Marcelino Avilés-Trigueros, Sergio Mayor-Torroglosa, Antonio García-Avilés, María P Lafuente, María E Rodríguez, Jaime Miralles de Imperial, María P Villegas-Pérez, Manuel Vidal-Sanz. Exp Neurol 2003
Times Cited: 60
Times Cited: 60
Times Cited
Times Co-cited
Similarity
Ischemia results 3 months later in altered ERG, degeneration of inner layers, and deafferented tectum: neuroprotection with brimonidine.
Sergio Mayor-Torroglosa, Pedro De la Villa, María Elena Rodríguez, María P Lafuente López-Herrera, Marcelino Avilés-Trigueros, Antonio García-Avilés, Jaime Miralles de Imperial, María P Villegas-Pérez, Manuel Vidal-Sanz. Invest Ophthalmol Vis Sci 2005
Sergio Mayor-Torroglosa, Pedro De la Villa, María Elena Rodríguez, María P Lafuente López-Herrera, Marcelino Avilés-Trigueros, Antonio García-Avilés, Jaime Miralles de Imperial, María P Villegas-Pérez, Manuel Vidal-Sanz. Invest Ophthalmol Vis Sci 2005
55
Transient ischemia of the retina results in altered retrograde axoplasmic transport: neuroprotection with brimonidine.
María P Lafuente López-Herrera, Sergio Mayor-Torroglosa, Jaime Miralles de Imperial, María P Villegas-Pérez, Manuel Vidal-Sanz. Exp Neurol 2002
María P Lafuente López-Herrera, Sergio Mayor-Torroglosa, Jaime Miralles de Imperial, María P Villegas-Pérez, Manuel Vidal-Sanz. Exp Neurol 2002
48
Neuroprotection of retinal ganglion cells by brimonidine in rats with laser-induced chronic ocular hypertension.
E WoldeMussie, G Ruiz, M Wijono, L A Wheeler. Invest Ophthalmol Vis Sci 2001
E WoldeMussie, G Ruiz, M Wijono, L A Wheeler. Invest Ophthalmol Vis Sci 2001
43
Brn3a as a marker of retinal ganglion cells: qualitative and quantitative time course studies in naive and optic nerve-injured retinas.
Francisco M Nadal-Nicolás, Manuel Jiménez-López, Paloma Sobrado-Calvo, Leticia Nieto-López, Isabel Cánovas-Martínez, Manuel Salinas-Navarro, Manuel Vidal-Sanz, Marta Agudo. Invest Ophthalmol Vis Sci 2009
Francisco M Nadal-Nicolás, Manuel Jiménez-López, Paloma Sobrado-Calvo, Leticia Nieto-López, Isabel Cánovas-Martínez, Manuel Salinas-Navarro, Manuel Vidal-Sanz, Marta Agudo. Invest Ophthalmol Vis Sci 2009
36
Neuroprotective effects of brimonidine against transient ischemia-induced retinal ganglion cell death: a dose response in vivo study.
M P Lafuente, M P Villegas-Pérez, S Mayor, M E Aguilera, J Miralles de Imperial, Manuel Vidal-Sanz. Exp Eye Res 2002
M P Lafuente, M P Villegas-Pérez, S Mayor, M E Aguilera, J Miralles de Imperial, Manuel Vidal-Sanz. Exp Eye Res 2002
35
Retinal ganglion cell death after different transient periods of pressure-induced ischemia and survival intervals. A quantitative in vivo study.
I Sellés-Navarro, M P Villegas-Pérez, M Salvador-Silva, J M Ruiz-Gómez, M Vidal-Sanz. Invest Ophthalmol Vis Sci 1996
I Sellés-Navarro, M P Villegas-Pérez, M Salvador-Silva, J M Ruiz-Gómez, M Vidal-Sanz. Invest Ophthalmol Vis Sci 1996
31
A computerized analysis of the entire retinal ganglion cell population and its spatial distribution in adult rats.
M Salinas-Navarro, S Mayor-Torroglosa, M Jiménez-López, M Avilés-Trigueros, T M Holmes, R D Lund, M P Villegas-Pérez, M Vidal-Sanz. Vision Res 2009
M Salinas-Navarro, S Mayor-Torroglosa, M Jiménez-López, M Avilés-Trigueros, T M Holmes, R D Lund, M P Villegas-Pérez, M Vidal-Sanz. Vision Res 2009
31
Effects of axotomy and intraocular administration of NT-4, NT-3, and brain-derived neurotrophic factor on the survival of adult rat retinal ganglion cells. A quantitative in vivo study.
P Peinado-Ramón, M Salvador, M P Villegas-Pérez, M Vidal-Sanz. Invest Ophthalmol Vis Sci 1996
P Peinado-Ramón, M Salvador, M P Villegas-Pérez, M Vidal-Sanz. Invest Ophthalmol Vis Sci 1996
30
Rapid and protracted phases of retinal ganglion cell loss follow axotomy in the optic nerve of adult rats.
M P Villegas-Pérez, M Vidal-Sanz, M Rasminsky, G M Bray, A J Aguayo. J Neurobiol 1993
M P Villegas-Pérez, M Vidal-Sanz, M Rasminsky, G M Bray, A J Aguayo. J Neurobiol 1993
30
Retinal ganglion cells downregulate gene expression and lose their axons within the optic nerve head in a mouse glaucoma model.
Ileana Soto, Ericka Oglesby, Brian P Buckingham, Janice L Son, Elisha D O Roberson, Michael R Steele, Denise M Inman, Monica L Vetter, Philip J Horner, Nicholas Marsh-Armstrong. J Neurosci 2008
Ileana Soto, Ericka Oglesby, Brian P Buckingham, Janice L Son, Elisha D O Roberson, Michael R Steele, Denise M Inman, Monica L Vetter, Philip J Horner, Nicholas Marsh-Armstrong. J Neurosci 2008
28
Retinal ganglion cell death after acute retinal ischemia is an ongoing process whose severity and duration depends on the duration of the insult.
M P Lafuente, M P Villegas-Pérez, I Sellés-Navarro, S Mayor-Torroglosa, J Miralles de Imperial, M Vidal-Sanz. Neuroscience 2002
M P Lafuente, M P Villegas-Pérez, I Sellés-Navarro, S Mayor-Torroglosa, J Miralles de Imperial, M Vidal-Sanz. Neuroscience 2002
26
Up-regulation of brain-derived neurotrophic factor expression by brimonidine in rat retinal ganglion cells.
Hua Gao, Xiaoxi Qiao, Louis B Cantor, Darrell WuDunn. Arch Ophthalmol 2002
Hua Gao, Xiaoxi Qiao, Louis B Cantor, Darrell WuDunn. Arch Ophthalmol 2002
26
Death and neuroprotection of retinal ganglion cells after different types of injury.
M Vidal-Sanz, M Lafuente, P Sobrado-Calvo, I Selles-Navarro, E Rodriguez, S Mayor-Torroglosa, M P Villegas-Perez. Neurotox Res 2000
M Vidal-Sanz, M Lafuente, P Sobrado-Calvo, I Selles-Navarro, E Rodriguez, S Mayor-Torroglosa, M P Villegas-Perez. Neurotox Res 2000
26
Rat retinal microglial cells under normal conditions, after optic nerve section, and after optic nerve section and intravitreal injection of trophic factors or macrophage inhibitory factor.
Paloma Sobrado-Calvo, Manuel Vidal-Sanz, María P Villegas-Pérez. J Comp Neurol 2007
Paloma Sobrado-Calvo, Manuel Vidal-Sanz, María P Villegas-Pérez. J Comp Neurol 2007
26
Ocular hypertension impairs optic nerve axonal transport leading to progressive retinal ganglion cell degeneration.
Manuel Salinas-Navarro, Luis Alarcón-Martínez, Francisco J Valiente-Soriano, Manuel Jiménez-López, Sergio Mayor-Torroglosa, Marcelino Avilés-Trigueros, María Paz Villegas-Pérez, Manuel Vidal-Sanz. Exp Eye Res 2010
Manuel Salinas-Navarro, Luis Alarcón-Martínez, Francisco J Valiente-Soriano, Manuel Jiménez-López, Sergio Mayor-Torroglosa, Marcelino Avilés-Trigueros, María Paz Villegas-Pérez, Manuel Vidal-Sanz. Exp Eye Res 2010
26
Functional and morphological effects of laser-induced ocular hypertension in retinas of adult albino Swiss mice.
Manuel Salinas-Navarro, Luis Alarcón-Martínez, Francisco Javier Valiente-Soriano, Arturo Ortín-Martínez, Manuel Jiménez-López, Marcelino Avilés-Trigueros, María Paz Villegas-Pérez, Pedro de la Villa, Manuel Vidal-Sanz. Mol Vis 2009
Manuel Salinas-Navarro, Luis Alarcón-Martínez, Francisco Javier Valiente-Soriano, Arturo Ortín-Martínez, Manuel Jiménez-López, Marcelino Avilés-Trigueros, María Paz Villegas-Pérez, Pedro de la Villa, Manuel Vidal-Sanz. Mol Vis 2009
26
Alpha2-adrenoreceptor agonists are neuroprotective in a rat model of optic nerve degeneration.
E Yoles, L A Wheeler, M Schwartz. Invest Ophthalmol Vis Sci 1999
E Yoles, L A Wheeler, M Schwartz. Invest Ophthalmol Vis Sci 1999
25
Neuroprotective effects of alpha(2)-selective adrenergic agonists against ischemia-induced retinal ganglion cell death.
M P Lafuente, M P Villegas-Pérez, P Sobrado-Calvo, A García-Avilés, J Miralles de Imperial, M Vidal-Sanz. Invest Ophthalmol Vis Sci 2001
M P Lafuente, M P Villegas-Pérez, P Sobrado-Calvo, A García-Avilés, J Miralles de Imperial, M Vidal-Sanz. Invest Ophthalmol Vis Sci 2001
25
Effects of ocular injury and administration of brain-derived neurotrophic factor on survival and regrowth of axotomized retinal ganglion cells.
S Mansour-Robaey, D B Clarke, Y C Wang, G M Bray, A J Aguayo. Proc Natl Acad Sci U S A 1994
S Mansour-Robaey, D B Clarke, Y C Wang, G M Bray, A J Aguayo. Proc Natl Acad Sci U S A 1994
23
Retinal ganglion cell death induced by retinal ischemia. neuroprotective effects of two alpha-2 agonists.
M Vidal-Sanz, M P Lafuente, S Mayor, J M de Imperial, M P Villegas-Pérez. Surv Ophthalmol 2001
M Vidal-Sanz, M P Lafuente, S Mayor, J M de Imperial, M P Villegas-Pérez. Surv Ophthalmol 2001
23
Progressive ganglion cell degeneration precedes neuronal loss in a mouse model of glaucoma.
Brian P Buckingham, Denise M Inman, Wendi Lambert, Ericka Oglesby, David J Calkins, Michael R Steele, Monica L Vetter, Nicholas Marsh-Armstrong, Philip J Horner. J Neurosci 2008
Brian P Buckingham, Denise M Inman, Wendi Lambert, Ericka Oglesby, David J Calkins, Michael R Steele, Monica L Vetter, Nicholas Marsh-Armstrong, Philip J Horner. J Neurosci 2008
23
Effects of different neurotrophic factors on the survival of retinal ganglion cells after a complete intraorbital nerve crush injury: a quantitative in vivo study.
Guillermo Parrilla-Reverter, Marta Agudo, Paloma Sobrado-Calvo, Manuel Salinas-Navarro, María P Villegas-Pérez, Manuel Vidal-Sanz. Exp Eye Res 2009
Guillermo Parrilla-Reverter, Marta Agudo, Paloma Sobrado-Calvo, Manuel Salinas-Navarro, María P Villegas-Pérez, Manuel Vidal-Sanz. Exp Eye Res 2009
23
Retinal ganglion cell population in adult albino and pigmented mice: a computerized analysis of the entire population and its spatial distribution.
M Salinas-Navarro, M Jiménez-López, F J Valiente-Soriano, L Alarcón-Martínez, M Avilés-Trigueros, S Mayor, T Holmes, R D Lund, M P Villegas-Pérez, M Vidal-Sanz. Vision Res 2009
M Salinas-Navarro, M Jiménez-López, F J Valiente-Soriano, L Alarcón-Martínez, M Avilés-Trigueros, S Mayor, T Holmes, R D Lund, M P Villegas-Pérez, M Vidal-Sanz. Vision Res 2009
23
Alpha 2-adrenergic agonists induce basic fibroblast growth factor expression in photoreceptors in vivo and ameliorate light damage.
R Wen, T Cheng, Y Li, W Cao, R H Steinberg. J Neurosci 1996
R Wen, T Cheng, Y Li, W Cao, R H Steinberg. J Neurosci 1996
21
Reinnervation of the pretectum in adult rats by regenerated retinal ganglion cell axons: anatomical and functional studies.
Manuel Vidal-Sanz, Marcelino Avilés-Trigueros, Simon J O Whiteley, Yves Sauvé, Raymond D Lund. Prog Brain Res 2002
Manuel Vidal-Sanz, Marcelino Avilés-Trigueros, Simon J O Whiteley, Yves Sauvé, Raymond D Lund. Prog Brain Res 2002
36
Immediate upregulation of proteins belonging to different branches of the apoptotic cascade in the retina after optic nerve transection and optic nerve crush.
Marta Agudo, Maria C Pérez-Marín, Paloma Sobrado-Calvo, Ulrika Lönngren, Manuel Salinas-Navarro, Isabel Cánovas, Francisco M Nadal-Nicolás, Jaime Miralles-Imperial, Finn Hallböök, Manuel Vidal-Sanz. Invest Ophthalmol Vis Sci 2009
Marta Agudo, Maria C Pérez-Marín, Paloma Sobrado-Calvo, Ulrika Lönngren, Manuel Salinas-Navarro, Isabel Cánovas, Francisco M Nadal-Nicolás, Jaime Miralles-Imperial, Finn Hallböök, Manuel Vidal-Sanz. Invest Ophthalmol Vis Sci 2009
21
Time course profiling of the retinal transcriptome after optic nerve transection and optic nerve crush.
Marta Agudo, Maria Cruz Pérez-Marín, Ulrika Lönngren, Paloma Sobrado, Ana Conesa, Isabel Cánovas, Manuel Salinas-Navarro, Jaime Miralles-Imperial, Finn Hallböök, Manuel Vidal-Sanz. Mol Vis 2008
Marta Agudo, Maria Cruz Pérez-Marín, Ulrika Lönngren, Paloma Sobrado, Ana Conesa, Isabel Cánovas, Manuel Salinas-Navarro, Jaime Miralles-Imperial, Finn Hallböök, Manuel Vidal-Sanz. Mol Vis 2008
21
The growth factor response in ischemic rat retina and superior colliculus after brimonidine pre-treatment.
Ulrika Lönngren, Ulla Näpänkangas, Maria Lafuente, Sergio Mayor, Niclas Lindqvist, Manuel Vidal-Sanz, Finn Hallböök. Brain Res Bull 2006
Ulrika Lönngren, Ulla Näpänkangas, Maria Lafuente, Sergio Mayor, Niclas Lindqvist, Manuel Vidal-Sanz, Finn Hallböök. Brain Res Bull 2006
24
Influences of peripheral nerve grafts on the survival and regrowth of axotomized retinal ganglion cells in adult rats.
M P Villegas-Pérez, M Vidal-Sanz, G M Bray, A J Aguayo. J Neurosci 1988
M P Villegas-Pérez, M Vidal-Sanz, G M Bray, A J Aguayo. J Neurosci 1988
20
alpha(2)-Adrenoceptor agonists inhibit vitreal glutamate and aspartate accumulation and preserve retinal function after transient ischemia.
J E Donello, E U Padillo, M L Webster, L A Wheeler, D W Gil. J Pharmacol Exp Ther 2001
J E Donello, E U Padillo, M L Webster, L A Wheeler, D W Gil. J Pharmacol Exp Ther 2001
20
Changes in Thy1 gene expression associated with damaged retinal ganglion cells.
C L Schlamp, E C Johnson, Y Li, J C Morrison, R W Nickells. Mol Vis 2001
C L Schlamp, E C Johnson, Y Li, J C Morrison, R W Nickells. Mol Vis 2001
20
Mechanism of retinal ganglion cell loss in inherited retinal dystrophy.
M P Villegas-Pérez, M Vidal-Sanz, R D Lund. Neuroreport 1996
M P Villegas-Pérez, M Vidal-Sanz, R D Lund. Neuroreport 1996
21
Extent and duration of recovered pupillary light reflex following retinal ganglion cell axon regeneration through peripheral nerve grafts directed to the pretectum in adult rats.
S J Whiteley, Y Sauvé, M Avilés-Trigueros, M Vidal-Sanz, R D Lund. Exp Neurol 1998
S J Whiteley, Y Sauvé, M Avilés-Trigueros, M Vidal-Sanz, R D Lund. Exp Neurol 1998
23
Measurement of retinal injury in the rat after optic nerve transection: an RT-PCR study.
Glyn Chidlow, Robert Casson, Paloma Sobrado-Calvo, Manuel Vidal-Sanz, Neville N Osborne. Mol Vis 2005
Glyn Chidlow, Robert Casson, Paloma Sobrado-Calvo, Manuel Vidal-Sanz, Neville N Osborne. Mol Vis 2005
20
Whole number, distribution and co-expression of brn3 transcription factors in retinal ganglion cells of adult albino and pigmented rats.
Francisco M Nadal-Nicolás, Manuel Jiménez-López, Manuel Salinas-Navarro, Paloma Sobrado-Calvo, Juan J Alburquerque-Béjar, Manuel Vidal-Sanz, Marta Agudo-Barriuso. PLoS One 2012
Francisco M Nadal-Nicolás, Manuel Jiménez-López, Manuel Salinas-Navarro, Paloma Sobrado-Calvo, Juan J Alburquerque-Béjar, Manuel Vidal-Sanz, Marta Agudo-Barriuso. PLoS One 2012
20
Understanding glaucomatous damage: anatomical and functional data from ocular hypertensive rodent retinas.
Manuel Vidal-Sanz, Manuel Salinas-Navarro, Francisco M Nadal-Nicolás, Luis Alarcón-Martínez, F Javier Valiente-Soriano, Jaime Miralles de Imperial, Marcelino Avilés-Trigueros, Marta Agudo-Barriuso, Maria P Villegas-Pérez. Prog Retin Eye Res 2012
Manuel Vidal-Sanz, Manuel Salinas-Navarro, Francisco M Nadal-Nicolás, Luis Alarcón-Martínez, F Javier Valiente-Soriano, Jaime Miralles de Imperial, Marcelino Avilés-Trigueros, Marta Agudo-Barriuso, Maria P Villegas-Pérez. Prog Retin Eye Res 2012
20
Alpha-2 adrenoceptor agonist protects retinal function after acute retinal ischemic injury in the rat.
Ronald K Lai, Teresa Chun, Dain Hasson, Steve Lee, Farrokh Mehrbod, Larry Wheeler. Vis Neurosci 2002
Ronald K Lai, Teresa Chun, Dain Hasson, Steve Lee, Farrokh Mehrbod, Larry Wheeler. Vis Neurosci 2002
18
Evidence for an amacrine cell system in the ganglion cell layer of the rat retina.
V H Perry. Neuroscience 1981
V H Perry. Neuroscience 1981
18
Retinal ganglion cell degeneration is topological but not cell type specific in DBA/2J mice.
Tatjana C Jakobs, Richard T Libby, Yixin Ben, Simon W M John, Richard H Masland. J Cell Biol 2005
Tatjana C Jakobs, Richard T Libby, Yixin Ben, Simon W M John, Richard H Masland. J Cell Biol 2005
18
Microglial cells in the retina of Carassius auratus: effects of optic nerve crush.
M Salvador-Silva, M Vidal-Sanz, M P Villegas-Pérez. J Comp Neurol 2000
M Salvador-Silva, M Vidal-Sanz, M P Villegas-Pérez. J Comp Neurol 2000
25
Time-course of the retinal nerve fibre layer degeneration after complete intra-orbital optic nerve transection or crush: a comparative study.
Guillermo Parrilla-Reverter, Marta Agudo, Francisco Nadal-Nicolás, Luis Alarcón-Martínez, Manuel Jiménez-López, Manuel Salinas-Navarro, Paloma Sobrado-Calvo, José M Bernal-Garro, María P Villegas-Pérez, Manuel Vidal-Sanz. Vision Res 2009
Guillermo Parrilla-Reverter, Marta Agudo, Francisco Nadal-Nicolás, Luis Alarcón-Martínez, Manuel Jiménez-López, Manuel Salinas-Navarro, Paloma Sobrado-Calvo, José M Bernal-Garro, María P Villegas-Pérez, Manuel Vidal-Sanz. Vision Res 2009
18
Automated quantification and topographical distribution of the whole population of S- and L-cones in adult albino and pigmented rats.
Arturo Ortín-Martínez, Manuel Jiménez-López, Francisco M Nadal-Nicolás, Manuel Salinas-Navarro, Luis Alarcón-Martínez, Yves Sauvé, Maria Paz Villegas-Pérez, Manuel Vidal-Sanz, Marta Agudo-Barriuso. Invest Ophthalmol Vis Sci 2010
Arturo Ortín-Martínez, Manuel Jiménez-López, Francisco M Nadal-Nicolás, Manuel Salinas-Navarro, Luis Alarcón-Martínez, Yves Sauvé, Maria Paz Villegas-Pérez, Manuel Vidal-Sanz, Marta Agudo-Barriuso. Invest Ophthalmol Vis Sci 2010
18
Neuroprotective effect of alpha(2) agonist (brimonidine) on adult rat retinal ganglion cells after increased intraocular pressure.
F A Ahmed, K Hegazy, P Chaudhary, S C Sharma. Brain Res 2001
F A Ahmed, K Hegazy, P Chaudhary, S C Sharma. Brain Res 2001
17
GDNF, Ret, GFRalpha1 and 2 in the adult rat retino-tectal system after optic nerve transection.
Niclas Lindqvist, Paloma Peinado-Ramónn, Manuel Vidal-Sanz, Finn Hallböök. Exp Neurol 2004
Niclas Lindqvist, Paloma Peinado-Ramónn, Manuel Vidal-Sanz, Finn Hallböök. Exp Neurol 2004
16
Translimbal laser photocoagulation to the trabecular meshwork as a model of glaucoma in rats.
Hana Levkovitch-Verbin, Harry A Quigley, Keith R G Martin, Danielle Valenta, Lisa A Baumrind, Mary Ellen Pease. Invest Ophthalmol Vis Sci 2002
Hana Levkovitch-Verbin, Harry A Quigley, Keith R G Martin, Danielle Valenta, Lisa A Baumrind, Mary Ellen Pease. Invest Ophthalmol Vis Sci 2002
16
A rat model of chronic pressure-induced optic nerve damage.
J C Morrison, C G Moore, L M Deppmeier, B G Gold, C K Meshul, E C Johnson. Exp Eye Res 1997
J C Morrison, C G Moore, L M Deppmeier, B G Gold, C K Meshul, E C Johnson. Exp Eye Res 1997
16
Axonal regeneration and synapse formation in the superior colliculus by retinal ganglion cells in the adult rat.
M Vidal-Sanz, G M Bray, M P Villegas-Pérez, S Thanos, A J Aguayo. J Neurosci 1987
M Vidal-Sanz, G M Bray, M P Villegas-Pérez, S Thanos, A J Aguayo. J Neurosci 1987
16
Selective innervation of retinorecipient brainstem nuclei by retinal ganglion cell axons regenerating through peripheral nerve grafts in adult rats.
M Avilés-Trigueros, Y Sauvé, R D Lund, M Vidal-Sanz. J Neurosci 2000
M Avilés-Trigueros, Y Sauvé, R D Lund, M Vidal-Sanz. J Neurosci 2000
28
Phototoxic-induced photoreceptor degeneration causes retinal ganglion cell degeneration in pigmented rats.
Marco Antonio Marco-Gomariz, Natalia Hurtado-Montalbán, Manuel Vidal-Sanz, Ray D Lund, María Paz Villegas-Pérez. J Comp Neurol 2006
Marco Antonio Marco-Gomariz, Natalia Hurtado-Montalbán, Manuel Vidal-Sanz, Ray D Lund, María Paz Villegas-Pérez. J Comp Neurol 2006
18
Progressive optic axon dystrophy and vacuslar changes in rd mice.
S Wang, M P Villegas-Pérez, M Vidal-Sanz, R D Lund. Invest Ophthalmol Vis Sci 2000
S Wang, M P Villegas-Pérez, M Vidal-Sanz, R D Lund. Invest Ophthalmol Vis Sci 2000
16
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.