Laura Kennedy, Elizabeth Evans, Chiung-Mei Chen, Lyndsey Craven, Peter J Detloff, Margaret Ennis, Peggy F Shelbourne. Hum Mol Genet 2003
Times Cited: 202
Times Cited: 202
Times Cited
Times Co-cited
Similarity
Somatic expansion of the Huntington's disease CAG repeat in the brain is associated with an earlier age of disease onset.
Meera Swami, Audrey E Hendricks, Tammy Gillis, Tiffany Massood, Jayalakshmi Mysore, Richard H Myers, Vanessa C Wheeler. Hum Mol Genet 2009
Meera Swami, Audrey E Hendricks, Tammy Gillis, Tiffany Massood, Jayalakshmi Mysore, Richard H Myers, Vanessa C Wheeler. Hum Mol Genet 2009
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Triplet repeat mutation length gains correlate with cell-type specific vulnerability in Huntington disease brain.
Peggy F Shelbourne, Christine Keller-McGandy, Wenya Linda Bi, Song-Ro Yoon, Louis Dubeau, Nicola J Veitch, Jean Paul Vonsattel, Nancy S Wexler, Norman Arnheim, Sarah J Augood. Hum Mol Genet 2007
Peggy F Shelbourne, Christine Keller-McGandy, Wenya Linda Bi, Song-Ro Yoon, Louis Dubeau, Nicola J Veitch, Jean Paul Vonsattel, Nancy S Wexler, Norman Arnheim, Sarah J Augood. Hum Mol Genet 2007
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Identification of genetic variants associated with Huntington's disease progression: a genome-wide association study.
Davina J Hensman Moss, Antonio F Pardiñas, Douglas Langbehn, Kitty Lo, Blair R Leavitt, Raymund Roos, Alexandra Durr, Simon Mead, Peter Holmans, Lesley Jones,[...]. Lancet Neurol 2017
Davina J Hensman Moss, Antonio F Pardiñas, Douglas Langbehn, Kitty Lo, Blair R Leavitt, Raymund Roos, Alexandra Durr, Simon Mead, Peter Holmans, Lesley Jones,[...]. Lancet Neurol 2017
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Mismatch repair genes Mlh1 and Mlh3 modify CAG instability in Huntington's disease mice: genome-wide and candidate approaches.
Ricardo Mouro Pinto, Ella Dragileva, Andrew Kirby, Alejandro Lloret, Edith Lopez, Jason St Claire, Gagan B Panigrahi, Caixia Hou, Kim Holloway, Tammy Gillis,[...]. PLoS Genet 2013
Ricardo Mouro Pinto, Ella Dragileva, Andrew Kirby, Alejandro Lloret, Edith Lopez, Jason St Claire, Gagan B Panigrahi, Caixia Hou, Kim Holloway, Tammy Gillis,[...]. PLoS Genet 2013
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DNA instability in postmitotic neurons.
Roman Gonitel, Hilary Moffitt, Kirupa Sathasivam, Ben Woodman, Peter J Detloff, Richard L M Faull, Gillian P Bates. Proc Natl Acad Sci U S A 2008
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MSH3 polymorphisms and protein levels affect CAG repeat instability in Huntington's disease mice.
Stéphanie Tomé, Kevin Manley, Jodie P Simard, Greg W Clark, Meghan M Slean, Meera Swami, Peggy F Shelbourne, Elisabeth R M Tillier, Darren G Monckton, Anne Messer,[...]. PLoS Genet 2013
Stéphanie Tomé, Kevin Manley, Jodie P Simard, Greg W Clark, Meghan M Slean, Meera Swami, Peggy F Shelbourne, Elisabeth R M Tillier, Darren G Monckton, Anne Messer,[...]. PLoS Genet 2013
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Intergenerational and striatal CAG repeat instability in Huntington's disease knock-in mice involve different DNA repair genes.
Ella Dragileva, Audrey Hendricks, Allison Teed, Tammy Gillis, Edith T Lopez, Errol C Friedberg, Raju Kucherlapati, Winfried Edelmann, Kathryn L Lunetta, Marcy E MacDonald,[...]. Neurobiol Dis 2009
Ella Dragileva, Audrey Hendricks, Allison Teed, Tammy Gillis, Edith T Lopez, Errol C Friedberg, Raju Kucherlapati, Winfried Edelmann, Kathryn L Lunetta, Marcy E MacDonald,[...]. Neurobiol Dis 2009
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Somatic and gonadal mosaicism of the Huntington disease gene CAG repeat in brain and sperm.
H Telenius, B Kremer, Y P Goldberg, J Theilmann, S E Andrew, J Zeisler, S Adam, C Greenberg, E J Ives, L A Clarke. Nat Genet 1994
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Mismatch repair gene Msh2 modifies the timing of early disease in Hdh(Q111) striatum.
Vanessa C Wheeler, Lori-Anne Lebel, Vladimir Vrbanac, Allison Teed, Hein te Riele, Marcy E MacDonald. Hum Mol Genet 2003
Vanessa C Wheeler, Lori-Anne Lebel, Vladimir Vrbanac, Allison Teed, Hein te Riele, Marcy E MacDonald. Hum Mol Genet 2003
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DNA repair pathways underlie a common genetic mechanism modulating onset in polyglutamine diseases.
Conceição Bettencourt, Davina Hensman-Moss, Michael Flower, Sarah Wiethoff, Alexis Brice, Cyril Goizet, Giovanni Stevanin, Georgios Koutsis, Georgia Karadima, Marios Panas,[...]. Ann Neurol 2016
Conceição Bettencourt, Davina Hensman-Moss, Michael Flower, Sarah Wiethoff, Alexis Brice, Cyril Goizet, Giovanni Stevanin, Georgios Koutsis, Georgia Karadima, Marios Panas,[...]. Ann Neurol 2016
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OGG1 initiates age-dependent CAG trinucleotide expansion in somatic cells.
Irina V Kovtun, Yuan Liu, Magnar Bjoras, Arne Klungland, Samuel H Wilson, Cynthia T McMurray. Nature 2007
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Length-dependent gametic CAG repeat instability in the Huntington's disease knock-in mouse.
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Msh2 deficiency prevents in vivo somatic instability of the CAG repeat in Huntington disease transgenic mice.
K Manley, T L Shirley, L Flaherty, A Messer. Nat Genet 1999
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Instability of highly expanded CAG repeats in mice transgenic for the Huntington's disease mutation.
L Mangiarini, K Sathasivam, A Mahal, R Mott, M Seller, G P Bates. Nat Genet 1997
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Dramatic mutation instability in HD mouse striatum: does polyglutamine load contribute to cell-specific vulnerability in Huntington's disease?
L Kennedy, P F Shelbourne. Hum Mol Genet 2000
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A novel approach to investigate tissue-specific trinucleotide repeat instability.
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Huntington disease.
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A genetic association study of glutamine-encoding DNA sequence structures, somatic CAG expansion, and DNA repair gene variants, with Huntington disease clinical outcomes.
Marc Ciosi, Alastair Maxwell, Sarah A Cumming, Davina J Hensman Moss, Asma M Alshammari, Michael D Flower, Alexandra Durr, Blair R Leavitt, Raymund A C Roos, Peter Holmans,[...]. EBioMedicine 2019
Marc Ciosi, Alastair Maxwell, Sarah A Cumming, Davina J Hensman Moss, Asma M Alshammari, Michael D Flower, Alexandra Durr, Blair R Leavitt, Raymund A C Roos, Peter Holmans,[...]. EBioMedicine 2019
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Trinucleotide expansion in haploid germ cells by gap repair.
I V Kovtun, C T McMurray. Nat Genet 2001
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Venezuelan kindreds reveal that genetic and environmental factors modulate Huntington's disease age of onset.
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20
Msh2 acts in medium-spiny striatal neurons as an enhancer of CAG instability and mutant huntingtin phenotypes in Huntington's disease knock-in mice.
Marina Kovalenko, Ella Dragileva, Jason St Claire, Tammy Gillis, Jolene R Guide, Jaclyn New, Hualing Dong, Raju Kucherlapati, Melanie H Kucherlapati, Michelle E Ehrlich,[...]. PLoS One 2012
Marina Kovalenko, Ella Dragileva, Jason St Claire, Tammy Gillis, Jolene R Guide, Jaclyn New, Hualing Dong, Raju Kucherlapati, Melanie H Kucherlapati, Michelle E Ehrlich,[...]. PLoS One 2012
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Suppression of Somatic Expansion Delays the Onset of Pathophysiology in a Mouse Model of Huntington's Disease.
Helen Budworth, Faye R Harris, Paul Williams, Do Yup Lee, Amy Holt, Jens Pahnke, Bartosz Szczesny, Karina Acevedo-Torres, Sylvette Ayala-Peña, Cynthia T McMurray. PLoS Genet 2015
Helen Budworth, Faye R Harris, Paul Williams, Do Yup Lee, Amy Holt, Jens Pahnke, Bartosz Szczesny, Karina Acevedo-Torres, Sylvette Ayala-Peña, Cynthia T McMurray. PLoS Genet 2015
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FAN1 modifies Huntington's disease progression by stabilizing the expanded HTT CAG repeat.
Robert Goold, Michael Flower, Davina Hensman Moss, Chris Medway, Alison Wood-Kaczmar, Ralph Andre, Pamela Farshim, Gill P Bates, Peter Holmans, Lesley Jones,[...]. Hum Mol Genet 2019
Robert Goold, Michael Flower, Davina Hensman Moss, Chris Medway, Alison Wood-Kaczmar, Ralph Andre, Pamela Farshim, Gill P Bates, Peter Holmans, Lesley Jones,[...]. Hum Mol Genet 2019
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MSH3 modifies somatic instability and disease severity in Huntington's and myotonic dystrophy type 1.
Michael Flower, Vilija Lomeikaite, Marc Ciosi, Sarah Cumming, Fernando Morales, Kitty Lo, Davina Hensman Moss, Lesley Jones, Peter Holmans, Darren G Monckton,[...]. Brain 2019
Michael Flower, Vilija Lomeikaite, Marc Ciosi, Sarah Cumming, Fernando Morales, Kitty Lo, Davina Hensman Moss, Lesley Jones, Peter Holmans, Darren G Monckton,[...]. Brain 2019
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The relationship between trinucleotide (CAG) repeat length and clinical features of Huntington's disease.
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Trinucleotide repeat length instability and age of onset in Huntington's disease.
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Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice.
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Repeat instability as the basis for human diseases and as a potential target for therapy.
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Pms2 is a genetic enhancer of trinucleotide CAG.CTG repeat somatic mosaicism: implications for the mechanism of triplet repeat expansion.
Mário Gomes-Pereira, M Teresa Fortune, Laura Ingram, John P McAbney, Darren G Monckton. Hum Mol Genet 2004
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Neuropathological classification of Huntington's disease.
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A modifier of Huntington's disease onset at the MLH1 locus.
Jong-Min Lee, Michael J Chao, Denise Harold, Kawther Abu Elneel, Tammy Gillis, Peter Holmans, Lesley Jones, Michael Orth, Richard H Myers, Seung Kwak,[...]. Hum Mol Genet 2017
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Length of Uninterrupted CAG, Independent of Polyglutamine Size, Results in Increased Somatic Instability, Hastening Onset of Huntington Disease.
Galen E B Wright, Jennifer A Collins, Chris Kay, Cassandra McDonald, Egor Dolzhenko, Qingwen Xia, Kristina Bečanović, Britt I Drögemöller, Alicia Semaka, Charlotte M Nguyen,[...]. Am J Hum Genet 2019
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Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain.
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Aberrant splicing of HTT generates the pathogenic exon 1 protein in Huntington disease.
Kirupa Sathasivam, Andreas Neueder, Theresa A Gipson, Christian Landles, Agnesska C Benjamin, Marie K Bondulich, Donna L Smith, Richard L M Faull, Raymund A C Roos, David Howland,[...]. Proc Natl Acad Sci U S A 2013
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Patterns of CAG repeat instability in the central nervous system and periphery in Huntington's disease and in spinocerebellar ataxia type 1.
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Ricardo Mouro Pinto, Larissa Arning, James V Giordano, Pedram Razghandi, Marissa A Andrew, Tammy Gillis, Kevin Correia, Jayalakshmi S Mysore, Debora-M Grote Urtubey, Constanze R Parwez,[...]. Hum Mol Genet 2020
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Disease-associated repeat instability and mismatch repair.
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Somatic expansion behaviour of the (CTG)n repeat in myotonic dystrophy knock-in mice is differentially affected by Msh3 and Msh6 mismatch-repair proteins.
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CAG repeat expansion in Huntington disease determines age at onset in a fully dominant fashion.
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(CAG)(n)-hairpin DNA binds to Msh2-Msh3 and changes properties of mismatch recognition.
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13
Msh3 is a limiting factor in the formation of intergenerational CTG expansions in DM1 transgenic mice.
Laurent Foiry, Li Dong, Cédric Savouret, Laurence Hubert, Hein te Riele, Claudine Junien, Geneviève Gourdon. Hum Genet 2006
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Quantification of age-dependent somatic CAG repeat instability in Hdh CAG knock-in mice reveals different expansion dynamics in striatum and liver.
Jong-Min Lee, Ricardo Mouro Pinto, Tammy Gillis, Jason C St Claire, Vanessa C Wheeler. PLoS One 2011
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Age-, tissue- and length-dependent bidirectional somatic CAG•CTG repeat instability in an allelic series of R6/2 Huntington disease mice.
Eloise Larson, Ian Fyfe, A Jennifer Morton, Darren G Monckton. Neurobiol Dis 2015
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Targeting Huntingtin Expression in Patients with Huntington's Disease.
Sarah J Tabrizi, Blair R Leavitt, G Bernhard Landwehrmeyer, Edward J Wild, Carsten Saft, Roger A Barker, Nick F Blair, David Craufurd, Josef Priller, Hugh Rickards,[...]. N Engl J Med 2019
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Xpa deficiency reduces CAG trinucleotide repeat instability in neuronal tissues in a mouse model of SCA1.
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Mechanisms of trinucleotide repeat instability during human development.
Cynthia T McMurray. Nat Rev Genet 2010
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Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.