A citation-based method for searching scientific literature

Juliette Gafni, Evan Hermel, Jessica E Young, Cheryl L Wellington, Michael R Hayden, Lisa M Ellerby. J Biol Chem 2004
Times Cited: 199







List of co-cited articles
1652 articles co-cited >1



Times Cited
  Times     Co-cited
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Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin.
Rona K Graham, Yu Deng, Elizabeth J Slow, Brendan Haigh, Nagat Bissada, Ge Lu, Jacqueline Pearson, Jacqueline Shehadeh, Lisa Bertram, Zoe Murphy,[...]. Cell 2006
458
54

Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain.
M DiFiglia, E Sapp, K O Chase, S W Davies, G P Bates, J P Vonsattel, N Aronin. Science 1997
46



Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice.
L Mangiarini, K Sathasivam, M Seller, B Cozens, A Harper, C Hetherington, M Lawton, Y Trottier, H Lehrach, S W Davies,[...]. Cell 1996
36

Caspase cleavage of mutant huntingtin precedes neurodegeneration in Huntington's disease.
Cheryl L Wellington, Lisa M Ellerby, Claire-Anne Gutekunst, Danny Rogers, Simon Warby, Rona K Graham, Odell Loubser, Jeremy van Raamsdonk, Roshni Singaraja, Yu-Zhou Yang,[...]. J Neurosci 2002
238
35

Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation.
S W Davies, M Turmaine, B A Cozens, M DiFiglia, A H Sharp, C A Ross, E Scherzinger, E E Wanker, L Mangiarini, G P Bates. Cell 1997
32

Calpain activation in Huntington's disease.
Juliette Gafni, Lisa M Ellerby. J Neurosci 2002
209
32

Proteases acting on mutant huntingtin generate cleaved products that differentially build up cytoplasmic and nuclear inclusions.
Astrid Lunkes, Katrin S Lindenberg, Léa Ben-Haïem, Chantal Weber, Didier Devys, G Bernhard Landwehrmeyer, Jean-Louis Mandel, Yvon Trottier. Mol Cell 2002
268
32

Inhibiting caspase cleavage of huntingtin reduces toxicity and aggregate formation in neuronal and nonneuronal cells.
C L Wellington, R Singaraja, L Ellerby, J Savill, S Roy, B Leavitt, E Cattaneo, A Hackam, A Sharp, N Thornberry,[...]. J Biol Chem 2000
254
31

Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract.
C L Wellington, L M Ellerby, A S Hackam, R L Margolis, M A Trifiro, R Singaraja, K McCutcheon, G S Salvesen, S S Propp, M Bromm,[...]. J Biol Chem 1998
420
29

Proteolysis of mutant huntingtin produces an exon 1 fragment that accumulates as an aggregated protein in neuronal nuclei in Huntington disease.
Christian Landles, Kirupa Sathasivam, Andreas Weiss, Ben Woodman, Hilary Moffitt, Steve Finkbeiner, Banghua Sun, Juliette Gafni, Lisa M Ellerby, Yvon Trottier,[...]. J Biol Chem 2010
207
27

Matrix metalloproteinases are modifiers of huntingtin proteolysis and toxicity in Huntington's disease.
John P Miller, Jennifer Holcomb, Ismael Al-Ramahi, Maria de Haro, Juliette Gafni, Ningzhe Zhang, Eugene Kim, Mario Sanhueza, Cameron Torcassi, Seung Kwak,[...]. Neuron 2010
116
26

Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death.
Montserrat Arrasate, Siddhartha Mitra, Erik S Schweitzer, Mark R Segal, Steven Finkbeiner. Nature 2004
22

Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease.
Elizabeth J Slow, Jeremy van Raamsdonk, Daniel Rogers, Sarah H Coleman, Rona K Graham, Yu Deng, Rosemary Oh, Nagat Bissada, Sazzad M Hossain, Yu-Zhou Yang,[...]. Hum Mol Genet 2003
552
21

Neuropathological classification of Huntington's disease.
J P Vonsattel, R H Myers, T J Stevens, R J Ferrante, E D Bird, E P Richardson. J Neuropathol Exp Neurol 1985
21

Specific caspase interactions and amplification are involved in selective neuronal vulnerability in Huntington's disease.
E Hermel, J Gafni, S S Propp, B R Leavitt, C L Wellington, J E Young, A S Hackam, A V Logvinova, A L Peel, S F Chen,[...]. Cell Death Differ 2004
148
20

Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract.
Y P Goldberg, D W Nicholson, D M Rasper, M A Kalchman, H B Koide, R K Graham, M Bromm, P Kazemi-Esfarjani, N A Thornberry, J P Vaillancourt,[...]. Nat Genet 1996
462
20

Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease.
C Zuccato, A Ciammola, D Rigamonti, B R Leavitt, D Goffredo, L Conti, M E MacDonald, R M Friedlander, V Silani, M R Hayden,[...]. Science 2001
908
19

SUMO modification of Huntingtin and Huntington's disease pathology.
Joan S Steffan, Namita Agrawal, Judit Pallos, Erica Rockabrand, Lloyd C Trotman, Natalia Slepko, Katalin Illes, Tamas Lukacsovich, Ya-Zhen Zhu, Elena Cattaneo,[...]. Science 2004
476
19

Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin.
G Schilling, M W Becher, A H Sharp, H A Jinnah, K Duan, J A Kotzuk, H H Slunt, T Ratovitski, J K Cooper, N A Jenkins,[...]. Hum Mol Genet 1999
572
19

Nuclear and neuropil aggregates in Huntington's disease: relationship to neuropathology.
C A Gutekunst, S H Li, H Yi, J S Mulroy, S Kuemmerle, R Jones, D Rye, R J Ferrante, S M Hersch, X J Li. J Neurosci 1999
608
18

Full-length human mutant huntingtin with a stable polyglutamine repeat can elicit progressive and selective neuropathogenesis in BACHD mice.
Michelle Gray, Dyna I Shirasaki, Carlos Cepeda, Véronique M André, Brian Wilburn, Xiao-Hong Lu, Jifang Tao, Irene Yamazaki, Shi-Hua Li, Yi E Sun,[...]. J Neurosci 2008
414
18

IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome.
Leslie Michels Thompson, Charity T Aiken, Linda S Kaltenbach, Namita Agrawal, Katalin Illes, Ali Khoshnan, Marta Martinez-Vincente, Montserrat Arrasate, Jacqueline Gire O'Rourke, Hasan Khashwji,[...]. J Cell Biol 2009
238
18

The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription.
J S Steffan, A Kazantsev, O Spasic-Boskovic, M Greenwald, Y Z Zhu, H Gohler, E E Wanker, G P Bates, D E Housman, L M Thompson. Proc Natl Acad Sci U S A 2000
773
17

Early increase in extrasynaptic NMDA receptor signaling and expression contributes to phenotype onset in Huntington's disease mice.
Austen J Milnerwood, Clare M Gladding, Mahmoud A Pouladi, Alexandra M Kaufman, Rochelle M Hines, Jamie D Boyd, Rebecca W Y Ko, Oana C Vasuta, Rona K Graham, Michael R Hayden,[...]. Neuron 2010
333
17

Length of huntingtin and its polyglutamine tract influences localization and frequency of intracellular aggregates.
D Martindale, A Hackam, A Wieczorek, L Ellerby, C Wellington, K McCutcheon, R Singaraja, P Kazemi-Esfarjani, R Devon, S U Kim,[...]. Nat Genet 1998
374
17

Targeted disruption of the Huntington's disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotes.
J Nasir, S B Floresco, J R O'Kusky, V M Diewert, J M Richman, J Zeisler, A Borowski, J D Marth, A G Phillips, M R Hayden. Cell 1995
578
17

Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila.
J S Steffan, L Bodai, J Pallos, M Poelman, A McCampbell, B L Apostol, A Kazantsev, E Schmidt, Y Z Zhu, M Greenwald,[...]. Nature 2001
884
16

Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines.
Alexander V Panov, Claire-Anne Gutekunst, Blair R Leavitt, Michael R Hayden, James R Burke, Warren J Strittmatter, J Timothy Greenamyre. Nat Neurosci 2002
723
16

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease.
Brinda Ravikumar, Coralie Vacher, Zdenek Berger, Janet E Davies, Shouqing Luo, Lourdes G Oroz, Francesco Scaravilli, Douglas F Easton, Rainer Duden, Cahir J O'Kane,[...]. Nat Genet 2004
16

Inactivation of the mouse Huntington's disease gene homolog Hdh.
M P Duyao, A B Auerbach, A Ryan, F Persichetti, G T Barnes, S M McNeil, P Ge, J P Vonsattel, J F Gusella, A L Joyner. Science 1995
482
16

A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration.
J G Hodgson, N Agopyan, C A Gutekunst, B R Leavitt, F LePiane, R Singaraja, D J Smith, N Bissada, K McCutcheon, J Nasir,[...]. Neuron 1999
616
15

Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes.
Chiara Zuccato, Marzia Tartari, Andrea Crotti, Donato Goffredo, Marta Valenza, Luciano Conti, Tiziana Cataudella, Blair R Leavitt, Michael R Hayden, Tõnis Timmusk,[...]. Nat Genet 2003
632
15

Huntington disease.
J P Vonsattel, M DiFiglia. J Neuropathol Exp Neurol 1998
15

Serines 13 and 16 are critical determinants of full-length human mutant huntingtin induced disease pathogenesis in HD mice.
Xiaofeng Gu, Erin R Greiner, Rakesh Mishra, Ravindra Kodali, Alex Osmand, Steven Finkbeiner, Joan S Steffan, Leslie Michels Thompson, Ronald Wetzel, X William Yang. Neuron 2009
211
15

The influence of huntingtin protein size on nuclear localization and cellular toxicity.
A S Hackam, R Singaraja, C L Wellington, M Metzler, K McCutcheon, T Zhang, M Kalchman, M R Hayden. J Cell Biol 1998
254
15

Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules.
Laurent R Gauthier, Bénédicte C Charrin, Maria Borrell-Pagès, Jim P Dompierre, Hélène Rangone, Fabrice P Cordelières, Jan De Mey, Marcy E MacDonald, Volkmar Lessmann, Sandrine Humbert,[...]. Cell 2004
764
15

Aberrant splicing of HTT generates the pathogenic exon 1 protein in Huntington disease.
Kirupa Sathasivam, Andreas Neueder, Theresa A Gipson, Christian Landles, Agnesska C Benjamin, Marie K Bondulich, Donna L Smith, Richard L M Faull, Raymund A C Roos, David Howland,[...]. Proc Natl Acad Sci U S A 2013
249
15

Normal huntingtin function: an alternative approach to Huntington's disease.
Elena Cattaneo, Chiara Zuccato, Marzia Tartari. Nat Rev Neurosci 2005
422
14

Acetylation targets mutant huntingtin to autophagosomes for degradation.
Hyunkyung Jeong, Florian Then, Thomas J Melia, Joseph R Mazzulli, Libin Cui, Jeffrey N Savas, Cindy Voisine, Paolo Paganetti, Naoko Tanese, Anne C Hart,[...]. Cell 2009
265
14

Cleavage at the 586 amino acid caspase-6 site in mutant huntingtin influences caspase-6 activation in vivo.
Rona K Graham, Yu Deng, Jeffery Carroll, Kuljeet Vaid, Catherine Cowan, Mahmoud A Pouladi, Martina Metzler, Nagat Bissada, Lili Wang, Richard L M Faull,[...]. J Neurosci 2010
73
19

Increased apoptosis and early embryonic lethality in mice nullizygous for the Huntington's disease gene homologue.
S Zeitlin, J P Liu, D L Chapman, V E Papaioannou, A Efstratiadis. Nat Genet 1995
545
14

Activated caspase-6 and caspase-6-cleaved fragments of huntingtin specifically colocalize in the nucleus.
Simon C Warby, Crystal N Doty, Rona K Graham, Jeffrey B Carroll, Yu-Zhou Yang, Roshni R Singaraja, Christopher M Overall, Michael R Hayden. Hum Mol Genet 2008
92
14

Huntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1,4,5) triphosphate receptor type 1.
Tie-Shan Tang, Huiping Tu, Edmond Y W Chan, Anton Maximov, Zhengnan Wang, Cheryl L Wellington, Michael R Hayden, Ilya Bezprozvanny. Neuron 2003
350
13


Neurological abnormalities in a knock-in mouse model of Huntington's disease.
C H Lin, S Tallaksen-Greene, W M Chien, J A Cearley, W S Jackson, A B Crouse, S Ren, X J Li, R L Albin, P J Detloff. Hum Mol Genet 2001
429
13


Polyglutamine-modulated striatal calpain activity in YAC transgenic huntington disease mouse model: impact on NMDA receptor function and toxicity.
Catherine M Cowan, Mannie M Y Fan, Jing Fan, Jacqueline Shehadeh, Lily Y J Zhang, Rona K Graham, Michael R Hayden, Lynn A Raymond. J Neurosci 2008
53
22

Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin.
Shu-ichi Okamoto, Mahmoud A Pouladi, Maria Talantova, Dongdong Yao, Peng Xia, Dagmar E Ehrnhoefer, Rameez Zaidi, Arjay Clemente, Marcus Kaul, Rona K Graham,[...]. Nat Med 2009
305
12


Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.