Tibor Vellai, Krisztina Takacs-Vellai, Yue Zhang, Attila L Kovacs, László Orosz, Fritz Müller. Nature 2003
Times Cited: 744
Times Cited: 744
Times Cited
Times Co-cited
Similarity
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice.
David E Harrison, Randy Strong, Zelton Dave Sharp, James F Nelson, Clinton M Astle, Kevin Flurkey, Nancy L Nadon, J Erby Wilkinson, Krystyna Frenkel, Christy S Carter,[...]. Nature 2009
David E Harrison, Randy Strong, Zelton Dave Sharp, James F Nelson, Clinton M Astle, Kevin Flurkey, Nancy L Nadon, J Erby Wilkinson, Krystyna Frenkel, Christy S Carter,[...]. Nature 2009
52
Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway.
Pankaj Kapahi, Brian M Zid, Tony Harper, Daniel Koslover, Viveca Sapin, Seymour Benzer. Curr Biol 2004
Pankaj Kapahi, Brian M Zid, Tony Harper, Daniel Koslover, Viveca Sapin, Seymour Benzer. Curr Biol 2004
45
Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients.
Matt Kaeberlein, R Wilson Powers, Kristan K Steffen, Eric A Westman, Di Hu, Nick Dang, Emily O Kerr, Kathryn T Kirkland, Stanley Fields, Brian K Kennedy. Science 2005
Matt Kaeberlein, R Wilson Powers, Kristan K Steffen, Eric A Westman, Di Hu, Nick Dang, Emily O Kerr, Kathryn T Kirkland, Stanley Fields, Brian K Kennedy. Science 2005
36
The hallmarks of aging.
Carlos López-Otín, Maria A Blasco, Linda Partridge, Manuel Serrano, Guido Kroemer. Cell 2013
Carlos López-Otín, Maria A Blasco, Linda Partridge, Manuel Serrano, Guido Kroemer. Cell 2013
36
The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span.
Kailiang Jia, Di Chen, Donald L Riddle. Development 2004
Kailiang Jia, Di Chen, Donald L Riddle. Development 2004
23
Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.
Colin Selman, Jennifer M A Tullet, Daniela Wieser, Elaine Irvine, Steven J Lingard, Agharul I Choudhury, Marc Claret, Hind Al-Qassab, Danielle Carmignac, Faruk Ramadani,[...]. Science 2009
Colin Selman, Jennifer M A Tullet, Daniela Wieser, Elaine Irvine, Steven J Lingard, Agharul I Choudhury, Marc Claret, Hind Al-Qassab, Danielle Carmignac, Faruk Ramadani,[...]. Science 2009
22
Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans.
Malene Hansen, Stefan Taubert, Douglas Crawford, Nataliya Libina, Seung-Jae Lee, Cynthia Kenyon. Aging Cell 2007
Malene Hansen, Stefan Taubert, Douglas Crawford, Nataliya Libina, Seung-Jae Lee, Cynthia Kenyon. Aging Cell 2007
20
A C. elegans mutant that lives twice as long as wild type.
C Kenyon, J Chang, E Gensch, A Rudner, R Tabtiang. Nature 1993
C Kenyon, J Chang, E Gensch, A Rudner, R Tabtiang. Nature 1993
20
Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction.
Richard A Miller, David E Harrison, Clinton M Astle, Elizabeth Fernandez, Kevin Flurkey, Melissa Han, Martin A Javors, Xinna Li, Nancy L Nadon, James F Nelson,[...]. Aging Cell 2014
Richard A Miller, David E Harrison, Clinton M Astle, Elizabeth Fernandez, Kevin Flurkey, Melissa Han, Martin A Javors, Xinna Li, Nancy L Nadon, James F Nelson,[...]. Aging Cell 2014
18
17
Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster.
Ivana Bjedov, Janne M Toivonen, Fiona Kerr, Cathy Slack, Jake Jacobson, Andrea Foley, Linda Partridge. Cell Metab 2010
Ivana Bjedov, Janne M Toivonen, Fiona Kerr, Cathy Slack, Jake Jacobson, Andrea Foley, Linda Partridge. Cell Metab 2010
16
Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity.
Dudley W Lamming, Lan Ye, Pekka Katajisto, Marcus D Goncalves, Maki Saitoh, Deanna M Stevens, James G Davis, Adam B Salmon, Arlan Richardson, Rexford S Ahima,[...]. Science 2012
Dudley W Lamming, Lan Ye, Pekka Katajisto, Marcus D Goncalves, Maki Saitoh, Deanna M Stevens, James G Davis, Adam B Salmon, Arlan Richardson, Rexford S Ahima,[...]. Science 2012
15
Extension of chronological life span in yeast by decreased TOR pathway signaling.
R Wilson Powers, Matt Kaeberlein, Seth D Caldwell, Brian K Kennedy, Stanley Fields. Genes Dev 2006
R Wilson Powers, Matt Kaeberlein, Seth D Caldwell, Brian K Kennedy, Stanley Fields. Genes Dev 2006
15
Increased mammalian lifespan and a segmental and tissue-specific slowing of aging after genetic reduction of mTOR expression.
J Julie Wu, Jie Liu, Edmund B Chen, Jennifer J Wang, Liu Cao, Nisha Narayan, Marie M Fergusson, Ilsa I Rovira, Michele Allen, Danielle A Springer,[...]. Cell Rep 2013
J Julie Wu, Jie Liu, Edmund B Chen, Jennifer J Wang, Liu Cao, Nisha Narayan, Marie M Fergusson, Ilsa I Rovira, Michele Allen, Danielle A Springer,[...]. Cell Rep 2013
15
Extending healthy life span--from yeast to humans.
Luigi Fontana, Linda Partridge, Valter D Longo. Science 2010
Luigi Fontana, Linda Partridge, Valter D Longo. Science 2010
15
TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO.
Stacey Robida-Stubbs, Kira Glover-Cutter, Dudley W Lamming, Masaki Mizunuma, Sri Devi Narasimhan, Elke Neumann-Haefelin, David M Sabatini, T Keith Blackwell. Cell Metab 2012
Stacey Robida-Stubbs, Kira Glover-Cutter, Dudley W Lamming, Masaki Mizunuma, Sri Devi Narasimhan, Elke Neumann-Haefelin, David M Sabatini, T Keith Blackwell. Cell Metab 2012
14
Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice.
Richard A Miller, David E Harrison, C M Astle, Joseph A Baur, Angela Rodriguez Boyd, Rafael de Cabo, Elizabeth Fernandez, Kevin Flurkey, Martin A Javors, James F Nelson,[...]. J Gerontol A Biol Sci Med Sci 2011
Richard A Miller, David E Harrison, C M Astle, Joseph A Baur, Angela Rodriguez Boyd, Rafael de Cabo, Elizabeth Fernandez, Kevin Flurkey, Martin A Javors, James F Nelson,[...]. J Gerontol A Biol Sci Med Sci 2011
13
mTOR is a key modulator of ageing and age-related disease.
Simon C Johnson, Peter S Rabinovitch, Matt Kaeberlein. Nature 2013
Simon C Johnson, Peter S Rabinovitch, Matt Kaeberlein. Nature 2013
13
12
Late-life rapamycin treatment reverses age-related heart dysfunction.
James M Flynn, Monique N O'Leary, Christopher A Zambataro, Emmeline C Academia, Michael P Presley, Brittany J Garrett, Artem Zykovich, Sean D Mooney, Randy Strong, Clifford J Rosen,[...]. Aging Cell 2013
James M Flynn, Monique N O'Leary, Christopher A Zambataro, Emmeline C Academia, Michael P Presley, Brittany J Garrett, Artem Zykovich, Sean D Mooney, Randy Strong, Clifford J Rosen,[...]. Aging Cell 2013
11
A role for autophagy in the extension of lifespan by dietary restriction in C. elegans.
Malene Hansen, Abha Chandra, Laura L Mitic, Brian Onken, Monica Driscoll, Cynthia Kenyon. PLoS Genet 2008
Malene Hansen, Abha Chandra, Laura L Mitic, Brian Onken, Monica Driscoll, Cynthia Kenyon. PLoS Genet 2008
11
Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans.
Coleen T Murphy, Steven A McCarroll, Cornelia I Bargmann, Andrew Fraser, Ravi S Kamath, Julie Ahringer, Hao Li, Cynthia Kenyon. Nature 2003
Coleen T Murphy, Steven A McCarroll, Cornelia I Bargmann, Andrew Fraser, Ravi S Kamath, Julie Ahringer, Hao Li, Cynthia Kenyon. Nature 2003
11
An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. elegans.
Eric L Greer, Dara Dowlatshahi, Max R Banko, Judit Villen, Kimmi Hoang, Daniel Blanchard, Steven P Gygi, Anne Brunet. Curr Biol 2007
Eric L Greer, Dara Dowlatshahi, Max R Banko, Judit Villen, Kimmi Hoang, Daniel Blanchard, Steven P Gygi, Anne Brunet. Curr Biol 2007
11
Metformin improves healthspan and lifespan in mice.
Alejandro Martin-Montalvo, Evi M Mercken, Sarah J Mitchell, Hector H Palacios, Patricia L Mote, Morten Scheibye-Knudsen, Ana P Gomes, Theresa M Ward, Robin K Minor, Marie-José Blouin,[...]. Nat Commun 2013
Alejandro Martin-Montalvo, Evi M Mercken, Sarah J Mitchell, Hector H Palacios, Patricia L Mote, Morten Scheibye-Knudsen, Ana P Gomes, Theresa M Ward, Robin K Minor, Marie-José Blouin,[...]. Nat Commun 2013
11
Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans.
H A Tissenbaum, L Guarente. Nature 2001
H A Tissenbaum, L Guarente. Nature 2001
11
Sir2 mediates longevity in the fly through a pathway related to calorie restriction.
Blanka Rogina, Stephen L Helfand. Proc Natl Acad Sci U S A 2004
Blanka Rogina, Stephen L Helfand. Proc Natl Acad Sci U S A 2004
11
Caloric restriction delays disease onset and mortality in rhesus monkeys.
Ricki J Colman, Rozalyn M Anderson, Sterling C Johnson, Erik K Kastman, Kristopher J Kosmatka, T Mark Beasley, David B Allison, Christina Cruzen, Heather A Simmons, Joseph W Kemnitz,[...]. Science 2009
Ricki J Colman, Rozalyn M Anderson, Sterling C Johnson, Erik K Kastman, Kristopher J Kosmatka, T Mark Beasley, David B Allison, Christina Cruzen, Heather A Simmons, Joseph W Kemnitz,[...]. Science 2009
11
Longevity pathways converge on autophagy genes to regulate life span in Caenorhabditis elegans.
Márton L Tóth, Tímea Sigmond, Eva Borsos, János Barna, Péter Erdélyi, Krisztina Takács-Vellai, László Orosz, Attila L Kovács, György Csikós, Miklós Sass,[...]. Autophagy 2008
Márton L Tóth, Tímea Sigmond, Eva Borsos, János Barna, Péter Erdélyi, Krisztina Takács-Vellai, László Orosz, Attila L Kovács, György Csikós, Miklós Sass,[...]. Autophagy 2008
11
Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB.
Dos D Sarbassov, Siraj M Ali, Shomit Sengupta, Joon-Ho Sheen, Peggy P Hsu, Alex F Bagley, Andrew L Markhard, David M Sabatini. Mol Cell 2006
Dos D Sarbassov, Siraj M Ali, Shomit Sengupta, Joon-Ho Sheen, Peggy P Hsu, Alex F Bagley, Andrew L Markhard, David M Sabatini. Mol Cell 2006
10
The TFEB orthologue HLH-30 regulates autophagy and modulates longevity in Caenorhabditis elegans.
Louis R Lapierre, C Daniel De Magalhaes Filho, Philip R McQuary, Chu-Chiao Chu, Orane Visvikis, Jessica T Chang, Sara Gelino, Binnan Ong, Andrew E Davis, Javier E Irazoqui,[...]. Nat Commun 2013
Louis R Lapierre, C Daniel De Magalhaes Filho, Philip R McQuary, Chu-Chiao Chu, Orane Visvikis, Jessica T Chang, Sara Gelino, Binnan Ong, Andrew E Davis, Javier E Irazoqui,[...]. Nat Commun 2013
10
Amino-acid imbalance explains extension of lifespan by dietary restriction in Drosophila.
Richard C Grandison, Matthew D W Piper, Linda Partridge. Nature 2009
Richard C Grandison, Matthew D W Piper, Linda Partridge. Nature 2009
10
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1.
Joungmok Kim, Mondira Kundu, Benoit Viollet, Kun-Liang Guan. Nat Cell Biol 2011
Joungmok Kim, Mondira Kundu, Benoit Viollet, Kun-Liang Guan. Nat Cell Biol 2011
10
AMPK phosphorylation of raptor mediates a metabolic checkpoint.
Dana M Gwinn, David B Shackelford, Daniel F Egan, Maria M Mihaylova, Annabelle Mery, Debbie S Vasquez, Benjamin E Turk, Reuben J Shaw. Mol Cell 2008
Dana M Gwinn, David B Shackelford, Daniel F Egan, Maria M Mihaylova, Annabelle Mery, Debbie S Vasquez, Benjamin E Turk, Reuben J Shaw. Mol Cell 2008
10
MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation.
Remi-Martin Laberge, Yu Sun, Arturo V Orjalo, Christopher K Patil, Adam Freund, Lili Zhou, Samuel C Curran, Albert R Davalos, Kathleen A Wilson-Edell, Su Liu,[...]. Nat Cell Biol 2015
Remi-Martin Laberge, Yu Sun, Arturo V Orjalo, Christopher K Patil, Adam Freund, Lili Zhou, Samuel C Curran, Albert R Davalos, Kathleen A Wilson-Edell, Su Liu,[...]. Nat Cell Biol 2015
10
daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans.
K D Kimura, H A Tissenbaum, Y Liu, G Ruvkun. Science 1997
K D Kimura, H A Tissenbaum, Y Liu, G Ruvkun. Science 1997
10
The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway.
Lynne Chantranupong, Sonia M Scaria, Robert A Saxton, Melanie P Gygi, Kuang Shen, Gregory A Wyant, Tim Wang, J Wade Harper, Steven P Gygi, David M Sabatini. Cell 2016
Lynne Chantranupong, Sonia M Scaria, Robert A Saxton, Melanie P Gygi, Kuang Shen, Gregory A Wyant, Tim Wang, J Wade Harper, Steven P Gygi, David M Sabatini. Cell 2016
9
The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1.
Yasemin Sancak, Timothy R Peterson, Yoav D Shaul, Robert A Lindquist, Carson C Thoreen, Liron Bar-Peled, David M Sabatini. Science 2008
Yasemin Sancak, Timothy R Peterson, Yoav D Shaul, Robert A Lindquist, Carson C Thoreen, Liron Bar-Peled, David M Sabatini. Science 2008
9
Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice.
Alessandro Bitto, Takashi K Ito, Victor V Pineda, Nicolas J LeTexier, Heather Z Huang, Elissa Sutlief, Herman Tung, Nicholas Vizzini, Belle Chen, Kaleb Smith,[...]. Elife 2016
Alessandro Bitto, Takashi K Ito, Victor V Pineda, Nicolas J LeTexier, Heather Z Huang, Elissa Sutlief, Herman Tung, Nicholas Vizzini, Belle Chen, Kaleb Smith,[...]. Elife 2016
9
Sestrin2 is a leucine sensor for the mTORC1 pathway.
Rachel L Wolfson, Lynne Chantranupong, Robert A Saxton, Kuang Shen, Sonia M Scaria, Jason R Cantor, David M Sabatini. Science 2016
Rachel L Wolfson, Lynne Chantranupong, Robert A Saxton, Kuang Shen, Sonia M Scaria, Jason R Cantor, David M Sabatini. Science 2016
9
Alternative rapamycin treatment regimens mitigate the impact of rapamycin on glucose homeostasis and the immune system.
Sebastian I Arriola Apelo, Joshua C Neuman, Emma L Baar, Faizan A Syed, Nicole E Cummings, Harpreet K Brar, Cassidy P Pumper, Michelle E Kimple, Dudley W Lamming. Aging Cell 2016
Sebastian I Arriola Apelo, Joshua C Neuman, Emma L Baar, Faizan A Syed, Nicole E Cummings, Harpreet K Brar, Cassidy P Pumper, Michelle E Kimple, Dudley W Lamming. Aging Cell 2016
9
The ratio of macronutrients, not caloric intake, dictates cardiometabolic health, aging, and longevity in ad libitum-fed mice.
Samantha M Solon-Biet, Aisling C McMahon, J William O Ballard, Kari Ruohonen, Lindsay E Wu, Victoria C Cogger, Alessandra Warren, Xin Huang, Nicolas Pichaud, Richard G Melvin,[...]. Cell Metab 2014
Samantha M Solon-Biet, Aisling C McMahon, J William O Ballard, Kari Ruohonen, Lindsay E Wu, Victoria C Cogger, Alessandra Warren, Xin Huang, Nicolas Pichaud, Richard G Melvin,[...]. Cell Metab 2014
9
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
Brian K Kennedy, Dudley W Lamming. Cell Metab 2016
Brian K Kennedy, Dudley W Lamming. Cell Metab 2016
9
Sirtuin activators mimic caloric restriction and delay ageing in metazoans.
Jason G Wood, Blanka Rogina, Siva Lavu, Konrad Howitz, Stephen L Helfand, Marc Tatar, David Sinclair. Nature 2004
Jason G Wood, Blanka Rogina, Siva Lavu, Konrad Howitz, Stephen L Helfand, Marc Tatar, David Sinclair. Nature 2004
9
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan.
Konrad T Howitz, Kevin J Bitterman, Haim Y Cohen, Dudley W Lamming, Siva Lavu, Jason G Wood, Robert E Zipkin, Phuong Chung, Anne Kisielewski, Li-Li Zhang,[...]. Nature 2003
Konrad T Howitz, Kevin J Bitterman, Haim Y Cohen, Dudley W Lamming, Siva Lavu, Jason G Wood, Robert E Zipkin, Phuong Chung, Anne Kisielewski, Li-Li Zhang,[...]. Nature 2003
9
Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism.
Filipe Cabreiro, Catherine Au, Kit-Yi Leung, Nuria Vergara-Irigaray, Helena M Cochemé, Tahereh Noori, David Weinkove, Eugene Schuster, Nicholas D E Greene, David Gems. Cell 2013
Filipe Cabreiro, Catherine Au, Kit-Yi Leung, Nuria Vergara-Irigaray, Helena M Cochemé, Tahereh Noori, David Weinkove, Eugene Schuster, Nicholas D E Greene, David Gems. Cell 2013
9
The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms.
M Kaeberlein, M McVey, L Guarente. Genes Dev 1999
M Kaeberlein, M McVey, L Guarente. Genes Dev 1999
9
Metformin as a Tool to Target Aging.
Nir Barzilai, Jill P Crandall, Stephen B Kritchevsky, Mark A Espeland. Cell Metab 2016
Nir Barzilai, Jill P Crandall, Stephen B Kritchevsky, Mark A Espeland. Cell Metab 2016
9
TOR signaling in growth and metabolism.
Stephan Wullschleger, Robbie Loewith, Michael N Hall. Cell 2006
Stephan Wullschleger, Robbie Loewith, Michael N Hall. Cell 2006
9
mTOR at the nexus of nutrition, growth, ageing and disease.
Grace Y Liu, David M Sabatini. Nat Rev Mol Cell Biol 2020
Grace Y Liu, David M Sabatini. Nat Rev Mol Cell Biol 2020
9
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.