Tom Stiff, Mark O'Driscoll, Nicole Rief, Kuniyoshi Iwabuchi, Markus Löbrich, Penny A Jeggo. Cancer Res 2004
Times Cited: 757
Times Cited: 757
Times Cited
Times Co-cited
Similarity
DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139.
E P Rogakou, D R Pilch, A H Orr, V S Ivanova, W M Bonner. J Biol Chem 1998
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ATM phosphorylates histone H2AX in response to DNA double-strand breaks.
S Burma, B P Chen, M Murphy, A Kurimasa, D J Chen. J Biol Chem 2001
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DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation.
Christopher J Bakkenist, Michael B Kastan. Nature 2003
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The DNA damage response: making it safe to play with knives.
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ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response.
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Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress.
I M Ward, J Chen. J Biol Chem 2001
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Megabase chromatin domains involved in DNA double-strand breaks in vivo.
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The DNA-damage response in human biology and disease.
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ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.
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Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks.
Arkady Celeste, Oscar Fernandez-Capetillo, Michael J Kruhlak, Duane R Pilch, David W Staudt, Alicia Lee, Robert F Bonner, William M Bonner, André Nussenzweig. Nat Cell Biol 2003
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Genomic instability in mice lacking histone H2AX.
Arkady Celeste, Simone Petersen, Peter J Romanienko, Oscar Fernandez-Capetillo, Hua Tang Chen, Olga A Sedelnikova, Bernardo Reina-San-Martin, Vincenzo Coppola, Eric Meffre, Michael J Difilippantonio,[...]. Science 2002
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11
MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks.
Manuel Stucki, Julie A Clapperton, Duaa Mohammad, Michael B Yaffe, Stephen J Smerdon, Stephen P Jackson. Cell 2005
Manuel Stucki, Julie A Clapperton, Duaa Mohammad, Michael B Yaffe, Stephen J Smerdon, Stephen P Jackson. Cell 2005
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Requirement of the MRN complex for ATM activation by DNA damage.
Tamar Uziel, Yaniv Lerenthal, Lilach Moyal, Yair Andegeko, Leonid Mittelman, Yosef Shiloh. EMBO J 2003
Tamar Uziel, Yaniv Lerenthal, Lilach Moyal, Yair Andegeko, Leonid Mittelman, Yosef Shiloh. EMBO J 2003
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53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark.
Amélie Fradet-Turcotte, Marella D Canny, Cristina Escribano-Díaz, Alexandre Orthwein, Charles C Y Leung, Hao Huang, Marie-Claude Landry, Julianne Kitevski-LeBlanc, Sylvie M Noordermeer, Frank Sicheri,[...]. Nature 2013
Amélie Fradet-Turcotte, Marella D Canny, Cristina Escribano-Díaz, Alexandre Orthwein, Charles C Y Leung, Hao Huang, Marie-Claude Landry, Julianne Kitevski-LeBlanc, Sylvie M Noordermeer, Frank Sicheri,[...]. Nature 2013
10
RNF168 ubiquitinates K13-15 on H2A/H2AX to drive DNA damage signaling.
Francesca Mattiroli, Joseph H A Vissers, Willem J van Dijk, Pauline Ikpa, Elisabetta Citterio, Wim Vermeulen, Jurgen A Marteijn, Titia K Sixma. Cell 2012
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ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex.
Ji-Hoon Lee, Tanya T Paull. Science 2005
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10
The ATM protein kinase: regulating the cellular response to genotoxic stress, and more.
Yosef Shiloh, Yael Ziv. Nat Rev Mol Cell Biol 2013
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10
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The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage.
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9
RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins.
Niels Mailand, Simon Bekker-Jensen, Helene Faustrup, Fredrik Melander, Jiri Bartek, Claudia Lukas, Jiri Lukas. Cell 2007
Niels Mailand, Simon Bekker-Jensen, Helene Faustrup, Fredrik Melander, Jiri Bartek, Claudia Lukas, Jiri Lukas. Cell 2007
9
Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage.
Jacob Falck, Julia Coates, Stephen P Jackson. Nature 2005
Jacob Falck, Julia Coates, Stephen P Jackson. Nature 2005
9
Non-homologous DNA end joining and alternative pathways to double-strand break repair.
Howard H Y Chang, Nicholas R Pannunzio, Noritaka Adachi, Michael R Lieber. Nat Rev Mol Cell Biol 2017
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9
DNA double-strand break repair-pathway choice in somatic mammalian cells.
Ralph Scully, Arvind Panday, Rajula Elango, Nicholas A Willis. Nat Rev Mol Cell Biol 2019
Ralph Scully, Arvind Panday, Rajula Elango, Nicholas A Willis. Nat Rev Mol Cell Biol 2019
9
Histone H1 couples initiation and amplification of ubiquitin signalling after DNA damage.
Tina Thorslund, Anita Ripplinger, Saskia Hoffmann, Thomas Wild, Michael Uckelmann, Bine Villumsen, Takeo Narita, Titia K Sixma, Chunaram Choudhary, Simon Bekker-Jensen,[...]. Nature 2015
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8
RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly.
Michael S Y Huen, Robert Grant, Isaac Manke, Kay Minn, Xiaochun Yu, Michael B Yaffe, Junjie Chen. Cell 2007
Michael S Y Huen, Robert Grant, Isaac Manke, Kay Minn, Xiaochun Yu, Michael B Yaffe, Junjie Chen. Cell 2007
8
Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes.
Lee Zou, Stephen J Elledge. Science 2003
Lee Zou, Stephen J Elledge. Science 2003
8
Double-strand break repair: 53BP1 comes into focus.
Stephanie Panier, Simon J Boulton. Nat Rev Mol Cell Biol 2014
Stephanie Panier, Simon J Boulton. Nat Rev Mol Cell Biol 2014
8
A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci.
Enriqueta Riballo, Martin Kühne, Nicole Rief, Aidan Doherty, Graeme C M Smith, María-José Recio, Caroline Reis, Kirsten Dahm, Andreas Fricke, Andrea Krempler,[...]. Mol Cell 2004
Enriqueta Riballo, Martin Kühne, Nicole Rief, Aidan Doherty, Graeme C M Smith, María-José Recio, Caroline Reis, Kirsten Dahm, Andreas Fricke, Andrea Krempler,[...]. Mol Cell 2004
8
A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage.
T T Paull, E P Rogakou, V Yamazaki, C U Kirchgessner, M Gellert, W M Bonner. Curr Biol 2000
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Repair Pathway Choices and Consequences at the Double-Strand Break.
Raphael Ceccaldi, Beatrice Rondinelli, Alan D D'Andrea. Trends Cell Biol 2016
Raphael Ceccaldi, Beatrice Rondinelli, Alan D D'Andrea. Trends Cell Biol 2016
8
Transcriptionally active chromatin recruits homologous recombination at DNA double-strand breaks.
François Aymard, Beatrix Bugler, Christine K Schmidt, Emmanuelle Guillou, Pierre Caron, Sébastien Briois, Jason S Iacovoni, Virginie Daburon, Kyle M Miller, Stephen P Jackson,[...]. Nat Struct Mol Biol 2014
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7
RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins.
Carsten Doil, Niels Mailand, Simon Bekker-Jensen, Patrice Menard, Dorthe Helena Larsen, Rainer Pepperkok, Jan Ellenberg, Stephanie Panier, Daniel Durocher, Jiri Bartek,[...]. Cell 2009
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7
Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair.
Maria Victoria Botuyan, Joseph Lee, Irene M Ward, Ja-Eun Kim, James R Thompson, Junjie Chen, Georges Mer. Cell 2006
Maria Victoria Botuyan, Joseph Lee, Irene M Ward, Ja-Eun Kim, James R Thompson, Junjie Chen, Georges Mer. Cell 2006
7
Histone H2A.Z controls a critical chromatin remodeling step required for DNA double-strand break repair.
Ye Xu, Marina K Ayrapetov, Chang Xu, Ozge Gursoy-Yuzugullu, Yiduo Hu, Brendan D Price. Mol Cell 2012
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Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM.
Ian Hickson, Yan Zhao, Caroline J Richardson, Sharon J Green, Niall M B Martin, Alisdair I Orr, Philip M Reaper, Stephen P Jackson, Nicola J Curtin, Graeme C M Smith. Cancer Res 2004
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53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks.
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Complex H2AX phosphorylation patterns by multiple kinases including ATM and DNA-PK in human cells exposed to ionizing radiation and treated with kinase inhibitors.
Hongyan Wang, Minli Wang, Huichen Wang, Wilfried Böcker, George Iliakis. J Cell Physiol 2005
Hongyan Wang, Minli Wang, Huichen Wang, Wilfried Böcker, George Iliakis. J Cell Physiol 2005
7
7
Ataxia telangiectasia mutated (ATM) is essential for DNA-PKcs phosphorylations at the Thr-2609 cluster upon DNA double strand break.
Benjamin P C Chen, Naoya Uematsu, Junya Kobayashi, Yaniv Lerenthal, Andrea Krempler, Hirohiko Yajima, Markus Löbrich, Yosef Shiloh, David J Chen. J Biol Chem 2007
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ATR: an essential regulator of genome integrity.
Karlene A Cimprich, David Cortez. Nat Rev Mol Cell Biol 2008
Karlene A Cimprich, David Cortez. Nat Rev Mol Cell Biol 2008
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Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase.
Helen E Bryant, Niklas Schultz, Huw D Thomas, Kayan M Parker, Dan Flower, Elena Lopez, Suzanne Kyle, Mark Meuth, Nicola J Curtin, Thomas Helleday. Nature 2005
Helen E Bryant, Niklas Schultz, Huw D Thomas, Kayan M Parker, Dan Flower, Elena Lopez, Suzanne Kyle, Mark Meuth, Nicola J Curtin, Thomas Helleday. Nature 2005
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Kinase-dead ATM protein causes genomic instability and early embryonic lethality in mice.
Kenta Yamamoto, Yunyue Wang, Wenxia Jiang, Xiangyu Liu, Richard L Dubois, Chyuan-Sheng Lin, Thomas Ludwig, Christopher J Bakkenist, Shan Zha. J Cell Biol 2012
Kenta Yamamoto, Yunyue Wang, Wenxia Jiang, Xiangyu Liu, Richard L Dubois, Chyuan-Sheng Lin, Thomas Ludwig, Christopher J Bakkenist, Shan Zha. J Cell Biol 2012
8
A single ataxia telangiectasia gene with a product similar to PI-3 kinase.
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DNA damage sensing by the ATM and ATR kinases.
Alexandre Maréchal, Lee Zou. Cold Spring Harb Perspect Biol 2013
Alexandre Maréchal, Lee Zou. Cold Spring Harb Perspect Biol 2013
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PARP inhibitors: Synthetic lethality in the clinic.
Christopher J Lord, Alan Ashworth. Science 2017
Christopher J Lord, Alan Ashworth. Science 2017
7
ATM, ATR and DNA-PKcs kinases-the lessons from the mouse models: inhibition ≠ deletion.
Demis Menolfi, Shan Zha. Cell Biosci 2020
Demis Menolfi, Shan Zha. Cell Biosci 2020
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A macrohistone variant links dynamic chromatin compaction to BRCA1-dependent genome maintenance.
Simran Khurana, Michael J Kruhlak, Jeongkyu Kim, Andy D Tran, Jinping Liu, Katherine Nyswaner, Lei Shi, Parthav Jailwala, Myong-Hee Sung, Ofir Hakim,[...]. Cell Rep 2014
Simran Khurana, Michael J Kruhlak, Jeongkyu Kim, Andy D Tran, Jinping Liu, Katherine Nyswaner, Lei Shi, Parthav Jailwala, Myong-Hee Sung, Ofir Hakim,[...]. Cell Rep 2014
6
WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity.
Andrew Xiao, Haitao Li, David Shechter, Sung Hee Ahn, Laura A Fabrizio, Hediye Erdjument-Bromage, Satoko Ishibe-Murakami, Bin Wang, Paul Tempst, Kay Hofmann,[...]. Nature 2009
Andrew Xiao, Haitao Li, David Shechter, Sung Hee Ahn, Laura A Fabrizio, Hediye Erdjument-Bromage, Satoko Ishibe-Murakami, Bin Wang, Paul Tempst, Kay Hofmann,[...]. Nature 2009
6
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