A citation-based method for searching scientific literature

The use of radiolabeled compounds for ADME studies in discovery and exploratory development.
P H Marathe, W C Shyu, W G Humphreys. Curr. Pharm. Des. 2004
Times Cited: 30






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List of co-cited articles
89 articles co-cited >1



Times Cited
  Times     Co-cited
Similarity


Recent advances in the applications of radioisotopes in drug metabolism, toxicology and pharmacokinetics.
D Dalvie. Curr. Pharm. Des. 2000
20
8
40

Use of radiolabeled compounds in drug metabolism and pharmacokinetic studies.
Emre M Isin, Charles S Elmore, Göran N Nilsson, Richard A Thompson, Lars Weidolf. Chem. Res. Toxicol. 2012
80
8
26

Drug-protein adducts: an industry perspective on minimizing the potential for drug bioactivation in drug discovery and development.
David C Evans, Alan P Watt, Deborah A Nicoll-Griffith, Thomas A Baillie. Chem. Res. Toxicol. 2004
349
6
20

Palladium-catalyzed ortho-selective C-H deuteration of arenes: evidence for superior reactivity of weakly coordinated palladacycles.
Sandy Ma, Giorgio Villa, Peter S Thuy-Boun, Anna Homs, Jin-Quan Yu. Angew. Chem. Int. Ed. Engl. 2014
56
5
16

Cytochrome p450 and chemical toxicology.
F Peter Guengerich. Chem. Res. Toxicol. 2008
725
4
13

Radiolabeled absorption, distribution, metabolism, and excretion studies in drug development: why, when, and how?
Natalia Penner, Lin Xu, Chandra Prakash. Chem. Res. Toxicol. 2012
62
4
13

Human radiolabeled mass balance studies: objectives, utilities and limitations.
Natalia Penner, Lewis J Klunk, Chandra Prakash. Biopharm Drug Dispos 2009
50
4
13

The renaissance of H/D exchange.
Jens Atzrodt, Volker Derdau, Thorsten Fey, Jochen Zimmermann. Angew. Chem. Int. Ed. Engl. 2007
177
4
13

Isotope chemistry; a useful tool in the drug discovery arsenal.
Charles S Elmore, Ryan A Bragg. Bioorg. Med. Chem. Lett. 2015
38
4
13

Photoredox-catalyzed deuteration and tritiation of pharmaceutical compounds.
Yong Yao Loh, Kazunori Nagao, Andrew J Hoover, David Hesk, Nelo R Rivera, Steven L Colletti, Ian W Davies, David W C MacMillan. Science 2017
75
4
13

Functional expression of sinusoidal drug transporters in primary human and rat hepatocytes.
Emilie Jigorel, Marc Le Vee, Claire Boursier-Neyret, Marc Bertrand, Olivier Fardel. Drug Metab. Dispos. 2005
80
3
10

Novel approach to performing metabolite identification in drug metabolism.
A-E F Nassar, D Y Lee. J Chromatogr Sci 2007
8
3
37

Safety assessment of drug metabolites: Characterization of chemically stable metabolites.
W Griffith Humphreys, Steve E Unger. Chem. Res. Toxicol. 2006
29
3
10

Dansyl glutathione as a trapping agent for the quantitative estimation and identification of reactive metabolites.
Jinping Gan, Timothy W Harper, Mei-Mann Hsueh, Qinling Qu, W Griffith Humphreys. Chem Res Toxicol 2005
78
3
10

What is the objective of the mass balance study? A retrospective analysis of data in animal and human excretion studies employing radiolabeled drugs.
Sarah J Roffey, R Scott Obach, Jenny I Gedge, Dennis A Smith. Drug Metab. Rev. 2007
115
3
10

Managing the challenge of chemically reactive metabolites in drug development.
B Kevin Park, Alan Boobis, Stephen Clarke, Chris E P Goldring, David Jones, J Gerry Kenna, Craig Lambert, Hugh G Laverty, Dean J Naisbitt, Sidney Nelson,[...]. Nat Rev Drug Discov 2011
220
3
10

Application of stable isotope-labeled compounds in metabolism and in metabolism-mediated toxicity studies.
Abdul E Mutlib. Chem. Res. Toxicol. 2008
61
3
10

Drug localization and targeting with receptor microscopic autoradiography.
Walter E Stumpf. J Pharmacol Toxicol Methods 2005
37
3
10

A perspective on tritium versus carbon-14: ensuring optimal label selection in pharmaceutical research and development.
Joel A Krauser. J Labelled Comp Radiopharm 2013
18
3
16

Heavy drugs draw heavy interest from pharma backers.
Alla Katsnelson. Nat. Med. 2013
60
3
10

C-H Functionalisation for Hydrogen Isotope Exchange.
Jens Atzrodt, Volker Derdau, William J Kerr, Marc Reid. Angew. Chem. Int. Ed. Engl. 2018
52
3
10

Iron-catalysed tritiation of pharmaceuticals.
Renyuan Pony Yu, David Hesk, Nelo Rivera, István Pelczer, Paul J Chirik. Nature 2016
77
3
10

Cytochrome P450 3A4-mediated bioactivation of raloxifene: irreversible enzyme inhibition and thiol adduct formation.
Qing Chen, Jason S Ngui, George A Doss, Regina W Wang, Xiaoxin Cai, Frank P DiNinno, Timothy A Blizzard, Milton L Hammond, Ralph A Stearns, David C Evans,[...]. Chem. Res. Toxicol. 2002
86
2
6

Addressing the metabolic activation potential of new leads in drug discovery: a case study using ion trap mass spectrometry and tritium labeling techniques.
Koppara Samuel, Wenji Yin, Ralph A Stearns, Yui S Tang, Ashok G Chaudhary, James P Jewell, Thomas Lanza, Linus S Lin, William K Hagmann, David C Evans,[...]. J Mass Spectrom 2003
34
2
6

Systematic LC/MS metabolite identification in drug discovery.
N J Clarke, D Rindgen, W A Korfmacher, K A Cox. Anal. Chem. 2001
63
2
6

The price of innovation: new estimates of drug development costs.
Joseph A DiMasi, Ronald W Hansen, Henry G Grabowski. J Health Econ 2003
1365
2
6

Valdecoxib withdrawal leaves pain relief treatment gap.
Les Lang. Gastroenterology 2005
4
2
50

Vioxx, the implosion of Merck, and aftershocks at the FDA.
Richard Horton. Lancet 2004
54
2
6

On-line liquid chromatography-accurate radioisotope counting coupled with a radioactivity detector and mass spectrometer for metabolite identification in drug discovery and development.
A E F Nassar, S M Bjorge, D Y Lee. Anal. Chem. 2003
26
2
7

Disposition of [14C]ruboxistaurin in humans.
Jennifer L Burkey, Kristina M Campanale, Robert Barbuch, Douglas O'Bannon, James Rash, Charles Benson, David Small. Drug Metab. Dispos. 2006
4
2
50

Metabolism and disposition of a potent group II metabotropic glutamate receptor agonist, in rats, dogs, and monkeys.
Joyce K James, Masato Nakamura, Atsuro Nakazato, Kanyin E Zhang, Merryl Cramer, Janice Brunner, Jacquelynn Cook, Weichao G Chen. Drug Metab. Dispos. 2005
4
2
50

Metabolite generation via microbial biotransformations with Actinomycetes: rapid screening for active strains and biosynthesis of important human metabolites of two development-stage compounds, 5-[(5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]non7-yl-methyl]-3-thiophenecarboxylic acid (BMS-587101) and dasatinib.
Wenying Li, Jonathan L Josephs, Gary L Skiles, W Griffith Humphreys. Drug Metab. Dispos. 2008
10
2
20

Analysis of low level radioactive metabolites in biological fluids using high-performance liquid chromatography with microplate scintillation counting: method validation and application.
Mingshe Zhu, Weiping Zhao, Natasha Vazquez, James G Mitroka. J Pharm Biomed Anal 2005
33
2
6

MSE with mass defect filtering for in vitro and in vivo metabolite identification.
Kevin P Bateman, Jose Castro-Perez, Mark Wrona, John P Shockcor, Kate Yu, Renata Oballa, Deborah A Nicoll-Griffith. Rapid Commun. Mass Spectrom. 2007
149
2
6

Development and evaluation of an electrochemical method for studying reactive phase-I metabolites: correlation to in vitro drug metabolism.
Kim G Madsen, Jørgen Olsen, Christian Skonberg, Steen H Hansen, Ulrik Jurva. Chem. Res. Toxicol. 2007
56
2
6

Biomimetic modeling of oxidative drug metabolism : Strategies, advantages and limitations.
Wiebke Lohmann, Uwe Karst. Anal Bioanal Chem 2008
61
2
6

Prediction of drug metabolism and interactions on the basis of in vitro investigations.
Olavi Pelkonen, Miia Turpeinen, Jouko Uusitalo, Arja Rautio, Hannu Raunio. Basic Clin. Pharmacol. Toxicol. 2005
76
2
6

Simulation of the detoxification of paracetamol using on-line electrochemistry/liquid chromatography/mass spectrometry.
Wiebke Lohmann, Uwe Karst. Anal Bioanal Chem 2006
45
2
6

Bioactivation of diclofenac in vitro and in vivo: correlation to electrochemical studies.
Kim G Madsen, Christian Skonberg, Ulrik Jurva, Claus Cornett, Steen H Hansen, Tommy N Johansen, Jørgen Olsen. Chem. Res. Toxicol. 2008
39
2
6

Mimicry of phase I drug metabolism--novel methods for metabolite characterization and synthesis.
Tove Johansson, Lars Weidolf, Ulrik Jurva. Rapid Commun. Mass Spectrom. 2007
62
2
6

On-line electrochemistry/liquid chromatography/mass spectrometry for the simulation of pesticide metabolism.
Wiebke Lohmann, Reinhard Dötzer, Gerald Gütter, Suze M Van Leeuwen, Uwe Karst. J. Am. Soc. Mass Spectrom. 2009
25
2
8

A regulatory perspective on issues and approaches in characterizing human metabolites.
Karen L Davis-Bruno, Aisar Atrakchi. Chem. Res. Toxicol. 2006
32
2
6

Prediction of clozapine metabolism by on-line electrochemistry/liquid chromatography/mass spectrometry.
Suze M van Leeuwen, Bertrand Blankert, Jean-Michel Kauffmann, Uwe Karst. Anal Bioanal Chem 2005
52
2
6

Comparison between electrochemistry/mass spectrometry and cytochrome P450 catalyzed oxidation reactions.
Ulrik Jurva, Håkan V Wikström, Lars Weidolf, Andries P Bruins. Rapid Commun. Mass Spectrom. 2003
96
2
6

Applying mechanisms of chemical toxicity to predict drug safety.
F Peter Guengerich, James S MacDonald. Chem. Res. Toxicol. 2007
102
2
6

An update on in vitro test methods in human hepatic drug biotransformation research: pros and cons.
Esther F A Brandon, Christiaan D Raap, Irma Meijerman, Jos H Beijnen, Jan H M Schellens. Toxicol. Appl. Pharmacol. 2003
293
2
6

Use of an electrochemically synthesised metabolite of a selective androgen receptor modulator for mass spectrometry-based sports drug testing.
Mario Thevis, Wiebke Lohmann, Yvonne Schrader, Maxie Kohler, Wolfgang Bornatsch, Uwe Karst, Wilhelm Schänzer. Eur J Mass Spectrom (Chichester) 2008
25
2
8

Generation and identification of reactive metabolites by electrochemistry and immobilized enzymes coupled on-line to liquid chromatography/mass spectrometry.
Wiebke Lohmann, Uwe Karst. Anal. Chem. 2007
45
2
6

Electrochemical generation of electrophilic drug metabolites: characterization of amodiaquine quinoneimine and cysteinyl conjugates by MS, IR, and NMR.
Ulrik Jurva, Anders Holmén, Gunnar Grönberg, Collen Masimirembwa, Lars Weidolf. Chem. Res. Toxicol. 2008
27
2
7

A generic method to detect electrophilic intermediates using isotopic pattern triggered data-dependent high-resolution accurate mass spectrometry.
Heng-Keang Lim, Jie Chen, Kevin Cook, Carlo Sensenhauser, Jose Silva, David C Evans. Rapid Commun. Mass Spectrom. 2008
47
2
6


Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.

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