A citation-based method for searching scientific literature

Joan S Steffan, Namita Agrawal, Judit Pallos, Erica Rockabrand, Lloyd C Trotman, Natalia Slepko, Katalin Illes, Tamas Lukacsovich, Ya-Zhen Zhu, Elena Cattaneo, Pier Paolo Pandolfi, Leslie Michels Thompson, J Lawrence Marsh. Science 2004
Times Cited: 497







List of co-cited articles
1536 articles co-cited >1



Times Cited
  Times     Co-cited
Similarity


IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome.
Leslie Michels Thompson, Charity T Aiken, Linda S Kaltenbach, Namita Agrawal, Katalin Illes, Ali Khoshnan, Marta Martinez-Vincente, Montserrat Arrasate, Jacqueline Gire O'Rourke, Hasan Khashwji,[...]. J Cell Biol 2009
255
28


The Biology of Huntingtin.
Frédéric Saudou, Sandrine Humbert. Neuron 2016
388
25

Serines 13 and 16 are critical determinants of full-length human mutant huntingtin induced disease pathogenesis in HD mice.
Xiaofeng Gu, Erin R Greiner, Rakesh Mishra, Ravindra Kodali, Alex Osmand, Steven Finkbeiner, Joan S Steffan, Leslie Michels Thompson, Ronald Wetzel, X William Yang. Neuron 2009
222
23

Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice.
L Mangiarini, K Sathasivam, M Seller, B Cozens, A Harper, C Hetherington, M Lawton, Y Trottier, H Lehrach, S W Davies,[...]. Cell 1996
19

SUMO-2 and PIAS1 modulate insoluble mutant huntingtin protein accumulation.
Jacqueline Gire O'Rourke, Jaclyn R Gareau, Joseph Ochaba, Wan Song, Tamás Raskó, David Reverter, John Lee, Alex Mas Monteys, Judit Pallos, Lisa Mee,[...]. Cell Rep 2013
65
29

Rhes, a striatal specific protein, mediates mutant-huntingtin cytotoxicity.
Srinivasa Subramaniam, Katherine M Sixt, Roxanne Barrow, Solomon H Snyder. Science 2009
236
18

Polyglutamine disruption of the huntingtin exon 1 N terminus triggers a complex aggregation mechanism.
Ashwani K Thakur, Murali Jayaraman, Rakesh Mishra, Monika Thakur, Veronique M Chellgren, In-Ja L Byeon, Dalaver H Anjum, Ravindra Kodali, Trevor P Creamer, James F Conway,[...]. Nat Struct Mol Biol 2009
308
18

Huntingtin has a membrane association signal that can modulate huntingtin aggregation, nuclear entry and toxicity.
Randy Singh Atwal, Jianrun Xia, Deborah Pinchev, Jillian Taylor, Richard M Epand, Ray Truant. Hum Mol Genet 2007
263
18

Phosphorylation of threonine 3: implications for Huntingtin aggregation and neurotoxicity.
Charity T Aiken, Joan S Steffan, Cortnie M Guerrero, Hasan Khashwji, Tamas Lukacsovich, Danielle Simmons, Judy M Purcell, Kimia Menhaji, Ya-Zhen Zhu, Kim Green,[...]. J Biol Chem 2009
111
18

Sumoylation: a regulatory protein modification in health and disease.
Annette Flotho, Frauke Melchior. Annu Rev Biochem 2013
686
18

Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain.
M DiFiglia, E Sapp, K O Chase, S W Davies, G P Bates, J P Vonsattel, N Aronin. Science 1997
18

Kinase inhibitors modulate huntingtin cell localization and toxicity.
Randy Singh Atwal, Carly R Desmond, Nicholas Caron, Tamara Maiuri, Jianrun Xia, Simonetta Sipione, Ray Truant. Nat Chem Biol 2011
120
17

Acetylation within the First 17 Residues of Huntingtin Exon 1 Alters Aggregation and Lipid Binding.
Maxmore Chaibva, Sudi Jawahery, Albert W Pilkington, James R Arndt, Olivia Sarver, Stephen Valentine, Silvina Matysiak, Justin Legleiter. Biophys J 2016
35
40

Sumoylation inhibits alpha-synuclein aggregation and toxicity.
Petranka Krumova, Erik Meulmeester, Manuel Garrido, Marilyn Tirard, He-Hsuan Hsiao, Guillaume Bossis, Henning Urlaub, Markus Zweckstetter, Sebastian Kügler, Frauke Melchior,[...]. J Cell Biol 2011
161
14

SUMOylation at K340 inhibits tau degradation through deregulating its phosphorylation and ubiquitination.
Hong-Bin Luo, Yi-Yuan Xia, Xi-Ji Shu, Zan-Chao Liu, Ye Feng, Xing-Hua Liu, Guang Yu, Gang Yin, Yan-Si Xiong, Kuan Zeng,[...]. Proc Natl Acad Sci U S A 2014
116
14

SUMO: a history of modification.
Ronald T Hay. Mol Cell 2005
14

The first 17 amino acids of Huntingtin modulate its sub-cellular localization, aggregation and effects on calcium homeostasis.
Erica Rockabrand, Natalia Slepko, Antonello Pantalone, Vidya N Nukala, Aleksey Kazantsev, J Lawrence Marsh, Patrick G Sullivan, Joan S Steffan, Stefano L Sensi, Leslie Michels Thompson. Hum Mol Genet 2007
192
14

Huntington's disease: from molecular pathogenesis to clinical treatment.
Christopher A Ross, Sarah J Tabrizi. Lancet Neurol 2011
933
14

The SUMO pathway: emerging mechanisms that shape specificity, conjugation and recognition.
Jaclyn R Gareau, Christopher D Lima. Nat Rev Mol Cell Biol 2010
786
13

The emerging role of the first 17 amino acids of huntingtin in Huntington's disease.
James R Arndt, Maxmore Chaibva, Justin Legleiter. Biomol Concepts 2015
39
30

Mutant Exon1 Huntingtin Aggregation is Regulated by T3 Phosphorylation-Induced Structural Changes and Crosstalk between T3 Phosphorylation and Acetylation at K6.
Anass Chiki, Sean M DeGuire, Francesco S Ruggeri, Domenico Sanfelice, Annalisa Ansaloni, Zhe-Ming Wang, Urszula Cendrowska, Ritwik Burai, Sophie Vieweg, Annalisa Pastore,[...]. Angew Chem Int Ed Engl 2017
38
31

Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation.
S W Davies, M Turmaine, B A Cozens, M DiFiglia, A H Sharp, C A Ross, E Scherzinger, E E Wanker, L Mangiarini, G P Bates. Cell 1997
12

Differential ubiquitination and degradation of huntingtin fragments modulated by ubiquitin-protein ligase E3A.
Kavita P Bhat, Sen Yan, Chuan-En Wang, Shihua Li, Xiao-Jiang Li. Proc Natl Acad Sci U S A 2014
70
17

Neuronal SUMOylation: mechanisms, physiology, and roles in neuronal dysfunction.
Jeremy M Henley, Tim J Craig, Kevin A Wilkinson. Physiol Rev 2014
119
12

A comprehensive compilation of SUMO proteomics.
Ivo A Hendriks, Alfred C O Vertegaal. Nat Rev Mol Cell Biol 2016
259
12


Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death.
Montserrat Arrasate, Siddhartha Mitra, Erik S Schweitzer, Mark R Segal, Steven Finkbeiner. Nature 2004
11

Potential function for the Huntingtin protein as a scaffold for selective autophagy.
Joseph Ochaba, Tamás Lukacsovich, George Csikos, Shuqiu Zheng, Julia Margulis, Lisa Salazar, Kai Mao, Alice L Lau, Sylvia Y Yeung, Sandrine Humbert,[...]. Proc Natl Acad Sci U S A 2014
166
11

Palmitoylation of huntingtin by HIP14 is essential for its trafficking and function.
Anat Yanai, Kun Huang, Rujun Kang, Roshni R Singaraja, Pamela Arstikaitis, Lu Gan, Paul C Orban, Asher Mullard, Catherine M Cowan, Lynn A Raymond,[...]. Nat Neurosci 2006
208
11

The chaperonin TRiC blocks a huntingtin sequence element that promotes the conformational switch to aggregation.
Stephen Tam, Christoph Spiess, William Auyeung, Lukasz Joachimiak, Bryan Chen, Michelle A Poirier, Judith Frydman. Nat Struct Mol Biol 2009
178
11

Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin.
Rona K Graham, Yu Deng, Elizabeth J Slow, Brendan Haigh, Nagat Bissada, Ge Lu, Jacqueline Pearson, Jacqueline Shehadeh, Lisa Bertram, Zoe Murphy,[...]. Cell 2006
471
11

Concepts in sumoylation: a decade on.
Ruth Geiss-Friedlander, Frauke Melchior. Nat Rev Mol Cell Biol 2007
11


Protein aggregates in Huntington's disease.
Montserrat Arrasate, Steven Finkbeiner. Exp Neurol 2012
193
11

Huntingtin-encoded polyglutamine expansions form amyloid-like protein aggregates in vitro and in vivo.
E Scherzinger, R Lurz, M Turmaine, L Mangiarini, B Hollenbach, R Hasenbank, G P Bates, S W Davies, H Lehrach, E E Wanker. Cell 1997
10


Acetylation targets mutant huntingtin to autophagosomes for degradation.
Hyunkyung Jeong, Florian Then, Thomas J Melia, Joseph R Mazzulli, Libin Cui, Jeffrey N Savas, Cindy Voisine, Paolo Paganetti, Naoko Tanese, Anne C Hart,[...]. Cell 2009
274
10

Proteins Containing Expanded Polyglutamine Tracts and Neurodegenerative Disease.
Adewale Adegbuyiro, Faezeh Sedighi, Albert W Pilkington, Sharon Groover, Justin Legleiter. Biochemistry 2017
69
14

Sumoylation of amyloid precursor protein negatively regulates Abeta aggregate levels.
Yu-Qian Zhang, Kevin D Sarge. Biochem Biophys Res Commun 2008
75
13

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease.
Brinda Ravikumar, Coralie Vacher, Zdenek Berger, Janet E Davies, Shouqing Luo, Lourdes G Oroz, Francesco Scaravilli, Douglas F Easton, Rainer Duden, Cahir J O'Kane,[...]. Nat Genet 2004
10

Slow amyloid nucleation via α-helix-rich oligomeric intermediates in short polyglutamine-containing huntingtin fragments.
Murali Jayaraman, Ravindra Kodali, Bankanidhi Sahoo, Ashwani K Thakur, Anand Mayasundari, Rakesh Mishra, Cynthia B Peterson, Ronald Wetzel. J Mol Biol 2012
130
10

Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules.
Laurent R Gauthier, Bénédicte C Charrin, Maria Borrell-Pagès, Jim P Dompierre, Hélène Rangone, Fabrice P Cordelières, Jan De Mey, Marcy E MacDonald, Volkmar Lessmann, Sandrine Humbert,[...]. Cell 2004
791
10

Serine phosphorylation suppresses huntingtin amyloid accumulation by altering protein aggregation properties.
Rakesh Mishra, Cody L Hoop, Ravindra Kodali, Bankanidhi Sahoo, Patrick C A van der Wel, Ronald Wetzel. J Mol Biol 2012
57
17

N-terminal Huntingtin (Htt) phosphorylation is a molecular switch regulating Htt aggregation, helical conformation, internalization, and nuclear targeting.
Sean M DeGuire, Francesco S Ruggeri, Mohamed-Bilal Fares, Anass Chiki, Urszula Cendrowska, Giovanni Dietler, Hilal A Lashuel. J Biol Chem 2018
35
28

Huntingtin proteolysis releases non-polyQ fragments that cause toxicity through dynamin 1 dysregulation.
Marie-Thérèse El-Daher, Emilie Hangen, Julie Bruyère, Ghislaine Poizat, Ismael Al-Ramahi, Raul Pardo, Nicolas Bourg, Sylvie Souquere, Céline Mayet, Gérard Pierron,[...]. EMBO J 2015
56
16

Post-Translational Modifications (PTMs), Identified on Endogenous Huntingtin, Cluster within Proteolytic Domains between HEAT Repeats.
Tamara Ratovitski, Robert N O'Meally, Mali Jiang, Raghothama Chaerkady, Ekaterine Chighladze, Jacqueline C Stewart, Xiaofang Wang, Nicolas Arbez, Elaine Roby, Athanasios Alexandris,[...]. J Proteome Res 2017
27
33

Co-chaperone CHIP associates with expanded polyglutamine protein and promotes their degradation by proteasomes.
Nihar Ranjan Jana, Priyanka Dikshit, Anand Goswami, Svetlana Kotliarova, Shigeo Murata, Keiji Tanaka, Nobuyuki Nukina. J Biol Chem 2005
240
9

Polyglutamine domain flexibility mediates the proximity between flanking sequences in huntingtin.
Nicholas Stephane Caron, Carly Robyn Desmond, Jianrun Xia, Ray Truant. Proc Natl Acad Sci U S A 2013
94
9

PIAS1 Regulates Mutant Huntingtin Accumulation and Huntington's Disease-Associated Phenotypes In Vivo.
Joseph Ochaba, Alex Mas Monteys, Jacqueline G O'Rourke, Jack C Reidling, Joan S Steffan, Beverly L Davidson, Leslie M Thompson. Neuron 2016
43
20


Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.