A citation-based method for searching scientific literature

P W Ingham, A P McMahon. Genes Dev 2001
Times Cited: 2259







List of co-cited articles
799 articles co-cited >1



Times Cited
  Times     Co-cited
Similarity


The mechanisms of Hedgehog signalling and its roles in development and disease.
James Briscoe, Pascal P Thérond. Nat Rev Mol Cell Biol 2013
26

Hedgehog: functions and mechanisms.
Markku Varjosalo, Jussi Taipale. Genes Dev 2008
856
15

Mutations affecting segment number and polarity in Drosophila.
C Nüsslein-Volhard, E Wieschaus. Nature 1980
12

Patched1 regulates hedgehog signaling at the primary cilium.
Rajat Rohatgi, Ljiljana Milenkovic, Matthew P Scott. Science 2007
989
11

Patched acts catalytically to suppress the activity of Smoothened.
J Taipale, M K Cooper, T Maiti, P A Beachy. Nature 2002
588
11

Developmental roles and clinical significance of hedgehog signaling.
Andrew P McMahon, Philip W Ingham, Clifford J Tabin. Curr Top Dev Biol 2003
677
11


Altered neural cell fates and medulloblastoma in mouse patched mutants.
L V Goodrich, L Milenković, K M Higgins, M P Scott. Science 1997
10

Cellular Cholesterol Directly Activates Smoothened in Hedgehog Signaling.
Pengxiang Huang, Daniel Nedelcu, Miyako Watanabe, Cindy Jao, Youngchang Kim, Jing Liu, Adrian Salic. Cell 2016
209
10

Small molecule modulation of Smoothened activity.
James K Chen, Jussi Taipale, Keith E Young, Tapan Maiti, Philip A Beachy. Proc Natl Acad Sci U S A 2002
763
9

Structures of human Patched and its complex with native palmitoylated sonic hedgehog.
Xiaofeng Qi, Philip Schmiege, Elias Coutavas, Jiawei Wang, Xiaochun Li. Nature 2018
112
9

Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function.
C Chiang, Y Litingtung, E Lee, K E Young, J L Corden, H Westphal, P A Beachy. Nature 1996
9

Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma.
Robert L Yauch, Gerrit J P Dijkgraaf, Bruno Alicke, Thomas Januario, Christina P Ahn, Thomas Holcomb, Kanan Pujara, Jeremy Stinson, Christopher A Callahan, Tracy Tang,[...]. Science 2009
637
9

The Hedgehog signal transduction network.
David J Robbins, Dennis Liang Fei, Natalia A Riobo. Sci Signal 2012
267
9

Overlapping roles and collective requirement for the coreceptors GAS1, CDO, and BOC in SHH pathway function.
Benjamin L Allen, Jane Y Song, Luisa Izzi, Irene W Althaus, Jong-Sun Kang, Frédéric Charron, Robert S Krauss, Andrew P McMahon. Dev Cell 2011
197
8

Structural basis for the recognition of Sonic Hedgehog by human Patched1.
Xin Gong, Hongwu Qian, Pingping Cao, Xin Zhao, Qiang Zhou, Jianlin Lei, Nieng Yan. Science 2018
122
8


Sonic Hedgehog dependent phosphorylation by CK1α and GRK2 is required for ciliary accumulation and activation of smoothened.
Yongbin Chen, Noriaki Sasai, Guoqiang Ma, Tao Yue, Jianhang Jia, James Briscoe, Jin Jiang. PLoS Biol 2011
145
8

Hedgehog signalling in prostate regeneration, neoplasia and metastasis.
Sunil S Karhadkar, G Steven Bova, Nadia Abdallah, Surajit Dhara, Dale Gardner, Anirban Maitra, John T Isaacs, David M Berman, Philip A Beachy. Nature 2004
814
7

Induction of sonic hedgehog mediators by transforming growth factor-beta: Smad3-dependent activation of Gli2 and Gli1 expression in vitro and in vivo.
Sylviane Dennler, Jocelyne André, Ismini Alexaki, Allen Li, Thierry Magnaldo, Peter ten Dijke, Xiao-Jing Wang, Franck Verrecchia, Alain Mauviel. Cancer Res 2007
277
7

Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours.
David M Berman, Sunil S Karhadkar, Anirban Maitra, Rocio Montes De Oca, Meg R Gerstenblith, Kimberly Briggs, Antony R Parker, Yutaka Shimada, James R Eshleman, D Neil Watkins,[...]. Nature 2003
7

Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists.
Matthias Lauth, Asa Bergström, Takashi Shimokawa, Rune Toftgård. Proc Natl Acad Sci U S A 2007
583
7

Sertoli cell signaling by Desert hedgehog regulates the male germline.
M J Bitgood, L Shen, A P McMahon. Curr Biol 1996
472
7

Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity.
Y Echelard, D J Epstein, B St-Jacques, L Shen, J Mohler, J A McMahon, A P McMahon. Cell 1993
7

Biochemical mechanisms of vertebrate hedgehog signaling.
Jennifer H Kong, Christian Siebold, Rajat Rohatgi. Development 2019
102
7

The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog.
D M Stone, M Hynes, M Armanini, T A Swanson, Q Gu, R L Johnson, M P Scott, D Pennica, A Goddard, H Phillips,[...]. Nature 1996
904
7

Cholesterol activates the G-protein coupled receptor Smoothened to promote Hedgehog signaling.
Giovanni Luchetti, Ria Sircar, Jennifer H Kong, Sigrid Nachtergaele, Andreas Sagner, Eamon Fx Byrne, Douglas F Covey, Christian Siebold, Rajat Rohatgi. Elife 2016
141
7

Sonic hedgehog mediates the polarizing activity of the ZPA.
R D Riddle, R L Johnson, E Laufer, C Tabin. Cell 1993
7

The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins.
Eric W Humke, Karolin V Dorn, Ljiljana Milenkovic, Matthew P Scott, Rajat Rohatgi. Genes Dev 2010
314
7

Activating Smoothened mutations in sporadic basal-cell carcinoma.
J Xie, M Murone, S M Luoh, A Ryan, Q Gu, C Zhang, J M Bonifas, C W Lam, M Hynes, A Goddard,[...]. Nature 1998
7

Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome.
H Hahn, C Wicking, P G Zaphiropoulous, M R Gailani, S Shanley, A Chidambaram, I Vorechovsky, E Holmberg, A B Unden, S Gillies,[...]. Cell 1996
7

Smoothened variants explain the majority of drug resistance in basal cell carcinoma.
Scott X Atwood, Kavita Y Sarin, Ramon J Whitson, Jiang R Li, Geurim Kim, Melika Rezaee, Mina S Ally, Jinah Kim, Catherine Yao, Anne Lynn S Chang,[...]. Cancer Cell 2015
251
7

Hedgehog signalling in cancer formation and maintenance.
Marina Pasca di Magliano, Matthias Hebrok. Nat Rev Cancer 2003
646
7

The Gli code: an information nexus regulating cell fate, stemness and cancer.
Ariel Ruiz i Altaba, Christophe Mas, Barbara Stecca. Trends Cell Biol 2007
285
7

Hedgehog signaling in development and cancer.
Jin Jiang, Chi-Chung Hui. Dev Cell 2008
760
7

Roles for Hedgehog signaling in adult organ homeostasis and repair.
Ralitsa Petrova, Alexandra L Joyner. Development 2014
220
7

Vertebrate Smoothened functions at the primary cilium.
Kevin C Corbit, Pia Aanstad, Veena Singla, Andrew R Norman, Didier Y R Stainier, Jeremy F Reiter. Nature 2005
7


Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer.
D Neil Watkins, David M Berman, Scott G Burkholder, Baolin Wang, Philip A Beachy, Stephen B Baylin. Nature 2003
843
6

Melanomas require HEDGEHOG-GLI signaling regulated by interactions between GLI1 and the RAS-MEK/AKT pathways.
Barbara Stecca, Christophe Mas, Virginie Clement, Marie Zbinden, Rafael Correa, Vincent Piguet, Friedrich Beermann, Ariel Ruiz i Altaba. Proc Natl Acad Sci U S A 2007
389
6

GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation.
Olivier Nolan-Stevaux, Janet Lau, Morgan L Truitt, Gerald C Chu, Matthias Hebrok, Martin E Fernández-Zapico, Douglas Hanahan. Genes Dev 2009
303
6

The Hedgehog pathway promotes blood-brain barrier integrity and CNS immune quiescence.
Jorge Ivan Alvarez, Aurore Dodelet-Devillers, Hania Kebir, Igal Ifergan, Pierre J Fabre, Simone Terouz, Mike Sabbagh, Karolina Wosik, Lyne Bourbonnière, Monique Bernard,[...]. Science 2011
462
6


Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis.
Sarah P Thayer, Marina Pasca di Magliano, Patrick W Heiser, Corinne M Nielsen, Drucilla J Roberts, Gregory Y Lauwers, Yan Ping Qi, Stephan Gysin, Carlos Fernández-del Castillo, Vijay Yajnik,[...]. Nature 2003
6

Recent Advances in the Clinical Targeting of Hedgehog/GLI Signaling in Cancer.
Hao Xie, Brooke D Paradise, Wen Wee Ma, Martin E Fernandez-Zapico. Cells 2019
37
16

Structural Basis for Cholesterol Transport-like Activity of the Hedgehog Receptor Patched.
Yunxiao Zhang, David P Bulkley, Yao Xin, Kelsey J Roberts, Daniel E Asarnow, Ashutosh Sharma, Benjamin R Myers, Wonhwa Cho, Yifan Cheng, Philip A Beachy. Cell 2018
118
6

Targeting the Hedgehog pathway in cancer.
Lee L Rubin, Frederic J de Sauvage. Nat Rev Drug Discov 2006
600
6

Structural basis of Smoothened regulation by its extracellular domains.
Eamon F X Byrne, Ria Sircar, Paul S Miller, George Hedger, Giovanni Luchetti, Sigrid Nachtergaele, Mark D Tully, Laurel Mydock-McGrane, Douglas F Covey, Robert P Rambo,[...]. Nature 2016
214
6

Cholesterol accessibility at the ciliary membrane controls hedgehog signaling.
Maia Kinnebrew, Ellen J Iverson, Bhaven B Patel, Ganesh V Pusapati, Jennifer H Kong, Kristen A Johnson, Giovanni Luchetti, Kaitlyn M Eckert, Jeffrey G McDonald, Douglas F Covey,[...]. Elife 2019
55
10

The Hedgehog response network: sensors, switches, and routers.
Lawrence Lum, Philip A Beachy. Science 2004
627
6


Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.