A citation-based method for searching scientific literature

Konrad T Howitz, Kevin J Bitterman, Haim Y Cohen, Dudley W Lamming, Siva Lavu, Jason G Wood, Robert E Zipkin, Phuong Chung, Anne Kisielewski, Li-Li Zhang, Brandy Scherer, David A Sinclair. Nature 2003
Times Cited: 2556







List of co-cited articles
1009 articles co-cited >1



Times Cited
  Times     Co-cited
Similarity


Sirtuin activators mimic caloric restriction and delay ageing in metazoans.
Jason G Wood, Blanka Rogina, Siva Lavu, Konrad Howitz, Stephen L Helfand, Marc Tatar, David Sinclair. Nature 2004
24

Resveratrol improves health and survival of mice on a high-calorie diet.
Joseph A Baur, Kevin J Pearson, Nathan L Price, Hamish A Jamieson, Carles Lerin, Avash Kalra, Vinayakumar V Prabhu, Joanne S Allard, Guillermo Lopez-Lluch, Kaitlyn Lewis,[...]. Nature 2006
24

The hallmarks of aging.
Carlos López-Otín, Maria A Blasco, Linda Partridge, Manuel Serrano, Guido Kroemer. Cell 2013
18

Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha.
Marie Lagouge, Carmen Argmann, Zachary Gerhart-Hines, Hamid Meziane, Carles Lerin, Frederic Daussin, Nadia Messadeq, Jill Milne, Philip Lambert, Peter Elliott,[...]. Cell 2006
18

SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function.
Nathan L Price, Ana P Gomes, Alvin J Y Ling, Filipe V Duarte, Alejandro Martin-Montalvo, Brian J North, Beamon Agarwal, Lan Ye, Giorgio Ramadori, Joao S Teodoro,[...]. Cell Metab 2012
898
17

Therapeutic potential of resveratrol: the in vivo evidence.
Joseph A Baur, David A Sinclair. Nat Rev Drug Discov 2006
15

Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes.
Jill C Milne, Philip D Lambert, Simon Schenk, David P Carney, Jesse J Smith, David J Gagne, Lei Jin, Olivier Boss, Robert B Perni, Chi B Vu,[...]. Nature 2007
15



Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span.
Kevin J Pearson, Joseph A Baur, Kaitlyn N Lewis, Leonid Peshkin, Nathan L Price, Nazar Labinskyy, William R Swindell, Davida Kamara, Robin K Minor, Evelyn Perez,[...]. Cell Metab 2008
797
11

Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase.
Fan Yeung, Jamie E Hoberg, Catherine S Ramsey, Michael D Keller, David R Jones, Roy A Frye, Marty W Mayo. EMBO J 2004
11

Mechanism of human SIRT1 activation by resveratrol.
Margie T Borra, Brian C Smith, John M Denu. J Biol Chem 2005
725
11

Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1.
Joseph T Rodgers, Carlos Lerin, Wilhelm Haas, Steven P Gygi, Bruce M Spiegelman, Pere Puigserver. Nature 2005
11

Metformin improves healthspan and lifespan in mice.
Alejandro Martin-Montalvo, Evi M Mercken, Sarah J Mitchell, Hector H Palacios, Patricia L Mote, Morten Scheibye-Knudsen, Ana P Gomes, Theresa M Ward, Robin K Minor, Marie-José Blouin,[...]. Nat Commun 2013
662
10

Evidence for a common mechanism of SIRT1 regulation by allosteric activators.
Basil P Hubbard, Ana P Gomes, Han Dai, Jun Li, April W Case, Thomas Considine, Thomas V Riera, Jessica E Lee, Sook Yen E, Dudley W Lamming,[...]. Science 2013
400
10

Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds.
Michael S Bonkowski, David A Sinclair. Nat Rev Mol Cell Biol 2016
310
10

Substrate-specific activation of sirtuins by resveratrol.
Matt Kaeberlein, Thomas McDonagh, Birgit Heltweg, Jeffrey Hixon, Eric A Westman, Seth D Caldwell, Andrew Napper, Rory Curtis, Peter S DiStefano, Stanley Fields,[...]. J Biol Chem 2005
570
9

Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism.
Filipe Cabreiro, Catherine Au, Kit-Yi Leung, Nuria Vergara-Irigaray, Helena M Cochemé, Tahereh Noori, David Weinkove, Eugene Schuster, Nicholas D E Greene, David Gems. Cell 2013
494
8

SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation.
Matthew D Hirschey, Tadahiro Shimazu, Eric Goetzman, Enxuan Jing, Bjoern Schwer, David B Lombard, Carrie A Grueter, Charles Harris, Sudha Biddinger, Olga R Ilkayeva,[...]. Nature 2010
8

Cancer chemopreventive activity of resveratrol, a natural product derived from grapes.
M Jang, L Cai, G O Udeani, K V Slowing, C F Thomas, C W Beecher, H H Fong, N R Farnsworth, A D Kinghorn, R G Mehta,[...]. Science 1997
8

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity.
Carles Cantó, Zachary Gerhart-Hines, Jerome N Feige, Marie Lagouge, Lilia Noriega, Jill C Milne, Peter J Elliott, Pere Puigserver, Johan Auwerx. Nature 2009
8

Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases.
Sung-Jun Park, Faiyaz Ahmad, Andrew Philp, Keith Baar, Tishan Williams, Haibin Luo, Hengming Ke, Holger Rehmann, Ronald Taussig, Alexandra L Brown,[...]. Cell 2012
872
8

Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans.
Silvie Timmers, Ellen Konings, Lena Bilet, Riekelt H Houtkooper, Tineke van de Weijer, Gijs H Goossens, Joris Hoeks, Sophie van der Krieken, Dongryeol Ryu, Sander Kersten,[...]. Cell Metab 2011
802
8

Mammalian sirtuins: biological insights and disease relevance.
Marcia C Haigis, David A Sinclair. Annu Rev Pathol 2010
8

Small molecule SIRT1 activators for the treatment of aging and age-related diseases.
Basil P Hubbard, David A Sinclair. Trends Pharmacol Sci 2014
339
8

Metformin as a Tool to Target Aging.
Nir Barzilai, Jill P Crandall, Stephen B Kritchevsky, Mark A Espeland. Cell Metab 2016
405
8

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice.
David E Harrison, Randy Strong, Zelton Dave Sharp, James F Nelson, Clinton M Astle, Kevin Flurkey, Nancy L Nadon, J Erby Wilkinson, Krystyna Frenkel, Christy S Carter,[...]. Nature 2009
7

Repeat dose study of the cancer chemopreventive agent resveratrol in healthy volunteers: safety, pharmacokinetics, and effect on the insulin-like growth factor axis.
Victoria A Brown, Ketan R Patel, Maria Viskaduraki, James A Crowell, Marjorie Perloff, Tristan D Booth, Grygoriy Vasilinin, Ananda Sen, Anna Maria Schinas, Gianfranca Piccirilli,[...]. Cancer Res 2010
360
7

Effects of resveratrol on lifespan in Drosophila melanogaster and Caenorhabditis elegans.
Timothy M Bass, David Weinkove, Koen Houthoofd, David Gems, Linda Partridge. Mech Ageing Dev 2007
292
7

Sirtuin activators and inhibitors: Promises, achievements, and challenges.
Han Dai, David A Sinclair, James L Ellis, Clemens Steegborn. Pharmacol Ther 2018
135
7

A molecular mechanism for direct sirtuin activation by resveratrol.
Melanie Gertz, Giang Thi Tuyet Nguyen, Frank Fischer, Benjamin Suenkel, Christine Schlicker, Benjamin Fränzel, Jana Tomaschewski, Firouzeh Aladini, Christian Becker, Dirk Wolters,[...]. PLoS One 2012
147
7

Nucleocytoplasmic shuttling of the NAD+-dependent histone deacetylase SIRT1.
Masaya Tanno, Jun Sakamoto, Tetsuji Miura, Kazuaki Shimamoto, Yoshiyuki Horio. J Biol Chem 2007
500
7


Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase.
Haim Y Cohen, Christine Miller, Kevin J Bitterman, Nathan R Wall, Brian Hekking, Benedikt Kessler, Konrad T Howitz, Myriam Gorospe, Rafael de Cabo, David A Sinclair. Science 2004
6

The sirtuin SIRT6 regulates lifespan in male mice.
Yariv Kanfi, Shoshana Naiman, Gail Amir, Victoria Peshti, Guy Zinman, Liat Nahum, Ziv Bar-Joseph, Haim Y Cohen. Nature 2012
607
6

Antagonistic crosstalk between NF-κB and SIRT1 in the regulation of inflammation and metabolic disorders.
Anu Kauppinen, Tiina Suuronen, Johanna Ojala, Kai Kaarniranta, Antero Salminen. Cell Signal 2013
469
6

Resveratrol prolongs lifespan and retards the onset of age-related markers in a short-lived vertebrate.
Dario R Valenzano, Eva Terzibasi, Tyrone Genade, Antonino Cattaneo, Luciano Domenici, Alessandro Cellerino. Curr Biol 2006
499
6

Resveratrol is not a direct activator of SIRT1 enzyme activity.
Dirk Beher, John Wu, Suzanne Cumine, Ki Won Kim, Shu-Chen Lu, Larissa Atangan, Minghan Wang. Chem Biol Drug Des 2009
323
6

Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy.
E Morselli, M C Maiuri, M Markaki, E Megalou, A Pasparaki, K Palikaras, A Criollo, L Galluzzi, S A Malik, I Vitale,[...]. Cell Death Dis 2010
403
6

A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease.
R Scott Turner, Ronald G Thomas, Suzanne Craft, Christopher H van Dyck, Jacobo Mintzer, Brigid A Reynolds, James B Brewer, Robert A Rissman, Rema Raman, Paul S Aisen. Neurology 2015
295
6

SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1.
Michelle Pacholec, John E Bleasdale, Boris Chrunyk, David Cunningham, Declan Flynn, Robert S Garofalo, David Griffith, Matt Griffor, Pat Loulakis, Brandon Pabst,[...]. J Biol Chem 2010
653
6

Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation.
David B Lombard, Frederick W Alt, Hwei-Ling Cheng, Jakob Bunkenborg, Ryan S Streeper, Raul Mostoslavsky, Jennifer Kim, George Yancopoulos, David Valenzuela, Andrew Murphy,[...]. Mol Cell Biol 2007
831
6

Sirt1 extends life span and delays aging in mice through the regulation of Nk2 homeobox 1 in the DMH and LH.
Akiko Satoh, Cynthia S Brace, Nick Rensing, Paul Cliften, David F Wozniak, Erik D Herzog, Kelvin A Yamada, Shin-Ichiro Imai. Cell Metab 2013
388
6

Sirt7 increases stress resistance of cardiomyocytes and prevents apoptosis and inflammatory cardiomyopathy in mice.
Olesya Vakhrusheva, Christian Smolka, Praveen Gajawada, Sawa Kostin, Thomas Boettger, Thomas Kubin, Thomas Braun, Eva Bober. Circ Res 2008
403
6

An accelerated assay for the identification of lifespan-extending interventions in Drosophila melanogaster.
Johannes H Bauer, Stephan Goupil, Graham B Garber, Stephen L Helfand. Proc Natl Acad Sci U S A 2004
156
6

Bioavailability of resveratrol.
Thomas Walle. Ann N Y Acad Sci 2011
439
6

Cardioprotection and lifespan extension by the natural polyamine spermidine.
Tobias Eisenberg, Mahmoud Abdellatif, Sabrina Schroeder, Uwe Primessnig, Slaven Stekovic, Tobias Pendl, Alexandra Harger, Julia Schipke, Andreas Zimmermann, Albrecht Schmidt,[...]. Nat Med 2016
439
6

Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1.
Andrew D Napper, Jeffrey Hixon, Thomas McDonagh, Kenneth Keavey, Jean-Francois Pons, Jonathan Barker, Wei Tsung Yau, Patricia Amouzegh, Adam Flegg, Estelle Hamelin,[...]. J Med Chem 2005
340
6


Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase.
Anne Brunet, Lora B Sweeney, J Fitzhugh Sturgill, Katrin F Chua, Paul L Greer, Yingxi Lin, Hien Tran, Sarah E Ross, Raul Mostoslavsky, Haim Y Cohen,[...]. Science 2004
6


Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.