A citation-based method for searching scientific literature

Montserrat Arrasate, Siddhartha Mitra, Erik S Schweitzer, Mark R Segal, Steven Finkbeiner. Nature 2004
Times Cited: 1460







List of co-cited articles
1158 articles co-cited >1



Times Cited
  Times     Co-cited
Similarity


Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain.
M DiFiglia, E Sapp, K O Chase, S W Davies, G P Bates, J P Vonsattel, N Aronin. Science 1997
20



Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation.
S W Davies, M Turmaine, B A Cozens, M DiFiglia, A H Sharp, C A Ross, E Scherzinger, E E Wanker, L Mangiarini, G P Bates. Cell 1997
16

In Situ Architecture and Cellular Interactions of PolyQ Inclusions.
Felix J B Bäuerlein, Itika Saha, Archana Mishra, Maria Kalemanov, Antonio Martínez-Sánchez, Rüdiger Klein, Irina Dudanova, Mark S Hipp, F Ulrich Hartl, Wolfgang Baumeister,[...]. Cell 2017
162
15

The Biology of Huntingtin.
Frédéric Saudou, Sandrine Humbert. Neuron 2016
436
15

Soluble Oligomers of PolyQ-Expanded Huntingtin Target a Multiplicity of Key Cellular Factors.
Yujin E Kim, Fabian Hosp, Frédéric Frottin, Hui Ge, Matthias Mann, Manajit Hayer-Hartl, F Ulrich Hartl. Mol Cell 2016
111
13

Misfolded proteins partition between two distinct quality control compartments.
Daniel Kaganovich, Ron Kopito, Judith Frydman. Nature 2008
664
13

Amyloid-like aggregates sequester numerous metastable proteins with essential cellular functions.
Heidi Olzscha, Sonya M Schermann, Andreas C Woerner, Stefan Pinkert, Michael H Hecht, Gian G Tartaglia, Michele Vendruscolo, Manajit Hayer-Hartl, F Ulrich Hartl, R Martin Vabulas. Cell 2011
477
12

Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice.
L Mangiarini, K Sathasivam, M Seller, B Cozens, A Harper, C Hetherington, M Lawton, Y Trottier, H Lehrach, S W Davies,[...]. Cell 1996
12

Aggresomes: a cellular response to misfolded proteins.
J A Johnston, C L Ward, R R Kopito. J Cell Biol 1998
10

Mutant huntingtin's interaction with mitochondrial protein Drp1 impairs mitochondrial biogenesis and causes defective axonal transport and synaptic degeneration in Huntington's disease.
Ulziibat P Shirendeb, Marcus J Calkins, Maria Manczak, Vishwanath Anekonda, Brett Dufour, Jodi L McBride, Peizhong Mao, P Hemachandra Reddy. Hum Mol Genet 2012
243
9

Soluble polyglutamine oligomers formed prior to inclusion body formation are cytotoxic.
Toshiaki Takahashi, Shinya Kikuchi, Shinichi Katada, Yoshitaka Nagai, Masatoyo Nishizawa, Osamu Onodera. Hum Mol Genet 2008
172
9

Huntingtin-encoded polyglutamine expansions form amyloid-like protein aggregates in vitro and in vivo.
E Scherzinger, R Lurz, M Turmaine, L Mangiarini, B Hollenbach, R Hasenbank, G P Bates, S W Davies, H Lehrach, E E Wanker. Cell 1997
9

Huntington disease.
Gillian P Bates, Ray Dorsey, James F Gusella, Michael R Hayden, Chris Kay, Blair R Leavitt, Martha Nance, Christopher A Ross, Rachael I Scahill, Ronald Wetzel,[...]. Nat Rev Dis Primers 2015
682
8

Identifying polyglutamine protein species in situ that best predict neurodegeneration.
Jason Miller, Montserrat Arrasate, Elizabeth Brooks, Clare Peters Libeu, Justin Legleiter, Danny Hatters, Jessica Curtis, Kenneth Cheung, Preethi Krishnan, Siddhartha Mitra,[...]. Nat Chem Biol 2011
141
8

mHTT Seeding Activity: A Marker of Disease Progression and Neurotoxicity in Models of Huntington's Disease.
Anne Ast, Alexander Buntru, Franziska Schindler, Regine Hasenkopf, Aline Schulz, Lydia Brusendorf, Konrad Klockmeier, Gerlinde Grelle, Benjamin McMahon, Hannah Niederlechner,[...]. Mol Cell 2018
35
22

Adapting proteostasis for disease intervention.
William E Balch, Richard I Morimoto, Andrew Dillin, Jeffery W Kelly. Science 2008
8


Widespread Proteome Remodeling and Aggregation in Aging C. elegans.
Dirk M Walther, Prasad Kasturi, Min Zheng, Stefan Pinkert, Giulia Vecchi, Prajwal Ciryam, Richard I Morimoto, Christopher M Dobson, Michele Vendruscolo, Matthias Mann,[...]. Cell 2015
328
8



Neuropathological classification of Huntington's disease.
J P Vonsattel, R H Myers, T J Stevens, R J Ferrante, E D Bird, E P Richardson. J Neuropathol Exp Neurol 1985
8

Huntington's disease: from molecular pathogenesis to clinical treatment.
Christopher A Ross, Sarah J Tabrizi. Lancet Neurol 2011
987
8

PolyQ proteins interfere with nuclear degradation of cytosolic proteins by sequestering the Sis1p chaperone.
Sae-Hun Park, Yury Kukushkin, Rajat Gupta, Taotao Chen, Ayano Konagai, Mark S Hipp, Manajit Hayer-Hartl, F Ulrich Hartl. Cell 2013
247
7

Self-assembly of polyglutamine-containing huntingtin fragments into amyloid-like fibrils: implications for Huntington's disease pathology.
E Scherzinger, A Sittler, K Schweiger, V Heiser, R Lurz, R Hasenbank, G P Bates, H Lehrach, E E Wanker. Proc Natl Acad Sci U S A 1999
535
7

Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis.
Manuela Neumann, Deepak M Sampathu, Linda K Kwong, Adam C Truax, Matthew C Micsenyi, Thomas T Chou, Jennifer Bruce, Theresa Schuck, Murray Grossman, Christopher M Clark,[...]. Science 2006
7

Protein aggregation and neurodegenerative disease.
Christopher A Ross, Michelle A Poirier. Nat Med 2004
7

The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress.
Yoshiharu Kawaguchi, Jeffrey J Kovacs, Adam McLaurin, Jeffery M Vance, Akihiro Ito, Tso Pang Yao. Cell 2003
7

Proteostasis impairment in protein-misfolding and -aggregation diseases.
Mark S Hipp, Sae-Hun Park, F Ulrich Hartl. Trends Cell Biol 2014
389
7

Widespread protein aggregation as an inherent part of aging in C. elegans.
Della C David, Noah Ollikainen, Jonathan C Trinidad, Michael P Cary, Alma L Burlingame, Cynthia Kenyon. PLoS Biol 2010
413
7

The biology of proteostasis in aging and disease.
Johnathan Labbadia, Richard I Morimoto. Annu Rev Biochem 2015
701
7

Spatiotemporal Proteomic Profiling of Huntington's Disease Inclusions Reveals Widespread Loss of Protein Function.
Fabian Hosp, Sara Gutiérrez-Ángel, Martin H Schaefer, Jürgen Cox, Felix Meissner, Mark S Hipp, F-Ulrich Hartl, Rüdiger Klein, Irina Dudanova, Matthias Mann. Cell Rep 2017
70
10

Nuclear and neuropil aggregates in Huntington's disease: relationship to neuropathology.
C A Gutekunst, S H Li, H Yi, J S Mulroy, S Kuemmerle, R Jones, D Rye, R J Ferrante, S M Hersch, X J Li. J Neurosci 1999
629
7

Comprehensive behavioral and molecular characterization of a new knock-in mouse model of Huntington's disease: zQ175.
Liliana B Menalled, Andrea E Kudwa, Sam Miller, Jon Fitzpatrick, Judy Watson-Johnson, Nicole Keating, Melinda Ruiz, Richard Mushlin, William Alosio, Kristi McConnell,[...]. PLoS One 2012
245
7

Huntington disease.
J P Vonsattel, M DiFiglia. J Neuropathol Exp Neurol 1998
7

Cytoplasmic mislocalization of TDP-43 is toxic to neurons and enhanced by a mutation associated with familial amyotrophic lateral sclerosis.
Sami J Barmada, Gaia Skibinski, Erica Korb, Elizabeth J Rao, Jane Y Wu, Steven Finkbeiner. J Neurosci 2010
338
6

Huntingtin spheroids and protofibrils as precursors in polyglutamine fibrilization.
Michelle A Poirier, Huilin Li, Jed Macosko, Shuowei Cai, Mario Amzel, Christopher A Ross. J Biol Chem 2002
281
6

Tracking mutant huntingtin aggregation kinetics in cells reveals three major populations that include an invariant oligomer pool.
Maya A Olshina, Lauren M Angley, Yasmin M Ramdzan, Jinwei Tang, Michael F Bailey, Andrew F Hill, Danny M Hatters. J Biol Chem 2010
93
6

Polyglutamine disruption of the huntingtin exon 1 N terminus triggers a complex aggregation mechanism.
Ashwani K Thakur, Murali Jayaraman, Rakesh Mishra, Monika Thakur, Veronique M Chellgren, In-Ja L Byeon, Dalaver H Anjum, Ravindra Kodali, Trevor P Creamer, James F Conway,[...]. Nat Struct Mol Biol 2009
317
6

Huntingtin has a membrane association signal that can modulate huntingtin aggregation, nuclear entry and toxicity.
Randy Singh Atwal, Jianrun Xia, Deborah Pinchev, Jillian Taylor, Richard M Epand, Ray Truant. Hum Mol Genet 2007
269
6

Disruption of the nuclear membrane by perinuclear inclusions of mutant huntingtin causes cell-cycle re-entry and striatal cell death in mouse and cell models of Huntington's disease.
Kuan-Yu Liu, Yu-Chiau Shyu, Brett A Barbaro, Yuan-Ta Lin, Yijuang Chern, Leslie Michels Thompson, Che-Kun James Shen, J Lawrence Marsh. Hum Mol Genet 2015
51
11

Protein aggregates in Huntington's disease.
Montserrat Arrasate, Steven Finkbeiner. Exp Neurol 2012
210
6

Mutational analysis implicates the amyloid fibril as the toxic entity in Huntington's disease.
Kenneth W Drombosky, Sascha Rode, Ravi Kodali, Tija C Jacob, Michael J Palladino, Ronald Wetzel. Neurobiol Dis 2018
26
23

The interaction of polyglutamine peptides with lipid membranes is regulated by flanking sequences associated with huntingtin.
Kathleen A Burke, Karlina J Kauffman, C Samuel Umbaugh, Shelli L Frey, Justin Legleiter. J Biol Chem 2013
62
9

IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome.
Leslie Michels Thompson, Charity T Aiken, Linda S Kaltenbach, Namita Agrawal, Katalin Illes, Ali Khoshnan, Marta Martinez-Vincente, Montserrat Arrasate, Jacqueline Gire O'Rourke, Hasan Khashwji,[...]. J Cell Biol 2009
263
6

Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging.
Anat Ben-Zvi, Elizabeth A Miller, Richard I Morimoto. Proc Natl Acad Sci U S A 2009
457
6

Molecular chaperones in protein folding and proteostasis.
F Ulrich Hartl, Andreas Bracher, Manajit Hayer-Hartl. Nature 2011
6


Polyglutamine tracts regulate beclin 1-dependent autophagy.
Avraham Ashkenazi, Carla F Bento, Thomas Ricketts, Mariella Vicinanza, Farah Siddiqi, Mariana Pavel, Ferdinando Squitieri, Maarten C Hardenberg, Sara Imarisio, Fiona M Menzies,[...]. Nature 2017
208
6


Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.