A citation-based method for searching scientific literature

Sung Hee Um, Francesca Frigerio, Mitsuhiro Watanabe, Frédéric Picard, Manel Joaquin, Melanie Sticker, Stefano Fumagalli, Peter R Allegrini, Sara C Kozma, Johan Auwerx, George Thomas. Nature 2004
Times Cited: 1255







List of co-cited articles
1010 articles co-cited >1



Times Cited
  Times     Co-cited
Similarity


mTOR signaling in growth control and disease.
Mathieu Laplante, David M Sabatini. Cell 2012
21

Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity.
Dudley W Lamming, Lan Ye, Pekka Katajisto, Marcus D Goncalves, Maki Saitoh, Deanna M Stevens, James G Davis, Adam B Salmon, Arlan Richardson, Rexford S Ahima,[...]. Science 2012
767
18

mTOR Signaling in Growth, Metabolism, and Disease.
Robert A Saxton, David M Sabatini. Cell 2017
18


The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling.
Peggy P Hsu, Seong A Kang, Jonathan Rameseder, Yi Zhang, Kathleen A Ottina, Daniel Lim, Timothy R Peterson, Yongmun Choi, Nathanael S Gray, Michael B Yaffe,[...]. Science 2011
755
17


The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins.
Laura S Harrington, Greg M Findlay, Alex Gray, Tatiana Tolkacheva, Simon Wigfield, Heike Rebholz, Jill Barnett, Nick R Leslie, Susan Cheng, Peter R Shepherd,[...]. J Cell Biol 2004
840
15

Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling.
Yonghao Yu, Sang-Oh Yoon, George Poulogiannis, Qian Yang, Xiaoju Max Ma, Judit Villén, Neil Kubica, Gregory R Hoffman, Lewis C Cantley, Steven P Gygi,[...]. Science 2011
610
15

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex.
D D Sarbassov, David A Guertin, Siraj M Ali, David M Sabatini. Science 2005
15

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling.
Ken Inoki, Yong Li, Tianquan Zhu, Jun Wu, Kun-Liang Guan. Nat Cell Biol 2002
15

AMPK phosphorylation of raptor mediates a metabolic checkpoint.
Dana M Gwinn, David B Shackelford, Daniel F Egan, Maria M Mihaylova, Annabelle Mery, Debbie S Vasquez, Benjamin E Turk, Reuben J Shaw. Mol Cell 2008
14

Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids.
Yasemin Sancak, Liron Bar-Peled, Roberto Zoncu, Andrew L Markhard, Shigeyuki Nada, David M Sabatini. Cell 2010
13

The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1.
Yasemin Sancak, Timothy R Peterson, Yoav D Shaul, Robert A Lindquist, Carson C Thoreen, Liron Bar-Peled, David M Sabatini. Science 2008
13


DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival.
Timothy R Peterson, Mathieu Laplante, Carson C Thoreen, Yasemin Sancak, Seong A Kang, W Michael Kuehl, Nathanael S Gray, David M Sabatini. Cell 2009
856
12

mTOR at the nexus of nutrition, growth, ageing and disease.
Grace Y Liu, David M Sabatini. Nat Rev Mol Cell Biol 2020
598
12


Rapamycin fed late in life extends lifespan in genetically heterogeneous mice.
David E Harrison, Randy Strong, Zelton Dave Sharp, James F Nelson, Clinton M Astle, Kevin Flurkey, Nancy L Nadon, J Erby Wilkinson, Krystyna Frenkel, Christy S Carter,[...]. Nature 2009
11

Adipose-specific knockout of raptor results in lean mice with enhanced mitochondrial respiration.
Pazit Polak, Nadine Cybulski, Jerome N Feige, Johan Auwerx, Markus A Rüegg, Michael N Hall. Cell Metab 2008
369
11

A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance.
Christopher B Newgard, Jie An, James R Bain, Michael J Muehlbauer, Robert D Stevens, Lillian F Lien, Andrea M Haqq, Svati H Shah, Michelle Arlotto, Cris A Slentz,[...]. Cell Metab 2009
11

mTOR as a central hub of nutrient signalling and cell growth.
Joungmok Kim, Kun-Liang Guan. Nat Cell Biol 2019
409
11

Elevated sensitivity to diet-induced obesity and insulin resistance in mice lacking 4E-BP1 and 4E-BP2.
Olivier Le Bacquer, Emmanuel Petroulakis, Sabina Paglialunga, Francis Poulin, Denis Richard, Katherine Cianflone, Nahum Sonenberg. J Clin Invest 2007
244
11

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton.
D D Sarbassov, Siraj M Ali, Do-Hyung Kim, David A Guertin, Robert R Latek, Hediye Erdjument-Bromage, Paul Tempst, David M Sabatini. Curr Biol 2004
11

PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex.
Pengda Liu, Wenjian Gan, Y Rebecca Chin, Kohei Ogura, Jianping Guo, Jinfang Zhang, Bin Wang, John Blenis, Lewis C Cantley, Alex Toker,[...]. Cancer Discov 2015
220
11

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery.
Do-Hyung Kim, D D Sarbassov, Siraj M Ali, Jessie E King, Robert R Latek, Hediye Erdjument-Bromage, Paul Tempst, David M Sabatini. Cell 2002
10

AKT/PKB Signaling: Navigating the Network.
Brendan D Manning, Alex Toker. Cell 2017
10



Activation of a metabolic gene regulatory network downstream of mTOR complex 1.
Katrin Düvel, Jessica L Yecies, Suchithra Menon, Pichai Raman, Alex I Lipovsky, Amanda L Souza, Ellen Triantafellow, Qicheng Ma, Regina Gorski, Stephen Cleaver,[...]. Mol Cell 2010
9

Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB.
Dos D Sarbassov, Siraj M Ali, Shomit Sengupta, Joon-Ho Sheen, Peggy P Hsu, Alex F Bagley, Andrew L Markhard, David M Sabatini. Mol Cell 2006
9

mTOR Signaling in Growth, Metabolism, and Disease.
Robert A Saxton, David M Sabatini. Cell 2017
984
9

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling.
Ken Inoki, Yong Li, Tian Xu, Kun-Liang Guan. Genes Dev 2003
9

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive.
Estela Jacinto, Robbie Loewith, Anja Schmidt, Shuo Lin, Markus A Rüegg, Alan Hall, Michael N Hall. Nat Cell Biol 2004
9

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1.
Joungmok Kim, Mondira Kundu, Benoit Viollet, Kun-Liang Guan. Nat Cell Biol 2011
9

Identification of IRS-1 Ser-1101 as a target of S6K1 in nutrient- and obesity-induced insulin resistance.
Frédéric Tremblay, Sophie Brûlé, Sung Hee Um, Yu Li, Kohei Masuda, Michael Roden, Xiao Jian Sun, Michael Krebs, Roberto D Polakiewicz, George Thomas,[...]. Proc Natl Acad Sci U S A 2007
319
8

Skeletal muscle-specific ablation of raptor, but not of rictor, causes metabolic changes and results in muscle dystrophy.
C Florian Bentzinger, Klaas Romanino, Dimitri Cloëtta, Shuo Lin, Joseph B Mascarenhas, Filippo Oliveri, Jinyu Xia, Emilio Casanova, Céline F Costa, Marijke Brink,[...]. Cell Metab 2008
458
8

Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action.
Kenta Hara, Yoshiko Maruki, Xiaomeng Long, Ken-ichi Yoshino, Noriko Oshiro, Sujuti Hidayat, Chiharu Tokunaga, Joseph Avruch, Kazuyoshi Yonezawa. Cell 2002
8

Raptor/mTORC1 loss in adipocytes causes progressive lipodystrophy and fatty liver disease.
Peter L Lee, Yuefeng Tang, Huawei Li, David A Guertin. Mol Metab 2016
64
12


Adipose tissue mTORC2 regulates ChREBP-driven de novo lipogenesis and hepatic glucose metabolism.
Yuefeng Tang, Martina Wallace, Joan Sanchez-Gurmaches, Wen-Yu Hsiao, Huawei Li, Peter L Lee, Santiago Vernia, Christian M Metallo, David A Guertin. Nat Commun 2016
103
8

Metabolite profiles and the risk of developing diabetes.
Thomas J Wang, Martin G Larson, Ramachandran S Vasan, Susan Cheng, Eugene P Rhee, Elizabeth McCabe, Gregory D Lewis, Caroline S Fox, Paul F Jacques, Céline Fernandez,[...]. Nat Med 2011
8

mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway.
Timothy R Peterson, Shomit S Sengupta, Thurl E Harris, Anne E Carmack, Seong A Kang, Eric Balderas, David A Guertin, Katherine L Madden, Anne E Carpenter, Brian N Finck,[...]. Cell 2011
731
8

Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.
Colin Selman, Jennifer M A Tullet, Daniela Wieser, Elaine Irvine, Steven J Lingard, Agharul I Choudhury, Marc Claret, Hind Al-Qassab, Danielle Carmignac, Faruk Ramadani,[...]. Science 2009
787
8

Regulation of TORC1 by Rag GTPases in nutrient response.
Eunjung Kim, Pankuri Goraksha-Hicks, Li Li, Thomas P Neufeld, Kun-Liang Guan. Nat Cell Biol 2008
902
8

Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome.
Suchithra Menon, Christian C Dibble, George Talbott, Gerta Hoxhaj, Alexander J Valvezan, Hidenori Takahashi, Lewis C Cantley, Brendan D Manning. Cell 2014
484
8

Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1.
David A Guertin, Deanna M Stevens, Carson C Thoreen, Aurora A Burds, Nada Y Kalaany, Jason Moffat, Michael Brown, Kevin J Fitzgerald, David M Sabatini. Dev Cell 2006
8

SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity.
Estela Jacinto, Valeria Facchinetti, Dou Liu, Nelyn Soto, Shiniu Wei, Sung Yun Jung, Qiaojia Huang, Jun Qin, Bing Su. Cell 2006
8

mTOR: from growth signal integration to cancer, diabetes and ageing.
Roberto Zoncu, Alejo Efeyan, David M Sabatini. Nat Rev Mol Cell Biol 2011
8

mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s.
Maria A Frias, Carson C Thoreen, Jacob D Jaffe, Wayne Schroder, Tom Sculley, Steven A Carr, David M Sabatini. Curr Biol 2006
503
8

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB.
Carmine Settembre, Roberto Zoncu, Diego L Medina, Francesco Vetrini, Serkan Erdin, SerpilUckac Erdin, Tuong Huynh, Mathieu Ferron, Gerard Karsenty, Michel C Vellard,[...]. EMBO J 2012
8


Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.