Filippo Del Bene, Kristin Tessmar-Raible, Joachim Wittbrodt. Nature 2004
Times Cited: 197
Times Cited: 197
Times Cited
Times Co-cited
Similarity
The cell-cycle regulator geminin inhibits Hox function through direct and polycomb-mediated interactions.
Lingfei Luo, Xiaoping Yang, Yoshihiro Takihara, Hendrik Knoetgen, Michael Kessel. Nature 2004
Lingfei Luo, Xiaoping Yang, Yoshihiro Takihara, Hendrik Knoetgen, Michael Kessel. Nature 2004
49
Geminin, an inhibitor of DNA replication, is degraded during mitosis.
T J McGarry, M W Kirschner. Cell 1998
T J McGarry, M W Kirschner. Cell 1998
43
Geminin regulates neuronal differentiation by antagonizing Brg1 activity.
Seongjin Seo, Anabel Herr, Jong-Won Lim, Genova A Richardson, Helena Richardson, Kristen L Kroll. Genes Dev 2005
Seongjin Seo, Anabel Herr, Jong-Won Lim, Genova A Richardson, Helena Richardson, Kristen L Kroll. Genes Dev 2005
42
Inhibition of eukaryotic DNA replication by geminin binding to Cdt1.
J A Wohlschlegel, B T Dwyer, S K Dhar, C Cvetic, J C Walter, A Dutta. Science 2000
J A Wohlschlegel, B T Dwyer, S K Dhar, C Cvetic, J C Walter, A Dutta. Science 2000
39
Geminin, a neuralizing molecule that demarcates the future neural plate at the onset of gastrulation.
K L Kroll, A N Salic, L M Evans, M W Kirschner. Development 1998
K L Kroll, A N Salic, L M Evans, M W Kirschner. Development 1998
32
Repression of origin assembly in metaphase depends on inhibition of RLF-B/Cdt1 by geminin.
S Tada, A Li, D Maiorano, M Méchali, J J Blow. Nat Cell Biol 2001
S Tada, A Li, D Maiorano, M Méchali, J J Blow. Nat Cell Biol 2001
28
Geminin is essential to prevent endoreduplication and to form pluripotent cells during mammalian development.
Michael A Gonzalez, Kiku-e K Tachibana, David J Adams, Louise van der Weyden, Myriam Hemberger, Nicholas Coleman, Allan Bradley, Ronald A Laskey. Genes Dev 2006
Michael A Gonzalez, Kiku-e K Tachibana, David J Adams, Louise van der Weyden, Myriam Hemberger, Nicholas Coleman, Allan Bradley, Ronald A Laskey. Genes Dev 2006
27
Six3 repression of Wnt signaling in the anterior neuroectoderm is essential for vertebrate forebrain development.
Oleg V Lagutin, Changqi C Zhu, Daisuke Kobayashi, Jacek Topczewski, Kenji Shimamura, Luis Puelles, Helen R C Russell, Peter J McKinnon, Lilianna Solnica-Krezel, Guillermo Oliver. Genes Dev 2003
Oleg V Lagutin, Changqi C Zhu, Daisuke Kobayashi, Jacek Topczewski, Kenji Shimamura, Luis Puelles, Helen R C Russell, Peter J McKinnon, Lilianna Solnica-Krezel, Guillermo Oliver. Genes Dev 2003
22
Geminin is essential for the development of preimplantation mouse embryos.
Kentaro Hara, Keiichi I Nakayama, Keiko Nakayama. Genes Cells 2006
Kentaro Hara, Keiichi I Nakayama, Keiko Nakayama. Genes Cells 2006
41
Six3, a murine homologue of the sine oculis gene, demarcates the most anterior border of the developing neural plate and is expressed during eye development.
G Oliver, A Mailhos, R Wehr, N G Copeland, N A Jenkins, P Gruss. Development 1995
G Oliver, A Mailhos, R Wehr, N G Copeland, N A Jenkins, P Gruss. Development 1995
18
Geminin promotes neural fate acquisition of embryonic stem cells by maintaining chromatin in an accessible and hyperacetylated state.
Dhananjay Yellajoshyula, Ethan S Patterson, Matthew S Elitt, Kristen L Kroll. Proc Natl Acad Sci U S A 2011
Dhananjay Yellajoshyula, Ethan S Patterson, Matthew S Elitt, Kristen L Kroll. Proc Natl Acad Sci U S A 2011
40
Haploinsufficiency of Six3 fails to activate Sonic hedgehog expression in the ventral forebrain and causes holoprosencephaly.
Xin Geng, Christina Speirs, Oleg Lagutin, Adi Inbal, Wei Liu, Lilianna Solnica-Krezel, Yongsu Jeong, Douglas J Epstein, Guillermo Oliver. Dev Cell 2008
Xin Geng, Christina Speirs, Oleg Lagutin, Adi Inbal, Wei Liu, Lilianna Solnica-Krezel, Yongsu Jeong, Douglas J Epstein, Guillermo Oliver. Dev Cell 2008
17
Loss of Geminin induces rereplication in the presence of functional p53.
Marina Melixetian, Andrea Ballabeni, Laura Masiero, Patrizia Gasparini, Raffaella Zamponi, Jiri Bartek, Jiri Lukas, Kristian Helin. J Cell Biol 2004
Marina Melixetian, Andrea Ballabeni, Laura Masiero, Patrizia Gasparini, Raffaella Zamponi, Jiri Bartek, Jiri Lukas, Kristian Helin. J Cell Biol 2004
16
The Drosophila Geminin homolog: roles for Geminin in limiting DNA replication, in anaphase and in neurogenesis.
L M Quinn, A Herr, T J McGarry, H Richardson. Genes Dev 2001
L M Quinn, A Herr, T J McGarry, H Richardson. Genes Dev 2001
16
Six3 functions in anterior neural plate specification by promoting cell proliferation and inhibiting Bmp4 expression.
Gaia Gestri, Matthias Carl, Irene Appolloni, Stephen W Wilson, Giuseppina Barsacchi, Massimiliano Andreazzoli. Development 2005
Gaia Gestri, Matthias Carl, Irene Appolloni, Stephen W Wilson, Giuseppina Barsacchi, Massimiliano Andreazzoli. Development 2005
21
Regulation of a remote Shh forebrain enhancer by the Six3 homeoprotein.
Yongsu Jeong, Federico Coluccio Leskow, Kenia El-Jaick, Erich Roessler, Maximilian Muenke, Anastasia Yocum, Christele Dubourg, Xue Li, Xin Geng, Guillermo Oliver,[...]. Nat Genet 2008
Yongsu Jeong, Federico Coluccio Leskow, Kenia El-Jaick, Erich Roessler, Maximilian Muenke, Anastasia Yocum, Christele Dubourg, Xue Li, Xin Geng, Guillermo Oliver,[...]. Nat Genet 2008
15
A Cdt1-geminin complex licenses chromatin for DNA replication and prevents rereplication during S phase in Xenopus.
Malik Lutzmann, Domenico Maiorano, Marcel Méchali. EMBO J 2006
Malik Lutzmann, Domenico Maiorano, Marcel Méchali. EMBO J 2006
19
Geminin coordinates cell cycle and developmental control.
Lingfei Luo, Michael Kessel. Cell Cycle 2004
Lingfei Luo, Michael Kessel. Cell Cycle 2004
38
Rereplication by depletion of geminin is seen regardless of p53 status and activates a G2/M checkpoint.
Wenge Zhu, Yuefeng Chen, Anindya Dutta. Mol Cell Biol 2004
Wenge Zhu, Yuefeng Chen, Anindya Dutta. Mol Cell Biol 2004
14
Licensing regulators Geminin and Cdt1 identify progenitor cells of the mouse CNS in a specific phase of the cell cycle.
M Spella, O Britz, P Kotantaki, Z Lygerou, H Nishitani, R G Ramsay, C Flordellis, F Guillemot, T Mantamadiotis, S Taraviras. Neuroscience 2007
M Spella, O Britz, P Kotantaki, Z Lygerou, H Nishitani, R G Ramsay, C Flordellis, F Guillemot, T Mantamadiotis, S Taraviras. Neuroscience 2007
38
Geminin's double life: chromatin connections that regulate transcription at the transition from proliferation to differentiation.
Seongjin Seo, Kristen L Kroll. Cell Cycle 2006
Seongjin Seo, Kristen L Kroll. Cell Cycle 2006
29
Selective killing of cancer cells by suppression of geminin activity.
Wenge Zhu, Melvin L Depamphilis. Cancer Res 2009
Wenge Zhu, Melvin L Depamphilis. Cancer Res 2009
16
Six3 overexpression initiates the formation of ectopic retina.
F Loosli, S Winkler, J Wittbrodt. Genes Dev 1999
F Loosli, S Winkler, J Wittbrodt. Genes Dev 1999
13
Six3 inactivation reveals its essential role for the formation and patterning of the vertebrate eye.
Matthias Carl, Felix Loosli, Joachim Wittbrodt. Development 2002
Matthias Carl, Felix Loosli, Joachim Wittbrodt. Development 2002
13
A mechanism regulating the onset of Sox2 expression in the embryonic neural plate.
Costis Papanayotou, Anne Mey, Anne-Marie Birot, Yasushi Saka, Sharon Boast, Jim C Smith, Jacques Samarut, Claudio D Stern. PLoS Biol 2008
Costis Papanayotou, Anne Mey, Anne-Marie Birot, Yasushi Saka, Sharon Boast, Jim C Smith, Jacques Samarut, Claudio D Stern. PLoS Biol 2008
14
Geminin deficiency causes a Chk1-dependent G2 arrest in Xenopus.
Thomas J McGarry. Mol Biol Cell 2002
Thomas J McGarry. Mol Biol Cell 2002
17
Geminin regulates cortical progenitor proliferation and differentiation.
Magda Spella, Christina Kyrousi, Eva Kritikou, Athanasia Stathopoulou, François Guillemot, Dimitris Kioussis, Vassilis Pachnis, Zoi Lygerou, Stavros Taraviras. Stem Cells 2011
Magda Spella, Christina Kyrousi, Eva Kritikou, Athanasia Stathopoulou, François Guillemot, Dimitris Kioussis, Vassilis Pachnis, Zoi Lygerou, Stavros Taraviras. Stem Cells 2011
33
Structural basis for inhibition of the replication licensing factor Cdt1 by geminin.
Changwook Lee, BumSoo Hong, Jung Min Choi, Yugene Kim, Saori Watanabe, Yukio Ishimi, Takemi Enomoto, Shusuke Tada, Youngchang Kim, Yunje Cho. Nature 2004
Changwook Lee, BumSoo Hong, Jung Min Choi, Yugene Kim, Saori Watanabe, Yukio Ishimi, Takemi Enomoto, Shusuke Tada, Youngchang Kim, Yunje Cho. Nature 2004
12
Cdt1 and geminin are down-regulated upon cell cycle exit and are over-expressed in cancer-derived cell lines.
Georgia Xouri, Zoi Lygerou, Hideo Nishitani, Vassilis Pachnis, Paul Nurse, Stavros Taraviras. Eur J Biochem 2004
Georgia Xouri, Zoi Lygerou, Hideo Nishitani, Vassilis Pachnis, Paul Nurse, Stavros Taraviras. Eur J Biochem 2004
12
Differential geminin requirement for proliferation of thymocytes and mature T cells.
Dimitris Karamitros, Panorea Kotantaki, Zoi Lygerou, Henrique Veiga-Fernandes, Vassilis Pachnis, Dimitris Kioussis, Stavros Taraviras. J Immunol 2010
Dimitris Karamitros, Panorea Kotantaki, Zoi Lygerou, Henrique Veiga-Fernandes, Vassilis Pachnis, Dimitris Kioussis, Stavros Taraviras. J Immunol 2010
42
Geminin deletion from hematopoietic cells causes anemia and thrombocytosis in mice.
Kathryn M Shinnick, Elizabeth A Eklund, Thomas J McGarry. J Clin Invest 2010
Kathryn M Shinnick, Elizabeth A Eklund, Thomas J McGarry. J Clin Invest 2010
44
Geminin cooperates with Polycomb to restrain multi-lineage commitment in the early embryo.
Jong-Won Lim, Pamela Hummert, Jason C Mills, Kristen L Kroll. Development 2011
Jong-Won Lim, Pamela Hummert, Jason C Mills, Kristen L Kroll. Development 2011
27
Overexpression of the forebrain-specific homeobox gene six3 induces rostral forebrain enlargement in zebrafish.
M Kobayashi, R Toyama, H Takeda, I B Dawid, K Kawakami. Development 1998
M Kobayashi, R Toyama, H Takeda, I B Dawid, K Kawakami. Development 1998
11
Mutations in the homeodomain of the human SIX3 gene cause holoprosencephaly.
D E Wallis, E Roessler, U Hehr, L Nanni, T Wiltshire, A Richieri-Costa, G Gillessen-Kaesbach, E H Zackai, J Rommens, M Muenke. Nat Genet 1999
D E Wallis, E Roessler, U Hehr, L Nanni, T Wiltshire, A Richieri-Costa, G Gillessen-Kaesbach, E H Zackai, J Rommens, M Muenke. Nat Genet 1999
11
Geminin escapes degradation in G1 of mouse pluripotent cells and mediates the expression of Oct4, Sox2, and Nanog.
Valerie S Yang, Stephanie A Carter, Sarah J Hyland, Kikuë Tachibana-Konwalski, Ronald A Laskey, Michael A Gonzalez. Curr Biol 2011
Valerie S Yang, Stephanie A Carter, Sarah J Hyland, Kikuë Tachibana-Konwalski, Ronald A Laskey, Michael A Gonzalez. Curr Biol 2011
18
A dimerized coiled-coil domain and an adjoining part of geminin interact with two sites on Cdt1 for replication inhibition.
Sandeep Saxena, Ping Yuan, Suman Kumar Dhar, Takeshi Senga, David Takeda, Howard Robinson, Sally Kornbluth, Kunchithapadam Swaminathan, Anindya Dutta. Mol Cell 2004
Sandeep Saxena, Ping Yuan, Suman Kumar Dhar, Takeshi Senga, David Takeda, Howard Robinson, Sally Kornbluth, Kunchithapadam Swaminathan, Anindya Dutta. Mol Cell 2004
14
The homeobox protein Six3 interacts with the Groucho corepressor and acts as a transcriptional repressor in eye and forebrain formation.
M Kobayashi, K Nishikawa, T Suzuki, M Yamamoto. Dev Biol 2001
M Kobayashi, K Nishikawa, T Suzuki, M Yamamoto. Dev Biol 2001
10
Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis.
Hideo Nishitani, Nozomi Sugimoto, Vassilis Roukos, Yohsuke Nakanishi, Masafumi Saijo, Chikashi Obuse, Toshiki Tsurimoto, Keiichi I Nakayama, Keiko Nakayama, Masatoshi Fujita,[...]. EMBO J 2006
Hideo Nishitani, Nozomi Sugimoto, Vassilis Roukos, Yohsuke Nakanishi, Masafumi Saijo, Chikashi Obuse, Toshiki Tsurimoto, Keiichi I Nakayama, Keiko Nakayama, Masatoshi Fujita,[...]. EMBO J 2006
10
Polycomb-group complex 1 acts as an E3 ubiquitin ligase for Geminin to sustain hematopoietic stem cell activity.
Motoaki Ohtsubo, Shin'ichiro Yasunaga, Yoshinori Ohno, Miyuki Tsumura, Satoshi Okada, Nobutsune Ishikawa, Kenichiro Shirao, Akira Kikuchi, Hideo Nishitani, Masao Kobayashi,[...]. Proc Natl Acad Sci U S A 2008
Motoaki Ohtsubo, Shin'ichiro Yasunaga, Yoshinori Ohno, Miyuki Tsumura, Satoshi Okada, Nobutsune Ishikawa, Kenichiro Shirao, Akira Kikuchi, Hideo Nishitani, Masao Kobayashi,[...]. Proc Natl Acad Sci U S A 2008
20
Mutations in the human SIX3 gene in holoprosencephaly are loss of function.
Sabina Domené, Erich Roessler, Kenia B El-Jaick, Mirit Snir, Jamie L Brown, Jorge I Vélez, Sherri Bale, Felicitas Lacbawan, Maximilian Muenke, Benjamin Feldman. Hum Mol Genet 2008
Sabina Domené, Erich Roessler, Kenia B El-Jaick, Mirit Snir, Jamie L Brown, Jorge I Vélez, Sherri Bale, Felicitas Lacbawan, Maximilian Muenke, Benjamin Feldman. Hum Mol Genet 2008
21
Six3 represses nodal activity to establish early brain asymmetry in zebrafish.
Adi Inbal, Seok-Hyung Kim, Jimann Shin, Lilianna Solnica-Krezel. Neuron 2007
Adi Inbal, Seok-Hyung Kim, Jimann Shin, Lilianna Solnica-Krezel. Neuron 2007
20
Human geminin promotes pre-RC formation and DNA replication by stabilizing CDT1 in mitosis.
Andrea Ballabeni, Marina Melixetian, Raffaella Zamponi, Laura Masiero, Federica Marinoni, Kristian Helin. EMBO J 2004
Andrea Ballabeni, Marina Melixetian, Raffaella Zamponi, Laura Masiero, Federica Marinoni, Kristian Helin. EMBO J 2004
9
Preventing re-replication of chromosomal DNA.
J Julian Blow, Anindya Dutta. Nat Rev Mol Cell Biol 2005
J Julian Blow, Anindya Dutta. Nat Rev Mol Cell Biol 2005
9
Six3, a medaka homologue of the Drosophila homeobox gene sine oculis is expressed in the anterior embryonic shield and the developing eye.
F Loosli, R W Köster, M Carl, A Krone, J Wittbrodt. Mech Dev 1998
F Loosli, R W Köster, M Carl, A Krone, J Wittbrodt. Mech Dev 1998
9
A repressor complex, AP4 transcription factor and geminin, negatively regulates expression of target genes in nonneuronal cells.
Mi-Young Kim, Byung Chul Jeong, Ji Hee Lee, Hae Jin Kee, Hyun Kook, Nack Sung Kim, Yoon Ha Kim, Jong-Keun Kim, Kyu Youn Ahn, Kyung Keun Kim. Proc Natl Acad Sci U S A 2006
Mi-Young Kim, Byung Chul Jeong, Ji Hee Lee, Hae Jin Kee, Hyun Kook, Nack Sung Kim, Yoon Ha Kim, Jong-Keun Kim, Kyu Youn Ahn, Kyung Keun Kim. Proc Natl Acad Sci U S A 2006
13
Cell type-specific responses of human cells to inhibition of replication licensing.
S Shreeram, Alison Sparks, David P Lane, J Julian Blow. Oncogene 2002
S Shreeram, Alison Sparks, David P Lane, J Julian Blow. Oncogene 2002
9
HBO1 histone acetylase activity is essential for DNA replication licensing and inhibited by Geminin.
Benoit Miotto, Kevin Struhl. Mol Cell 2010
Benoit Miotto, Kevin Struhl. Mol Cell 2010
9
Geminin has dimerization, Cdt1-binding, and destruction domains that are required for biological activity.
Jacqueline M Benjamin, Susanna J Torke, Borries Demeler, Thomas J McGarry. J Biol Chem 2004
Jacqueline M Benjamin, Susanna J Torke, Borries Demeler, Thomas J McGarry. J Biol Chem 2004
23
Quaternary structure of the human Cdt1-Geminin complex regulates DNA replication licensing.
V De Marco, P J Gillespie, A Li, N Karantzelis, E Christodoulou, R Klompmaker, S van Gerwen, A Fish, M V Petoukhov, M S Iliou,[...]. Proc Natl Acad Sci U S A 2009
V De Marco, P J Gillespie, A Li, N Karantzelis, E Christodoulou, R Klompmaker, S van Gerwen, A Fish, M V Petoukhov, M S Iliou,[...]. Proc Natl Acad Sci U S A 2009
16
Chromatin unfolding by Cdt1 regulates MCM loading via opposing functions of HBO1 and HDAC11-geminin.
Philip G Wong, Michele A Glozak, Thinh V Cao, Cyrus Vaziri, Edward Seto, Mark Alexandrow. Cell Cycle 2010
Philip G Wong, Michele A Glozak, Thinh V Cao, Cyrus Vaziri, Edward Seto, Mark Alexandrow. Cell Cycle 2010
17
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.