A citation-based method for searching scientific literature

Nissim Hay, Nahum Sonenberg. Genes Dev 2004
Times Cited: 3140







List of co-cited articles
282 articles co-cited >1



Times Cited
  Times     Co-cited
Similarity


TOR signaling in growth and metabolism.
Stephan Wullschleger, Robbie Loewith, Michael N Hall. Cell 2006
10

The neurology of mTOR.
Jonathan O Lipton, Mustafa Sahin. Neuron 2014
396
8

mTOR signaling in growth control and disease.
Mathieu Laplante, David M Sabatini. Cell 2012
8

mTOR at the nexus of nutrition, growth, ageing and disease.
Grace Y Liu, David M Sabatini. Nat Rev Mol Cell Biol 2020
598
7

mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists.
Nanxin Li, Boyoung Lee, Rong-Jian Liu, Mounira Banasr, Jason M Dwyer, Masaaki Iwata, Xiao-Yuan Li, George Aghajanian, Ronald S Duman. Science 2010
7

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery.
Do-Hyung Kim, D D Sarbassov, Siraj M Ali, Jessie E King, Robert R Latek, Hediye Erdjument-Bromage, Paul Tempst, David M Sabatini. Cell 2002
6

Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids.
Yasemin Sancak, Liron Bar-Peled, Roberto Zoncu, Andrew L Markhard, Shigeyuki Nada, David M Sabatini. Cell 2010
6

mTOR Signaling in Growth, Metabolism, and Disease.
Robert A Saxton, David M Sabatini. Cell 2017
984
6

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries.
Freddie Bray, Jacques Ferlay, Isabelle Soerjomataram, Rebecca L Siegel, Lindsey A Torre, Ahmedin Jemal. CA Cancer J Clin 2018
5

AKT/PKB signaling: navigating downstream.
Brendan D Manning, Lewis C Cantley. Cell 2007
5

mTOR Signaling in Growth, Metabolism, and Disease.
Robert A Saxton, David M Sabatini. Cell 2017
5

The PTEN-PI3K pathway: of feedbacks and cross-talks.
A Carracedo, P P Pandolfi. Oncogene 2008
612
4


Dysregulation and restoration of translational homeostasis in fragile X syndrome.
Joel D Richter, Gary J Bassell, Eric Klann. Nat Rev Neurosci 2015
163
4

mTOR signaling: at the crossroads of plasticity, memory and disease.
Charles A Hoeffer, Eric Klann. Trends Neurosci 2010
764
4

The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1.
Yasemin Sancak, Timothy R Peterson, Yoav D Shaul, Robert A Lindquist, Carson C Thoreen, Liron Bar-Peled, David M Sabatini. Science 2008
4

Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1.
Liron Bar-Peled, Lawrence D Schweitzer, Roberto Zoncu, David M Sabatini. Cell 2012
598
4

Regulation of TORC1 by Rag GTPases in nutrient response.
Eunjung Kim, Pankuri Goraksha-Hicks, Li Li, Thomas P Neufeld, Kun-Liang Guan. Nat Cell Biol 2008
902
4

Mechanisms of ketamine action as an antidepressant.
P Zanos, T D Gould. Mol Psychiatry 2018
327
4

NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses.
Anita E Autry, Megumi Adachi, Elena Nosyreva, Elisa S Na, Maarten F Los, Peng-fei Cheng, Ege T Kavalali, Lisa M Monteggia. Nature 2011
4

AMPK phosphorylation of raptor mediates a metabolic checkpoint.
Dana M Gwinn, David B Shackelford, Daniel F Egan, Maria M Mihaylova, Annabelle Mery, Debbie S Vasquez, Benjamin E Turk, Reuben J Shaw. Mol Cell 2008
4

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1.
Joungmok Kim, Mondira Kundu, Benoit Viollet, Kun-Liang Guan. Nat Cell Biol 2011
4

Defining the role of mTOR in cancer.
David A Guertin, David M Sabatini. Cancer Cell 2007
4

mTOR as a central hub of nutrient signalling and cell growth.
Joungmok Kim, Kun-Liang Guan. Nat Cell Biol 2019
409
4

Judicious Toggling of mTOR Activity to Combat Insulin Resistance and Cancer: Current Evidence and Perspectives.
Pei Shi Ong, Louis Z Wang, Xiaoyun Dai, Sheng Hsuan Tseng, Shang Jun Loo, Gautam Sethi. Front Pharmacol 2016
89
3

mTORC1 as the main gateway to autophagy.
Yoana Rabanal-Ruiz, Elsje G Otten, Viktor I Korolchuk. Essays Biochem 2017
231
3


Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40.
Haijuan Yang, Xiaolu Jiang, Buren Li, Hyo J Yang, Meredith Miller, Angela Yang, Ankita Dhar, Nikola P Pavletich. Nature 2017
219
3

Modulation of the antidepressant effects of ketamine by the mTORC1 inhibitor rapamycin.
Chadi G Abdallah, Lynnette A Averill, Ralitza Gueorguieva, Selin Goktas, Prerana Purohit, Mohini Ranganathan, Mohamed Sherif, Kyung-Heup Ahn, Deepak Cyril D'Souza, Richard Formica,[...]. Neuropsychopharmacology 2020
59
5

Metformin ameliorates core deficits in a mouse model of fragile X syndrome.
Ilse Gantois, Arkady Khoutorsky, Jelena Popic, Argel Aguilar-Valles, Erika Freemantle, Ruifeng Cao, Vijendra Sharma, Tine Pooters, Anmol Nagpal, Agnieszka Skalecka,[...]. Nat Med 2017
111
3

Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism.
A C Gingras, S P Gygi, B Raught, R D Polakiewicz, R T Abraham, M F Hoekstra, R Aebersold, N Sonenberg. Genes Dev 1999
952
3

mTORC1 signaling and the metabolic control of cell growth.
Issam Ben-Sahra, Brendan D Manning. Curr Opin Cell Biol 2017
286
3

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton.
D D Sarbassov, Siraj M Ali, Do-Hyung Kim, David A Guertin, Robert R Latek, Hediye Erdjument-Bromage, Paul Tempst, David M Sabatini. Curr Biol 2004
3

GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR.
Do-Hyung Kim, D D Sarbassov, Siraj M Ali, Robert R Latek, Kalyani V P Guntur, Hediye Erdjument-Bromage, Paul Tempst, David M Sabatini. Mol Cell 2003
688
3

Regulation of translation initiation by FRAP/mTOR.
A C Gingras, B Raught, N Sonenberg. Genes Dev 2001
3

mTOR kinase structure, mechanism and regulation.
Haijuan Yang, Derek G Rudge, Joseph D Koos, Bhamini Vaidialingam, Hyo J Yang, Nikola P Pavletich. Nature 2013
580
3

A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1.
Liron Bar-Peled, Lynne Chantranupong, Andrew D Cherniack, Walter W Chen, Kathleen A Ottina, Brian C Grabiner, Eric D Spear, Scott L Carter, Matthew Meyerson, David M Sabatini. Science 2013
611
3

Sestrin2 is a leucine sensor for the mTORC1 pathway.
Rachel L Wolfson, Lynne Chantranupong, Robert A Saxton, Kuang Shen, Sonia M Scaria, Jason R Cantor, David M Sabatini. Science 2016
604
3

Dysregulation of Mammalian Target of Rapamycin Signaling in Mouse Models of Autism.
Kimberly M Huber, Eric Klann, Mauro Costa-Mattioli, R Suzanne Zukin. J Neurosci 2015
107
3


TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling.
Ken Inoki, Yong Li, Tianquan Zhu, Jun Wu, Kun-Liang Guan. Nat Cell Biol 2002
3

Fueling immunity: insights into metabolism and lymphocyte function.
Erika L Pearce, Maya C Poffenberger, Chih-Hao Chang, Russell G Jones. Science 2013
760
3

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling.
Ken Inoki, Yong Li, Tian Xu, Kun-Liang Guan. Genes Dev 2003
3



Regulation of TORC1 in response to amino acid starvation via lysosomal recruitment of TSC2.
Constantinos Demetriades, Nikolaos Doumpas, Aurelio A Teleman. Cell 2014
268
3

Differential effects of antidepressant drugs on mTOR signalling in rat hippocampal neurons.
Sung Woo Park, Jung Goo Lee, Mi Kyoung Seo, Chan Hong Lee, Hye Yeon Cho, Bong Ju Lee, Wongi Seol, Young Hoon Kim. Int J Neuropsychopharmacol 2014
74
4

The TSC1-TSC2 complex: a molecular switchboard controlling cell growth.
Jingxiang Huang, Brendan D Manning. Biochem J 2008
825
3

Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome.
Suchithra Menon, Christian C Dibble, George Talbott, Gerta Hoxhaj, Alexander J Valvezan, Hidenori Takahashi, Lewis C Cantley, Brendan D Manning. Cell 2014
484
3

Regulation of amino acid transporter trafficking by mTORC1 in primary human trophoblast cells is mediated by the ubiquitin ligase Nedd4-2.
Fredrick J Rosario, Kris Genelyn Dimasuay, Yoshikatsu Kanai, Theresa L Powell, Thomas Jansson. Clin Sci (Lond) 2016
53
5


Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.