O WARBURG. Science 1956
Times Cited: 8208
Times Cited: 8208
Times Cited
Times Co-cited
Similarity
Understanding the Warburg effect: the metabolic requirements of cell proliferation.
Matthew G Vander Heiden, Lewis C Cantley, Craig B Thompson. Science 2009
Matthew G Vander Heiden, Lewis C Cantley, Craig B Thompson. Science 2009
24
Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries.
Freddie Bray, Jacques Ferlay, Isabelle Soerjomataram, Rebecca L Siegel, Lindsey A Torre, Ahmedin Jemal. CA Cancer J Clin 2018
Freddie Bray, Jacques Ferlay, Isabelle Soerjomataram, Rebecca L Siegel, Lindsey A Torre, Ahmedin Jemal. CA Cancer J Clin 2018
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The biology of cancer: metabolic reprogramming fuels cell growth and proliferation.
Ralph J DeBerardinis, Julian J Lum, Georgia Hatzivassiliou, Craig B Thompson. Cell Metab 2008
Ralph J DeBerardinis, Julian J Lum, Georgia Hatzivassiliou, Craig B Thompson. Cell Metab 2008
8
The Warburg Effect: How Does it Benefit Cancer Cells?
Maria V Liberti, Jason W Locasale. Trends Biochem Sci 2016
Maria V Liberti, Jason W Locasale. Trends Biochem Sci 2016
7
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth.
Heather R Christofk, Matthew G Vander Heiden, Marian H Harris, Arvind Ramanathan, Robert E Gerszten, Ru Wei, Mark D Fleming, Stuart L Schreiber, Lewis C Cantley. Nature 2008
Heather R Christofk, Matthew G Vander Heiden, Marian H Harris, Arvind Ramanathan, Robert E Gerszten, Ru Wei, Mark D Fleming, Stuart L Schreiber, Lewis C Cantley. Nature 2008
6
Metabolic reprogramming: a cancer hallmark even warburg did not anticipate.
Patrick S Ward, Craig B Thompson. Cancer Cell 2012
Patrick S Ward, Craig B Thompson. Cancer Cell 2012
6
6
The tumor suppressor p53 down-regulates glucose transporters GLUT1 and GLUT4 gene expression.
Fabiana Schwartzenberg-Bar-Yoseph, Michal Armoni, Eddy Karnieli. Cancer Res 2004
Fabiana Schwartzenberg-Bar-Yoseph, Michal Armoni, Eddy Karnieli. Cancer Res 2004
6
Why do cancers have high aerobic glycolysis?
Robert A Gatenby, Robert J Gillies. Nat Rev Cancer 2004
Robert A Gatenby, Robert J Gillies. Nat Rev Cancer 2004
6
Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice.
Pierre Sonveaux, Frédérique Végran, Thies Schroeder, Melanie C Wergin, Julien Verrax, Zahid N Rabbani, Christophe J De Saedeleer, Kelly M Kennedy, Caroline Diepart, Bénédicte F Jordan,[...]. J Clin Invest 2008
Pierre Sonveaux, Frédérique Végran, Thies Schroeder, Melanie C Wergin, Julien Verrax, Zahid N Rabbani, Christophe J De Saedeleer, Kelly M Kennedy, Caroline Diepart, Bénédicte F Jordan,[...]. J Clin Invest 2008
6
Otto Warburg's contributions to current concepts of cancer metabolism.
Willem H Koppenol, Patricia L Bounds, Chi V Dang. Nat Rev Cancer 2011
Willem H Koppenol, Patricia L Bounds, Chi V Dang. Nat Rev Cancer 2011
6
The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate.
Patrick S Ward, Jay Patel, David R Wise, Omar Abdel-Wahab, Bryson D Bennett, Hilary A Coller, Justin R Cross, Valeria R Fantin, Cyrus V Hedvat, Alexander E Perl,[...]. Cancer Cell 2010
Patrick S Ward, Jay Patel, David R Wise, Omar Abdel-Wahab, Bryson D Bennett, Hilary A Coller, Justin R Cross, Valeria R Fantin, Cyrus V Hedvat, Alexander E Perl,[...]. Cancer Cell 2010
5
Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012.
Jacques Ferlay, Isabelle Soerjomataram, Rajesh Dikshit, Sultan Eser, Colin Mathers, Marise Rebelo, Donald Maxwell Parkin, David Forman, Freddie Bray. Int J Cancer 2015
Jacques Ferlay, Isabelle Soerjomataram, Rajesh Dikshit, Sultan Eser, Colin Mathers, Marise Rebelo, Donald Maxwell Parkin, David Forman, Freddie Bray. Int J Cancer 2015
5
From Krebs to clinic: glutamine metabolism to cancer therapy.
Brian J Altman, Zachary E Stine, Chi V Dang. Nat Rev Cancer 2016
Brian J Altman, Zachary E Stine, Chi V Dang. Nat Rev Cancer 2016
5
Mitochondrial TCA cycle metabolites control physiology and disease.
Inmaculada Martínez-Reyes, Navdeep S Chandel. Nat Commun 2020
Inmaculada Martínez-Reyes, Navdeep S Chandel. Nat Commun 2020
5
c-Myc transactivation of LDH-A: implications for tumor metabolism and growth.
H Shim, C Dolde, B C Lewis, C S Wu, G Dang, R A Jungmann, R Dalla-Favera, C V Dang. Proc Natl Acad Sci U S A 1997
H Shim, C Dolde, B C Lewis, C S Wu, G Dang, R A Jungmann, R Dalla-Favera, C V Dang. Proc Natl Acad Sci U S A 1997
4
Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism.
Haoqiang Ying, Alec C Kimmelman, Costas A Lyssiotis, Sujun Hua, Gerald C Chu, Eliot Fletcher-Sananikone, Jason W Locasale, Jaekyoung Son, Hailei Zhang, Jonathan L Coloff,[...]. Cell 2012
Haoqiang Ying, Alec C Kimmelman, Costas A Lyssiotis, Sujun Hua, Gerald C Chu, Eliot Fletcher-Sananikone, Jason W Locasale, Jaekyoung Son, Hailei Zhang, Jonathan L Coloff,[...]. Cell 2012
4
The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes.
Arnold J Levine, Anna M Puzio-Kuter. Science 2010
Arnold J Levine, Anna M Puzio-Kuter. Science 2010
4
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate.
Lenny Dang, David W White, Stefan Gross, Bryson D Bennett, Mark A Bittinger, Edward M Driggers, Valeria R Fantin, Hyun Gyung Jang, Shengfang Jin, Marie C Keenan,[...]. Nature 2009
Lenny Dang, David W White, Stefan Gross, Bryson D Bennett, Mark A Bittinger, Edward M Driggers, Valeria R Fantin, Hyun Gyung Jang, Shengfang Jin, Marie C Keenan,[...]. Nature 2009
4
4
4
4
Glucose transporters in the 21st Century.
Bernard Thorens, Mike Mueckler. Am J Physiol Endocrinol Metab 2010
Bernard Thorens, Mike Mueckler. Am J Physiol Endocrinol Metab 2010
4
Aerobic glycolysis: meeting the metabolic requirements of cell proliferation.
Sophia Y Lunt, Matthew G Vander Heiden. Annu Rev Cell Dev Biol 2011
Sophia Y Lunt, Matthew G Vander Heiden. Annu Rev Cell Dev Biol 2011
4
HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia.
Jung-whan Kim, Irina Tchernyshyov, Gregg L Semenza, Chi V Dang. Cell Metab 2006
Jung-whan Kim, Irina Tchernyshyov, Gregg L Semenza, Chi V Dang. Cell Metab 2006
4
Glutamine addiction: a new therapeutic target in cancer.
David R Wise, Craig B Thompson. Trends Biochem Sci 2010
David R Wise, Craig B Thompson. Trends Biochem Sci 2010
4
Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway.
Jaekyoung Son, Costas A Lyssiotis, Haoqiang Ying, Xiaoxu Wang, Sujun Hua, Matteo Ligorio, Rushika M Perera, Cristina R Ferrone, Edouard Mullarky, Ng Shyh-Chang,[...]. Nature 2013
Jaekyoung Son, Costas A Lyssiotis, Haoqiang Ying, Xiaoxu Wang, Sujun Hua, Matteo Ligorio, Rushika M Perera, Cristina R Ferrone, Edouard Mullarky, Ng Shyh-Chang,[...]. Nature 2013
4
Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation.
Maria E Figueroa, Omar Abdel-Wahab, Chao Lu, Patrick S Ward, Jay Patel, Alan Shih, Yushan Li, Neha Bhagwat, Aparna Vasanthakumar, Hugo F Fernandez,[...]. Cancer Cell 2010
Maria E Figueroa, Omar Abdel-Wahab, Chao Lu, Patrick S Ward, Jay Patel, Alan Shih, Yushan Li, Neha Bhagwat, Aparna Vasanthakumar, Hugo F Fernandez,[...]. Cancer Cell 2010
4
Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases.
Wei Xu, Hui Yang, Ying Liu, Ying Yang, Ping Wang, Se-Hee Kim, Shinsuke Ito, Chen Yang, Pu Wang, Meng-Tao Xiao,[...]. Cancer Cell 2011
Wei Xu, Hui Yang, Ying Liu, Ying Yang, Ping Wang, Se-Hee Kim, Shinsuke Ito, Chen Yang, Pu Wang, Meng-Tao Xiao,[...]. Cancer Cell 2011
4
IDH1 and IDH2 mutations in gliomas.
Hai Yan, D Williams Parsons, Genglin Jin, Roger McLendon, B Ahmed Rasheed, Weishi Yuan, Ivan Kos, Ines Batinic-Haberle, Siân Jones, Gregory J Riggins,[...]. N Engl J Med 2009
Hai Yan, D Williams Parsons, Genglin Jin, Roger McLendon, B Ahmed Rasheed, Weishi Yuan, Ivan Kos, Ines Batinic-Haberle, Siân Jones, Gregory J Riggins,[...]. N Engl J Med 2009
4
Metabolic state of glioma stem cells and nontumorigenic cells.
Erina Vlashi, Chann Lagadec, Laurent Vergnes, Tomoo Matsutani, Kenta Masui, Maria Poulou, Ruxandra Popescu, Lorenza Della Donna, Patrick Evers, Carmen Dekmezian,[...]. Proc Natl Acad Sci U S A 2011
Erina Vlashi, Chann Lagadec, Laurent Vergnes, Tomoo Matsutani, Kenta Masui, Maria Poulou, Ruxandra Popescu, Lorenza Della Donna, Patrick Evers, Carmen Dekmezian,[...]. Proc Natl Acad Sci U S A 2011
4
HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer.
Charles J David, Mo Chen, Marcela Assanah, Peter Canoll, James L Manley. Nature 2010
Charles J David, Mo Chen, Marcela Assanah, Peter Canoll, James L Manley. Nature 2010
3
HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations.
Gregg L Semenza. J Clin Invest 2013
Gregg L Semenza. J Clin Invest 2013
3
Long non-coding RNA UCA1 promotes glycolysis by upregulating hexokinase 2 through the mTOR-STAT3/microRNA143 pathway.
Zhengkun Li, Xu Li, Shouzhen Wu, Mei Xue, Wei Chen. Cancer Sci 2014
Zhengkun Li, Xu Li, Shouzhen Wu, Mei Xue, Wei Chen. Cancer Sci 2014
3
CRNDE, a long non-coding RNA responsive to insulin/IGF signaling, regulates genes involved in central metabolism.
Blake C Ellis, Lloyd D Graham, Peter L Molloy. Biochim Biophys Acta 2014
Blake C Ellis, Lloyd D Graham, Peter L Molloy. Biochim Biophys Acta 2014
3
Reciprocal regulation of HIF-1α and lincRNA-p21 modulates the Warburg effect.
Fan Yang, Huafeng Zhang, Yide Mei, Mian Wu. Mol Cell 2014
Fan Yang, Huafeng Zhang, Yide Mei, Mian Wu. Mol Cell 2014
3
Cancer metabolism: fatty acid oxidation in the limelight.
Arkaitz Carracedo, Lewis C Cantley, Pier Paolo Pandolfi. Nat Rev Cancer 2013
Arkaitz Carracedo, Lewis C Cantley, Pier Paolo Pandolfi. Nat Rev Cancer 2013
3
Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction.
David R Wise, Ralph J DeBerardinis, Anthony Mancuso, Nabil Sayed, Xiao-Yong Zhang, Harla K Pfeiffer, Ilana Nissim, Evgueni Daikhin, Marc Yudkoff, Steven B McMahon,[...]. Proc Natl Acad Sci U S A 2008
David R Wise, Ralph J DeBerardinis, Anthony Mancuso, Nabil Sayed, Xiao-Yong Zhang, Harla K Pfeiffer, Ilana Nissim, Evgueni Daikhin, Marc Yudkoff, Steven B McMahon,[...]. Proc Natl Acad Sci U S A 2008
3
An integrated genomic analysis of human glioblastoma multiforme.
D Williams Parsons, Siân Jones, Xiaosong Zhang, Jimmy Cheng-Ho Lin, Rebecca J Leary, Philipp Angenendt, Parminder Mankoo, Hannah Carter, I-Mei Siu, Gary L Gallia,[...]. Science 2008
D Williams Parsons, Siân Jones, Xiaosong Zhang, Jimmy Cheng-Ho Lin, Rebecca J Leary, Philipp Angenendt, Parminder Mankoo, Hannah Carter, I-Mei Siu, Gary L Gallia,[...]. Science 2008
3
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.