A citation-based method for searching scientific literature

G Zhou, R Myers, Y Li, Y Chen, X Shen, J Fenyk-Melody, M Wu, J Ventre, T Doebber, N Fujii, N Musi, M F Hirshman, L J Goodyear, D E Moller. J Clin Invest 2001
Times Cited: 3768







List of co-cited articles
542 articles co-cited >1



Times Cited
  Times     Co-cited
Similarity


The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin.
Reuben J Shaw, Katja A Lamia, Debbie Vasquez, Seung-Hoi Koo, Nabeel Bardeesy, Ronald A Depinho, Marc Montminy, Lewis C Cantley. Science 2005
12

The mechanisms of action of metformin.
Graham Rena, D Grahame Hardie, Ewan R Pearson. Diabetologia 2017
632
11

Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I.
M Y El-Mir, V Nogueira, E Fontaine, N Avéret, M Rigoulet, X Leverve. J Biol Chem 2000
922
10

Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state.
Marc Foretz, Sophie Hébrard, Jocelyne Leclerc, Elham Zarrinpashneh, Maud Soty, Gilles Mithieux, Kei Sakamoto, Fabrizio Andreelli, Benoit Viollet. J Clin Invest 2010
800
10

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1.
Joungmok Kim, Mondira Kundu, Benoit Viollet, Kun-Liang Guan. Nat Cell Biol 2011
9

Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP.
Russell A Miller, Qingwei Chu, Jianxin Xie, Marc Foretz, Benoit Viollet, Morris J Birnbaum. Nature 2013
492
8

10-year follow-up of intensive glucose control in type 2 diabetes.
Rury R Holman, Sanjoy K Paul, M Angelyn Bethel, David R Matthews, H Andrew W Neil. N Engl J Med 2008
8


Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase.
Anila K Madiraju, Derek M Erion, Yasmeen Rahimi, Xian-Man Zhang, Demetrios T Braddock, Ronald A Albright, Brett J Prigaro, John L Wood, Sanjay Bhanot, Michael J MacDonald,[...]. Nature 2014
662
7

Metformin: from mechanisms of action to therapies.
Marc Foretz, Bruno Guigas, Luc Bertrand, Michael Pollak, Benoit Viollet. Cell Metab 2014
598
7

Cellular and molecular mechanisms of metformin: an overview.
Benoit Viollet, Bruno Guigas, Nieves Sanz Garcia, Jocelyne Leclerc, Marc Foretz, Fabrizio Andreelli. Clin Sci (Lond) 2012
948
7



Metabolic effects of metformin in non-insulin-dependent diabetes mellitus.
M Stumvoll, N Nurjhan, G Perriello, G Dailey, J E Gerich. N Engl J Med 1995
819
6

Metformin and reduced risk of cancer in diabetic patients.
Josie M M Evans, Louise A Donnelly, Alistair M Emslie-Smith, Dario R Alessi, Andrew D Morris. BMJ 2005
6

Metformin improves healthspan and lifespan in mice.
Alejandro Martin-Montalvo, Evi M Mercken, Sarah J Mitchell, Hector H Palacios, Patricia L Mote, Morten Scheibye-Knudsen, Ana P Gomes, Theresa M Ward, Robin K Minor, Marie-José Blouin,[...]. Nat Commun 2013
662
6

Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria.
Hannah R Bridges, Andrew J Y Jones, Michael N Pollak, Judy Hirst. Biochem J 2014
350
6

AMPK: a nutrient and energy sensor that maintains energy homeostasis.
D Grahame Hardie, Fiona A Ross, Simon A Hawley. Nat Rev Mol Cell Biol 2012
6

AMPK: guardian of metabolism and mitochondrial homeostasis.
Sébastien Herzig, Reuben J Shaw. Nat Rev Mol Cell Biol 2018
858
6

AMPK: Sensing Glucose as well as Cellular Energy Status.
Sheng-Cai Lin, D Grahame Hardie. Cell Metab 2018
320
6

AMPK: An Energy-Sensing Pathway with Multiple Inputs and Outputs.
D Grahame Hardie, Bethany E Schaffer, Anne Brunet. Trends Cell Biol 2016
419
6


Activation of AMP-activated protein kinase by metformin improves left ventricular function and survival in heart failure.
Susheel Gundewar, John W Calvert, Saurabh Jha, Iris Toedt-Pingel, Sang Yong Ji, Denise Nunez, Arun Ramachandran, Mauricio Anaya-Cisneros, Rong Tian, David J Lefer. Circ Res 2009
284
5


Use of cells expressing gamma subunit variants to identify diverse mechanisms of AMPK activation.
Simon A Hawley, Fiona A Ross, Cyrille Chevtzoff, Kevin A Green, Ashleigh Evans, Sarah Fogarty, Mhairi C Towler, Laura J Brown, Oluseye A Ogunbayo, A Mark Evans,[...]. Cell Metab 2010
515
5

The ROS production induced by a reverse-electron flux at respiratory-chain complex 1 is hampered by metformin.
Cécile Batandier, Bruno Guigas, Dominique Detaille, M-Yehia El-Mir, Eric Fontaine, M Rigoulet, Xavier M Leverve. J Bioenerg Biomembr 2006
181
5


Metformin.
C J Bailey, R C Turner. N Engl J Med 1996
5


Metformin increases AMP-activated protein kinase activity in skeletal muscle of subjects with type 2 diabetes.
Nicolas Musi, Michael F Hirshman, Jonas Nygren, Monika Svanfeldt, Peter Bavenholm, Olav Rooyackers, Gaochao Zhou, Joanne M Williamson, Olle Ljunqvist, Suad Efendic,[...]. Diabetes 2002
558
5

Mechanism by which metformin reduces glucose production in type 2 diabetes.
R S Hundal, M Krssak, S Dufour, D Laurent, V Lebon, V Chandramouli, S E Inzucchi, W C Schumann, K F Petersen, B R Landau,[...]. Diabetes 2000
682
5

Understanding the glucoregulatory mechanisms of metformin in type 2 diabetes mellitus.
Marc Foretz, Bruno Guigas, Benoit Viollet. Nat Rev Endocrinol 2019
126
5

Metformin Inhibits Hepatic mTORC1 Signaling via Dose-Dependent Mechanisms Involving AMPK and the TSC Complex.
Jessica J Howell, Kristina Hellberg, Marc Turner, George Talbott, Matthew J Kolar, Debbie S Ross, Gerta Hoxhaj, Alan Saghatelian, Reuben J Shaw, Brendan D Manning. Cell Metab 2017
162
5


Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy.
Vlado Perkovic, Meg J Jardine, Bruce Neal, Severine Bompoint, Hiddo J L Heerspink, David M Charytan, Robert Edwards, Rajiv Agarwal, George Bakris, Scott Bull,[...]. N Engl J Med 2019
5

Liraglutide and Cardiovascular Outcomes in Type 2 Diabetes.
Steven P Marso, Gilbert H Daniels, Kirstine Brown-Frandsen, Peter Kristensen, Johannes F E Mann, Michael A Nauck, Steven E Nissen, Stuart Pocock, Neil R Poulter, Lasse S Ravn,[...]. N Engl J Med 2016
5

AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice.
Yu Li, Shanqin Xu, Maria M Mihaylova, Bin Zheng, Xiuyun Hou, Bingbing Jiang, Ogyi Park, Zhijun Luo, Etienne Lefai, John Y-J Shyy,[...]. Cell Metab 2011
902
5


Dapagliflozin in Patients with Heart Failure and Reduced Ejection Fraction.
John J V McMurray, Scott D Solomon, Silvio E Inzucchi, Lars Køber, Mikhail N Kosiborod, Felipe A Martinez, Piotr Ponikowski, Marc S Sabatine, Inder S Anand, Jan Bělohlávek,[...]. N Engl J Med 2019
4

Efficacy and metabolic effects of metformin and troglitazone in type II diabetes mellitus.
S E Inzucchi, D G Maggs, G R Spollett, S L Page, F S Rife, V Walton, G I Shulman. N Engl J Med 1998
603
4

Metformin activates a duodenal Ampk-dependent pathway to lower hepatic glucose production in rats.
Frank A Duca, Clémence D Côté, Brittany A Rasmussen, Melika Zadeh-Tahmasebi, Guy A Rutter, Beatrice M Filippi, Tony K T Lam. Nat Med 2015
215
4

Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin.
William C Knowler, Elizabeth Barrett-Connor, Sarah E Fowler, Richard F Hamman, John M Lachin, Elizabeth A Walker, David M Nathan. N Engl J Med 2002
4

The ancient drug salicylate directly activates AMP-activated protein kinase.
Simon A Hawley, Morgan D Fullerton, Fiona A Ross, Jonathan D Schertzer, Cyrille Chevtzoff, Katherine J Walker, Mark W Peggie, Darya Zibrova, Kevin A Green, Kirsty J Mustard,[...]. Science 2012
474
4

AMP-activated protein kinase: the current landscape for drug development.
Gregory R Steinberg, David Carling. Nat Rev Drug Discov 2019
141
4

Metformin--mode of action and clinical implications for diabetes and cancer.
Ida Pernicova, Márta Korbonits. Nat Rev Endocrinol 2014
596
4

Role of Mitochondria in the Mechanism(s) of Action of Metformin.
Guillaume Vial, Dominique Detaille, Bruno Guigas. Front Endocrinol (Lausanne) 2019
72
5

Metformin and insulin suppress hepatic gluconeogenesis through phosphorylation of CREB binding protein.
Ling He, Amin Sabet, Stephen Djedjos, Ryan Miller, Xiaojian Sun, Mehboob A Hussain, Sally Radovick, Fredric E Wondisford. Cell 2009
302
4


AMPK activators: mechanisms of action and physiological activities.
Joungmok Kim, Goowon Yang, Yeji Kim, Jin Kim, Joohun Ha. Exp Mol Med 2016
268
4

Treatment of nonalcoholic fatty liver disease: role of AMPK.
Brennan K Smith, Katarina Marcinko, Eric M Desjardins, James S Lally, Rebecca J Ford, Gregory R Steinberg. Am J Physiol Endocrinol Metab 2016
188
4


Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.