced CA1 long-term potentiation (LTP) but normal CA3 LTP.
Y M Lu, Z Jia, C Janus, J T Henderson, R Gerlai, J M Wojtowicz, J C Roder. J Neurosci 1997
Y M Lu, Z Jia, C Janus, J T Henderson, R Gerlai, J M Wojtowicz, J C Roder. J Neurosci 1997
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The mGluR theory of fragile X mental retardation.
Mark F Bear, Kimberly M Huber, Stephen T Warren. Trends Neurosci 2004
Mark F Bear, Kimberly M Huber, Stephen T Warren. Trends Neurosci 2004
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Chemical induction of mGluR5- and protein synthesis--dependent long-term depression in hippocampal area CA1.
K M Huber, J C Roder, M F Bear. J Neurophysiol 2001
K M Huber, J C Roder, M F Bear. J Neurophysiol 2001
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Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity.
Alice L Rodriguez, Mark D Grier, Carrie K Jones, Elizabeth J Herman, Alexander S Kane, Randy L Smith, Richard Williams, Ya Zhou, Joy E Marlo, Emily L Days,[...]. Mol Pharmacol 2010
Alice L Rodriguez, Mark D Grier, Carrie K Jones, Elizabeth J Herman, Alexander S Kane, Randy L Smith, Richard Williams, Ya Zhou, Joy E Marlo, Emily L Days,[...]. Mol Pharmacol 2010
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Role for rapid dendritic protein synthesis in hippocampal mGluR-dependent long-term depression.
K M Huber, M S Kayser, M F Bear. Science 2000
K M Huber, M S Kayser, M F Bear. Science 2000
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Metabotropic glutamate receptor 5 mediates the potentiation of N-methyl-D-aspartate responses in medium spiny striatal neurons.
A Pisani, P Gubellini, P Bonsi, F Conquet, B Picconi, D Centonze, G Bernardi, P Calabresi. Neuroscience 2001
A Pisani, P Gubellini, P Bonsi, F Conquet, B Picconi, D Centonze, G Bernardi, P Calabresi. Neuroscience 2001
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A novel selective positive allosteric modulator of metabotropic glutamate receptor subtype 5 has in vivo activity and antipsychotic-like effects in rat behavioral models.
Gene G Kinney, Julie A O'Brien, Wei Lemaire, Maryann Burno, Denise J Bickel, Michelle K Clements, Tsing-Bau Chen, David D Wisnoski, Craig W Lindsley, Philip R Tiller,[...]. J Pharmacol Exp Ther 2005
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Group 1 mGluR-dependent synaptic long-term depression: mechanisms and implications for circuitry and disease.
Christian Lüscher, Kimberly M Huber. Neuron 2010
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The group I mGlu receptor agonist DHPG induces a novel form of LTD in the CA1 region of the hippocampus.
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The metabotropic glutamate receptor (mGluR1 alpha) is concentrated at perisynaptic membrane of neuronal subpopulations as detected by immunogold reaction.
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Metabotropic glutamate subtype 5 receptors modulate locomotor activity and sensorimotor gating in rodents.
Gene G Kinney, Maryann Burno, Una C Campbell, Lisa M Hernandez, Dana Rodriguez, Linda J Bristow, P Jeffrey Conn. J Pharmacol Exp Ther 2003
Gene G Kinney, Maryann Burno, Una C Campbell, Lisa M Hernandez, Dana Rodriguez, Linda J Bristow, P Jeffrey Conn. J Pharmacol Exp Ther 2003
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Altered synaptic plasticity in a mouse model of fragile X mental retardation.
Kimberly M Huber, Sean M Gallagher, Stephen T Warren, Mark F Bear. Proc Natl Acad Sci U S A 2002
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Metabotropic glutamate receptor 1 (mGluR1) and 5 (mGluR5) regulate late phases of LTP and LTD in the hippocampal CA1 region in vitro.
Sergey Neyman, Denise Manahan-Vaughan. Eur J Neurosci 2008
Sergey Neyman, Denise Manahan-Vaughan. Eur J Neurosci 2008
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Regulation by metabotropic glutamate receptor 5 of LTP in the dentate gyrus of freely moving rats: relevance for learning and memory formation.
Katja Naie, Denise Manahan-Vaughan. Cereb Cortex 2004
Katja Naie, Denise Manahan-Vaughan. Cereb Cortex 2004
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2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist.
F Gasparini, K Lingenhöhl, N Stoehr, P J Flor, M Heinrich, I Vranesic, M Biollaz, H Allgeier, R Heckendorn, S Urwyler,[...]. Neuropharmacology 1999
F Gasparini, K Lingenhöhl, N Stoehr, P J Flor, M Heinrich, I Vranesic, M Biollaz, H Allgeier, R Heckendorn, S Urwyler,[...]. Neuropharmacology 1999
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Involvement of the metabotropic glutamate receptor mGluR5 in NMDA receptor-dependent, learning-facilitated long-term depression in CA1 synapses.
Stoyan G Popkirov, Denise Manahan-Vaughan. Cereb Cortex 2011
Stoyan G Popkirov, Denise Manahan-Vaughan. Cereb Cortex 2011
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Molecular characterization of a novel metabotropic glutamate receptor mGluR5 coupled to inositol phosphate/Ca2+ signal transduction.
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T Abe, H Sugihara, H Nawa, R Shigemoto, N Mizuno, S Nakanishi. J Biol Chem 1992
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ADX47273 [S-(4-fluoro-phenyl)-{3-[3-(4-fluoro-phenyl)-[1,2,4]-oxadiazol-5-yl]-piperidin-1-yl}-methanone]: a novel metabotropic glutamate receptor 5-selective positive allosteric modulator with preclinical antipsychotic-like and procognitive activities.
Feng Liu, Steve Grauer, Cody Kelley, Rachel Navarra, Radka Graf, Guoming Zhang, Peter J Atkinson, Michael Popiolek, Caitlin Wantuch, Xavier Khawaja,[...]. J Pharmacol Exp Ther 2008
Feng Liu, Steve Grauer, Cody Kelley, Rachel Navarra, Radka Graf, Guoming Zhang, Peter J Atkinson, Michael Popiolek, Caitlin Wantuch, Xavier Khawaja,[...]. J Pharmacol Exp Ther 2008
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Role of metabotropic glutamate receptors in persistent forms of hippocampal plasticity and learning.
Sreedeep Mukherjee, Denise Manahan-Vaughan. Neuropharmacology 2013
Sreedeep Mukherjee, Denise Manahan-Vaughan. Neuropharmacology 2013
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Functional Interaction Between NMDA and mGlu5 Receptors: Effects on Working Memory, Instrumental Learning, Motor Behaviors, and Dopamine Release.
Houman Homayoun, Mark R Stefani, Barbara W Adams, Gilles D Tamagan, Bita Moghaddam. Neuropsychopharmacology 2004
Houman Homayoun, Mark R Stefani, Barbara W Adams, Gilles D Tamagan, Bita Moghaddam. Neuropsychopharmacology 2004
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Two distinct forms of long-term depression coexist in CA1 hippocampal pyramidal cells.
S H Oliet, R C Malenka, R A Nicoll. Neuron 1997
S H Oliet, R C Malenka, R A Nicoll. Neuron 1997
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Structural, signalling and regulatory properties of the group I metabotropic glutamate receptors: prototypic family C G-protein-coupled receptors.
E Hermans, R A Challiss. Biochem J 2001
E Hermans, R A Challiss. Biochem J 2001
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Chronic pharmacological mGlu5 inhibition corrects fragile X in adult mice.
Aubin Michalon, Michael Sidorov, Theresa M Ballard, Laurence Ozmen, Will Spooren, Joseph G Wettstein, Georg Jaeschke, Mark F Bear, Lothar Lindemann. Neuron 2012
Aubin Michalon, Michael Sidorov, Theresa M Ballard, Laurence Ozmen, Will Spooren, Joseph G Wettstein, Georg Jaeschke, Mark F Bear, Lothar Lindemann. Neuron 2012
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Differential roles for group 1 mGluR subtypes in induction and expression of chemically induced hippocampal long-term depression.
Lenora J Volk, Christine A Daly, Kimberly M Huber. J Neurophysiol 2006
Lenora J Volk, Christine A Daly, Kimberly M Huber. J Neurophysiol 2006
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Two distinct signaling pathways upregulate NMDA receptor responses via two distinct metabotropic glutamate receptor subtypes.
Pascal Benquet, Christine E Gee, Urs Gerber. J Neurosci 2002
Pascal Benquet, Christine E Gee, Urs Gerber. J Neurosci 2002
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Correction of fragile X syndrome in mice.
Gül Dölen, Emily Osterweil, B S Shankaranarayana Rao, Gordon B Smith, Benjamin D Auerbach, Sumantra Chattarji, Mark F Bear. Neuron 2007
Gül Dölen, Emily Osterweil, B S Shankaranarayana Rao, Gordon B Smith, Benjamin D Auerbach, Sumantra Chattarji, Mark F Bear. Neuron 2007
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A specific role for group I mGluRs in hippocampal LTP and hippocampus-dependent spatial learning.
D Balschun, D Manahan-Vaughan, T Wagner, T Behnisch, K G Reymann, W Wetzel. Learn Mem 1999
D Balschun, D Manahan-Vaughan, T Wagner, T Behnisch, K G Reymann, W Wetzel. Learn Mem 1999
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Reduced hippocampal long-term potentiation and context-specific deficit in associative learning in mGluR1 mutant mice.
A Aiba, C Chen, K Herrup, C Rosenmund, C F Stevens, S Tonegawa. Cell 1994
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Hippocampal long-term depression and long-term potentiation encode different aspects of novelty acquisition.
Anne Kemp, Denise Manahan-Vaughan. Proc Natl Acad Sci U S A 2004
Anne Kemp, Denise Manahan-Vaughan. Proc Natl Acad Sci U S A 2004
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The metabotropic glutamate receptors: structure and functions.
J P Pin, R Duvoisin. Neuropharmacology 1995
J P Pin, R Duvoisin. Neuropharmacology 1995
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Differential presynaptic localization of metabotropic glutamate receptor subtypes in the rat hippocampus.
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Distribution of the mRNA for a metabotropic glutamate receptor (mGluR1) in the central nervous system: an in situ hybridization study in adult and developing rat.
R Shigemoto, S Nakanishi, N Mizuno. J Comp Neurol 1992
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Activation of metabotropic glutamate receptors as a novel approach for the treatment of schizophrenia.
P Jeffrey Conn, Craig W Lindsley, Carrie K Jones. Trends Pharmacol Sci 2009
P Jeffrey Conn, Craig W Lindsley, Carrie K Jones. Trends Pharmacol Sci 2009
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Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans. Psychotomimetic, perceptual, cognitive, and neuroendocrine responses.
J H Krystal, L P Karper, J P Seibyl, G K Freeman, R Delaney, J D Bremner, G R Heninger, M B Bowers, D S Charney. Arch Gen Psychiatry 1994
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Co-stimulation of mGluR5 and N-methyl-D-aspartate receptors is required for potentiation of excitatory synaptic transmission in hippocampal neurons.
Suhas A Kotecha, Michael F Jackson, Azza Al-Mahrouki, John C Roder, Beverley A Orser, John F MacDonald. J Biol Chem 2003
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Unique signaling profiles of positive allosteric modulators of metabotropic glutamate receptor subtype 5 determine differences in in vivo activity.
Jerri M Rook, Meredith J Noetzel, Wendy A Pouliot, Thomas M Bridges, Paige N Vinson, Hyekyung P Cho, Ya Zhou, Rocco D Gogliotti, Jason T Manka, Karen J Gregory,[...]. Biol Psychiatry 2013
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From revolution to evolution: the glutamate hypothesis of schizophrenia and its implication for treatment.
Bita Moghaddam, Daniel Javitt. Neuropsychopharmacology 2012
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Reversal of phencyclidine effects by a group II metabotropic glutamate receptor agonist in rats.
B Moghaddam, B W Adams. Science 1998
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