A citation-based method for searching scientific literature

P H Marathe, W C Shyu, W G Humphreys. Curr. Pharm. Des. 2004
Times Cited: 30







List of co-cited articles
89 articles co-cited >1



Times Cited
  Times     Co-cited
Similarity



Use of radiolabeled compounds in drug metabolism and pharmacokinetic studies.
Emre M Isin, Charles S Elmore, Göran N Nilsson, Richard A Thompson, Lars Weidolf. Chem. Res. Toxicol. 2012
80
26

Drug-protein adducts: an industry perspective on minimizing the potential for drug bioactivation in drug discovery and development.
David C Evans, Alan P Watt, Deborah A Nicoll-Griffith, Thomas A Baillie. Chem. Res. Toxicol. 2004
349
20

Palladium-catalyzed ortho-selective C-H deuteration of arenes: evidence for superior reactivity of weakly coordinated palladacycles.
Sandy Ma, Giorgio Villa, Peter S Thuy-Boun, Anna Homs, Jin-Quan Yu. Angew. Chem. Int. Ed. Engl. 2014
56
16

Cytochrome p450 and chemical toxicology.
F Peter Guengerich. Chem. Res. Toxicol. 2008
725
13


Human radiolabeled mass balance studies: objectives, utilities and limitations.
Natalia Penner, Lewis J Klunk, Chandra Prakash. Biopharm Drug Dispos 2009
50
13

The renaissance of H/D exchange.
Jens Atzrodt, Volker Derdau, Thorsten Fey, Jochen Zimmermann. Angew. Chem. Int. Ed. Engl. 2007
177
13

Isotope chemistry; a useful tool in the drug discovery arsenal.
Charles S Elmore, Ryan A Bragg. Bioorg. Med. Chem. Lett. 2015
38
13

Photoredox-catalyzed deuteration and tritiation of pharmaceutical compounds.
Yong Yao Loh, Kazunori Nagao, Andrew J Hoover, David Hesk, Nelo R Rivera, Steven L Colletti, Ian W Davies, David W C MacMillan. Science 2017
75
13

Functional expression of sinusoidal drug transporters in primary human and rat hepatocytes.
Emilie Jigorel, Marc Le Vee, Claire Boursier-Neyret, Marc Bertrand, Olivier Fardel. Drug Metab. Dispos. 2005
80
10


Safety assessment of drug metabolites: Characterization of chemically stable metabolites.
W Griffith Humphreys, Steve E Unger. Chem. Res. Toxicol. 2006
29
10

Dansyl glutathione as a trapping agent for the quantitative estimation and identification of reactive metabolites.
Jinping Gan, Timothy W Harper, Mei-Mann Hsueh, Qinling Qu, W Griffith Humphreys. Chem Res Toxicol 2005
78
10


Managing the challenge of chemically reactive metabolites in drug development.
B Kevin Park, Alan Boobis, Stephen Clarke, Chris E P Goldring, David Jones, J Gerry Kenna, Craig Lambert, Hugh G Laverty, Dean J Naisbitt, Sidney Nelson,[...]. Nat Rev Drug Discov 2011
220
10


Drug localization and targeting with receptor microscopic autoradiography.
Walter E Stumpf. J Pharmacol Toxicol Methods 2005
37
10



C-H Functionalisation for Hydrogen Isotope Exchange.
Jens Atzrodt, Volker Derdau, William J Kerr, Marc Reid. Angew. Chem. Int. Ed. Engl. 2018
52
10

Iron-catalysed tritiation of pharmaceuticals.
Renyuan Pony Yu, David Hesk, Nelo Rivera, István Pelczer, Paul J Chirik. Nature 2016
77
10

Cytochrome P450 3A4-mediated bioactivation of raloxifene: irreversible enzyme inhibition and thiol adduct formation.
Qing Chen, Jason S Ngui, George A Doss, Regina W Wang, Xiaoxin Cai, Frank P DiNinno, Timothy A Blizzard, Milton L Hammond, Ralph A Stearns, David C Evans,[...]. Chem. Res. Toxicol. 2002
86
6

Addressing the metabolic activation potential of new leads in drug discovery: a case study using ion trap mass spectrometry and tritium labeling techniques.
Koppara Samuel, Wenji Yin, Ralph A Stearns, Yui S Tang, Ashok G Chaudhary, James P Jewell, Thomas Lanza, Linus S Lin, William K Hagmann, David C Evans,[...]. J Mass Spectrom 2003
34
6

Systematic LC/MS metabolite identification in drug discovery.
N J Clarke, D Rindgen, W A Korfmacher, K A Cox. Anal. Chem. 2001
63
6

The price of innovation: new estimates of drug development costs.
Joseph A DiMasi, Ronald W Hansen, Henry G Grabowski. J Health Econ 2003
6




Disposition of [14C]ruboxistaurin in humans.
Jennifer L Burkey, Kristina M Campanale, Robert Barbuch, Douglas O'Bannon, James Rash, Charles Benson, David Small. Drug Metab. Dispos. 2006
4
50

Metabolism and disposition of a potent group II metabotropic glutamate receptor agonist, in rats, dogs, and monkeys.
Joyce K James, Masato Nakamura, Atsuro Nakazato, Kanyin E Zhang, Merryl Cramer, Janice Brunner, Jacquelynn Cook, Weichao G Chen. Drug Metab. Dispos. 2005
4
50



MSE with mass defect filtering for in vitro and in vivo metabolite identification.
Kevin P Bateman, Jose Castro-Perez, Mark Wrona, John P Shockcor, Kate Yu, Renata Oballa, Deborah A Nicoll-Griffith. Rapid Commun. Mass Spectrom. 2007
149
6

Development and evaluation of an electrochemical method for studying reactive phase-I metabolites: correlation to in vitro drug metabolism.
Kim G Madsen, Jørgen Olsen, Christian Skonberg, Steen H Hansen, Ulrik Jurva. Chem. Res. Toxicol. 2007
56
6


Prediction of drug metabolism and interactions on the basis of in vitro investigations.
Olavi Pelkonen, Miia Turpeinen, Jouko Uusitalo, Arja Rautio, Hannu Raunio. Basic Clin. Pharmacol. Toxicol. 2005
76
6


Bioactivation of diclofenac in vitro and in vivo: correlation to electrochemical studies.
Kim G Madsen, Christian Skonberg, Ulrik Jurva, Claus Cornett, Steen H Hansen, Tommy N Johansen, Jørgen Olsen. Chem. Res. Toxicol. 2008
39
6

Mimicry of phase I drug metabolism--novel methods for metabolite characterization and synthesis.
Tove Johansson, Lars Weidolf, Ulrik Jurva. Rapid Commun. Mass Spectrom. 2007
62
6

On-line electrochemistry/liquid chromatography/mass spectrometry for the simulation of pesticide metabolism.
Wiebke Lohmann, Reinhard Dötzer, Gerald Gütter, Suze M Van Leeuwen, Uwe Karst. J. Am. Soc. Mass Spectrom. 2009
25
8

A regulatory perspective on issues and approaches in characterizing human metabolites.
Karen L Davis-Bruno, Aisar Atrakchi. Chem. Res. Toxicol. 2006
32
6

Prediction of clozapine metabolism by on-line electrochemistry/liquid chromatography/mass spectrometry.
Suze M van Leeuwen, Bertrand Blankert, Jean-Michel Kauffmann, Uwe Karst. Anal Bioanal Chem 2005
52
6

Comparison between electrochemistry/mass spectrometry and cytochrome P450 catalyzed oxidation reactions.
Ulrik Jurva, Håkan V Wikström, Lars Weidolf, Andries P Bruins. Rapid Commun. Mass Spectrom. 2003
96
6

Applying mechanisms of chemical toxicity to predict drug safety.
F Peter Guengerich, James S MacDonald. Chem. Res. Toxicol. 2007
102
6

An update on in vitro test methods in human hepatic drug biotransformation research: pros and cons.
Esther F A Brandon, Christiaan D Raap, Irma Meijerman, Jos H Beijnen, Jan H M Schellens. Toxicol. Appl. Pharmacol. 2003
293
6

Use of an electrochemically synthesised metabolite of a selective androgen receptor modulator for mass spectrometry-based sports drug testing.
Mario Thevis, Wiebke Lohmann, Yvonne Schrader, Maxie Kohler, Wolfgang Bornatsch, Uwe Karst, Wilhelm Schänzer. Eur J Mass Spectrom (Chichester) 2008
25
8


Electrochemical generation of electrophilic drug metabolites: characterization of amodiaquine quinoneimine and cysteinyl conjugates by MS, IR, and NMR.
Ulrik Jurva, Anders Holmén, Gunnar Grönberg, Collen Masimirembwa, Lars Weidolf. Chem. Res. Toxicol. 2008
27
7

A generic method to detect electrophilic intermediates using isotopic pattern triggered data-dependent high-resolution accurate mass spectrometry.
Heng-Keang Lim, Jie Chen, Kevin Cook, Carlo Sensenhauser, Jose Silva, David C Evans. Rapid Commun. Mass Spectrom. 2008
47
6


Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.