A citation-based method for searching scientific literature

Y Makino, R Cao, K Svensson, G Bertilsson, M Asman, H Tanaka, Y Cao, A Berkenstam, L Poellinger. Nature 2001
Times Cited: 457







List of co-cited articles
1088 articles co-cited >1



Times Cited
  Times     Co-cited
Similarity


Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.
G L Wang, B H Jiang, E A Rue, G L Semenza. Proc Natl Acad Sci U S A 1995
43

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation.
P Jaakkola, D R Mole, Y M Tian, M I Wilson, J Gielbert, S J Gaskell, A von Kriegsheim, H F Hebestreit, M Mukherji, C J Schofield,[...]. Science 2001
29




The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis.
P H Maxwell, M S Wiesener, G W Chang, S C Clifford, E C Vaux, M E Cockman, C C Wykoff, C W Pugh, E R Maher, P J Ratcliffe. Nature 1999
24

Inhibitory PAS domain protein (IPAS) is a hypoxia-inducible splicing variant of the hypoxia-inducible factor-3alpha locus.
Yuichi Makino, Arvydas Kanopka, William J Wilson, Hirotoshi Tanaka, Lorenz Poellinger. J Biol Chem 2002
256
24

FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor.
David Lando, Daniel J Peet, Jeffrey J Gorman, Dean A Whelan, Murray L Whitelaw, Richard K Bruick. Genes Dev 2002
22

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing.
M Ivan, K Kondo, H Yang, W Kim, J Valiando, M Ohh, A Salic, J M Asara, W S Lane, W G Kaelin. Science 2001
20

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation.
A C Epstein, J M Gleadle, L A McNeill, K S Hewitson, J O'Rourke, D R Mole, M Mukherji, E Metzen, M I Wilson, A Dhanda,[...]. Cell 2001
20




Abnormal heart development and lung remodeling in mice lacking the hypoxia-inducible factor-related basic helix-loop-helix PAS protein NEPAS.
Toshiharu Yamashita, Osamu Ohneda, Masumi Nagano, Motoyuki Iemitsu, Yuichi Makino, Hirotoshi Tanaka, Takashi Miyauchi, Katsutoshi Goto, Kinuko Ohneda, Yoshiaki Fujii-Kuriyama,[...]. Mol Cell Biol 2008
79
21


Widespread hypoxia-inducible expression of HIF-2alpha in distinct cell populations of different organs.
Michael S Wiesener, Jan Steffen Jürgensen, Christian Rosenberger, Charlotte K Scholze, Jan H Hörstrup, Christina Warnecke, Stefano Mandriota, Ingo Bechmann, Ulrich A Frei, Christopher W Pugh,[...]. FASEB J 2003
476
16

Human HIF-3alpha4 is a dominant-negative regulator of HIF-1 and is down-regulated in renal cell carcinoma.
Mindy A Maynard, Andrew J Evans, Tomoko Hosomi, Shuntaro Hara, Michael A S Jewett, Michael Ohh. FASEB J 2005
124
16

High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq.
Johannes Schödel, Spyros Oikonomopoulos, Jiannis Ragoussis, Christopher W Pugh, Peter J Ratcliffe, David R Mole. Blood 2011
431
16


Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch.
David Lando, Daniel J Peet, Dean A Whelan, Jeffrey J Gorman, Murray L Whitelaw. Science 2002
14


Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation.
Cheng-Jun Hu, Li-Yi Wang, Lewis A Chodosh, Brian Keith, M Celeste Simon. Mol Cell Biol 2003
920
14




Recruitment of HIF-1alpha and HIF-2alpha to common target genes is differentially regulated in neuroblastoma: HIF-2alpha promotes an aggressive phenotype.
Linda Holmquist-Mengelbier, Erik Fredlund, Tobias Löfstedt, Rosa Noguera, Samuel Navarro, Helén Nilsson, Alexander Pietras, Johan Vallon-Christersson, Ake Borg, Katarina Gradin,[...]. Cancer Cell 2006
473
14

Roles of the human hypoxia-inducible factor (HIF)-3α variants in the hypoxia response.
Minna Heikkilä, Annika Pasanen, Kari I Kivirikko, Johanna Myllyharju. Cell Mol Life Sci 2011
118
13


Hypoxia-inducible nuclear factors bind to an enhancer element located 3' to the human erythropoietin gene.
G L Semenza, M K Nejfelt, S M Chi, S E Antonarakis. Proc Natl Acad Sci U S A 1991
621
12



HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression.
Brian Keith, Randall S Johnson, M Celeste Simon. Nat Rev Cancer 2011
11

Transcriptional up-regulation of inhibitory PAS domain protein gene expression by hypoxia-inducible factor 1 (HIF-1): a negative feedback regulatory circuit in HIF-1-mediated signaling in hypoxic cells.
Yuichi Makino, Rie Uenishi, Kensaku Okamoto, Tsubasa Isoe, Osamu Hosono, Hirotoshi Tanaka, Arvydas Kanopka, Lorenz Poellinger, Masakazu Haneda, Chikao Morimoto. J Biol Chem 2007
79
13

Multiple splice variants of the human HIF-3 alpha locus are targets of the von Hippel-Lindau E3 ubiquitin ligase complex.
Mindy A Maynard, Heng Qi, Jacky Chung, Eric H L Lee, Yukihiro Kondo, Shuntaro Hara, Ronald C Conaway, Joan W Conaway, Michael Ohh. J Biol Chem 2003
211
11

Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1.
B H Jiang, E Rue, G L Wang, R Roe, G L Semenza. J Biol Chem 1996
805
11

Genome-wide association of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha DNA binding with expression profiling of hypoxia-inducible transcripts.
David R Mole, Christine Blancher, Richard R Copley, Patrick J Pollard, Jonathan M Gleadle, Jiannis Ragoussis, Peter J Ratcliffe. J Biol Chem 2009
375
10

Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein.
M E Cockman, N Masson, D R Mole, P Jaakkola, G W Chang, S C Clifford, E R Maher, C W Pugh, P J Ratcliffe, P H Maxwell. J Biol Chem 2000
823
10

Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1.
J A Forsythe, B H Jiang, N V Iyer, F Agani, S W Leung, R D Koos, G L Semenza. Mol Cell Biol 1996
10

Hypoxia-inducible factor (HIF)-3alpha is subject to extensive alternative splicing in human tissues and cancer cells and is regulated by HIF-1 but not HIF-2.
Annika Pasanen, Minna Heikkilä, Kati Rautavuoma, Maija Hirsilä, Kari I Kivirikko, Johanna Myllyharju. Int J Biochem Cell Biol 2010
73
13



The human HIF (hypoxia-inducible factor)-3alpha gene is a HIF-1 target gene and may modulate hypoxic gene induction.
Tetsuhiro Tanaka, Michael Wiesener, Wanja Bernhardt, Kai-Uwe Eckardt, Christina Warnecke. Biochem J 2009
70
12

Integration of oxygen signaling at the consensus HRE.
Roland H Wenger, Daniel P Stiehl, Gieri Camenisch. Sci STKE 2005
624
9

Hypoxia-inducible factors and the response to hypoxic stress.
Amar J Majmundar, Waihay J Wong, M Celeste Simon. Mol Cell 2010
9

HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia.
Edurne Berra, Emmanuel Benizri, Amandine Ginouvès, Véronique Volmat, Danièle Roux, Jacques Pouysségur. EMBO J 2003
964
9

NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha.
Jordi Rius, Monica Guma, Christian Schachtrup, Katerina Akassoglou, Annelies S Zinkernagel, Victor Nizet, Randall S Johnson, Gabriel G Haddad, Michael Karin. Nature 2008
989
9




Oxygen sensing by HIF hydroxylases.
Christopher J Schofield, Peter J Ratcliffe. Nat Rev Mol Cell Biol 2004
9


Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.