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Times Cited: 790
Times Cited: 790
Times Cited
Times Co-cited
Similarity
34
Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease.
C Zuccato, A Ciammola, D Rigamonti, B R Leavitt, D Goffredo, L Conti, M E MacDonald, R M Friedlander, V Silani, M R Hayden,[...]. Science 2001
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Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice.
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Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain.
M DiFiglia, E Sapp, K O Chase, S W Davies, G P Bates, J P Vonsattel, N Aronin. Science 1997
M DiFiglia, E Sapp, K O Chase, S W Davies, G P Bates, J P Vonsattel, N Aronin. Science 1997
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Huntingtin functions as a scaffold for selective macroautophagy.
Yan-Ning Rui, Zhen Xu, Bindi Patel, Zhihua Chen, Dongsheng Chen, Antonio Tito, Gabriela David, Yamin Sun, Erin F Stimming, Hugo J Bellen,[...]. Nat Cell Biol 2015
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The regulation of autophagosome dynamics by huntingtin and HAP1 is disrupted by expression of mutant huntingtin, leading to defective cargo degradation.
Yvette C Wong, Erika L F Holzbaur. J Neurosci 2014
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Huntington's disease: from molecular pathogenesis to clinical treatment.
Christopher A Ross, Sarah J Tabrizi. Lancet Neurol 2011
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Huntingtin facilitates dynein/dynactin-mediated vesicle transport.
Juliane P Caviston, Jennifer L Ross, Sheila M Antony, Mariko Tokito, Erika L F Holzbaur. Proc Natl Acad Sci U S A 2007
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Disruption of axonal transport by loss of huntingtin or expression of pathogenic polyQ proteins in Drosophila.
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Potential function for the Huntingtin protein as a scaffold for selective autophagy.
Joseph Ochaba, Tamás Lukacsovich, George Csikos, Shuqiu Zheng, Julia Margulis, Lisa Salazar, Kai Mao, Alice L Lau, Sylvia Y Yeung, Sandrine Humbert,[...]. Proc Natl Acad Sci U S A 2014
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Inactivation of Hdh in the brain and testis results in progressive neurodegeneration and sterility in mice.
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Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes.
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Interaction of Huntingtin-associated protein-1 with kinesin light chain: implications in intracellular trafficking in neurons.
John Russel McGuire, Juan Rong, Shi-Hua Li, Xiao-Jiang Li. J Biol Chem 2006
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Mutant huntingtin impairs axonal trafficking in mammalian neurons in vivo and in vitro.
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Mutant Huntingtin alters retrograde transport of TrkB receptors in striatal dendrites.
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Targeted disruption of the Huntington's disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotes.
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Huntington disease.
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12
Huntingtin phosphorylation acts as a molecular switch for anterograde/retrograde transport in neurons.
Emilie Colin, Diana Zala, Géraldine Liot, Hélène Rangone, Maria Borrell-Pagès, Xiao-Jiang Li, Frédéric Saudou, Sandrine Humbert. EMBO J 2008
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Huntingtin-associated protein 1 (HAP1) interacts with the p150Glued subunit of dynactin.
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Mutant huntingtin binds the mitochondrial fission GTPase dynamin-related protein-1 and increases its enzymatic activity.
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Neuropathological classification of Huntington's disease.
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Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation.
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Vesicular glycolysis provides on-board energy for fast axonal transport.
Diana Zala, Maria-Victoria Hinckelmann, Hua Yu, Marcel Menezes Lyra da Cunha, Géraldine Liot, Fabrice P Cordelières, Sergio Marco, Frédéric Saudou. Cell 2013
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10
Huntingtin is required for mitotic spindle orientation and mammalian neurogenesis.
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Targeting Huntingtin Expression in Patients with Huntington's Disease.
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10
Huntingtin is required for normal excitatory synapse development in cortical and striatal circuits.
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Inactivation of the mouse Huntington's disease gene homolog Hdh.
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Elimination of huntingtin in the adult mouse leads to progressive behavioral deficits, bilateral thalamic calcification, and altered brain iron homeostasis.
Paula Dietrich, Irudayam Maria Johnson, Shanta Alli, Ioannis Dragatsis. PLoS Genet 2017
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Delivery of GABAARs to synapses is mediated by HAP1-KIF5 and disrupted by mutant huntingtin.
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Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines.
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Huntington's disease alters human neurodevelopment.
Monia Barnat, Mariacristina Capizzi, Esther Aparicio, Susana Boluda, Doris Wennagel, Radhia Kacher, Rayane Kassem, Sophie Lenoir, Fabienne Agasse, Barbara Y Braz,[...]. Science 2020
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Phosphorylation of mutant huntingtin at S421 restores anterograde and retrograde transport in neurons.
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Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons.
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N-terminal mutant huntingtin associates with mitochondria and impairs mitochondrial trafficking.
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SUMO modification of Huntingtin and Huntington's disease pathology.
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A huntingtin-associated protein enriched in brain with implications for pathology.
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Role of brain-derived neurotrophic factor in Huntington's disease.
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Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease.
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8
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.