Jeffrey C Rathmell, Tullia Lindsten, Wei-Xing Zong, Ryan M Cinalli, Craig B Thompson. Nat Immunol 2002
Times Cited: 240
Times Cited: 240
Times Cited
Times Co-cited
Similarity
Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity.
P Bouillet, D Metcalf, D C Huang, D M Tarlinton, T W Kay, F Köntgen, J M Adams, A Strasser. Science 1999
P Bouillet, D Metcalf, D C Huang, D M Tarlinton, T W Kay, F Köntgen, J M Adams, A Strasser. Science 1999
46
The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues.
T Lindsten, A J Ross, A King, W X Zong, J C Rathmell, H A Shiels, E Ulrich, K G Waymire, P Mahar, K Frauwirth,[...]. Mol Cell 2000
T Lindsten, A J Ross, A King, W X Zong, J C Rathmell, H A Shiels, E Ulrich, K G Waymire, P Mahar, K Frauwirth,[...]. Mol Cell 2000
42
BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes.
Philippe Bouillet, Jared F Purton, Dale I Godfrey, Li-Chen Zhang, Leigh Coultas, Hamsa Puthalakath, Marc Pellegrini, Suzanne Cory, Jerry M Adams, Andreas Strasser. Nature 2002
Philippe Bouillet, Jared F Purton, Dale I Godfrey, Li-Chen Zhang, Leigh Coultas, Hamsa Puthalakath, Marc Pellegrini, Suzanne Cory, Jerry M Adams, Andreas Strasser. Nature 2002
28
Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death.
M C Wei, W X Zong, E H Cheng, T Lindsten, V Panoutsakopoulou, A J Ross, K A Roth, G R MacGregor, C B Thompson, S J Korsmeyer. Science 2001
M C Wei, W X Zong, E H Cheng, T Lindsten, V Panoutsakopoulou, A J Ross, K A Roth, G R MacGregor, C B Thompson, S J Korsmeyer. Science 2001
26
The BCL-2 protein family: opposing activities that mediate cell death.
Richard J Youle, Andreas Strasser. Nat Rev Mol Cell Biol 2008
Richard J Youle, Andreas Strasser. Nat Rev Mol Cell Biol 2008
26
Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair.
D J Veis, C M Sorenson, J R Shutter, S J Korsmeyer. Cell 1993
D J Veis, C M Sorenson, J R Shutter, S J Korsmeyer. Cell 1993
22
Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function.
Lin Chen, Simon N Willis, Andrew Wei, Brian J Smith, Jamie I Fletcher, Mark G Hinds, Peter M Colman, Catherine L Day, Jerry M Adams, David C S Huang. Mol Cell 2005
Lin Chen, Simon N Willis, Andrew Wei, Brian J Smith, Jamie I Fletcher, Mark G Hinds, Peter M Colman, Catherine L Day, Jerry M Adams, David C S Huang. Mol Cell 2005
21
Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1.
Joseph T Opferman, Anthony Letai, Caroline Beard, Mia D Sorcinelli, Christy C Ong, Stanley J Korsmeyer. Nature 2003
Joseph T Opferman, Anthony Letai, Caroline Beard, Mia D Sorcinelli, Christy C Ong, Stanley J Korsmeyer. Nature 2003
21
An inhibitor of Bcl-2 family proteins induces regression of solid tumours.
Tilman Oltersdorf, Steven W Elmore, Alexander R Shoemaker, Robert C Armstrong, David J Augeri, Barbara A Belli, Milan Bruncko, Thomas L Deckwerth, Jurgen Dinges, Philip J Hajduk,[...]. Nature 2005
Tilman Oltersdorf, Steven W Elmore, Alexander R Shoemaker, Robert C Armstrong, David J Augeri, Barbara A Belli, Milan Bruncko, Thomas L Deckwerth, Jurgen Dinges, Philip J Hajduk,[...]. Nature 2005
20
Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak.
Simon N Willis, Jamie I Fletcher, Thomas Kaufmann, Mark F van Delft, Lin Chen, Peter E Czabotar, Helen Ierino, Erinna F Lee, W Douglas Fairlie, Philippe Bouillet,[...]. Science 2007
Simon N Willis, Jamie I Fletcher, Thomas Kaufmann, Mark F van Delft, Lin Chen, Peter E Czabotar, Helen Ierino, Erinna F Lee, W Douglas Fairlie, Philippe Bouillet,[...]. Science 2007
20
BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis.
E H Cheng, M C Wei, S Weiler, R A Flavell, T W Mak, T Lindsten, S J Korsmeyer. Mol Cell 2001
E H Cheng, M C Wei, S Weiler, R A Flavell, T W Mak, T Lindsten, S J Korsmeyer. Mol Cell 2001
19
Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins.
Simon N Willis, Lin Chen, Grant Dewson, Andrew Wei, Edwina Naik, Jamie I Fletcher, Jerry M Adams, David C S Huang. Genes Dev 2005
Simon N Willis, Lin Chen, Grant Dewson, Andrew Wei, Edwina Naik, Jamie I Fletcher, Jerry M Adams, David C S Huang. Genes Dev 2005
19
p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa.
Andreas Villunger, Ewa M Michalak, Leigh Coultas, Franziska Müllauer, Gunther Böck, Michael J Ausserlechner, Jerry M Adams, Andreas Strasser. Science 2003
Andreas Villunger, Ewa M Michalak, Leigh Coultas, Franziska Müllauer, Gunther Böck, Michael J Ausserlechner, Jerry M Adams, Andreas Strasser. Science 2003
19
bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship.
A Strasser, A W Harris, S Cory. Cell 1991
A Strasser, A W Harris, S Cory. Cell 1991
18
Bax-deficient mice with lymphoid hyperplasia and male germ cell death.
C M Knudson, K S Tung, W G Tourtellotte, G A Brown, S J Korsmeyer. Science 1995
C M Knudson, K S Tung, W G Tourtellotte, G A Brown, S J Korsmeyer. Science 1995
17
Puma cooperates with Bim, the rate-limiting BH3-only protein in cell death during lymphocyte development, in apoptosis induction.
Miriam Erlacher, Verena Labi, Claudia Manzl, Günther Böck, Alexandar Tzankov, Georg Häcker, Ewa Michalak, Andreas Strasser, Andreas Villunger. J Exp Med 2006
Miriam Erlacher, Verena Labi, Claudia Manzl, Günther Böck, Alexandar Tzankov, Georg Häcker, Ewa Michalak, Andreas Strasser, Andreas Villunger. J Exp Med 2006
17
BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly.
Tomomi Kuwana, Lisa Bouchier-Hayes, Jerry E Chipuk, Christine Bonzon, Barbara A Sullivan, Douglas R Green, Donald D Newmeyer. Mol Cell 2005
Tomomi Kuwana, Lisa Bouchier-Hayes, Jerry E Chipuk, Christine Bonzon, Barbara A Sullivan, Douglas R Green, Donald D Newmeyer. Mol Cell 2005
16
BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak.
W X Zong, T Lindsten, A J Ross, G R MacGregor, C B Thompson. Genes Dev 2001
W X Zong, T Lindsten, A J Ross, G R MacGregor, C B Thompson. Genes Dev 2001
16
Degenerative disorders caused by Bcl-2 deficiency prevented by loss of its BH3-only antagonist Bim.
P Bouillet, S Cory, L C Zhang, A Strasser, J M Adams. Dev Cell 2001
P Bouillet, S Cory, L C Zhang, A Strasser, J M Adams. Dev Cell 2001
15
15
The anti-apoptotic Bcl-2 family member Mcl-1 promotes T lymphocyte survival at multiple stages.
Ivan Dzhagalov, Alexis Dunkle, You-Wen He. J Immunol 2008
Ivan Dzhagalov, Alexis Dunkle, You-Wen He. J Immunol 2008
14
Programmed anuclear cell death delimits platelet life span.
Kylie D Mason, Marina R Carpinelli, Jamie I Fletcher, Janelle E Collinge, Adrienne A Hilton, Sarah Ellis, Priscilla N Kelly, Paul G Ekert, Donald Metcalf, Andrew W Roberts,[...]. Cell 2007
Kylie D Mason, Marina R Carpinelli, Jamie I Fletcher, Janelle E Collinge, Adrienne A Hilton, Sarah Ellis, Priscilla N Kelly, Paul G Ekert, Donald Metcalf, Andrew W Roberts,[...]. Cell 2007
14
The role of BH3-only protein Bim extends beyond inhibiting Bcl-2-like prosurvival proteins.
Delphine Mérino, Maybelline Giam, Peter D Hughes, Owen M Siggs, Klaus Heger, Lorraine A O'Reilly, Jerry M Adams, Andreas Strasser, Erinna F Lee, Walter D Fairlie,[...]. J Cell Biol 2009
Delphine Mérino, Maybelline Giam, Peter D Hughes, Owen M Siggs, Klaus Heger, Lorraine A O'Reilly, Jerry M Adams, Andreas Strasser, Erinna F Lee, Walter D Fairlie,[...]. J Cell Biol 2009
13
Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics.
Anthony Letai, Michael C Bassik, Loren D Walensky, Mia D Sorcinelli, Solly Weiler, Stanley J Korsmeyer. Cancer Cell 2002
Anthony Letai, Michael C Bassik, Loren D Walensky, Mia D Sorcinelli, Solly Weiler, Stanley J Korsmeyer. Cancer Cell 2002
13
Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice.
N Motoyama, F Wang, K A Roth, H Sawa, K Nakayama, K Nakayama, I Negishi, S Senju, Q Zhang, S Fujii. Science 1995
N Motoyama, F Wang, K A Roth, H Sawa, K Nakayama, K Nakayama, I Negishi, S Senju, Q Zhang, S Fujii. Science 1995
13
BH3-only proteins Puma and Bim are rate-limiting for gamma-radiation- and glucocorticoid-induced apoptosis of lymphoid cells in vivo.
Miriam Erlacher, Ewa M Michalak, Priscilla N Kelly, Verena Labi, Harald Niederegger, Leigh Coultas, Jerry M Adams, Andreas Strasser, Andreas Villunger. Blood 2005
Miriam Erlacher, Ewa M Michalak, Priscilla N Kelly, Verena Labi, Harald Niederegger, Leigh Coultas, Jerry M Adams, Andreas Strasser, Andreas Villunger. Blood 2005
13
Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells.
D L Vaux, S Cory, J M Adams. Nature 1988
D L Vaux, S Cory, J M Adams. Nature 1988
13
Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome.
Vanessa S Marsden, Liam O'Connor, Lorraine A O'Reilly, John Silke, Donald Metcalf, Paul G Ekert, David C S Huang, Francesco Cecconi, Keisuke Kuida, Kevin J Tomaselli,[...]. Nature 2002
Vanessa S Marsden, Liam O'Connor, Lorraine A O'Reilly, John Silke, Donald Metcalf, Paul G Ekert, David C S Huang, Francesco Cecconi, Keisuke Kuida, Kevin J Tomaselli,[...]. Nature 2002
12
Activated T cell death in vivo mediated by proapoptotic bcl-2 family member bim.
David A Hildeman, Yanan Zhu, Thomas C Mitchell, Philippe Bouillet, Andreas Strasser, John Kappler, Philippa Marrack. Immunity 2002
David A Hildeman, Yanan Zhu, Thomas C Mitchell, Philippe Bouillet, Andreas Strasser, John Kappler, Philippa Marrack. Immunity 2002
12
Bclx regulates the survival of double-positive thymocytes.
A Ma, J C Pena, B Chang, E Margosian, L Davidson, F W Alt, C B Thompson. Proc Natl Acad Sci U S A 1995
A Ma, J C Pena, B Chang, E Margosian, L Davidson, F W Alt, C B Thompson. Proc Natl Acad Sci U S A 1995
12
Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis.
H Li, H Zhu, C J Xu, J Yuan. Cell 1998
H Li, H Zhu, C J Xu, J Yuan. Cell 1998
12
Mcl-1 deficiency results in peri-implantation embryonic lethality.
J L Rinkenberger, S Horning, B Klocke, K Roth, S J Korsmeyer. Genes Dev 2000
J L Rinkenberger, S Horning, B Klocke, K Roth, S J Korsmeyer. Genes Dev 2000
12
Puma is an essential mediator of p53-dependent and -independent apoptotic pathways.
John R Jeffers, Evan Parganas, Youngsoo Lee, Chunying Yang, JinLing Wang, Jennifer Brennan, Kirsteen H MacLean, Jiawen Han, Thomas Chittenden, James N Ihle,[...]. Cancer Cell 2003
John R Jeffers, Evan Parganas, Youngsoo Lee, Chunying Yang, JinLing Wang, Jennifer Brennan, Kirsteen H MacLean, Jiawen Han, Thomas Chittenden, James N Ihle,[...]. Cancer Cell 2003
12
How do BCL-2 proteins induce mitochondrial outer membrane permeabilization?
Jerry E Chipuk, Douglas R Green. Trends Cell Biol 2008
Jerry E Chipuk, Douglas R Green. Trends Cell Biol 2008
12
BCL-2 family member BOK is widely expressed but its loss has only minimal impact in mice.
F Ke, A Voss, J B Kerr, L A O'Reilly, L Tai, N Echeverry, P Bouillet, A Strasser, T Kaufmann. Cell Death Differ 2012
F Ke, A Voss, J B Kerr, L A O'Reilly, L Tai, N Echeverry, P Bouillet, A Strasser, T Kaufmann. Cell Death Differ 2012
14
Microarray analysis uncovers the induction of the proapoptotic BH3-only protein Bim in multiple models of glucocorticoid-induced apoptosis.
Zhengqi Wang, Michael H Malone, Huiling He, Karen S McColl, Clark W Distelhorst. J Biol Chem 2003
Zhengqi Wang, Michael H Malone, Huiling He, Karen S McColl, Clark W Distelhorst. J Biol Chem 2003
11
Obligate role of anti-apoptotic MCL-1 in the survival of hematopoietic stem cells.
Joseph T Opferman, Hiromi Iwasaki, Christy C Ong, Heikyung Suh, Shin-ichi Mizuno, Koichi Akashi, Stanley J Korsmeyer. Science 2005
Joseph T Opferman, Hiromi Iwasaki, Christy C Ong, Heikyung Suh, Shin-ichi Mizuno, Koichi Akashi, Stanley J Korsmeyer. Science 2005
11
Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins.
H Puthalakath, A Strasser. Cell Death Differ 2002
H Puthalakath, A Strasser. Cell Death Differ 2002
11
11
Shutdown of an acute T cell immune response to viral infection is mediated by the proapoptotic Bcl-2 homology 3-only protein Bim.
Marc Pellegrini, Gabrielle Belz, Philippe Bouillet, Andreas Strasser. Proc Natl Acad Sci U S A 2003
Marc Pellegrini, Gabrielle Belz, Philippe Bouillet, Andreas Strasser. Proc Natl Acad Sci U S A 2003
11
The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.
Mark F van Delft, Andrew H Wei, Kylie D Mason, Cassandra J Vandenberg, Lin Chen, Peter E Czabotar, Simon N Willis, Clare L Scott, Catherine L Day, Suzanne Cory,[...]. Cancer Cell 2006
Mark F van Delft, Andrew H Wei, Kylie D Mason, Cassandra J Vandenberg, Lin Chen, Peter E Czabotar, Simon N Willis, Clare L Scott, Catherine L Day, Suzanne Cory,[...]. Cancer Cell 2006
11
Bim is a suppressor of Myc-induced mouse B cell leukemia.
Alexander Egle, Alan W Harris, Philippe Bouillet, Suzanne Cory. Proc Natl Acad Sci U S A 2004
Alexander Egle, Alan W Harris, Philippe Bouillet, Suzanne Cory. Proc Natl Acad Sci U S A 2004
11
ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor.
Christin Tse, Alexander R Shoemaker, Jessica Adickes, Mark G Anderson, Jun Chen, Sha Jin, Eric F Johnson, Kennan C Marsh, Michael J Mitten, Paul Nimmer,[...]. Cancer Res 2008
Christin Tse, Alexander R Shoemaker, Jessica Adickes, Mark G Anderson, Jun Chen, Sha Jin, Eric F Johnson, Kennan C Marsh, Michael J Mitten, Paul Nimmer,[...]. Cancer Res 2008
11
The BH3-only proteins Bim and Puma cooperate to impose deletional tolerance of organ-specific antigens.
Daniel H D Gray, Fiona Kupresanin, Stuart P Berzins, Marco J Herold, Lorraine A O'Reilly, Philippe Bouillet, Andreas Strasser. Immunity 2012
Daniel H D Gray, Fiona Kupresanin, Stuart P Berzins, Marco J Herold, Lorraine A O'Reilly, Philippe Bouillet, Andreas Strasser. Immunity 2012
21
Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy.
Peter E Czabotar, Guillaume Lessene, Andreas Strasser, Jerry M Adams. Nat Rev Mol Cell Biol 2014
Peter E Czabotar, Guillaume Lessene, Andreas Strasser, Jerry M Adams. Nat Rev Mol Cell Biol 2014
11
Essential role of BAX,BAK in B cell homeostasis and prevention of autoimmune disease.
Osamu Takeuchi, Jill Fisher, Heikyung Suh, Hisashi Harada, Barbara A Malynn, Stanley J Korsmeyer. Proc Natl Acad Sci U S A 2005
Osamu Takeuchi, Jill Fisher, Heikyung Suh, Hisashi Harada, Barbara A Malynn, Stanley J Korsmeyer. Proc Natl Acad Sci U S A 2005
10
Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics.
J F Kerr, A H Wyllie, A R Currie. Br J Cancer 1972
J F Kerr, A H Wyllie, A R Currie. Br J Cancer 1972
10
Bim/Bcl-2 balance is critical for maintaining naive and memory T cell homeostasis.
Sara Wojciechowski, Pulak Tripathi, Tristan Bourdeau, Luis Acero, H Leighton Grimes, Jonathan D Katz, Fred D Finkelman, David A Hildeman. J Exp Med 2007
Sara Wojciechowski, Pulak Tripathi, Tristan Bourdeau, Luis Acero, H Leighton Grimes, Jonathan D Katz, Fred D Finkelman, David A Hildeman. J Exp Med 2007
10
Disappearance of the lymphoid system in Bcl-2 homozygous mutant chimeric mice.
K Nakayama, K Nakayama, I Negishi, K Kuida, Y Shinkai, M C Louie, L E Fields, P J Lucas, V Stewart, F W Alt. Science 1993
K Nakayama, K Nakayama, I Negishi, K Kuida, Y Shinkai, M C Louie, L E Fields, P J Lucas, V Stewart, F W Alt. Science 1993
10
bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes.
C L Sentman, J R Shutter, D Hockenbery, O Kanagawa, S J Korsmeyer. Cell 1991
C L Sentman, J R Shutter, D Hockenbery, O Kanagawa, S J Korsmeyer. Cell 1991
10
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.