Andreas Ludwig, Thomas Budde, Juliane Stieber, Sven Moosmang, Christian Wahl, Knut Holthoff, Anke Langebartels, Carsten Wotjak, Thomas Munsch, Xiangang Zong, Susanne Feil, Robert Feil, Marike Lancel, Kenneth R Chien, Arthur Konnerth, Hans-Christian Pape, Martin Biel, Franz Hofmann. EMBO J 2003
Times Cited: 370
Times Cited: 370
Times Cited
Times Co-cited
Similarity
Hyperpolarization-activated cation channels: from genes to function.
Martin Biel, Christian Wahl-Schott, Stylianos Michalakis, Xiangang Zong. Physiol Rev 2009
Martin Biel, Christian Wahl-Schott, Stylianos Michalakis, Xiangang Zong. Physiol Rev 2009
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Immunohistochemical localization of Ih channel subunits, HCN1-4, in the rat brain.
Takuya Notomi, Ryuichi Shigemoto. J Comp Neurol 2004
Takuya Notomi, Ryuichi Shigemoto. J Comp Neurol 2004
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Deep bradycardia and heart block caused by inducible cardiac-specific knockout of the pacemaker channel gene Hcn4.
Mirko Baruscotti, Annalisa Bucchi, Carlo Viscomi, Giacomo Mandelli, Giacomo Consalez, Tomaso Gnecchi-Rusconi, Nicola Montano, Karina Rabello Casali, Stefano Micheloni, Andrea Barbuti,[...]. Proc Natl Acad Sci U S A 2011
Mirko Baruscotti, Annalisa Bucchi, Carlo Viscomi, Giacomo Mandelli, Giacomo Consalez, Tomaso Gnecchi-Rusconi, Nicola Montano, Karina Rabello Casali, Stefano Micheloni, Andrea Barbuti,[...]. Proc Natl Acad Sci U S A 2011
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A family of hyperpolarization-activated mammalian cation channels.
A Ludwig, X Zong, M Jeglitsch, F Hofmann, M Biel. Nature 1998
A Ludwig, X Zong, M Jeglitsch, F Hofmann, M Biel. Nature 1998
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Loss of dendritic HCN1 subunits enhances cortical excitability and epileptogenesis.
Zhuo Huang, Matthew C Walker, Mala M Shah. J Neurosci 2009
Zhuo Huang, Matthew C Walker, Mala M Shah. J Neurosci 2009
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Hyperpolarization-activated cation currents: from molecules to physiological function.
Richard B Robinson, Steven A Siegelbaum. Annu Rev Physiol 2003
Richard B Robinson, Steven A Siegelbaum. Annu Rev Physiol 2003
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The hyperpolarization-activated HCN1 channel is important for motor learning and neuronal integration by cerebellar Purkinje cells.
Matthew F Nolan, Gaël Malleret, Ka Hung Lee, Emma Gibbs, Joshua T Dudman, Bina Santoro, Deqi Yin, Richard F Thompson, Steven A Siegelbaum, Eric R Kandel,[...]. Cell 2003
Matthew F Nolan, Gaël Malleret, Ka Hung Lee, Emma Gibbs, Joshua T Dudman, Bina Santoro, Deqi Yin, Richard F Thompson, Steven A Siegelbaum, Eric R Kandel,[...]. Cell 2003
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HCN2 ion channels play a central role in inflammatory and neuropathic pain.
Edward C Emery, Gareth T Young, Esther M Berrocoso, Lubin Chen, Peter A McNaughton. Science 2011
Edward C Emery, Gareth T Young, Esther M Berrocoso, Lubin Chen, Peter A McNaughton. Science 2011
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Sick sinus syndrome in HCN1-deficient mice.
Stefanie Fenske, Stefanie C Krause, Sami I H Hassan, Elvir Becirovic, Franziska Auer, Rebekka Bernard, Christian Kupatt, Philipp Lange, Tilman Ziegler, Carsten T Wotjak,[...]. Circulation 2013
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HCN4 provides a 'depolarization reserve' and is not required for heart rate acceleration in mice.
Stefan Herrmann, Juliane Stieber, Georg Stöckl, Franz Hofmann, Andreas Ludwig. EMBO J 2007
Stefan Herrmann, Juliane Stieber, Georg Stöckl, Franz Hofmann, Andreas Ludwig. EMBO J 2007
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De novo mutations in HCN1 cause early infantile epileptic encephalopathy.
Caroline Nava, Carine Dalle, Agnès Rastetter, Pasquale Striano, Carolien G F de Kovel, Rima Nabbout, Claude Cancès, Dorothée Ville, Eva H Brilstra, Giuseppe Gobbi,[...]. Nat Genet 2014
Caroline Nava, Carine Dalle, Agnès Rastetter, Pasquale Striano, Carolien G F de Kovel, Rima Nabbout, Claude Cancès, Dorothée Ville, Eva H Brilstra, Giuseppe Gobbi,[...]. Nat Genet 2014
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Recessive loss-of-function mutation in the pacemaker HCN2 channel causing increased neuronal excitability in a patient with idiopathic generalized epilepsy.
Jacopo C DiFrancesco, Andrea Barbuti, Raffaella Milanesi, Stefania Coco, Annalisa Bucchi, Georgia Bottelli, Carlo Ferrarese, Silvana Franceschetti, Benedetta Terragni, Mirko Baruscotti,[...]. J Neurosci 2011
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Absence epilepsy in apathetic, a spontaneous mutant mouse lacking the h channel subunit, HCN2.
Wendy K Chung, Minyoung Shin, Thomas C Jaramillo, Rudolph L Leibel, Charles A LeDuc, Stuart G Fischer, Efthia Tzilianos, Ayman A Gheith, Alan S Lewis, Dane M Chetkovich. Neurobiol Dis 2009
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Queer current and pacemaker: the hyperpolarization-activated cation current in neurons.
H C Pape. Annu Rev Physiol 1996
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The hyperpolarization-activated channel HCN4 is required for the generation of pacemaker action potentials in the embryonic heart.
Juliane Stieber, Stefan Herrmann, Susanne Feil, Jana Löster, Robert Feil, Martin Biel, Franz Hofmann, Andreas Ludwig. Proc Natl Acad Sci U S A 2003
Juliane Stieber, Stefan Herrmann, Susanne Feil, Jana Löster, Robert Feil, Martin Biel, Franz Hofmann, Andreas Ludwig. Proc Natl Acad Sci U S A 2003
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Cellular expression and functional characterization of four hyperpolarization-activated pacemaker channels in cardiac and neuronal tissues.
S Moosmang, J Stieber, X Zong, M Biel, F Hofmann, A Ludwig. Eur J Biochem 2001
S Moosmang, J Stieber, X Zong, M Biel, F Hofmann, A Ludwig. Eur J Biochem 2001
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Augmented currents of an HCN2 variant in patients with febrile seizure syndromes.
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Differential distribution of four hyperpolarization-activated cation channels in mouse brain.
S Moosmang, M Biel, F Hofmann, A Ludwig. Biol Chem 1999
S Moosmang, M Biel, F Hofmann, A Ludwig. Biol Chem 1999
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Molecular and functional heterogeneity of hyperpolarization-activated pacemaker channels in the mouse CNS.
B Santoro, S Chen, A Luthi, P Pavlidis, G P Shumyatsky, G R Tibbs, S A Siegelbaum. J Neurosci 2000
B Santoro, S Chen, A Luthi, P Pavlidis, G P Shumyatsky, G R Tibbs, S A Siegelbaum. J Neurosci 2000
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A behavioral role for dendritic integration: HCN1 channels constrain spatial memory and plasticity at inputs to distal dendrites of CA1 pyramidal neurons.
Matthew F Nolan, Gaël Malleret, Josh T Dudman, Derek L Buhl, Bina Santoro, Emma Gibbs, Svetlana Vronskaya, György Buzsáki, Steven A Siegelbaum, Eric R Kandel,[...]. Cell 2004
Matthew F Nolan, Gaël Malleret, Josh T Dudman, Derek L Buhl, Bina Santoro, Emma Gibbs, Svetlana Vronskaya, György Buzsáki, Steven A Siegelbaum, Eric R Kandel,[...]. Cell 2004
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HCN3 contributes to the ventricular action potential waveform in the murine heart.
Stefanie Fenske, Robert Mader, Andreas Scharr, Christos Paparizos, Xiaochun Cao-Ehlker, Stylianos Michalakis, Lior Shaltiel, Martha Weidinger, Juliane Stieber, Susanne Feil,[...]. Circ Res 2011
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Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain.
B Santoro, D T Liu, H Yao, D Bartsch, E R Kandel, S A Siegelbaum, G R Tibbs. Cell 1998
B Santoro, D T Liu, H Yao, D Bartsch, E R Kandel, S A Siegelbaum, G R Tibbs. Cell 1998
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Regulation of HCN channel surface expression by a novel C-terminal protein-protein interaction.
Bina Santoro, Brian J Wainger, Steven A Siegelbaum. J Neurosci 2004
Bina Santoro, Brian J Wainger, Steven A Siegelbaum. J Neurosci 2004
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Novel HCN2 mutation contributes to febrile seizures by shifting the channel's kinetics in a temperature-dependent manner.
Yuki Nakamura, Xiuyu Shi, Tomohiro Numata, Yasuo Mori, Ryuji Inoue, Christoph Lossin, Tallie Z Baram, Shinichi Hirose. PLoS One 2013
Yuki Nakamura, Xiuyu Shi, Tomohiro Numata, Yasuo Mori, Ryuji Inoue, Christoph Lossin, Tallie Z Baram, Shinichi Hirose. PLoS One 2013
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Mutation analysis of the hyperpolarization-activated cyclic nucleotide-gated channels HCN1 and HCN2 in idiopathic generalized epilepsy.
Bin Tang, Thomas Sander, Kimberley B Craven, Anne Hempelmann, Andrew Escayg. Neurobiol Dis 2008
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HCN channels: structure, cellular regulation and physiological function.
C Wahl-Schott, M Biel. Cell Mol Life Sci 2009
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Neurophysiology of HCN channels: from cellular functions to multiple regulations.
Chao He, Fang Chen, Bo Li, Zhian Hu. Prog Neurobiol 2014
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Dysfunctional HCN ion channels in neurological diseases.
Jacopo C DiFrancesco, Dario DiFrancesco. Front Cell Neurosci 2015
Jacopo C DiFrancesco, Dario DiFrancesco. Front Cell Neurosci 2015
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Molecular mechanism of cAMP modulation of HCN pacemaker channels.
B J Wainger, M DeGennaro, B Santoro, S A Siegelbaum, G R Tibbs. Nature 2001
B J Wainger, M DeGennaro, B Santoro, S A Siegelbaum, G R Tibbs. Nature 2001
14
Deletion of the hyperpolarization-activated cyclic nucleotide-gated channel auxiliary subunit TRIP8b impairs hippocampal Ih localization and function and promotes antidepressant behavior in mice.
Alan S Lewis, Sachin P Vaidya, Cory A Blaiss, Zhiqiang Liu, Travis R Stoub, Darrin H Brager, Xiangdong Chen, Roland A Bender, Chad M Estep, Andrey B Popov,[...]. J Neurosci 2011
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Molecular characterization of a slowly gating human hyperpolarization-activated channel predominantly expressed in thalamus, heart, and testis.
R Seifert, A Scholten, R Gauss, A Mincheva, P Lichter, U B Kaupp. Proc Natl Acad Sci U S A 1999
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Increased seizure severity and seizure-related death in mice lacking HCN1 channels.
Bina Santoro, Janet Y Lee, Dario J Englot, Sandra Gildersleeve, Rebecca A Piskorowski, Steven A Siegelbaum, Melodie R Winawer, Hal Blumenfeld. Epilepsia 2010
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Structures of the Human HCN1 Hyperpolarization-Activated Channel.
Chia-Hsueh Lee, Roderick MacKinnon. Cell 2017
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Direct activation of cardiac pacemaker channels by intracellular cyclic AMP.
D DiFrancesco, P Tortora. Nature 1991
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Alternatively spliced isoforms of TRIP8b differentially control h channel trafficking and function.
Alan S Lewis, Emily Schwartz, C Savio Chan, Yoav Noam, Minyoung Shin, Wytse J Wadman, D James Surmeier, Tallie Z Baram, Robert L Macdonald, Dane M Chetkovich. J Neurosci 2009
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Association with the auxiliary subunit PEX5R/Trip8b controls responsiveness of HCN channels to cAMP and adrenergic stimulation.
Gerd Zolles, Daniela Wenzel, Wolfgang Bildl, Uwe Schulte, Andreas Hofmann, Catrin S Müller, Jörg-Oliver Thumfart, Andreas Vlachos, Thomas Deller, Alexander Pfeifer,[...]. Neuron 2009
Gerd Zolles, Daniela Wenzel, Wolfgang Bildl, Uwe Schulte, Andreas Hofmann, Catrin S Müller, Jörg-Oliver Thumfart, Andreas Vlachos, Thomas Deller, Alexander Pfeifer,[...]. Neuron 2009
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Role of the hyperpolarization-activated current Ih in somatosensory neurons.
Aliakmal Momin, Hervé Cadiou, Adrian Mason, Peter A McNaughton. J Physiol 2008
Aliakmal Momin, Hervé Cadiou, Adrian Mason, Peter A McNaughton. J Physiol 2008
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Inflammatory and neuropathic pain are rapidly suppressed by peripheral block of hyperpolarisation-activated cyclic nucleotide-gated ion channels.
Gareth T Young, Edward C Emery, Elizabeth R Mooney, Christoforos Tsantoulas, Peter A McNaughton. Pain 2014
Gareth T Young, Edward C Emery, Elizabeth R Mooney, Christoforos Tsantoulas, Peter A McNaughton. Pain 2014
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Structural basis for modulation and agonist specificity of HCN pacemaker channels.
William N Zagotta, Nelson B Olivier, Kevin D Black, Edgar C Young, Rich Olson, Eric Gouaux. Nature 2003
William N Zagotta, Nelson B Olivier, Kevin D Black, Edgar C Young, Rich Olson, Eric Gouaux. Nature 2003
13
12
TRIP8b splice variants form a family of auxiliary subunits that regulate gating and trafficking of HCN channels in the brain.
Bina Santoro, Rebecca A Piskorowski, Phillip Pian, Lei Hu, Haiying Liu, Steven A Siegelbaum. Neuron 2009
Bina Santoro, Rebecca A Piskorowski, Phillip Pian, Lei Hu, Haiying Liu, Steven A Siegelbaum. Neuron 2009
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Neuronal hyperpolarization-activated pacemaker channels drive neuropathic pain.
Sandra R Chaplan, Hong-Qing Guo, Doo Hyun Lee, Lin Luo, Changlu Liu, Chester Kuei, Alexander A Velumian, Matthew P Butler, Sean M Brown, Adrienne E Dubin. J Neurosci 2003
Sandra R Chaplan, Hong-Qing Guo, Doo Hyun Lee, Lin Luo, Changlu Liu, Chester Kuei, Alexander A Velumian, Matthew P Butler, Sean M Brown, Adrienne E Dubin. J Neurosci 2003
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Two pacemaker channels from human heart with profoundly different activation kinetics.
A Ludwig, X Zong, J Stieber, R Hullin, F Hofmann, M Biel. EMBO J 1999
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Familial sinus bradycardia associated with a mutation in the cardiac pacemaker channel.
Raffaella Milanesi, Mirko Baruscotti, Tomaso Gnecchi-Ruscone, Dario DiFrancesco. N Engl J Med 2006
Raffaella Milanesi, Mirko Baruscotti, Tomaso Gnecchi-Ruscone, Dario DiFrancesco. N Engl J Med 2006
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Pacemaker channel dysfunction in a patient with sinus node disease.
Eric Schulze-Bahr, Axel Neu, Patrick Friederich, U Benjamin Kaupp, Günter Breithardt, Olaf Pongs, Dirk Isbrandt. J Clin Invest 2003
Eric Schulze-Bahr, Axel Neu, Patrick Friederich, U Benjamin Kaupp, Günter Breithardt, Olaf Pongs, Dirk Isbrandt. J Clin Invest 2003
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Persistently modified h-channels after complex febrile seizures convert the seizure-induced enhancement of inhibition to hyperexcitability.
K Chen, I Aradi, N Thon, M Eghbal-Ahmadi, T Z Baram, I Soltesz. Nat Med 2001
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Membrane resting potential of thalamocortical relay neurons is shaped by the interaction among TASK3 and HCN2 channels.
Sven G Meuth, Tatyana Kanyshkova, Patrick Meuth, Peter Landgraf, Thomas Munsch, Andreas Ludwig, Franz Hofmann, Hans-Christian Pape, Thomas Budde. J Neurophysiol 2006
Sven G Meuth, Tatyana Kanyshkova, Patrick Meuth, Peter Landgraf, Thomas Munsch, Andreas Ludwig, Franz Hofmann, Hans-Christian Pape, Thomas Budde. J Neurophysiol 2006
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Distribution and prevalence of hyperpolarization-activated cation channel (HCN) mRNA expression in cardiac tissues.
W Shi, R Wymore, H Yu, J Wu, R T Wymore, Z Pan, R B Robinson, J E Dixon, D McKinnon, I S Cohen. Circ Res 1999
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HCN-related channelopathies.
Mirko Baruscotti, Georgia Bottelli, Raffaella Milanesi, Jacopo C DiFrancesco, Dario DiFrancesco. Pflugers Arch 2010
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Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.