A citation-based method for searching scientific literature

X Zhu, C A Rottkamp, A Hartzler, Z Sun, A Takeda, H Boux, S Shimohama, G Perry, M A Smith. J Neurochem 2001
Times Cited: 116







List of co-cited articles
971 articles co-cited >1



Times Cited
  Times     Co-cited
Similarity


p38 kinase is activated in the Alzheimer's disease brain.
K Hensley, R A Floyd, N Y Zheng, R Nael, K A Robinson, X Nguyen, Q N Pye, C A Stewart, J Geddes, W R Markesbery,[...]. J Neurochem 1999
281
39

Activation of p38 kinase links tau phosphorylation, oxidative stress, and cell cycle-related events in Alzheimer disease.
X Zhu, C A Rottkamp, H Boux, A Takeda, G Perry, M A Smith. J Neuropathol Exp Neurol 2000
266
35

Localization of active forms of C-jun kinase (JNK) and p38 kinase in Alzheimer's disease brains at different stages of neurofibrillary degeneration.
Jin-Jing Pei, Eva Braak, Heiko Braak, Inge Grundke-Iqbal, Khalid Iqbal, Bengt Winblad, Richard F. Cowburn. J Alzheimers Dis 2001
118
28

P38 MAP kinase is activated at early stages in Alzheimer's disease brain.
Anyang Sun, Mei Liu, Xuan V Nguyen, Guoying Bing. Exp Neurol 2003
150
24


Differential activation of neuronal ERK, JNK/SAPK and p38 in Alzheimer disease: the 'two hit' hypothesis.
X Zhu, R J Castellani, A Takeda, A Nunomura, C S Atwood, G Perry, M A Smith. Mech Ageing Dev 2001
252
21

Activation of c-Jun N-terminal kinase and p38 in an Alzheimer's disease model is associated with amyloid deposition.
Mary J Savage, Yin-Guo Lin, John R Ciallella, Dorothy G Flood, Richard W Scott. J Neurosci 2002
219
20

Phosphorylation of microtubule-associated protein tau by stress-activated protein kinases.
M Goedert, M Hasegawa, R Jakes, S Lawler, A Cuenda, P Cohen. FEBS Lett 1997
241
15


Reactivating kinase/p38 phosphorylates tau protein in vitro.
C H Reynolds, A R Nebreda, G M Gibb, M A Utton, B H Anderton. J Neurochem 1997
127
15

Oxidative damage is the earliest event in Alzheimer disease.
A Nunomura, G Perry, G Aliev, K Hirai, A Takeda, E K Balraj, P K Jones, H Ghanbari, T Wataya, S Shimohama,[...]. J Neuropathol Exp Neurol 2001
14

A novel p38 alpha MAPK inhibitor suppresses brain proinflammatory cytokine up-regulation and attenuates synaptic dysfunction and behavioral deficits in an Alzheimer's disease mouse model.
Lenka Munoz, Hantamalala Ralay Ranaivo, Saktimayee M Roy, Wenhui Hu, Jeffrey M Craft, Laurie K McNamara, Laura Wing Chico, Linda J Van Eldik, D Martin Watterson. J Neuroinflammation 2007
171
14

RNA oxidation is a prominent feature of vulnerable neurons in Alzheimer's disease.
A Nunomura, G Perry, M A Pappolla, R Wade, K Hirai, S Chiba, M A Smith. J Neurosci 1999
543
13

Activation of neuronal extracellular receptor kinase (ERK) in Alzheimer disease links oxidative stress to abnormal phosphorylation.
G Perry, H Roder, A Nunomura, A Takeda, A L Friedlich, X Zhu, A K Raina, N Holbrook, S L Siedlak, P L Harris,[...]. Neuroreport 1999
242
13

Widespread peroxynitrite-mediated damage in Alzheimer's disease.
M A Smith, P L Richey Harris, L M Sayre, J S Beckman, G Perry. J Neurosci 1997
988
13

Beta-amyloid-induced inflammation and cholinergic hypofunction in the rat brain in vivo: involvement of the p38MAPK pathway.
Maria Grazia Giovannini, Carla Scali, Costanza Prosperi, Arianna Bellucci, Maria Giuliana Vannucchi, Susanna Rosi, Giancarlo Pepeu, Fiorella Casamenti. Neurobiol Dis 2002
168
13

Importance of MAPK pathways for microglial pro-inflammatory cytokine IL-1 beta production.
Seon H Kim, Carolyn J Smith, Linda J Van Eldik. Neurobiol Aging 2004
179
13

JKK1, an upstream activator of JNK/SAPK, is activated in Alzheimer's disease.
Xiongwei Zhu, Osamu Ogawa, Yang Wang, George Perry, Mark A Smith. J Neurochem 2003
54
22


In Alzheimer's disease, heme oxygenase is coincident with Alz50, an epitope of tau induced by 4-hydroxy-2-nonenal modification.
A Takeda, M A Smith, J Avilá, A Nunomura, S L Siedlak, X Zhu, G Perry, L M Sayre. J Neurochem 2000
161
12

Activation of the JNK/p38 pathway occurs in diseases characterized by tau protein pathology and is related to tau phosphorylation but not to apoptosis.
C Atzori, B Ghetti, R Piva, A N Srinivasan, P Zolo, M B Delisle, S S Mirra, A Migheli. J Neuropathol Exp Neurol 2001
133
12

Beta-amyloid induces neuronal apoptosis via a mechanism that involves the c-Jun N-terminal kinase pathway and the induction of Fas ligand.
Y Morishima, Y Gotoh, J Zieg, T Barrett, H Takano, R Flavell, R J Davis, Y Shirasaki, M E Greenberg. J Neurosci 2001
385
12

Amyloid-beta deposition in Alzheimer transgenic mice is associated with oxidative stress.
M A Smith, K Hirai, K Hsiao, M A Pappolla, P L Harris, S L Siedlak, M Tabaton, G Perry. J Neurochem 1998
454
11

4-Hydroxynonenal-derived advanced lipid peroxidation end products are increased in Alzheimer's disease.
L M Sayre, D A Zelasko, P L Harris, G Perry, R G Salomon, M A Smith. J Neurochem 1997
795
11




Distribution, levels, and activation of MEK1 in Alzheimer's disease.
Xiongwei Zhu, Zheng Sun, Hyoung-gon Lee, Sandra L Siedlak, George Perry, Mark A Smith. J Neurochem 2003
51
19

Evidence that phosphorylation of the microtubule-associated protein Tau by SAPK4/p38delta at Thr50 promotes microtubule assembly.
Carmen Feijoo, David G Campbell, Ross Jakes, Michel Goedert, Ana Cuenda. J Cell Sci 2005
96
10

Neuronal oxidative stress precedes amyloid-beta deposition in Down syndrome.
A Nunomura, G Perry, M A Pappolla, R P Friedland, K Hirai, S Chiba, M A Smith. J Neuropathol Exp Neurol 2000
245
9

The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
Xiongwei Zhu, Hyoung-gon Lee, Arun K Raina, George Perry, Mark A Smith. Neurosignals 2002
281
9

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis.
J C Lee, J T Laydon, P C McDonnell, T F Gallagher, S Kumar, D Green, D McNulty, M J Blumenthal, J R Heys, S W Landvatter,[...]. Nature 1994
9

beta-Amyloid-induced neuronal apoptosis requires c-Jun N-terminal kinase activation.
C M Troy, S A Rabacchi, Z Xu, A C Maroney, T J Connors, M L Shelanski, L A Greene. J Neurochem 2001
207
9

Neurotoxicity induces cleavage of p35 to p25 by calpain.
M S Lee, Y T Kwon, M Li, J Peng, R M Friedlander, L H Tsai. Nature 2000
848
9

Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration.
G N Patrick, L Zukerberg, M Nikolic, S de la Monte, P Dikkes, L H Tsai. Nature 1999
9

The p38 MAP kinase signaling pathway in Alzheimer's disease.
Gail V W Johnson, Craig D C Bailey. Exp Neurol 2003
72
12

Tau protein isoforms, phosphorylation and role in neurodegenerative disorders.
L Buée, T Bussière, V Buée-Scherrer, A Delacourte, P R Hof. Brain Res Brain Res Rev 2000
9

P38 activation mediates amyloid-beta cytotoxicity.
Xiongwei Zhu, Matthew Mei, Hyoung-Gon Lee, Yang Wang, Jiahuai Han, George Perry, Mark A Smith. Neurochem Res 2005
38
23

Cdk5 is a major regulator of p38 cascade: relevance to neurotoxicity in Alzheimer's disease.
Kuei-Hua Chang, Yolanda de Pablo, Hyun-pil Lee, Hyoung-gon Lee, Mark A Smith, Kavita Shah. J Neurochem 2010
56
16

Stress-activated protein kinase/c-jun N-terminal kinase phosphorylates tau protein.
C H Reynolds, M A Utton, G M Gibb, A Yates, B H Anderton. J Neurochem 1997
179
8


The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease.
S S Mirra, A Heyman, D McKeel, S M Sumi, B J Crain, L M Brownlee, F S Vogel, J P Hughes, G van Belle, L Berg. Neurology 1991
8

Alzheimer disease.
M A Smith. Int Rev Neurobiol 1998
194
8


Iron accumulation in Alzheimer disease is a source of redox-generated free radicals.
M A Smith, P L Harris, L M Sayre, G Perry. Proc Natl Acad Sci U S A 1997
979
8

Copper, iron and zinc in Alzheimer's disease senile plaques.
M A Lovell, J D Robertson, W J Teesdale, J L Campbell, W R Markesbery. J Neurol Sci 1998
8

Neurons may live for decades with neurofibrillary tangles.
R Morsch, W Simon, P D Coleman. J Neuropathol Exp Neurol 1999
282
8

MAPK-activated protein kinase 2 deficiency in microglia inhibits pro-inflammatory mediator release and resultant neurotoxicity. Relevance to neuroinflammation in a transgenic mouse model of Alzheimer disease.
Ainsley A Culbert, Stephen D Skaper, David R Howlett, Nicholas A Evans, Laura Facci, Peter E Soden, Zoe M Seymour, Florence Guillot, Matthias Gaestel, Jill C Richardson. J Biol Chem 2006
127
8


Targeting p38 MAPK pathway for the treatment of Alzheimer's disease.
Lenka Munoz, Alaina J Ammit. Neuropharmacology 2010
236
8


Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.