A citation-based method for searching scientific literature

James K Chen, Jussi Taipale, Michael K Cooper, Philip A Beachy. Genes Dev 2002
Times Cited: 1089







List of co-cited articles
857 articles co-cited >1



Times Cited
  Times     Co-cited
Similarity


Small molecule modulation of Smoothened activity.
James K Chen, Jussi Taipale, Keith E Young, Tapan Maiti, Philip A Beachy. Proc Natl Acad Sci U S A 2002
740
22


Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine.
J Taipale, J K Chen, M K Cooper, B Wang, R K Mann, L Milenkovic, M P Scott, P A Beachy. Nature 2000
21

The mechanisms of Hedgehog signalling and its roles in development and disease.
James Briscoe, Pascal P Thérond. Nat Rev Mol Cell Biol 2013
945
18

Cellular Cholesterol Directly Activates Smoothened in Hedgehog Signaling.
Pengxiang Huang, Daniel Nedelcu, Miyako Watanabe, Cindy Jao, Youngchang Kim, Jing Liu, Adrian Salic. Cell 2016
187
15

Hedgehog: functions and mechanisms.
Markku Varjosalo, Jussi Taipale. Genes Dev 2008
819
15

Activating Smoothened mutations in sporadic basal-cell carcinoma.
J Xie, M Murone, S M Luoh, A Ryan, Q Gu, C Zhang, J M Bonifas, C W Lam, M Hynes, A Goddard,[...]. Nature 1998
982
13

Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma.
Robert L Yauch, Gerrit J P Dijkgraaf, Bruno Alicke, Thomas Januario, Christina P Ahn, Thomas Holcomb, Kanan Pujara, Jeremy Stinson, Christopher A Callahan, Tracy Tang,[...]. Science 2009
617
13

Structural basis of Smoothened regulation by its extracellular domains.
Eamon F X Byrne, Ria Sircar, Paul S Miller, George Hedger, Giovanni Luchetti, Sigrid Nachtergaele, Mark D Tully, Laurel Mydock-McGrane, Douglas F Covey, Robert P Rambo,[...]. Nature 2016
190
13

Targeting the Sonic Hedgehog Signaling Pathway: Review of Smoothened and GLI Inhibitors.
Tadas K Rimkus, Richard L Carpenter, Shadi Qasem, Michael Chan, Hui-Wen Lo. Cancers (Basel) 2016
321
13

Mutations affecting segment number and polarity in Drosophila.
C Nüsslein-Volhard, E Wieschaus. Nature 1980
12

The teratogenic Veratrum alkaloid cyclopamine inhibits sonic hedgehog signal transduction.
J P Incardona, W Gaffield, R P Kapur, H Roelink. Development 1998
507
12

Hedgehog Signaling: From Basic Biology to Cancer Therapy.
Fujia Wu, Yu Zhang, Bo Sun, Andrew P McMahon, Yu Wang. Cell Chem Biol 2017
148
12

Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449.
Charles M Rudin, Christine L Hann, John Laterra, Robert L Yauch, Christopher A Callahan, Ling Fu, Thomas Holcomb, Jeremy Stinson, Stephen E Gould, Barbara Coleman,[...]. N Engl J Med 2009
744
11

Smoothened variants explain the majority of drug resistance in basal cell carcinoma.
Scott X Atwood, Kavita Y Sarin, Ramon J Whitson, Jiang R Li, Geurim Kim, Melika Rezaee, Mina S Ally, Jinah Kim, Catherine Yao, Anne Lynn S Chang,[...]. Cancer Cell 2015
238
10

Inhibition of the hedgehog pathway in advanced basal-cell carcinoma.
Daniel D Von Hoff, Patricia M LoRusso, Charles M Rudin, Josina C Reddy, Robert L Yauch, Raoul Tibes, Glen J Weiss, Mitesh J Borad, Christine L Hann, Julie R Brahmer,[...]. N Engl J Med 2009
803
10

Genomic analysis of smoothened inhibitor resistance in basal cell carcinoma.
Hayley J Sharpe, Gregoire Pau, Gerrit J Dijkgraaf, Nicole Basset-Seguin, Zora Modrusan, Thomas Januario, Vickie Tsui, Alison B Durham, Andrzej A Dlugosz, Peter M Haverty,[...]. Cancer Cell 2015
221
10

Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function.
C Chiang, Y Litingtung, E Lee, K E Young, J L Corden, H Westphal, P A Beachy. Nature 1996
10

Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists.
Maria Frank-Kamenetsky, Xiaoyan M Zhang, Steve Bottega, Oivin Guicherit, Hynek Wichterle, Henryk Dudek, David Bumcrot, Frank Y Wang, Simon Jones, Janine Shulok,[...]. J Biol 2002
347
9

GDC-0449-a potent inhibitor of the hedgehog pathway.
Kirk D Robarge, Shirley A Brunton, Georgette M Castanedo, Yong Cui, Michael S Dina, Richard Goldsmith, Stephen E Gould, Oivin Guichert, Janet L Gunzner, Jason Halladay,[...]. Bioorg Med Chem Lett 2009
274
9

Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity.
Y Echelard, D J Epstein, B St-Jacques, L Shen, J Mohler, J A McMahon, A P McMahon. Cell 1993
9

Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists.
Matthias Lauth, Asa Bergström, Takashi Shimokawa, Rune Toftgård. Proc Natl Acad Sci U S A 2007
554
9

Cyclopamine-mediated hedgehog pathway inhibition depletes stem-like cancer cells in glioblastoma.
Eli E Bar, Aneeka Chaudhry, Alex Lin, Xing Fan, Karisa Schreck, William Matsui, Sara Piccirillo, Angelo L Vescovi, Francesco DiMeco, Alessandro Olivi,[...]. Stem Cells 2007
446
9

Oxysterol binding to the extracellular domain of Smoothened in Hedgehog signaling.
Daniel Nedelcu, Jing Liu, Yangqing Xu, Cindy Jao, Adrian Salic. Nat Chem Biol 2013
128
9

Structural Basis for Cholesterol Transport-like Activity of the Hedgehog Receptor Patched.
Yunxiao Zhang, David P Bulkley, Yao Xin, Kelsey J Roberts, Daniel E Asarnow, Ashutosh Sharma, Benjamin R Myers, Wonhwa Cho, Yifan Cheng, Philip A Beachy. Cell 2018
96
9

Oxysterols are allosteric activators of the oncoprotein Smoothened.
Sigrid Nachtergaele, Laurel K Mydock, Kathiresan Krishnan, Jayan Rammohan, Paul H Schlesinger, Douglas F Covey, Rajat Rohatgi. Nat Chem Biol 2012
173
9


Patched acts catalytically to suppress the activity of Smoothened.
J Taipale, M K Cooper, T Maiti, P A Beachy. Nature 2002
571
9

Biochemical mechanisms of vertebrate hedgehog signaling.
Jennifer H Kong, Christian Siebold, Rajat Rohatgi. Development 2019
76
11

Cholesterol activates the G-protein coupled receptor Smoothened to promote Hedgehog signaling.
Giovanni Luchetti, Ria Sircar, Jennifer H Kong, Sigrid Nachtergaele, Andreas Sagner, Eamon Fx Byrne, Douglas F Covey, Christian Siebold, Rajat Rohatgi. Elife 2016
125
8

Regulation of the oncoprotein Smoothened by small molecules.
Hayley J Sharpe, Weiru Wang, Rami N Hannoush, Frederic J de Sauvage. Nat Chem Biol 2015
85
9

Patched1 regulates hedgehog signaling at the primary cilium.
Rajat Rohatgi, Ljiljana Milenkovic, Matthew P Scott. Science 2007
942
8


Human homolog of patched, a candidate gene for the basal cell nevus syndrome.
R L Johnson, A L Rothman, J Xie, L V Goodrich, J W Bare, J M Bonifas, A G Quinn, R M Myers, D R Cox, E H Epstein,[...]. Science 1996
8

Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugs.
Chong Wang, Huixian Wu, Tama Evron, Eyal Vardy, Gye Won Han, Xi-Ping Huang, Sandy J Hufeisen, Thomas J Mangano, Dan J Urban, Vsevolod Katritch,[...]. Nat Commun 2014
153
8

Cilia-Associated Oxysterols Activate Smoothened.
David R Raleigh, Navdar Sever, Pervinder K Choksi, Monika Abedin Sigg, Kelly M Hines, Bonne M Thompson, Daniel Elnatan, Priyadarshini Jaishankar, Paola Bisignano, Francesc R Garcia-Gonzalo,[...]. Mol Cell 2018
55
14

Targeting the Hedgehog pathway in cancer.
Lee L Rubin, Frederic J de Sauvage. Nat Rev Drug Discov 2006
572
8


Basal cell carcinomas: attack of the hedgehog.
Ervin H Epstein. Nat Rev Cancer 2008
510
8

Altered neural cell fates and medulloblastoma in mouse patched mutants.
L V Goodrich, L Milenković, K M Higgins, M P Scott. Science 1997
8


Rapid, direct activity assays for Smoothened reveal Hedgehog pathway regulation by membrane cholesterol and extracellular sodium.
Benjamin R Myers, Lila Neahring, Yunxiao Zhang, Kelsey J Roberts, Philip A Beachy. Proc Natl Acad Sci U S A 2017
60
11

Vertebrate Smoothened functions at the primary cilium.
Kevin C Corbit, Pia Aanstad, Veena Singla, Andrew R Norman, Didier Y R Stainier, Jeremy F Reiter. Nature 2005
993
7

Mechanisms of Hedgehog pathway activation in cancer and implications for therapy.
Suzie J Scales, Frederic J de Sauvage. Trends Pharmacol Sci 2009
476
7


Arsenic trioxide inhibits human cancer cell growth and tumor development in mice by blocking Hedgehog/GLI pathway.
Elspeth M Beauchamp, Lymor Ringer, Gülay Bulut, Kamal P Sajwan, Michael D Hall, Yi-Chien Lee, Daniel Peaceman, Metin Ozdemirli, Olga Rodriguez, Tobey J Macdonald,[...]. J Clin Invest 2011
225
7

Hedgehog signaling in development and cancer.
Jin Jiang, Chi-Chung Hui. Dev Cell 2008
739
7

Hedgehog signaling pathway is a new therapeutic target for patients with breast cancer.
Makoto Kubo, Masafumi Nakamura, Akira Tasaki, Naoki Yamanaka, Hiroshi Nakashima, Masatoshi Nomura, Syoji Kuroki, Mitsuo Katano. Cancer Res 2004
361
7

Hedgehog signalling in cancer formation and maintenance.
Marina Pasca di Magliano, Matthias Hebrok. Nat Rev Cancer 2003
630
7

Structural Basis of Smoothened Activation in Hedgehog Signaling.
Pengxiang Huang, Sanduo Zheng, Bradley M Wierbowski, Youngchang Kim, Daniel Nedelcu, Laura Aravena, Jing Liu, Andrew C Kruse, Adrian Salic. Cell 2018
70
10


Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.