Nissim Hay, Nahum Sonenberg. Genes Dev 2004
Times Cited: 3140
Times Cited: 3140
Times Cited
Times Co-cited
Similarity
TOR signaling in growth and metabolism.
Stephan Wullschleger, Robbie Loewith, Michael N Hall. Cell 2006
Stephan Wullschleger, Robbie Loewith, Michael N Hall. Cell 2006
10
8
mTOR at the nexus of nutrition, growth, ageing and disease.
Grace Y Liu, David M Sabatini. Nat Rev Mol Cell Biol 2020
Grace Y Liu, David M Sabatini. Nat Rev Mol Cell Biol 2020
7
mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists.
Nanxin Li, Boyoung Lee, Rong-Jian Liu, Mounira Banasr, Jason M Dwyer, Masaaki Iwata, Xiao-Yuan Li, George Aghajanian, Ronald S Duman. Science 2010
Nanxin Li, Boyoung Lee, Rong-Jian Liu, Mounira Banasr, Jason M Dwyer, Masaaki Iwata, Xiao-Yuan Li, George Aghajanian, Ronald S Duman. Science 2010
7
mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery.
Do-Hyung Kim, D D Sarbassov, Siraj M Ali, Jessie E King, Robert R Latek, Hediye Erdjument-Bromage, Paul Tempst, David M Sabatini. Cell 2002
Do-Hyung Kim, D D Sarbassov, Siraj M Ali, Jessie E King, Robert R Latek, Hediye Erdjument-Bromage, Paul Tempst, David M Sabatini. Cell 2002
6
Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids.
Yasemin Sancak, Liron Bar-Peled, Roberto Zoncu, Andrew L Markhard, Shigeyuki Nada, David M Sabatini. Cell 2010
Yasemin Sancak, Liron Bar-Peled, Roberto Zoncu, Andrew L Markhard, Shigeyuki Nada, David M Sabatini. Cell 2010
6
6
Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries.
Freddie Bray, Jacques Ferlay, Isabelle Soerjomataram, Rebecca L Siegel, Lindsey A Torre, Ahmedin Jemal. CA Cancer J Clin 2018
Freddie Bray, Jacques Ferlay, Isabelle Soerjomataram, Rebecca L Siegel, Lindsey A Torre, Ahmedin Jemal. CA Cancer J Clin 2018
5
5
4
Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks.
Brian Magnuson, Bilgen Ekim, Diane C Fingar. Biochem J 2012
Brian Magnuson, Bilgen Ekim, Diane C Fingar. Biochem J 2012
4
Dysregulation and restoration of translational homeostasis in fragile X syndrome.
Joel D Richter, Gary J Bassell, Eric Klann. Nat Rev Neurosci 2015
Joel D Richter, Gary J Bassell, Eric Klann. Nat Rev Neurosci 2015
4
mTOR signaling: at the crossroads of plasticity, memory and disease.
Charles A Hoeffer, Eric Klann. Trends Neurosci 2010
Charles A Hoeffer, Eric Klann. Trends Neurosci 2010
4
The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1.
Yasemin Sancak, Timothy R Peterson, Yoav D Shaul, Robert A Lindquist, Carson C Thoreen, Liron Bar-Peled, David M Sabatini. Science 2008
Yasemin Sancak, Timothy R Peterson, Yoav D Shaul, Robert A Lindquist, Carson C Thoreen, Liron Bar-Peled, David M Sabatini. Science 2008
4
Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1.
Liron Bar-Peled, Lawrence D Schweitzer, Roberto Zoncu, David M Sabatini. Cell 2012
Liron Bar-Peled, Lawrence D Schweitzer, Roberto Zoncu, David M Sabatini. Cell 2012
4
Regulation of TORC1 by Rag GTPases in nutrient response.
Eunjung Kim, Pankuri Goraksha-Hicks, Li Li, Thomas P Neufeld, Kun-Liang Guan. Nat Cell Biol 2008
Eunjung Kim, Pankuri Goraksha-Hicks, Li Li, Thomas P Neufeld, Kun-Liang Guan. Nat Cell Biol 2008
4
NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses.
Anita E Autry, Megumi Adachi, Elena Nosyreva, Elisa S Na, Maarten F Los, Peng-fei Cheng, Ege T Kavalali, Lisa M Monteggia. Nature 2011
Anita E Autry, Megumi Adachi, Elena Nosyreva, Elisa S Na, Maarten F Los, Peng-fei Cheng, Ege T Kavalali, Lisa M Monteggia. Nature 2011
4
AMPK phosphorylation of raptor mediates a metabolic checkpoint.
Dana M Gwinn, David B Shackelford, Daniel F Egan, Maria M Mihaylova, Annabelle Mery, Debbie S Vasquez, Benjamin E Turk, Reuben J Shaw. Mol Cell 2008
Dana M Gwinn, David B Shackelford, Daniel F Egan, Maria M Mihaylova, Annabelle Mery, Debbie S Vasquez, Benjamin E Turk, Reuben J Shaw. Mol Cell 2008
4
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1.
Joungmok Kim, Mondira Kundu, Benoit Viollet, Kun-Liang Guan. Nat Cell Biol 2011
Joungmok Kim, Mondira Kundu, Benoit Viollet, Kun-Liang Guan. Nat Cell Biol 2011
4
mTOR as a central hub of nutrient signalling and cell growth.
Joungmok Kim, Kun-Liang Guan. Nat Cell Biol 2019
Joungmok Kim, Kun-Liang Guan. Nat Cell Biol 2019
4
Judicious Toggling of mTOR Activity to Combat Insulin Resistance and Cancer: Current Evidence and Perspectives.
Pei Shi Ong, Louis Z Wang, Xiaoyun Dai, Sheng Hsuan Tseng, Shang Jun Loo, Gautam Sethi. Front Pharmacol 2016
Pei Shi Ong, Louis Z Wang, Xiaoyun Dai, Sheng Hsuan Tseng, Shang Jun Loo, Gautam Sethi. Front Pharmacol 2016
3
mTORC1 as the main gateway to autophagy.
Yoana Rabanal-Ruiz, Elsje G Otten, Viktor I Korolchuk. Essays Biochem 2017
Yoana Rabanal-Ruiz, Elsje G Otten, Viktor I Korolchuk. Essays Biochem 2017
3
mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events.
Marina K Holz, Bryan A Ballif, Steven P Gygi, John Blenis. Cell 2005
Marina K Holz, Bryan A Ballif, Steven P Gygi, John Blenis. Cell 2005
3
Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40.
Haijuan Yang, Xiaolu Jiang, Buren Li, Hyo J Yang, Meredith Miller, Angela Yang, Ankita Dhar, Nikola P Pavletich. Nature 2017
Haijuan Yang, Xiaolu Jiang, Buren Li, Hyo J Yang, Meredith Miller, Angela Yang, Ankita Dhar, Nikola P Pavletich. Nature 2017
3
Modulation of the antidepressant effects of ketamine by the mTORC1 inhibitor rapamycin.
Chadi G Abdallah, Lynnette A Averill, Ralitza Gueorguieva, Selin Goktas, Prerana Purohit, Mohini Ranganathan, Mohamed Sherif, Kyung-Heup Ahn, Deepak Cyril D'Souza, Richard Formica,[...]. Neuropsychopharmacology 2020
Chadi G Abdallah, Lynnette A Averill, Ralitza Gueorguieva, Selin Goktas, Prerana Purohit, Mohini Ranganathan, Mohamed Sherif, Kyung-Heup Ahn, Deepak Cyril D'Souza, Richard Formica,[...]. Neuropsychopharmacology 2020
5
Metformin ameliorates core deficits in a mouse model of fragile X syndrome.
Ilse Gantois, Arkady Khoutorsky, Jelena Popic, Argel Aguilar-Valles, Erika Freemantle, Ruifeng Cao, Vijendra Sharma, Tine Pooters, Anmol Nagpal, Agnieszka Skalecka,[...]. Nat Med 2017
Ilse Gantois, Arkady Khoutorsky, Jelena Popic, Argel Aguilar-Valles, Erika Freemantle, Ruifeng Cao, Vijendra Sharma, Tine Pooters, Anmol Nagpal, Agnieszka Skalecka,[...]. Nat Med 2017
3
Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism.
A C Gingras, S P Gygi, B Raught, R D Polakiewicz, R T Abraham, M F Hoekstra, R Aebersold, N Sonenberg. Genes Dev 1999
A C Gingras, S P Gygi, B Raught, R D Polakiewicz, R T Abraham, M F Hoekstra, R Aebersold, N Sonenberg. Genes Dev 1999
3
mTORC1 signaling and the metabolic control of cell growth.
Issam Ben-Sahra, Brendan D Manning. Curr Opin Cell Biol 2017
Issam Ben-Sahra, Brendan D Manning. Curr Opin Cell Biol 2017
3
Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton.
D D Sarbassov, Siraj M Ali, Do-Hyung Kim, David A Guertin, Robert R Latek, Hediye Erdjument-Bromage, Paul Tempst, David M Sabatini. Curr Biol 2004
D D Sarbassov, Siraj M Ali, Do-Hyung Kim, David A Guertin, Robert R Latek, Hediye Erdjument-Bromage, Paul Tempst, David M Sabatini. Curr Biol 2004
3
GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR.
Do-Hyung Kim, D D Sarbassov, Siraj M Ali, Robert R Latek, Kalyani V P Guntur, Hediye Erdjument-Bromage, Paul Tempst, David M Sabatini. Mol Cell 2003
Do-Hyung Kim, D D Sarbassov, Siraj M Ali, Robert R Latek, Kalyani V P Guntur, Hediye Erdjument-Bromage, Paul Tempst, David M Sabatini. Mol Cell 2003
3
Regulation of translation initiation by FRAP/mTOR.
A C Gingras, B Raught, N Sonenberg. Genes Dev 2001
A C Gingras, B Raught, N Sonenberg. Genes Dev 2001
3
mTOR kinase structure, mechanism and regulation.
Haijuan Yang, Derek G Rudge, Joseph D Koos, Bhamini Vaidialingam, Hyo J Yang, Nikola P Pavletich. Nature 2013
Haijuan Yang, Derek G Rudge, Joseph D Koos, Bhamini Vaidialingam, Hyo J Yang, Nikola P Pavletich. Nature 2013
3
A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1.
Liron Bar-Peled, Lynne Chantranupong, Andrew D Cherniack, Walter W Chen, Kathleen A Ottina, Brian C Grabiner, Eric D Spear, Scott L Carter, Matthew Meyerson, David M Sabatini. Science 2013
Liron Bar-Peled, Lynne Chantranupong, Andrew D Cherniack, Walter W Chen, Kathleen A Ottina, Brian C Grabiner, Eric D Spear, Scott L Carter, Matthew Meyerson, David M Sabatini. Science 2013
3
Sestrin2 is a leucine sensor for the mTORC1 pathway.
Rachel L Wolfson, Lynne Chantranupong, Robert A Saxton, Kuang Shen, Sonia M Scaria, Jason R Cantor, David M Sabatini. Science 2016
Rachel L Wolfson, Lynne Chantranupong, Robert A Saxton, Kuang Shen, Sonia M Scaria, Jason R Cantor, David M Sabatini. Science 2016
3
Dysregulation of Mammalian Target of Rapamycin Signaling in Mouse Models of Autism.
Kimberly M Huber, Eric Klann, Mauro Costa-Mattioli, R Suzanne Zukin. J Neurosci 2015
Kimberly M Huber, Eric Klann, Mauro Costa-Mattioli, R Suzanne Zukin. J Neurosci 2015
3
TSC2 mediates cellular energy response to control cell growth and survival.
Ken Inoki, Tianqing Zhu, Kun-Liang Guan. Cell 2003
Ken Inoki, Tianqing Zhu, Kun-Liang Guan. Cell 2003
3
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling.
Ken Inoki, Yong Li, Tianquan Zhu, Jun Wu, Kun-Liang Guan. Nat Cell Biol 2002
Ken Inoki, Yong Li, Tianquan Zhu, Jun Wu, Kun-Liang Guan. Nat Cell Biol 2002
3
Fueling immunity: insights into metabolism and lymphocyte function.
Erika L Pearce, Maya C Poffenberger, Chih-Hao Chang, Russell G Jones. Science 2013
Erika L Pearce, Maya C Poffenberger, Chih-Hao Chang, Russell G Jones. Science 2013
3
Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling.
Ken Inoki, Yong Li, Tian Xu, Kun-Liang Guan. Genes Dev 2003
Ken Inoki, Yong Li, Tian Xu, Kun-Liang Guan. Genes Dev 2003
3
3
Proliferation, survival and metabolism: the role of PI3K/AKT/mTOR signalling in pluripotency and cell fate determination.
Jason S L Yu, Wei Cui. Development 2016
Jason S L Yu, Wei Cui. Development 2016
3
Regulation of TORC1 in response to amino acid starvation via lysosomal recruitment of TSC2.
Constantinos Demetriades, Nikolaos Doumpas, Aurelio A Teleman. Cell 2014
Constantinos Demetriades, Nikolaos Doumpas, Aurelio A Teleman. Cell 2014
3
Differential effects of antidepressant drugs on mTOR signalling in rat hippocampal neurons.
Sung Woo Park, Jung Goo Lee, Mi Kyoung Seo, Chan Hong Lee, Hye Yeon Cho, Bong Ju Lee, Wongi Seol, Young Hoon Kim. Int J Neuropsychopharmacol 2014
Sung Woo Park, Jung Goo Lee, Mi Kyoung Seo, Chan Hong Lee, Hye Yeon Cho, Bong Ju Lee, Wongi Seol, Young Hoon Kim. Int J Neuropsychopharmacol 2014
4
The TSC1-TSC2 complex: a molecular switchboard controlling cell growth.
Jingxiang Huang, Brendan D Manning. Biochem J 2008
Jingxiang Huang, Brendan D Manning. Biochem J 2008
3
Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome.
Suchithra Menon, Christian C Dibble, George Talbott, Gerta Hoxhaj, Alexander J Valvezan, Hidenori Takahashi, Lewis C Cantley, Brendan D Manning. Cell 2014
Suchithra Menon, Christian C Dibble, George Talbott, Gerta Hoxhaj, Alexander J Valvezan, Hidenori Takahashi, Lewis C Cantley, Brendan D Manning. Cell 2014
3
Regulation of amino acid transporter trafficking by mTORC1 in primary human trophoblast cells is mediated by the ubiquitin ligase Nedd4-2.
Fredrick J Rosario, Kris Genelyn Dimasuay, Yoshikatsu Kanai, Theresa L Powell, Thomas Jansson. Clin Sci (Lond) 2016
Fredrick J Rosario, Kris Genelyn Dimasuay, Yoshikatsu Kanai, Theresa L Powell, Thomas Jansson. Clin Sci (Lond) 2016
5
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.