Yasuaki Itoh, Yuji Kawamata, Masataka Harada, Makoto Kobayashi, Ryo Fujii, Shoji Fukusumi, Kazuhiro Ogi, Masaki Hosoya, Yasuhiro Tanaka, Hiroshi Uejima, Hideyuki Tanaka, Minoru Maruyama, Rie Satoh, Shoichi Okubo, Hideki Kizawa, Hidetoshi Komatsu, Fumika Matsumura, Yuko Noguchi, Tokuyuki Shinohara, Shuji Hinuma, Yukio Fujisawa, Masahiko Fujino. Nature 2003
Times Cited: 1109
Times Cited: 1109
Times Cited
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Similarity
The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids.
Celia P Briscoe, Mohammad Tadayyon, John L Andrews, William G Benson, Jon K Chambers, Michelle M Eilert, Catherine Ellis, Nabil A Elshourbagy, Aaron S Goetz, Dana T Minnick,[...]. J Biol Chem 2003
Celia P Briscoe, Mohammad Tadayyon, John L Andrews, William G Benson, Jon K Chambers, Michelle M Eilert, Catherine Ellis, Nabil A Elshourbagy, Aaron S Goetz, Dana T Minnick,[...]. J Biol Chem 2003
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Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120.
Akira Hirasawa, Keiko Tsumaya, Takeo Awaji, Susumu Katsuma, Tetsuya Adachi, Masateru Yamada, Yukihiko Sugimoto, Shunichi Miyazaki, Gozoh Tsujimoto. Nat Med 2005
Akira Hirasawa, Keiko Tsumaya, Takeo Awaji, Susumu Katsuma, Tetsuya Adachi, Masateru Yamada, Yukihiko Sugimoto, Shunichi Miyazaki, Gozoh Tsujimoto. Nat Med 2005
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GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects.
Da Young Oh, Saswata Talukdar, Eun Ju Bae, Takeshi Imamura, Hidetaka Morinaga, WuQiang Fan, Pingping Li, Wendell J Lu, Steven M Watkins, Jerrold M Olefsky. Cell 2010
Da Young Oh, Saswata Talukdar, Eun Ju Bae, Takeshi Imamura, Hidetaka Morinaga, WuQiang Fan, Pingping Li, Wendell J Lu, Steven M Watkins, Jerrold M Olefsky. Cell 2010
27
GPR40 (FFAR1) - Combined Gs and Gq signaling in vitro is associated with robust incretin secretagogue action ex vivo and in vivo.
Maria Hauge, Marie A Vestmar, Anna S Husted, Jeppe P Ekberg, Michael J Wright, Jerry Di Salvo, Adam B Weinglass, Maja S Engelstoft, Andreas N Madsen, Michael Lückmann,[...]. Mol Metab 2014
Maria Hauge, Marie A Vestmar, Anna S Husted, Jeppe P Ekberg, Michael J Wright, Jerry Di Salvo, Adam B Weinglass, Maja S Engelstoft, Andreas N Madsen, Michael Lückmann,[...]. Mol Metab 2014
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The FFA receptor GPR40 links hyperinsulinemia, hepatic steatosis, and impaired glucose homeostasis in mouse.
Pär Steneberg, Nir Rubins, Reut Bartoov-Shifman, Michael D Walker, Helena Edlund. Cell Metab 2005
Pär Steneberg, Nir Rubins, Reut Bartoov-Shifman, Michael D Walker, Helena Edlund. Cell Metab 2005
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Efficacy and safety of fasiglifam (TAK-875), a G protein-coupled receptor 40 agonist, in Japanese patients with type 2 diabetes inadequately controlled by diet and exercise: a randomized, double-blind, placebo-controlled, phase III trial.
K Kaku, K Enya, R Nakaya, T Ohira, R Matsuno. Diabetes Obes Metab 2015
K Kaku, K Enya, R Nakaya, T Ohira, R Matsuno. Diabetes Obes Metab 2015
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Gpr40 is expressed in enteroendocrine cells and mediates free fatty acid stimulation of incretin secretion.
Sara Edfalk, Pär Steneberg, Helena Edlund. Diabetes 2008
Sara Edfalk, Pär Steneberg, Helena Edlund. Diabetes 2008
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Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: identification of agonist and antagonist small molecules.
Celia P Briscoe, Andrew J Peat, Stephen C McKeown, David F Corbett, Aaron S Goetz, Thomas R Littleton, David C McCoy, Terry P Kenakin, John L Andrews, Carina Ammala,[...]. Br J Pharmacol 2006
Celia P Briscoe, Andrew J Peat, Stephen C McKeown, David F Corbett, Aaron S Goetz, Thomas R Littleton, David C McCoy, Terry P Kenakin, John L Andrews, Carina Ammala,[...]. Br J Pharmacol 2006
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The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids.
Andrew J Brown, Susan M Goldsworthy, Ashley A Barnes, Michelle M Eilert, Lili Tcheang, Dion Daniels, Alison I Muir, Mark J Wigglesworth, Ian Kinghorn, Neil J Fraser,[...]. J Biol Chem 2003
Andrew J Brown, Susan M Goldsworthy, Ashley A Barnes, Michelle M Eilert, Lili Tcheang, Dion Daniels, Alison I Muir, Mark J Wigglesworth, Ian Kinghorn, Neil J Fraser,[...]. J Biol Chem 2003
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A human cell surface receptor activated by free fatty acids and thiazolidinedione drugs.
Knut Kotarsky, Niclas E Nilsson, Erik Flodgren, Christer Owman, Björn Olde. Biochem Biophys Res Commun 2003
Knut Kotarsky, Niclas E Nilsson, Erik Flodgren, Christer Owman, Björn Olde. Biochem Biophys Res Commun 2003
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Loss of FFA2 and FFA3 increases insulin secretion and improves glucose tolerance in type 2 diabetes.
Cong Tang, Kashan Ahmed, Andreas Gille, Shun Lu, Hermann-Josef Gröne, Sorin Tunaru, Stefan Offermanns. Nat Med 2015
Cong Tang, Kashan Ahmed, Andreas Gille, Shun Lu, Hermann-Josef Gröne, Sorin Tunaru, Stefan Offermanns. Nat Med 2015
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Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation.
Emmanuel Le Poul, Cecile Loison, Sofie Struyf, Jean-Yves Springael, Vincent Lannoy, Marie-Eve Decobecq, Stephane Brezillon, Vincent Dupriez, Gilbert Vassart, Jo Van Damme,[...]. J Biol Chem 2003
Emmanuel Le Poul, Cecile Loison, Sofie Struyf, Jean-Yves Springael, Vincent Lannoy, Marie-Eve Decobecq, Stephane Brezillon, Vincent Dupriez, Gilbert Vassart, Jo Van Damme,[...]. J Biol Chem 2003
14
Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human.
Atsuhiko Ichimura, Akira Hirasawa, Odile Poulain-Godefroy, Amélie Bonnefond, Takafumi Hara, Loïc Yengo, Ikuo Kimura, Audrey Leloire, Ning Liu, Keiko Iida,[...]. Nature 2012
Atsuhiko Ichimura, Akira Hirasawa, Odile Poulain-Godefroy, Amélie Bonnefond, Takafumi Hara, Loïc Yengo, Ikuo Kimura, Audrey Leloire, Ning Liu, Keiko Iida,[...]. Nature 2012
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Free Fatty Acid Receptors in Health and Disease.
Ikuo Kimura, Atsuhiko Ichimura, Ryuji Ohue-Kitano, Miki Igarashi. Physiol Rev 2020
Ikuo Kimura, Atsuhiko Ichimura, Ryuji Ohue-Kitano, Miki Igarashi. Physiol Rev 2020
14
The fatty acid receptor GPR40 plays a role in insulin secretion in vivo after high-fat feeding.
Melkam Kebede, Thierry Alquier, Martin G Latour, Meriem Semache, Caroline Tremblay, Vincent Poitout. Diabetes 2008
Melkam Kebede, Thierry Alquier, Martin G Latour, Meriem Semache, Caroline Tremblay, Vincent Poitout. Diabetes 2008
13
Free Fatty Acid Receptor 1 (FFAR1) as an Emerging Therapeutic Target for Type 2 Diabetes Mellitus: Recent Progress and Prevailing Challenges.
Zheng Li, Xue Xu, Wenlong Huang, Hai Qian. Med Res Rev 2018
Zheng Li, Xue Xu, Wenlong Huang, Hai Qian. Med Res Rev 2018
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β-Arrestin Recruitment and Biased Agonism at Free Fatty Acid Receptor 1.
Arturo D Mancini, Gyslaine Bertrand, Kevin Vivot, Éric Carpentier, Caroline Tremblay, Julien Ghislain, Michel Bouvier, Vincent Poitout. J Biol Chem 2015
Arturo D Mancini, Gyslaine Bertrand, Kevin Vivot, Éric Carpentier, Caroline Tremblay, Julien Ghislain, Michel Bouvier, Vincent Poitout. J Biol Chem 2015
21
Oleic acid interacts with GPR40 to induce Ca2+ signaling in rat islet beta-cells: mediation by PLC and L-type Ca2+ channel and link to insulin release.
Ken Fujiwara, Fumihiko Maekawa, Toshihiko Yada. Am J Physiol Endocrinol Metab 2005
Ken Fujiwara, Fumihiko Maekawa, Toshihiko Yada. Am J Physiol Endocrinol Metab 2005
13
Short-chain fatty acids stimulate glucagon-like peptide-1 secretion via the G-protein-coupled receptor FFAR2.
Gwen Tolhurst, Helen Heffron, Yu Shan Lam, Helen E Parker, Abdella M Habib, Eleftheria Diakogiannaki, Jennifer Cameron, Johannes Grosse, Frank Reimann, Fiona M Gribble. Diabetes 2012
Gwen Tolhurst, Helen Heffron, Yu Shan Lam, Helen E Parker, Abdella M Habib, Eleftheria Diakogiannaki, Jennifer Cameron, Johannes Grosse, Frank Reimann, Fiona M Gribble. Diabetes 2012
12
A Gpr120-selective agonist improves insulin resistance and chronic inflammation in obese mice.
Da Young Oh, Evelyn Walenta, Taro E Akiyama, William S Lagakos, Denise Lackey, Ariane R Pessentheiner, Roman Sasik, Nasun Hah, Tyler J Chi, Jason M Cox,[...]. Nat Med 2014
Da Young Oh, Evelyn Walenta, Taro E Akiyama, William S Lagakos, Denise Lackey, Ariane R Pessentheiner, Roman Sasik, Nasun Hah, Tyler J Chi, Jason M Cox,[...]. Nat Med 2014
12
Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41).
Ikuo Kimura, Daisuke Inoue, Takeshi Maeda, Takafumi Hara, Atsuhiko Ichimura, Satoshi Miyauchi, Makio Kobayashi, Akira Hirasawa, Gozoh Tsujimoto. Proc Natl Acad Sci U S A 2011
Ikuo Kimura, Daisuke Inoue, Takeshi Maeda, Takafumi Hara, Atsuhiko Ichimura, Satoshi Miyauchi, Makio Kobayashi, Akira Hirasawa, Gozoh Tsujimoto. Proc Natl Acad Sci U S A 2011
12
Discovery of TAK-875: A Potent, Selective, and Orally Bioavailable GPR40 Agonist.
Nobuyuki Negoro, Shinobu Sasaki, Satoshi Mikami, Masahiro Ito, Masami Suzuki, Yoshiyuki Tsujihata, Ryo Ito, Ayako Harada, Koji Takeuchi, Nobuhiro Suzuki,[...]. ACS Med Chem Lett 2010
Nobuyuki Negoro, Shinobu Sasaki, Satoshi Mikami, Masahiro Ito, Masami Suzuki, Yoshiyuki Tsujihata, Ryo Ito, Ayako Harada, Koji Takeuchi, Nobuhiro Suzuki,[...]. ACS Med Chem Lett 2010
12
Seven transmembrane G protein-coupled receptor repertoire of gastric ghrelin cells.
Maja S Engelstoft, Won-Mee Park, Ichiro Sakata, Line V Kristensen, Anna Sofie Husted, Sherri Osborne-Lawrence, Paul K Piper, Angela K Walker, Maria H Pedersen, Mark K Nøhr,[...]. Mol Metab 2013
Maja S Engelstoft, Won-Mee Park, Ichiro Sakata, Line V Kristensen, Anna Sofie Husted, Sherri Osborne-Lawrence, Paul K Piper, Angela K Walker, Maria H Pedersen, Mark K Nøhr,[...]. Mol Metab 2013
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Complex Pharmacology of Free Fatty Acid Receptors.
Graeme Milligan, Bharat Shimpukade, Trond Ulven, Brian D Hudson. Chem Rev 2017
Graeme Milligan, Bharat Shimpukade, Trond Ulven, Brian D Hudson. Chem Rev 2017
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Role of GPR40 in fatty acid action on the beta cell line INS-1E.
Hagit Shapiro, Sigal Shachar, Israel Sekler, Michal Hershfinkel, Michael D Walker. Biochem Biophys Res Commun 2005
Hagit Shapiro, Sigal Shachar, Israel Sekler, Michal Hershfinkel, Michael D Walker. Biochem Biophys Res Commun 2005
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The regulation of adipogenesis through GPR120.
Chizu Gotoh, Yeon-Hee Hong, Tomoyo Iga, Daisuke Hishikawa, Yasuki Suzuki, Sang-Houn Song, Ki-Choon Choi, Tetsuya Adachi, Akira Hirasawa, Gozoh Tsujimoto,[...]. Biochem Biophys Res Commun 2007
Chizu Gotoh, Yeon-Hee Hong, Tomoyo Iga, Daisuke Hishikawa, Yasuki Suzuki, Sang-Houn Song, Ki-Choon Choi, Tetsuya Adachi, Akira Hirasawa, Gozoh Tsujimoto,[...]. Biochem Biophys Res Commun 2007
11
GPR40 is necessary but not sufficient for fatty acid stimulation of insulin secretion in vivo.
Martin G Latour, Thierry Alquier, Elizabeth Oseid, Caroline Tremblay, Thomas L Jetton, Jian Luo, Daniel C-H Lin, Vincent Poitout. Diabetes 2007
Martin G Latour, Thierry Alquier, Elizabeth Oseid, Caroline Tremblay, Thomas L Jetton, Jian Luo, Daniel C-H Lin, Vincent Poitout. Diabetes 2007
11
Lack of FFAR1/GPR40 does not protect mice from high-fat diet-induced metabolic disease.
Hong Lan, Lizbeth M Hoos, Li Liu, Glen Tetzloff, Weiwen Hu, Susan J Abbondanzo, Galya Vassileva, Eric L Gustafson, Joseph A Hedrick, Harry R Davis. Diabetes 2008
Hong Lan, Lizbeth M Hoos, Li Liu, Glen Tetzloff, Weiwen Hu, Susan J Abbondanzo, Galya Vassileva, Eric L Gustafson, Joseph A Hedrick, Harry R Davis. Diabetes 2008
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Current status of GPR40/FFAR1 modulators in medicinal chemistry (2016-2019): a patent review.
Zheng Li, Zongtao Zhou, Luyong Zhang. Expert Opin Ther Pat 2020
Zheng Li, Zongtao Zhou, Luyong Zhang. Expert Opin Ther Pat 2020
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TAK-875, an orally available G protein-coupled receptor 40/free fatty acid receptor 1 agonist, enhances glucose-dependent insulin secretion and improves both postprandial and fasting hyperglycemia in type 2 diabetic rats.
Yoshiyuki Tsujihata, Ryo Ito, Masami Suzuki, Ayako Harada, Nobuyuki Negoro, Tsuneo Yasuma, Yu Momose, Koji Takeuchi. J Pharmacol Exp Ther 2011
Yoshiyuki Tsujihata, Ryo Ito, Masami Suzuki, Ayako Harada, Nobuyuki Negoro, Tsuneo Yasuma, Yu Momose, Koji Takeuchi. J Pharmacol Exp Ther 2011
10
TAK-875 versus placebo or glimepiride in type 2 diabetes mellitus: a phase 2, randomised, double-blind, placebo-controlled trial.
Charles F Burant, Prabhakar Viswanathan, John Marcinak, Charlie Cao, Majid Vakilynejad, Benhuai Xie, Eckhard Leifke. Lancet 2012
Charles F Burant, Prabhakar Viswanathan, John Marcinak, Charlie Cao, Majid Vakilynejad, Benhuai Xie, Eckhard Leifke. Lancet 2012
10
Discovery of AM-1638: A Potent and Orally Bioavailable GPR40/FFA1 Full Agonist.
Sean P Brown, Paul J Dransfield, Marc Vimolratana, XianYun Jiao, Liusheng Zhu, Vatee Pattaropong, Ying Sun, Jinqian Liu, Jian Luo, Jane Zhang,[...]. ACS Med Chem Lett 2012
Sean P Brown, Paul J Dransfield, Marc Vimolratana, XianYun Jiao, Liusheng Zhu, Vatee Pattaropong, Ying Sun, Jinqian Liu, Jian Luo, Jane Zhang,[...]. ACS Med Chem Lett 2012
15
Medium-chain fatty acids as ligands for orphan G protein-coupled receptor GPR84.
Jinghong Wang, Xiaosu Wu, Nicole Simonavicius, Hui Tian, Lei Ling. J Biol Chem 2006
Jinghong Wang, Xiaosu Wu, Nicole Simonavicius, Hui Tian, Lei Ling. J Biol Chem 2006
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A potent class of GPR40 full agonists engages the enteroinsular axis to promote glucose control in rodents.
Jian Luo, Gayathri Swaminath, Sean P Brown, Jane Zhang, Qi Guo, Michael Chen, Kathy Nguyen, Thanhvien Tran, Lynn Miao, Paul J Dransfield,[...]. PLoS One 2012
Jian Luo, Gayathri Swaminath, Sean P Brown, Jane Zhang, Qi Guo, Michael Chen, Kathy Nguyen, Thanhvien Tran, Lynn Miao, Paul J Dransfield,[...]. PLoS One 2012
10
Activation of G protein-coupled receptor 43 in adipocytes leads to inhibition of lipolysis and suppression of plasma free fatty acids.
Hongfei Ge, Xiaofan Li, Jennifer Weiszmann, Ping Wang, Helene Baribault, Jin-Long Chen, Hui Tian, Yang Li. Endocrinology 2008
Hongfei Ge, Xiaofan Li, Jennifer Weiszmann, Ping Wang, Helene Baribault, Jin-Long Chen, Hui Tian, Yang Li. Endocrinology 2008
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Free fatty acid receptor agonists for the treatment of type 2 diabetes: drugs in preclinical to phase II clinical development.
Zheng Li, Qianqian Qiu, Xinqian Geng, Jianyong Yang, Wenlong Huang, Hai Qian. Expert Opin Investig Drugs 2016
Zheng Li, Qianqian Qiu, Xinqian Geng, Jianyong Yang, Wenlong Huang, Hai Qian. Expert Opin Investig Drugs 2016
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High-resolution structure of the human GPR40 receptor bound to allosteric agonist TAK-875.
Ankita Srivastava, Jason Yano, Yoshihiko Hirozane, Georgia Kefala, Franz Gruswitz, Gyorgy Snell, Weston Lane, Anthony Ivetac, Kathleen Aertgeerts, Jasmine Nguyen,[...]. Nature 2014
Ankita Srivastava, Jason Yano, Yoshihiko Hirozane, Georgia Kefala, Franz Gruswitz, Gyorgy Snell, Weston Lane, Anthony Ivetac, Kathleen Aertgeerts, Jasmine Nguyen,[...]. Nature 2014
10
Identification and pharmacological characterization of multiple allosteric binding sites on the free fatty acid 1 receptor.
Daniel C-H Lin, Qi Guo, Jian Luo, Jane Zhang, Kathy Nguyen, Michael Chen, Thanh Tran, Paul J Dransfield, Sean P Brown, Jonathan Houze,[...]. Mol Pharmacol 2012
Daniel C-H Lin, Qi Guo, Jian Luo, Jane Zhang, Kathy Nguyen, Michael Chen, Thanh Tran, Paul J Dransfield, Sean P Brown, Jonathan Houze,[...]. Mol Pharmacol 2012
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A novel antidiabetic drug, fasiglifam/TAK-875, acts as an ago-allosteric modulator of FFAR1.
Chiori Yabuki, Hidetoshi Komatsu, Yoshiyuki Tsujihata, Risa Maeda, Ryo Ito, Kae Matsuda-Nagasumi, Kensuke Sakuma, Kazumasa Miyawaki, Naoya Kikuchi, Koji Takeuchi,[...]. PLoS One 2013
Chiori Yabuki, Hidetoshi Komatsu, Yoshiyuki Tsujihata, Risa Maeda, Ryo Ito, Kae Matsuda-Nagasumi, Kensuke Sakuma, Kazumasa Miyawaki, Naoya Kikuchi, Koji Takeuchi,[...]. PLoS One 2013
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GPR43 Potentiates β-Cell Function in Obesity.
Joanne C McNelis, Yun Sok Lee, Rafael Mayoral, Rik van der Kant, Andrew M F Johnson, Joshua Wollam, Jerrold M Olefsky. Diabetes 2015
Joanne C McNelis, Yun Sok Lee, Rafael Mayoral, Rik van der Kant, Andrew M F Johnson, Joshua Wollam, Jerrold M Olefsky. Diabetes 2015
9
Identification of a free fatty acid receptor, FFA2R, expressed on leukocytes and activated by short-chain fatty acids.
Niclas E Nilsson, Knut Kotarsky, Christer Owman, Björn Olde. Biochem Biophys Res Commun 2003
Niclas E Nilsson, Knut Kotarsky, Christer Owman, Björn Olde. Biochem Biophys Res Commun 2003
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The effects of TAK-875, a selective G protein-coupled receptor 40/free fatty acid 1 agonist, on insulin and glucagon secretion in isolated rat and human islets.
Hiroaki Yashiro, Yoshiyuki Tsujihata, Koji Takeuchi, Masatoshi Hazama, Paul R V Johnson, Patrik Rorsman. J Pharmacol Exp Ther 2012
Hiroaki Yashiro, Yoshiyuki Tsujihata, Koji Takeuchi, Masatoshi Hazama, Paul R V Johnson, Patrik Rorsman. J Pharmacol Exp Ther 2012
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G protein-coupled receptor (GPR)40-dependent potentiation of insulin secretion in mouse islets is mediated by protein kinase D1.
M Ferdaoussi, V Bergeron, B Zarrouki, J Kolic, J Cantley, J Fielitz, E N Olson, M Prentki, T Biden, P E MacDonald,[...]. Diabetologia 2012
M Ferdaoussi, V Bergeron, B Zarrouki, J Kolic, J Cantley, J Fielitz, E N Olson, M Prentki, T Biden, P E MacDonald,[...]. Diabetologia 2012
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Fasiglifam (TAK-875) Inhibits Hepatobiliary Transporters: A Possible Factor Contributing to Fasiglifam-Induced Liver Injury.
Xiuli Li, Kan Zhong, Zitao Guo, Dafang Zhong, Xiaoyan Chen. Drug Metab Dispos 2015
Xiuli Li, Kan Zhong, Zitao Guo, Dafang Zhong, Xiaoyan Chen. Drug Metab Dispos 2015
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Differential signaling by splice variants of the human free fatty acid receptor GPR120.
Sarah-Jane Watson, Alastair J H Brown, Nicholas D Holliday. Mol Pharmacol 2012
Sarah-Jane Watson, Alastair J H Brown, Nicholas D Holliday. Mol Pharmacol 2012
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Free fatty acid receptors as therapeutic targets for the treatment of diabetes.
Atsuhiko Ichimura, Sae Hasegawa, Mayu Kasubuchi, Ikuo Kimura. Front Pharmacol 2014
Atsuhiko Ichimura, Sae Hasegawa, Mayu Kasubuchi, Ikuo Kimura. Front Pharmacol 2014
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Structural basis for GPR40 allosteric agonism and incretin stimulation.
Joseph D Ho, Betty Chau, Logan Rodgers, Frances Lu, Kelly L Wilbur, Keith A Otto, Yanyun Chen, Min Song, Jonathan P Riley, Hsiu-Chiung Yang,[...]. Nat Commun 2018
Joseph D Ho, Betty Chau, Logan Rodgers, Frances Lu, Kelly L Wilbur, Keith A Otto, Yanyun Chen, Min Song, Jonathan P Riley, Hsiu-Chiung Yang,[...]. Nat Commun 2018
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The pharmacology of TUG-891, a potent and selective agonist of the free fatty acid receptor 4 (FFA4/GPR120), demonstrates both potential opportunity and possible challenges to therapeutic agonism.
Brian D Hudson, Bharat Shimpukade, Amanda E Mackenzie, Adrian J Butcher, John D Pediani, Elisabeth Christiansen, Helen Heathcote, Andrew B Tobin, Trond Ulven, Graeme Milligan. Mol Pharmacol 2013
Brian D Hudson, Bharat Shimpukade, Amanda E Mackenzie, Adrian J Butcher, John D Pediani, Elisabeth Christiansen, Helen Heathcote, Andrew B Tobin, Trond Ulven, Graeme Milligan. Mol Pharmacol 2013
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Roles of GPR41 and GPR43 in leptin secretory responses of murine adipocytes to short chain fatty acids.
Mohamed S Zaibi, Claire J Stocker, Jacqueline O'Dowd, Alison Davies, Mohamed Bellahcene, Michael A Cawthorne, Alastair J H Brown, David M Smith, Jonathan R S Arch. FEBS Lett 2010
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FFAR2-FFAR3 receptor heteromerization modulates short-chain fatty acid sensing.
Zhiwei Ang, Ding Xiong, Min Wu, Jeak Ling Ding. FASEB J 2018
Zhiwei Ang, Ding Xiong, Min Wu, Jeak Ling Ding. FASEB J 2018
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Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.