B N Atkinson, S C Bell, M De Vivo, L R Kowalski, S M Lechner, V I Ognyanov, C S Tham, C Tsai, J Jia, D Ashton, M A Klitenick. Mol Pharmacol 2001
Times Cited: 144
Times Cited: 144
Times Cited
Times Co-cited
Similarity
Localization of the GLYT1 glycine transporter at glutamatergic synapses in the rat brain.
Beatriz Cubelos, Cecilio Giménez, Francisco Zafra. Cereb Cortex 2005
Beatriz Cubelos, Cecilio Giménez, Francisco Zafra. Cereb Cortex 2005
47
Neurochemical, electrophysiological and pharmacological profiles of the selective inhibitor of the glycine transporter-1 SSR504734, a potential new type of antipsychotic.
Ronan Depoortère, Gihad Dargazanli, Genevieve Estenne-Bouhtou, Annick Coste, Christophe Lanneau, Christophe Desvignes, Martine Poncelet, Michel Heaulme, Vincent Santucci, Michel Decobert,[...]. Neuropsychopharmacology 2005
Ronan Depoortère, Gihad Dargazanli, Genevieve Estenne-Bouhtou, Annick Coste, Christophe Lanneau, Christophe Desvignes, Martine Poncelet, Michel Heaulme, Vincent Santucci, Michel Decobert,[...]. Neuropsychopharmacology 2005
41
Modulation of N-methyl-D-aspartate receptor function by glycine transport.
R Bergeron, T M Meyer, J T Coyle, R W Greene. Proc Natl Acad Sci U S A 1998
R Bergeron, T M Meyer, J T Coyle, R W Greene. Proc Natl Acad Sci U S A 1998
39
Glycine potentiates the NMDA response in cultured mouse brain neurons.
J W Johnson, P Ascher. Nature 1987
J W Johnson, P Ascher. Nature 1987
37
Glycine transporters are differentially expressed among CNS cells.
F Zafra, C Aragón, L Olivares, N C Danbolt, C Giménez, J Storm-Mathisen. J Neurosci 1995
F Zafra, C Aragón, L Olivares, N C Danbolt, C Giménez, J Storm-Mathisen. J Neurosci 1995
35
The glycine transporter type 1 inhibitor N-[3-(4'-fluorophenyl)-3-(4'-phenylphenoxy)propyl]sarcosine potentiates NMDA receptor-mediated responses in vivo and produces an antipsychotic profile in rodent behavior.
Gene G Kinney, Cyrille Sur, Maryann Burno, Pierre J Mallorga, Jacinta B Williams, David J Figueroa, Marion Wittmann, Wei Lemaire, P Jeffrey Conn. J Neurosci 2003
Gene G Kinney, Cyrille Sur, Maryann Burno, Pierre J Mallorga, Jacinta B Williams, David J Figueroa, Marion Wittmann, Wei Lemaire, P Jeffrey Conn. J Neurosci 2003
35
Glycine transporters: essential regulators of neurotransmission.
Volker Eulenburg, Wencke Armsen, Heinrich Betz, Jesús Gomeza. Trends Biochem Sci 2005
Volker Eulenburg, Wencke Armsen, Heinrich Betz, Jesús Gomeza. Trends Biochem Sci 2005
34
N[3-(4'-fluorophenyl)-3-(4'-phenylphenoxy)propyl]sarcosine (NFPS) is a selective persistent inhibitor of glycine transport.
K R Aubrey, R J Vandenberg. Br J Pharmacol 2001
K R Aubrey, R J Vandenberg. Br J Pharmacol 2001
43
Regional distribution and developmental variation of the glycine transporters GLYT1 and GLYT2 in the rat CNS.
F Zafra, J Gomeza, L Olivares, C Aragón, C Giménez. Eur J Neurosci 1995
F Zafra, J Gomeza, L Olivares, C Aragón, C Giménez. Eur J Neurosci 1995
32
Glycine transporter I inhibitor, N-methylglycine (sarcosine), added to antipsychotics for the treatment of schizophrenia.
Guochuan Tsai, Hsien-Yuan Lane, Pinchen Yang, Mian-Yoon Chong, Nicholas Lange. Biol Psychiatry 2004
Guochuan Tsai, Hsien-Yuan Lane, Pinchen Yang, Mian-Yoon Chong, Nicholas Lange. Biol Psychiatry 2004
25
Inactivation of the glycine transporter 1 gene discloses vital role of glial glycine uptake in glycinergic inhibition.
Jesús Gomeza, Swen Hülsmann, Koji Ohno, Volker Eulenburg, Katalin Szöke, Diethelm Richter, Heinrich Betz. Neuron 2003
Jesús Gomeza, Swen Hülsmann, Koji Ohno, Volker Eulenburg, Katalin Szöke, Diethelm Richter, Heinrich Betz. Neuron 2003
25
Glycine transporter type-1 and its inhibitors.
L G Harsing, Z Juranyi, I Gacsalyi, P Tapolcsanyi, A Czompa, P Matyus. Curr Med Chem 2006
L G Harsing, Z Juranyi, I Gacsalyi, P Tapolcsanyi, A Czompa, P Matyus. Curr Med Chem 2006
46
The glycine transporter-1 inhibitors NFPS and Org 24461: a pharmacological study.
Laszlo G Harsing, Istvan Gacsalyi, Geza Szabo, Eva Schmidt, Nora Sziray, Claude Sebban, Brigitte Tesolin-Decros, Peter Matyus, Andras Egyed, Michael Spedding,[...]. Pharmacol Biochem Behav 2003
Laszlo G Harsing, Istvan Gacsalyi, Geza Szabo, Eva Schmidt, Nora Sziray, Claude Sebban, Brigitte Tesolin-Decros, Peter Matyus, Andras Egyed, Michael Spedding,[...]. Pharmacol Biochem Behav 2003
27
Glycine tranporter-1 blockade potentiates NMDA-mediated responses in rat prefrontal cortical neurons in vitro and in vivo.
Long Chen, Mark Muhlhauser, Charles R Yang. J Neurophysiol 2003
Long Chen, Mark Muhlhauser, Charles R Yang. J Neurophysiol 2003
23
Recent advances in the phencyclidine model of schizophrenia.
D C Javitt, S R Zukin. Am J Psychiatry 1991
D C Javitt, S R Zukin. Am J Psychiatry 1991
23
Neurochemical and behavioral profiling of the selective GlyT1 inhibitors ALX5407 and LY2365109 indicate a preferential action in caudal vs. cortical brain areas.
Kenneth W Perry, Julie F Falcone, Matthew J Fell, John W Ryder, Hong Yu, Patrick L Love, Jason Katner, Kimberly D Gordon, Mark R Wade, Teresa Man,[...]. Neuropharmacology 2008
Kenneth W Perry, Julie F Falcone, Matthew J Fell, John W Ryder, Hong Yu, Patrick L Love, Jason Katner, Kimberly D Gordon, Mark R Wade, Teresa Man,[...]. Neuropharmacology 2008
33
Cloning and expression of a glycine transporter reveal colocalization with NMDA receptors.
K E Smith, L A Borden, P R Hartig, T Branchek, R L Weinshank. Neuron 1992
K E Smith, L A Borden, P R Hartig, T Branchek, R L Weinshank. Neuron 1992
21
The first potent and selective inhibitors of the glycine transporter type 2.
W L Caulfield, I T Collie, R S Dickins, O Epemolu, R McGuire, D R Hill, G McVey, J R Morphy, Z Rankovic, H Sundaram. J Med Chem 2001
W L Caulfield, I T Collie, R S Dickins, O Epemolu, R McGuire, D R Hill, G McVey, J R Morphy, Z Rankovic, H Sundaram. J Med Chem 2001
28
Discovery and SAR of org 24598-a selective glycine uptake inhibitor.
A Brown, I Carlyle, J Clark, W Hamilton, S Gibson, G McGarry, S McEachen, D Rae, S Thorn, G Walker. Bioorg Med Chem Lett 2001
A Brown, I Carlyle, J Clark, W Hamilton, S Gibson, G McGarry, S McEachen, D Rae, S Thorn, G Walker. Bioorg Med Chem Lett 2001
25
Glycine and N-methyl-D-aspartate receptors: physiological significance and possible therapeutic applications.
W Danysz, C G Parsons. Pharmacol Rev 1998
W Danysz, C G Parsons. Pharmacol Rev 1998
20
Selective GlyT1 inhibitors: discovery of [4-(3-fluoro-5-trifluoromethylpyridin-2-yl)piperazin-1-yl][5-methanesulfonyl-2-((S)-2,2,2-trifluoro-1-methylethoxy)phenyl]methanone (RG1678), a promising novel medicine to treat schizophrenia.
Emmanuel Pinard, Alexander Alanine, Daniela Alberati, Markus Bender, Edilio Borroni, Patrick Bourdeaux, Virginie Brom, Serge Burner, Holger Fischer, Dominik Hainzl,[...]. J Med Chem 2010
Emmanuel Pinard, Alexander Alanine, Daniela Alberati, Markus Bender, Edilio Borroni, Patrick Bourdeaux, Virginie Brom, Serge Burner, Holger Fischer, Dominik Hainzl,[...]. J Med Chem 2010
21
Progress in the preparation and testing of glycine transporter type-1 (GlyT1) inhibitors.
Craig W Lindsley, Scott E Wolkenberg, Gene G Kinney. Curr Top Med Chem 2006
Craig W Lindsley, Scott E Wolkenberg, Gene G Kinney. Curr Top Med Chem 2006
54
Neuronal and glial glycine transporters have different stoichiometries.
M J Roux, S Supplisson. Neuron 2000
M J Roux, S Supplisson. Neuron 2000
18
Modulators of the glycine site on NMDA receptors, D-serine and ALX 5407, display similar beneficial effects to clozapine in mouse models of schizophrenia.
Tatiana Lipina, Viviane Labrie, Ina Weiner, John Roder. Psychopharmacology (Berl) 2005
Tatiana Lipina, Viviane Labrie, Ina Weiner, John Roder. Psychopharmacology (Berl) 2005
18
Pharmacological assessment of the role of the glycine transporter GlyT-1 in mediating high-affinity glycine uptake by rat cerebral cortex and cerebellum synaptosomes.
H J Herdon, F M Godfrey, A M Brown, S Coulton, J R Evans, W J Cairns. Neuropharmacology 2001
H J Herdon, F M Godfrey, A M Brown, S Coulton, J R Evans, W J Cairns. Neuropharmacology 2001
24
Cloning of the human glycine transporter type 1: molecular and pharmacological characterization of novel isoform variants and chromosomal localization of the gene in the human and mouse genomes.
K M Kim, S F Kingsmore, H Han, T L Yang-Feng, N Godinot, M F Seldin, M G Caron, B Giros. Mol Pharmacol 1994
K M Kim, S F Kingsmore, H Han, T L Yang-Feng, N Godinot, M F Seldin, M G Caron, B Giros. Mol Pharmacol 1994
17
Prepulse inhibition deficits of the startle reflex in neonatal ventral hippocampal-lesioned rats: reversal by glycine and a glycine transporter inhibitor.
Gwenaëlle Le Pen, James Kew, Daniela Alberati, Edilio Borroni, Marie Paule Heitz, Jean-Luc Moreau. Biol Psychiatry 2003
Gwenaëlle Le Pen, James Kew, Daniela Alberati, Edilio Borroni, Marie Paule Heitz, Jean-Luc Moreau. Biol Psychiatry 2003
18
Glycine transporter type 1 blockade changes NMDA receptor-mediated responses and LTP in hippocampal CA1 pyramidal cells by altering extracellular glycine levels.
Marzia Martina, Yelena Gorfinkel, Samantha Halman, John A Lowe, Pranav Periyalwar, Christopher J Schmidt, Richard Bergeron. J Physiol 2004
Marzia Martina, Yelena Gorfinkel, Samantha Halman, John A Lowe, Pranav Periyalwar, Christopher J Schmidt, Richard Bergeron. J Physiol 2004
17
Disruption of glycine transporter 1 restricted to forebrain neurons is associated with a procognitive and antipsychotic phenotypic profile.
Benjamin K Yee, Ela Balic, Philipp Singer, Cornelia Schwerdel, Thomas Grampp, Laetitia Gabernet, Irene Knuesel, Dietmar Benke, Joram Feldon, Hanns Mohler,[...]. J Neurosci 2006
Benjamin K Yee, Ela Balic, Philipp Singer, Cornelia Schwerdel, Thomas Grampp, Laetitia Gabernet, Irene Knuesel, Dietmar Benke, Joram Feldon, Hanns Mohler,[...]. J Neurosci 2006
17
Gene knockout of glycine transporter 1: characterization of the behavioral phenotype.
Guochuan Tsai, Rebecca J Ralph-Williams, Marzia Martina, Richard Bergeron, Joanne Berger-Sweeney, Kevin S Dunham, Zhichun Jiang, S Barak Caine, Joseph T Coyle. Proc Natl Acad Sci U S A 2004
Guochuan Tsai, Rebecca J Ralph-Williams, Marzia Martina, Richard Bergeron, Joanne Berger-Sweeney, Kevin S Dunham, Zhichun Jiang, S Barak Caine, Joseph T Coyle. Proc Natl Acad Sci U S A 2004
17
Characterization of SSR103800, a selective inhibitor of the glycine transporter-1 in models predictive of therapeutic activity in schizophrenia.
Denis Boulay, Philippe Pichat, Gihad Dargazanli, Genevieve Estenne-Bouhtou, Jean Paul Terranova, Nancy Rogacki, Jeanne Stemmelin, Annick Coste, Christophe Lanneau, Christophe Desvignes,[...]. Pharmacol Biochem Behav 2008
Denis Boulay, Philippe Pichat, Gihad Dargazanli, Genevieve Estenne-Bouhtou, Jean Paul Terranova, Nancy Rogacki, Jeanne Stemmelin, Annick Coste, Christophe Lanneau, Christophe Desvignes,[...]. Pharmacol Biochem Behav 2008
24
Inhibitors of GlyT1 affect glycine transport via discrete binding sites.
Mario Mezler, Wilfried Hornberger, Reinhold Mueller, Martin Schmidt, Willi Amberg, Wilfried Braje, Michael Ochse, Hans Schoemaker, Berthold Behl. Mol Pharmacol 2008
Mario Mezler, Wilfried Hornberger, Reinhold Mueller, Martin Schmidt, Willi Amberg, Wilfried Braje, Michael Ochse, Hans Schoemaker, Berthold Behl. Mol Pharmacol 2008
37
Sarcosine or D-serine add-on treatment for acute exacerbation of schizophrenia: a randomized, double-blind, placebo-controlled study.
Hsien-Yuan Lane, Yue-Cune Chang, Yi-Ching Liu, Chih-Chiang Chiu, Guochuan E Tsai. Arch Gen Psychiatry 2005
Hsien-Yuan Lane, Yue-Cune Chang, Yi-Ching Liu, Chih-Chiang Chiu, Guochuan E Tsai. Arch Gen Psychiatry 2005
16
Pharmacology and expression analysis of glycine transporter GlyT1 with [3H]-(N-[3-(4'-fluorophenyl)-3-(4'phenylphenoxy)propyl])sarcosine.
Pierre J Mallorga, Jacinta B Williams, Marlene Jacobson, Rosemary Marques, Ashok Chaudhary, P Jeffrey Conn, Douglas J Pettibone, Cyrille Sur. Neuropharmacology 2003
Pierre J Mallorga, Jacinta B Williams, Marlene Jacobson, Rosemary Marques, Ashok Chaudhary, P Jeffrey Conn, Douglas J Pettibone, Cyrille Sur. Neuropharmacology 2003
30
Two glycine transporter variants with distinct localization in the CNS and peripheral tissues are encoded by a common gene.
B Borowsky, E Mezey, B J Hoffman. Neuron 1993
B Borowsky, E Mezey, B J Hoffman. Neuron 1993
16
Glycine transporters: crucial roles of pharmacological interest revealed by gene deletion.
Carmen Aragón, Beatriz López-Corcuera. Trends Pharmacol Sci 2005
Carmen Aragón, Beatriz López-Corcuera. Trends Pharmacol Sci 2005
17
Deletion of the mouse glycine transporter 2 results in a hyperekplexia phenotype and postnatal lethality.
Jesús Gomeza, Koji Ohno, Swen Hülsmann, Wencke Armsen, Volker Eulenburg, Diethelm W Richter, Bodo Laube, Heinrich Betz. Neuron 2003
Jesús Gomeza, Koji Ohno, Swen Hülsmann, Wencke Armsen, Volker Eulenburg, Diethelm W Richter, Bodo Laube, Heinrich Betz. Neuron 2003
16
Efficacy of high-dose glycine in the treatment of enduring negative symptoms of schizophrenia.
U Heresco-Levy, D C Javitt, M Ermilov, C Mordel, G Silipo, M Lichtenstein. Arch Gen Psychiatry 1999
U Heresco-Levy, D C Javitt, M Ermilov, C Mordel, G Silipo, M Lichtenstein. Arch Gen Psychiatry 1999
15
Design, synthesis, and in vivo efficacy of glycine transporter-1 (GlyT1) inhibitors derived from a series of [4-phenyl-1-(propylsulfonyl)piperidin-4-yl]methyl benzamides.
Craig W Lindsley, Zhijian Zhao, William H Leister, Julie O'Brien, Wei Lemaire, David L Williams, Tsing-Bau Chen, Raymond S L Chang, Maryann Burno, Marlene A Jacobson,[...]. ChemMedChem 2006
Craig W Lindsley, Zhijian Zhao, William H Leister, Julie O'Brien, Wei Lemaire, David L Williams, Tsing-Bau Chen, Raymond S L Chang, Maryann Burno, Marlene A Jacobson,[...]. ChemMedChem 2006
44
14
The therapeutic potential of glycine transporter-1 inhibitors.
Cyrille Sur, Gene G Kinney. Expert Opin Investig Drugs 2004
Cyrille Sur, Gene G Kinney. Expert Opin Investig Drugs 2004
31
Glycine transporter 1 inhibitors and modulation of NMDA receptor-mediated excitatory neurotransmission.
Cyrille Sur, Gene G Kinney. Curr Drug Targets 2007
Cyrille Sur, Gene G Kinney. Curr Drug Targets 2007
30
Why glycine transporters have different stoichiometries.
Stéphane Supplisson, Michel J Roux. FEBS Lett 2002
Stéphane Supplisson, Michel J Roux. FEBS Lett 2002
15
Glycine transport inhibitors for the treatment of schizophrenia: symptom and disease modification.
Daniel C Javitt. Curr Opin Drug Discov Devel 2009
Daniel C Javitt. Curr Opin Drug Discov Devel 2009
15
Discovery of N-(2-hydroxy-2-aryl-cyclohexyl) substituted spiropiperidines as GlyT1 antagonists with improved pharmacological profile.
Simona M Ceccarelli, Emmanuel Pinard, Henri Stalder, Daniela Alberati. Bioorg Med Chem Lett 2006
Simona M Ceccarelli, Emmanuel Pinard, Henri Stalder, Daniela Alberati. Bioorg Med Chem Lett 2006
54
High-dose glycine added to olanzapine and risperidone for the treatment of schizophrenia.
Uriel Heresco-Levy, Marina Ermilov, Pesah Lichtenberg, Gali Bar, Daniel C Javitt. Biol Psychiatry 2004
Uriel Heresco-Levy, Marina Ermilov, Pesah Lichtenberg, Gali Bar, Daniel C Javitt. Biol Psychiatry 2004
13
Glutamate and schizophrenia: beyond the dopamine hypothesis.
Joseph T Coyle. Cell Mol Neurobiol 2006
Joseph T Coyle. Cell Mol Neurobiol 2006
13
Discovery of benzoylpiperazines as a novel class of potent and selective GlyT1 inhibitors.
Emmanuel Pinard, Daniela Alberati, Edilio Borroni, Holger Fischer, Dominik Hainzl, Synèse Jolidon, Jean-Luc Moreau, Robert Narquizian, Matthias Nettekoven, Roger D Norcross,[...]. Bioorg Med Chem Lett 2008
Emmanuel Pinard, Daniela Alberati, Edilio Borroni, Holger Fischer, Dominik Hainzl, Synèse Jolidon, Jean-Luc Moreau, Robert Narquizian, Matthias Nettekoven, Roger D Norcross,[...]. Bioorg Med Chem Lett 2008
56
Recent progress in the discovery of non-sarcosine based GlyT1 inhibitors.
Scott E Wolkenberg, Cyrille Sur. Curr Top Med Chem 2010
Scott E Wolkenberg, Cyrille Sur. Curr Top Med Chem 2010
44
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.