A citation-based method for searching scientific literature

L Alexopoulou, A C Holt, R Medzhitov, R A Flavell. Nature 2001
Times Cited: 4295







List of co-cited articles
613 articles co-cited >1



Times Cited
  Times     Co-cited
Similarity



Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8.
Florian Heil, Hiroaki Hemmi, Hubertus Hochrein, Franziska Ampenberger, Carsten Kirschning, Shizuo Akira, Grayson Lipford, Hermann Wagner, Stefan Bauer. Science 2004
22

Pathogen recognition and innate immunity.
Shizuo Akira, Satoshi Uematsu, Osamu Takeuchi. Cell 2006
17

A Toll-like receptor recognizes bacterial DNA.
H Hemmi, O Takeuchi, T Kawai, T Kaisho, S Sato, H Sanjo, M Matsumoto, K Hoshino, H Wagner, K Takeda,[...]. Nature 2000
15

Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA.
Sandra S Diebold, Tsuneyasu Kaisho, Hiroaki Hemmi, Shizuo Akira, Caetano Reis e Sousa. Science 2004
14

The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses.
Mitsutoshi Yoneyama, Mika Kikuchi, Takashi Natsukawa, Noriaki Shinobu, Tadaatsu Imaizumi, Makoto Miyagishi, Kazunari Taira, Shizuo Akira, Takashi Fujita. Nat Immunol 2004
13

Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses.
Hiroki Kato, Osamu Takeuchi, Shintaro Sato, Mitsutoshi Yoneyama, Masahiro Yamamoto, Kosuke Matsui, Satoshi Uematsu, Andreas Jung, Taro Kawai, Ken J Ishii,[...]. Nature 2006
11

Toll-like receptor signalling.
Shizuo Akira, Kiyoshi Takeda. Nat Rev Immunol 2004
11

Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene.
A Poltorak, X He, I Smirnova, M Y Liu, C Van Huffel, X Du, D Birdwell, E Alejos, M Silva, C Galanos,[...]. Science 1998
9


Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway.
Masahiro Yamamoto, Shintaro Sato, Hiroaki Hemmi, Katsuaki Hoshino, Tsuneyasu Kaisho, Hideki Sanjo, Osamu Takeuchi, Masanaka Sugiyama, Masaru Okabe, Kiyoshi Takeda,[...]. Science 2003
9


mRNA is an endogenous ligand for Toll-like receptor 3.
Katalin Karikó, Houping Ni, John Capodici, Marc Lamphier, Drew Weissman. J Biol Chem 2004
709
8

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China.
Chaolin Huang, Yeming Wang, Xingwang Li, Lili Ren, Jianping Zhao, Yi Hu, Li Zhang, Guohui Fan, Jiuyang Xu, Xiaoying Gu,[...]. Lancet 2020
8

Pattern recognition receptors and inflammation.
Osamu Takeuchi, Shizuo Akira. Cell 2010
8

Toll-like Receptors and the Control of Immunity.
Katherine A Fitzgerald, Jonathan C Kagan. Cell 2020
181
8

Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway.
Hiroaki Hemmi, Tsuneyasu Kaisho, Osamu Takeuchi, Shintaro Sato, Hideki Sanjo, Katsuaki Hoshino, Takao Horiuchi, Hideyuki Tomizawa, Kiyoshi Takeda, Shizuo Akira. Nat Immunol 2002
8

Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway.
Lijun Sun, Jiaxi Wu, Fenghe Du, Xiang Chen, Zhijian J Chen. Science 2013
7

5'-Triphosphate RNA is the ligand for RIG-I.
Veit Hornung, Jana Ellegast, Sarah Kim, Krzysztof Brzózka, Andreas Jung, Hiroki Kato, Hendrik Poeck, Shizuo Akira, Karl-Klaus Conzelmann, Martin Schlee,[...]. Science 2006
7

Toll-like receptor signaling pathways.
Takumi Kawasaki, Taro Kawai. Front Immunol 2014
7

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor.
Markus Hoffmann, Hannah Kleine-Weber, Simon Schroeder, Nadine Krüger, Tanja Herrler, Sandra Erichsen, Tobias S Schiergens, Georg Herrler, Nai-Huei Wu, Andreas Nitsche,[...]. Cell 2020
7

Interferon-stimulated genes: a complex web of host defenses.
William M Schneider, Meike Dittmann Chevillotte, Charles M Rice. Annu Rev Immunol 2014
7

Maternal immune activation alters fetal brain development through interleukin-6.
Stephen E P Smith, Jennifer Li, Krassimira Garbett, Karoly Mirnics, Paul H Patterson. J Neurosci 2007
888
7

Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6.
Taro Kawai, Shintaro Sato, Ken J Ishii, Cevayir Coban, Hiroaki Hemmi, Masahiro Yamamoto, Kenta Terai, Michiyuki Matsuda, Jun-ichiro Inoue, Satoshi Uematsu,[...]. Nat Immunol 2004
702
7

The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5.
F Hayashi, K D Smith, A Ozinsky, T R Hawn, E C Yi, D R Goodlett, J K Eng, S Akira, D M Underhill, A Aderem. Nature 2001
6

Structural basis of toll-like receptor 3 signaling with double-stranded RNA.
Lin Liu, Istvan Botos, Yan Wang, Joshua N Leonard, Joseph Shiloach, David M Segal, David R Davies. Science 2008
486
6


AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC.
Veit Hornung, Andrea Ablasser, Marie Charrel-Dennis, Franz Bauernfeind, Gabor Horvath, Daniel R Caffrey, Eicke Latz, Katherine A Fitzgerald. Nature 2009
5

Regulation of type I interferon responses.
Lionel B Ivashkiv, Laura T Donlin. Nat Rev Immunol 2014
5

The structural biology of Toll-like receptors.
Istvan Botos, David M Segal, David R Davies. Structure 2011
347
5


Innate immune recognition.
Charles A Janeway, Ruslan Medzhitov. Annu Rev Immunol 2002
5


Assembly and localization of Toll-like receptor signalling complexes.
Nicholas J Gay, Martyn F Symmons, Monique Gangloff, Clare E Bryant. Nat Rev Immunol 2014
401
5


mRNA-based therapeutics--developing a new class of drugs.
Ugur Sahin, Katalin Karikó, Özlem Türeci. Nat Rev Drug Discov 2014
586
5

LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF.
Katherine A Fitzgerald, Daniel C Rowe, Betsy J Barnes, Daniel R Caffrey, Alberto Visintin, Eicke Latz, Brian Monks, Paula M Pitha, Douglas T Golenbock. J Exp Med 2003
833
5

Clinical Characteristics of Coronavirus Disease 2019 in China.
Wei-Jie Guan, Zheng-Yi Ni, Yu Hu, Wen-Hua Liang, Chun-Quan Ou, Jian-Xing He, Lei Liu, Hong Shan, Chun-Liang Lei, David S C Hui,[...]. N Engl J Med 2020
5

Toll-Like Receptor 3 Signaling via TRIF Contributes to a Protective Innate Immune Response to Severe Acute Respiratory Syndrome Coronavirus Infection.
Allison L Totura, Alan Whitmore, Sudhakar Agnihothram, Alexandra Schäfer, Michael G Katze, Mark T Heise, Ralph S Baric. mBio 2015
220
5

Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5.
Hiroki Kato, Osamu Takeuchi, Eriko Mikamo-Satoh, Reiko Hirai, Tomoji Kawai, Kazufumi Matsushita, Akane Hiiragi, Terence S Dermody, Takashi Fujita, Shizuo Akira. J Exp Med 2008
995
5


Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA.
Jiaxi Wu, Lijun Sun, Xiang Chen, Fenghe Du, Heping Shi, Chuo Chen, Zhijian J Chen. Science 2013
990
5

Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation.
Siqi Liu, Xin Cai, Jiaxi Wu, Qian Cong, Xiang Chen, Tuo Li, Fenghe Du, Junyao Ren, You-Tong Wu, Nick V Grishin,[...]. Science 2015
631
5

IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction.
Taro Kawai, Ken Takahashi, Shintaro Sato, Cevayir Coban, Himanshu Kumar, Hiroki Kato, Ken J Ishii, Osamu Takeuchi, Shizuo Akira. Nat Immunol 2005
5

Innate immune pattern recognition: a cell biological perspective.
Sky W Brubaker, Kevin S Bonham, Ivan Zanoni, Jonathan C Kagan. Annu Rev Immunol 2015
644
5

TLR3 is an endogenous sensor of tissue necrosis during acute inflammatory events.
Karen A Cavassani, Makoto Ishii, Haitao Wen, Matthew A Schaller, Pamela M Lincoln, Nicholas W Lukacs, Cory M Hogaboam, Steven L Kunkel. J Exp Med 2008
328
4

Toll-like Receptor 9 Contains Two DNA Binding Sites that Function Cooperatively to Promote Receptor Dimerization and Activation.
Umeharu Ohto, Hanako Ishida, Takuma Shibata, Ryota Sato, Kensuke Miyake, Toshiyuki Shimizu. Immunity 2018
45
8

TLR8 Is a Sensor of RNase T2 Degradation Products.
Wilhelm Greulich, Mirko Wagner, Moritz M Gaidt, Che Stafford, Yiming Cheng, Andreas Linder, Thomas Carell, Veit Hornung. Cell 2019
29
13

RIG-I and Other RNA Sensors in Antiviral Immunity.
Kwan T Chow, Michael Gale, Yueh-Ming Loo. Annu Rev Immunol 2018
169
4

cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING.
Andrea Ablasser, Marion Goldeck, Taner Cavlar, Tobias Deimling, Gregor Witte, Ingo Röhl, Karl-Peter Hopfner, Janos Ludwig, Veit Hornung. Nature 2013
676
4


Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.