A citation-based method for searching scientific literature

Jing Li, Ying Yang, Yue Peng, Richard J Austin, Winfried G van Eyndhoven, Ken C Q Nguyen, Tim Gabriele, Mila E McCurrach, Jeffrey R Marks, Timothy Hoey, Scott W Lowe, Scott Powers. Nat Genet 2002
Times Cited: 195







List of co-cited articles
551 articles co-cited >1



Times Cited
  Times     Co-cited
Similarity


Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity.
Dmitry V Bulavin, Oleg N Demidov, Shin'ichi Saito, Paivikki Kauraniemi, Crissy Phillips, Sally A Amundson, Concetta Ambrosino, Guido Sauter, Angel R Nebreda, Carl W Anderson,[...]. Nat Genet 2002
327
67

PPM1D is a potential target for 17q gain in neuroblastoma.
Fumiko Saito-Ohara, Issei Imoto, Jun Inoue, Hajime Hosoi, Akira Nakagawara, Tohru Sugimoto, Johji Inazawa. Cancer Res 2003
193
53

Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner.
M Fiscella, H Zhang, S Fan, K Sakaguchi, S Shen, W E Mercer, G F Vande Woude, P M O'Connor, E Appella. Proc Natl Acad Sci U S A 1997
408
52

Medulloblastomas overexpress the p53-inactivating oncogene WIP1/PPM1D.
Robert C Castellino, Massimiliano De Bortoli, Xiongbin Lu, Sung-Hwan Moon, Thuy-Ai Nguyen, Mark A Shepard, Pulivarthi H Rao, Lawrence A Donehower, John Y H Kim. J Neurooncol 2008
100
41

PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints.
Xiongbin Lu, Bonnie Nannenga, Lawrence A Donehower. Genes Dev 2005
286
39

The type 2C phosphatase Wip1: an oncogenic regulator of tumor suppressor and DNA damage response pathways.
Xiongbin Lu, Thuy-Ai Nguyen, Sung-Hwan Moon, Yolanda Darlington, Matthias Sommer, Lawrence A Donehower. Cancer Metastasis Rev 2008
173
38

Inactivation of the Wip1 phosphatase inhibits mammary tumorigenesis through p38 MAPK-mediated activation of the p16(Ink4a)-p19(Arf) pathway.
Dmitry V Bulavin, Crissy Phillips, Bonnie Nannenga, Oleg Timofeev, Larry A Donehower, Carl W Anderson, Ettore Appella, Albert J Fornace. Nat Genet 2004
332
37

p53-inducible wip1 phosphatase mediates a negative feedback regulation of p38 MAPK-p53 signaling in response to UV radiation.
M Takekawa, M Adachi, A Nakahata, I Nakayama, F Itoh, H Tsukuda, Y Taya, K Imai. EMBO J 2000
324
36

Wip1 phosphatase modulates ATM-dependent signaling pathways.
Sathyavageeswaran Shreeram, Oleg N Demidov, Weng Kee Hee, Hiroshi Yamaguchi, Nobuyuki Onishi, Calvina Kek, Oleg N Timofeev, Crissy Dudgeon, Albert J Fornace, Carl W Anderson,[...]. Mol Cell 2006
247
36

Association of 17q21-q24 gain in ovarian clear cell adenocarcinomas with poor prognosis and identification of PPM1D and APPBP2 as likely amplification targets.
Akira Hirasawa, Fumiko Saito-Ohara, Jun Inoue, Daisuke Aoki, Nobuyuki Susumu, Tetsuji Yokoyama, Shiro Nozawa, Johji Inazawa, Issei Imoto. Clin Cancer Res 2003
146
36

PPM1D is a potential therapeutic target in ovarian clear cell carcinomas.
David S P Tan, Maryou B K Lambros, Sydonia Rayter, Rachael Natrajan, Radost Vatcheva, Qiong Gao, Caterina Marchiò, Felipe C Geyer, Kay Savage, Suzanne Parry,[...]. Clin Cancer Res 2009
122
33

The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop.
Xiongbin Lu, Ou Ma, Thuy-Ai Nguyen, Stephen N Jones, Moshe Oren, Lawrence A Donehower. Cancer Cell 2007
191
29

The serine-threonine protein phosphatase PPM1D is frequently activated through amplification in aggressive primary breast tumours.
Jenita Rauta, Emma-Leena Alarmo, Päivikki Kauraniemi, Ritva Karhu, Tuula Kuukasjärvi, Anne Kallioniemi. Breast Cancer Res Treat 2006
76
38

Regulation of the antioncogenic Chk2 kinase by the oncogenic Wip1 phosphatase.
H Fujimoto, N Onishi, N Kato, M Takekawa, X Z Xu, A Kosugi, T Kondo, M Imamura, I Oishi, A Yoda,[...]. Cell Death Differ 2006
148
26

Mice deficient for the wild-type p53-induced phosphatase gene (Wip1) exhibit defects in reproductive organs, immune function, and cell cycle control.
Jene Choi, Bonnie Nannenga, Oleg N Demidov, Dmitry V Bulavin, Austin Cooney, Cory Brayton, Yongxin Zhang, Innocent N Mbawuike, Allan Bradley, Ettore Appella,[...]. Mol Cell Biol 2002
135
23

Allosteric Wip1 phosphatase inhibition through flap-subdomain interaction.
Aidan G Gilmartin, Thomas H Faitg, Mark Richter, Arthur Groy, Mark A Seefeld, Michael G Darcy, Xin Peng, Kelly Federowicz, Jingsong Yang, Shu-Yun Zhang,[...]. Nat Chem Biol 2014
116
23


Genome-wide array-based comparative genomic hybridization analysis of pancreatic adenocarcinoma: identification of genetic indicators that predict patient outcome.
Panayiotis Loukopoulos, Tatsuhiro Shibata, Hiroto Katoh, Akiko Kokubu, Michiie Sakamoto, Ken Yamazaki, Tomoo Kosuge, Yae Kanai, Fumie Hosoda, Issei Imoto,[...]. Cancer Sci 2007
113
20

The role of the MKK6/p38 MAPK pathway in Wip1-dependent regulation of ErbB2-driven mammary gland tumorigenesis.
O N Demidov, C Kek, S Shreeram, O Timofeev, A J Fornace, E Appella, D V Bulavin. Oncogene 2007
83
24

A chemical inhibitor of PPM1D that selectively kills cells overexpressing PPM1D.
S Rayter, R Elliott, J Travers, M G Rowlands, T B Richardson, K Boxall, K Jones, S Linardopoulos, P Workman, W Aherne,[...]. Oncogene 2008
66
27

Wip1 phosphatase is associated with chromatin and dephosphorylates gammaH2AX to promote checkpoint inhibition.
L Macůrek, A Lindqvist, O Voets, J Kool, H R Vos, R H Medema. Oncogene 2010
108
18

Augmented cancer resistance and DNA damage response phenotypes in PPM1D null mice.
Bonnie Nannenga, Xiongbin Lu, Melissa Dumble, Marc Van Maanen, Thuy-Ai Nguyen, Richard Sutton, T Rajendra Kumar, Lawrence A Donehower. Mol Carcinog 2006
64
28

Wip1 directly dephosphorylates gamma-H2AX and attenuates the DNA damage response.
Hyukjin Cha, Julie M Lowe, Henghong Li, Ji-Seon Lee, Galina I Belova, Dmitry V Bulavin, Albert J Fornace. Cancer Res 2010
103
18

Mosaic PPM1D mutations are associated with predisposition to breast and ovarian cancer.
Elise Ruark, Katie Snape, Peter Humburg, Chey Loveday, Ilirjana Bajrami, Rachel Brough, Daniel Nava Rodrigues, Anthony Renwick, Sheila Seal, Emma Ramsay,[...]. Nature 2013
167
18

Gain-of-function mutations of PPM1D/Wip1 impair the p53-dependent G1 checkpoint.
Petra Kleiblova, Indra A Shaltiel, Jan Benada, Jan Ševčík, Soňa Pecháčková, Petr Pohlreich, Emile E Voest, Pavel Dundr, Jiri Bartek, Zdenek Kleibl,[...]. J Cell Biol 2013
87
20

Wild-type p53-induced phosphatase 1 dephosphorylates histone variant gamma-H2AX and suppresses DNA double strand break repair.
Sung-Hwan Moon, Lin Lin, Xinna Zhang, Thuy-Ai Nguyen, Yolanda Darlington, Alan S Waldman, Xiongbin Lu, Lawrence A Donehower. J Biol Chem 2010
83
20

WIP1 phosphatase at the crossroads of cancer and aging.
Xavier Le Guezennec, Dmitry V Bulavin. Trends Biochem Sci 2010
101
17

Chemical inhibition of Wip1 phosphatase contributes to suppression of tumorigenesis.
Galina I Belova, Oleg N Demidov, Albert J Fornace, Dmitry V Bulavin. Cancer Biol Ther 2005
60
28

Wip1 confers G2 checkpoint recovery competence by counteracting p53-dependent transcriptional repression.
Arne Lindqvist, Menno de Bruijn, Libor Macurek, Alexandra Brás, Anneloes Mensinga, Wytse Bruinsma, Olaf Voets, Onno Kranenburg, René H Medema. EMBO J 2009
59
27

Regulation of ATM/p53-dependent suppression of myc-induced lymphomas by Wip1 phosphatase.
Sathyavageeswaran Shreeram, Weng Kee Hee, Oleg N Demidov, Calvina Kek, Hiroshi Yamaguchi, Albert J Fornace, Carl W Anderson, Ettore Appella, Dmitry V Bulavin. J Exp Med 2006
101
15

Oncogenic phosphatase Wip1 is a novel prognostic marker for lung adenocarcinoma patient survival.
Naoyuki Satoh, Yoshimasa Maniwa, Vladimir P Bermudez, Kunihiro Nishimura, Wataru Nishio, Masahiro Yoshimura, Yutaka Okita, Chiho Ohbayashi, Jerard Hurwitz, Yoshitake Hayashi. Cancer Sci 2011
33
45

Genomic and protein expression profiling identifies CDK6 as novel independent prognostic marker in medulloblastoma.
Frank Mendrzyk, Bernhard Radlwimmer, Stefan Joos, Felix Kokocinski, Axel Benner, Daniel E Stange, Kai Neben, Heike Fiegler, Nigel P Carter, Guido Reifenberger,[...]. J Clin Oncol 2005
174
15

Development of a substrate-based cyclic phosphopeptide inhibitor of protein phosphatase 2Cdelta, Wip1.
Hiroshi Yamaguchi, Stewart R Durell, Hanqiao Feng, Yawen Bai, Carl W Anderson, Ettore Appella. Biochemistry 2006
47
29

Phosphorylation and degradation of MdmX is inhibited by Wip1 phosphatase in the DNA damage response.
Xinna Zhang, Lin Lin, Huarong Guo, Jianhua Yang, Stephen N Jones, Aart Jochemsen, Xiongbin Lu. Cancer Res 2009
47
29

Recurrent initiation: a mechanism for triggering p53 pulses in response to DNA damage.
Eric Batchelor, Caroline S Mock, Irun Bhan, Alexander Loewer, Galit Lahav. Mol Cell 2008
256
14

Overexpression of the wip1 gene abrogates the p38 MAPK/p53/Wip1 pathway and silences p16 expression in human breast cancers.
Eunsil Yu, Yeon Sun Ahn, Se Jin Jang, Mi-Jung Kim, Ho Sung Yoon, Gyungyub Gong, Jene Choi. Breast Cancer Res Treat 2007
50
28

Wip1 phosphatase regulates p53-dependent apoptosis of stem cells and tumorigenesis in the mouse intestine.
Oleg N Demidov, Oleg Timofeev, Hnin N Y Lwin, Calvina Kek, Ettore Appella, Dmitry V Bulavin. Cell Stem Cell 2007
83
15

The Wip1 phosphatase (PPM1D) antagonizes activation of the Chk2 tumour suppressor kinase.
M Oliva-Trastoy, V Berthonaud, A Chevalier, C Ducrot, M-C Marsolier-Kergoat, C Mann, F Leteurtre. Oncogene 2007
86
15

PPM1D gene amplification and overexpression in breast cancer: a qRT-PCR and chromogenic in situ hybridization study.
Maryou B Lambros, Rachael Natrajan, Felipe C Geyer, Maria A Lopez-Garcia, Konstantin J Dedes, Kay Savage, Magali Lacroix-Triki, Robin L Jones, Christopher J Lord, Spiros Linardopoulos,[...]. Mod Pathol 2010
41
31

Regulation of the Wip1 phosphatase and its effects on the stress response.
Julie Lowe, Hyukjin Cha, Mi-Ok Lee, Sharlyn J Mazur, Ettore Appella, Albert J Fornace. Front Biosci (Landmark Ed) 2012
64
20

Exome sequencing identifies somatic gain-of-function PPM1D mutations in brainstem gliomas.
Liwei Zhang, Lee H Chen, Hong Wan, Rui Yang, Zhaohui Wang, Jie Feng, Shaohua Yang, Siân Jones, Sizhen Wang, Weixin Zhou,[...]. Nat Genet 2014
95
13

Comprehensive genomic analysis of desmoplastic medulloblastomas: identification of novel amplified genes and separate evaluation of the different histological components.
A Ehrbrecht, U Müller, M Wolter, A Hoischen, A Koch, B Radlwimmer, B Actor, A Mincheva, T Pietsch, P Lichter,[...]. J Pathol 2006
99
12

Oncogenic Wip1 phosphatase is inhibited by miR-16 in the DNA damage signaling pathway.
Xinna Zhang, Guohui Wan, Sizolwenkosi Mlotshwa, Vicki Vance, Franklin G Berger, Hexin Chen, Xiongbin Lu. Cancer Res 2010
114
12


Intrinsic kinase activity and SQ/TQ domain of Chk2 kinase as well as N-terminal domain of Wip1 phosphatase are required for regulation of Chk2 by Wip1.
Akinori Yoda, Xiao Zhou Xu, Nobuyuki Onishi, Kyoko Toyoshima, Hiroko Fujimoto, Naoko Kato, Isao Oishi, Takeshi Kondo, Yasuhiro Minami. J Biol Chem 2006
41
29

The p53-induced oncogenic phosphatase PPM1D interacts with uracil DNA glycosylase and suppresses base excision repair.
Xiongbin Lu, Dora Bocangel, Bonnie Nannenga, Hiroshi Yamaguchi, Ettore Appella, Lawrence A Donehower. Mol Cell 2004
98
12

Over-expression of wild-type p53-induced phosphatase 1 confers poor prognosis of patients with gliomas.
Chaohui Liang, Erkun Guo, Shengkui Lu, Shuai Wang, Chunsheng Kang, Liang Chang, Liqiang Liu, Guangyu Zhang, Zhendong Wu, Zongmao Zhao,[...]. Brain Res 2012
20
60

Reversal of the ATM/ATR-mediated DNA damage response by the oncogenic phosphatase PPM1D.
Xiongbin Lu, Thuy-Ai Nguyen, Lawrence A Donehower. Cell Cycle 2005
55
20

WIP1 phosphatase is a negative regulator of NF-kappaB signalling.
Joanne Chew, Subhra Biswas, Sathyavageeswaran Shreeram, Mahathir Humaidi, Ee Tsin Wong, Manprit Kaur Dhillion, Hsiangling Teo, Amit Hazra, Cheok Chit Fang, Eduardo López-Collazo,[...]. Nat Cell Biol 2009
121
11

PPM1D silencing by RNA interference inhibits proliferation and induces apoptosis in breast cancer cell lines with wild-type p53.
Jenita Pärssinen, Emma-Leena Alarmo, Ritva Karhu, Anne Kallioniemi. Cancer Genet Cytogenet 2008
30
36


Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.