Jan Karlseder, Agata Smogorzewska, Titia de Lange. Science 2002
Times Cited: 599
Times Cited: 599
Times Cited
Times Co-cited
Similarity
Shelterin: the protein complex that shapes and safeguards human telomeres.
Titia de Lange. Genes Dev 2005
Titia de Lange. Genes Dev 2005
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Telomeres shorten during ageing of human fibroblasts.
C B Harley, A B Futcher, C W Greider. Nature 1990
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A DNA damage checkpoint response in telomere-initiated senescence.
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DNA damage foci at dysfunctional telomeres.
Hiroyuki Takai, Agata Smogorzewska, Titia de Lange. Curr Biol 2003
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TRF2 protects human telomeres from end-to-end fusions.
B van Steensel, A Smogorzewska, T de Lange. Cell 1998
B van Steensel, A Smogorzewska, T de Lange. Cell 1998
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Mammalian telomeres end in a large duplex loop.
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Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation.
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Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1.
Eros Lazzerini Denchi, Titia de Lange. Nature 2007
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Super-resolution fluorescence imaging of telomeres reveals TRF2-dependent T-loop formation.
Ylli Doksani, John Y Wu, Titia de Lange, Xiaowei Zhuang. Cell 2013
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Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a).
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Control of human telomere length by TRF1 and TRF2.
A Smogorzewska, B van Steensel, A Bianchi, S Oelmann, M R Schaefer, G Schnapp, T de Lange. Mol Cell Biol 2000
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The telomere deprotection response is functionally distinct from the genomic DNA damage response.
Anthony J Cesare, Makoto T Hayashi, Laure Crabbe, Jan Karlseder. Mol Cell 2013
Anthony J Cesare, Makoto T Hayashi, Laure Crabbe, Jan Karlseder. Mol Cell 2013
13
Mammalian telomeres resemble fragile sites and require TRF1 for efficient replication.
Agnel Sfeir, Settapong T Kosiyatrakul, Dirk Hockemeyer, Sheila L MacRae, Jan Karlseder, Carl L Schildkraut, Titia de Lange. Cell 2009
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The hallmarks of aging.
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Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders.
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Five dysfunctional telomeres predict onset of senescence in human cells.
Zeenia Kaul, Anthony J Cesare, Lily I Huschtscha, Axel A Neumann, Roger R Reddel. EMBO Rep 2011
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Control of telomere length by the human telomeric protein TRF1.
B van Steensel, T de Lange. Nature 1997
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Identification of a specific telomere terminal transferase activity in Tetrahymena extracts.
C W Greider, E H Blackburn. Cell 1985
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Telomere length predicts replicative capacity of human fibroblasts.
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Telomere shortening and tumor formation by mouse cells lacking telomerase RNA.
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p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2.
J Karlseder, D Broccoli, Y Dai, S Hardy, T de Lange. Science 1999
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12
A biomarker that identifies senescent human cells in culture and in aging skin in vivo.
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The senescence-associated secretory phenotype: the dark side of tumor suppression.
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POT1 as a terminal transducer of TRF1 telomere length control.
Diego Loayza, Titia De Lange. Nature 2003
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Essential role of mouse telomerase in highly proliferative organs.
H W Lee, M A Blasco, G J Gottlieb, J W Horner, C W Greider, R A DePinho. Nature 1998
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Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2.
D Broccoli, A Smogorzewska, L Chong, T de Lange. Nat Genet 1997
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DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion.
Giulia B Celli, Titia de Lange. Nat Cell Biol 2005
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The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability.
M T Hemann, M A Strong, L Y Hao, C W Greider. Cell 2001
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Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan.
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A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes.
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Alternative lengthening of telomeres: models, mechanisms and implications.
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Removal of shelterin reveals the telomere end-protection problem.
Agnel Sfeir, Titia de Lange. Science 2012
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The RNA component of human telomerase.
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T-loop assembly in vitro involves binding of TRF2 near the 3' telomeric overhang.
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Cell death during crisis is mediated by mitotic telomere deprotection.
Makoto T Hayashi, Anthony J Cesare, Teresa Rivera, Jan Karlseder. Nature 2015
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Spontaneous occurrence of telomeric DNA damage response in the absence of chromosome fusions.
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Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence.
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Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor.
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Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a.
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The telomere terminal transferase of Tetrahymena is a ribonucleoprotein enzyme with two kinds of primer specificity.
C W Greider, E H Blackburn. Cell 1987
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Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice.
Mariela Jaskelioff, Florian L Muller, Ji-Hye Paik, Emily Thomas, Shan Jiang, Andrew C Adams, Ergun Sahin, Maria Kost-Alimova, Alexei Protopopov, Juan Cadiñanos,[...]. Nature 2011
Mariela Jaskelioff, Florian L Muller, Ji-Hye Paik, Emily Thomas, Shan Jiang, Andrew C Adams, Ergun Sahin, Maria Kost-Alimova, Alexei Protopopov, Juan Cadiñanos,[...]. Nature 2011
9
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