Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes.
Chiara Zuccato, Marzia Tartari, Andrea Crotti, Donato Goffredo, Marta Valenza, Luciano Conti, Tiziana Cataudella, Blair R Leavitt, Michael R Hayden, Tõnis Timmusk, Dorotea Rigamonti, Elena Cattaneo. Nat Genet 2003
Times Cited: 655
Times Cited: 655
Times Cited
Times Co-cited
Similarity
32
Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules.
Laurent R Gauthier, Bénédicte C Charrin, Maria Borrell-Pagès, Jim P Dompierre, Hélène Rangone, Fabrice P Cordelières, Jan De Mey, Marcy E MacDonald, Volkmar Lessmann, Sandrine Humbert,[...]. Cell 2004
Laurent R Gauthier, Bénédicte C Charrin, Maria Borrell-Pagès, Jim P Dompierre, Hélène Rangone, Fabrice P Cordelières, Jan De Mey, Marcy E MacDonald, Volkmar Lessmann, Sandrine Humbert,[...]. Cell 2004
25
Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease.
C Zuccato, A Ciammola, D Rigamonti, B R Leavitt, D Goffredo, L Conti, M E MacDonald, R M Friedlander, V Silani, M R Hayden,[...]. Science 2001
C Zuccato, A Ciammola, D Rigamonti, B R Leavitt, D Goffredo, L Conti, M E MacDonald, R M Friedlander, V Silani, M R Hayden,[...]. Science 2001
23
Widespread disruption of repressor element-1 silencing transcription factor/neuron-restrictive silencer factor occupancy at its target genes in Huntington's disease.
Chiara Zuccato, Nikolai Belyaev, Paola Conforti, Lezanne Ooi, Marzia Tartari, Evangelia Papadimou, Marcy MacDonald, Elisa Fossale, Scott Zeitlin, Noel Buckley,[...]. J Neurosci 2007
Chiara Zuccato, Nikolai Belyaev, Paola Conforti, Lezanne Ooi, Marzia Tartari, Evangelia Papadimou, Marcy MacDonald, Elisa Fossale, Scott Zeitlin, Noel Buckley,[...]. J Neurosci 2007
23
REST and stress resistance in ageing and Alzheimer's disease.
Tao Lu, Liviu Aron, Joseph Zullo, Ying Pan, Haeyoung Kim, Yiwen Chen, Tun-Hsiang Yang, Hyun-Min Kim, Derek Drake, X Shirley Liu,[...]. Nature 2014
Tao Lu, Liviu Aron, Joseph Zullo, Ying Pan, Haeyoung Kim, Yiwen Chen, Tun-Hsiang Yang, Hyun-Min Kim, Derek Drake, X Shirley Liu,[...]. Nature 2014
22
The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription.
J S Steffan, A Kazantsev, O Spasic-Boskovic, M Greenwald, Y Z Zhu, H Gohler, E E Wanker, G P Bates, D E Housman, L M Thompson. Proc Natl Acad Sci U S A 2000
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The neuron-restrictive silencer factor (NRSF): a coordinate repressor of multiple neuron-specific genes.
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REST: a mammalian silencer protein that restricts sodium channel gene expression to neurons.
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Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice.
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Genome-wide analysis of repressor element 1 silencing transcription factor/neuron-restrictive silencing factor (REST/NRSF) target genes.
Alexander W Bruce, Ian J Donaldson, Ian C Wood, Sally A Yerbury, Michael I Sadowski, Michael Chapman, Berthold Göttgens, Noel J Buckley. Proc Natl Acad Sci U S A 2004
Alexander W Bruce, Ian J Donaldson, Ian C Wood, Sally A Yerbury, Michael I Sadowski, Michael Chapman, Berthold Göttgens, Noel J Buckley. Proc Natl Acad Sci U S A 2004
15
Regional and cellular gene expression changes in human Huntington's disease brain.
Angela Hodges, Andrew D Strand, Aaron K Aragaki, Alexandre Kuhn, Thierry Sengstag, Gareth Hughes, Lyn A Elliston, Cathy Hartog, Darlene R Goldstein, Doris Thu,[...]. Hum Mol Genet 2006
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14
Huntington disease.
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14
REST and its corepressors mediate plasticity of neuronal gene chromatin throughout neurogenesis.
Nurit Ballas, Christopher Grunseich, Diane D Lu, Joan C Speh, Gail Mandel. Cell 2005
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13
REST, a master transcriptional regulator in neurodegenerative disease.
Jee-Yeon Hwang, R Suzanne Zukin. Curr Opin Neurobiol 2018
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13
Huntington's disease: from molecular pathogenesis to clinical treatment.
Christopher A Ross, Sarah J Tabrizi. Lancet Neurol 2011
Christopher A Ross, Sarah J Tabrizi. Lancet Neurol 2011
12
Huntingtin regulates RE1-silencing transcription factor/neuron-restrictive silencer factor (REST/NRSF) nuclear trafficking indirectly through a complex with REST/NRSF-interacting LIM domain protein (RILP) and dynactin p150 Glued.
Masahito Shimojo. J Biol Chem 2008
Masahito Shimojo. J Biol Chem 2008
17
Huntingtin facilitates polycomb repressive complex 2.
Ihn Sik Seong, Juliana M Woda, Ji-Joon Song, Alejandro Lloret, Priyanka D Abeyrathne, Caroline J Woo, Gillian Gregory, Jong-Min Lee, Vanessa C Wheeler, Thomas Walz,[...]. Hum Mol Genet 2010
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12
Transcriptional repression of PGC-1alpha by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration.
Libin Cui, Hyunkyung Jeong, Fran Borovecki, Christopher N Parkhurst, Naoko Tanese, Dimitri Krainc. Cell 2006
Libin Cui, Hyunkyung Jeong, Fran Borovecki, Christopher N Parkhurst, Naoko Tanese, Dimitri Krainc. Cell 2006
12
A microRNA-based gene dysregulation pathway in Huntington's disease.
Rory Johnson, Chiara Zuccato, Nikolai D Belyaev, Deborah J Guest, Elena Cattaneo, Noel J Buckley. Neurobiol Dis 2008
Rory Johnson, Chiara Zuccato, Nikolai D Belyaev, Deborah J Guest, Elena Cattaneo, Noel J Buckley. Neurobiol Dis 2008
11
The bifunctional microRNA miR-9/miR-9* regulates REST and CoREST and is downregulated in Huntington's disease.
Amy N Packer, Yi Xing, Scott Q Harper, Lesley Jones, Beverly L Davidson. J Neurosci 2008
Amy N Packer, Yi Xing, Scott Q Harper, Lesley Jones, Beverly L Davidson. J Neurosci 2008
11
Aberrant splicing of HTT generates the pathogenic exon 1 protein in Huntington disease.
Kirupa Sathasivam, Andreas Neueder, Theresa A Gipson, Christian Landles, Agnesska C Benjamin, Marie K Bondulich, Donna L Smith, Richard L M Faull, Raymund A C Roos, David Howland,[...]. Proc Natl Acad Sci U S A 2013
Kirupa Sathasivam, Andreas Neueder, Theresa A Gipson, Christian Landles, Agnesska C Benjamin, Marie K Bondulich, Donna L Smith, Richard L M Faull, Raymund A C Roos, David Howland,[...]. Proc Natl Acad Sci U S A 2013
11
The transcription factor NRSF contributes to epileptogenesis by selective repression of a subset of target genes.
Shawn McClelland, Gary P Brennan, Celine Dubé, Seeta Rajpara, Shruti Iyer, Cristina Richichi, Christophe Bernard, Tallie Z Baram. Elife 2014
Shawn McClelland, Gary P Brennan, Celine Dubé, Seeta Rajpara, Shruti Iyer, Cristina Richichi, Christophe Bernard, Tallie Z Baram. Elife 2014
13
Identification of Genetic Factors that Modify Clinical Onset of Huntington's Disease.
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11
Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines.
Alexander V Panov, Claire-Anne Gutekunst, Blair R Leavitt, Michael R Hayden, James R Burke, Warren J Strittmatter, J Timothy Greenamyre. Nat Neurosci 2002
Alexander V Panov, Claire-Anne Gutekunst, Blair R Leavitt, Michael R Hayden, James R Burke, Warren J Strittmatter, J Timothy Greenamyre. Nat Neurosci 2002
11
Targeted disruption of the Huntington's disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotes.
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11
Role of brain-derived neurotrophic factor in Huntington's disease.
Chiara Zuccato, Elena Cattaneo. Prog Neurobiol 2007
Chiara Zuccato, Elena Cattaneo. Prog Neurobiol 2007
10
Interference by huntingtin and atrophin-1 with cbp-mediated transcription leading to cellular toxicity.
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Chromatin crosstalk in development and disease: lessons from REST.
Lezanne Ooi, Ian C Wood. Nat Rev Genet 2007
Lezanne Ooi, Ian C Wood. Nat Rev Genet 2007
10
Altered microRNA regulation in Huntington's disease models.
Soon-Tae Lee, Kon Chu, Woo-Seok Im, Hye-Jin Yoon, Ji-Yeon Im, Jung-Eun Park, Ki-Ho Park, Keun-Hwa Jung, Sang Kun Lee, Manho Kim,[...]. Exp Neurol 2011
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10
Molecular mechanisms and potential therapeutical targets in Huntington's disease.
Chiara Zuccato, Marta Valenza, Elena Cattaneo. Physiol Rev 2010
Chiara Zuccato, Marta Valenza, Elena Cattaneo. Physiol Rev 2010
10
Ischemic insults derepress the gene silencer REST in neurons destined to die.
Agata Calderone, Teresa Jover, Kyung-min Noh, Hidenobu Tanaka, Hidenori Yokota, Ying Lin, Sonja Y Grooms, Roodland Regis, Michael V L Bennett, R Suzanne Zukin. J Neurosci 2003
Agata Calderone, Teresa Jover, Kyung-min Noh, Hidenobu Tanaka, Hidenori Yokota, Ying Lin, Sonja Y Grooms, Roodland Regis, Michael V L Bennett, R Suzanne Zukin. J Neurosci 2003
10
Integrated genomics and proteomics define huntingtin CAG length-dependent networks in mice.
Peter Langfelder, Jeffrey P Cantle, Doxa Chatzopoulou, Nan Wang, Fuying Gao, Ismael Al-Ramahi, Xiao-Hong Lu, Eliana Marisa Ramos, Karla El-Zein, Yining Zhao,[...]. Nat Neurosci 2016
Peter Langfelder, Jeffrey P Cantle, Doxa Chatzopoulou, Nan Wang, Fuying Gao, Ismael Al-Ramahi, Xiao-Hong Lu, Eliana Marisa Ramos, Karla El-Zein, Yining Zhao,[...]. Nat Neurosci 2016
10
Increased apoptosis and early embryonic lethality in mice nullizygous for the Huntington's disease gene homologue.
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10
Sustained therapeutic reversal of Huntington's disease by transient repression of huntingtin synthesis.
Holly B Kordasiewicz, Lisa M Stanek, Edward V Wancewicz, Curt Mazur, Melissa M McAlonis, Kimberly A Pytel, Jonathan W Artates, Andreas Weiss, Seng H Cheng, Lamya S Shihabuddin,[...]. Neuron 2012
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9
Transcriptional repression by REST: recruitment of Sin3A and histone deacetylase to neuronal genes.
Y Huang, S J Myers, R Dingledine. Nat Neurosci 1999
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9
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9
Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain.
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Inactivation of the mouse Huntington's disease gene homolog Hdh.
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Mitochondrial loss, dysfunction and altered dynamics in Huntington's disease.
Jinho Kim, Jennifer P Moody, Christina K Edgerly, Olivia L Bordiuk, Kerry Cormier, Karen Smith, M Flint Beal, Robert J Ferrante. Hum Mol Genet 2010
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9
Targeting Huntingtin Expression in Patients with Huntington's Disease.
Sarah J Tabrizi, Blair R Leavitt, G Bernhard Landwehrmeyer, Edward J Wild, Carsten Saft, Roger A Barker, Nick F Blair, David Craufurd, Josef Priller, Hugh Rickards,[...]. N Engl J Med 2019
Sarah J Tabrizi, Blair R Leavitt, G Bernhard Landwehrmeyer, Edward J Wild, Carsten Saft, Roger A Barker, Nick F Blair, David Craufurd, Josef Priller, Hugh Rickards,[...]. N Engl J Med 2019
9
The Transcription Repressor REST in Adult Neurons: Physiology, Pathology, and Diseases
Pietro Baldelli, Jacopo Meldolesi. eNeuro 2015
Pietro Baldelli, Jacopo Meldolesi. eNeuro 2015
19
Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease.
Marta Martinez-Vicente, Zsolt Talloczy, Esther Wong, Guomei Tang, Hiroshi Koga, Susmita Kaushik, Rosa de Vries, Esperanza Arias, Spike Harris, David Sulzer,[...]. Nat Neurosci 2010
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8
Silencing mutant huntingtin by adeno-associated virus-mediated RNA interference ameliorates disease manifestations in the YAC128 mouse model of Huntington's disease.
Lisa M Stanek, Sergio P Sardi, Bryan Mastis, Amy R Richards, Christopher M Treleaven, Tatyana Taksir, Kuma Misra, Seng H Cheng, Lamya S Shihabuddin. Hum Gene Ther 2014
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8
CoREST: a functional corepressor required for regulation of neural-specific gene expression.
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8
Novel repression of Kcc2 transcription by REST-RE-1 controls developmental switch in neuronal chloride.
Michele Yeo, Ken Berglund, George Augustine, Wolfgang Liedtke. J Neurosci 2009
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13
NRSF/REST neuronal deficient mice are more vulnerable to the neurotoxin MPTP.
Mei Yu, Haiyun Suo, Ming Liu, Lei Cai, Jie Liu, Yufang Huang, Jing Xu, Yancong Wang, Cuiqing Zhu, Jian Fei,[...]. Neurobiol Aging 2013
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22
Transcription, epigenetics and ameliorative strategies in Huntington's Disease: a genome-wide perspective.
Luis M Valor. Mol Neurobiol 2015
Luis M Valor. Mol Neurobiol 2015
14
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.