A citation-based method for searching scientific literature

Montserrat Arrasate, Siddhartha Mitra, Erik S Schweitzer, Mark R Segal, Steven Finkbeiner. Nature 2004
Times Cited: 1301







List of co-cited articles
1414 articles co-cited >1



Times Cited
  Times     Co-cited
Similarity


In Situ Architecture and Cellular Interactions of PolyQ Inclusions.
Felix J B Bäuerlein, Itika Saha, Archana Mishra, Maria Kalemanov, Antonio Martínez-Sánchez, Rüdiger Klein, Irina Dudanova, Mark S Hipp, F Ulrich Hartl, Wolfgang Baumeister,[...]. Cell 2017
108
19

Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain.
M DiFiglia, E Sapp, K O Chase, S W Davies, G P Bates, J P Vonsattel, N Aronin. Science 1997
19


Misfolded proteins partition between two distinct quality control compartments.
Daniel Kaganovich, Ron Kopito, Judith Frydman. Nature 2008
614
15

Molecular chaperones in protein folding and proteostasis.
F Ulrich Hartl, Andreas Bracher, Manajit Hayer-Hartl. Nature 2011
15

Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation.
S W Davies, M Turmaine, B A Cozens, M DiFiglia, A H Sharp, C A Ross, E Scherzinger, E E Wanker, L Mangiarini, G P Bates. Cell 1997
15



The Biology of Huntingtin.
Frédéric Saudou, Sandrine Humbert. Neuron 2016
302
13

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease.
Brinda Ravikumar, Coralie Vacher, Zdenek Berger, Janet E Davies, Shouqing Luo, Lourdes G Oroz, Francesco Scaravilli, Douglas F Easton, Rainer Duden, Cahir J O'Kane,[...]. Nat Genet 2004
13

Amyloid-like aggregates sequester numerous metastable proteins with essential cellular functions.
Heidi Olzscha, Sonya M Schermann, Andreas C Woerner, Stefan Pinkert, Michael H Hecht, Gian G Tartaglia, Michele Vendruscolo, Manajit Hayer-Hartl, F Ulrich Hartl, R Martin Vabulas. Cell 2011
420
12

Soluble Oligomers of PolyQ-Expanded Huntingtin Target a Multiplicity of Key Cellular Factors.
Yujin E Kim, Fabian Hosp, Frédéric Frottin, Hui Ge, Matthias Mann, Manajit Hayer-Hartl, F Ulrich Hartl. Mol Cell 2016
80
15

Self-assembly of polyglutamine-containing huntingtin fragments into amyloid-like fibrils: implications for Huntington's disease pathology.
E Scherzinger, A Sittler, K Schweiger, V Heiser, R Lurz, R Hasenbank, G P Bates, H Lehrach, E E Wanker. Proc Natl Acad Sci U S A 1999
459
12

Aggresomes: a cellular response to misfolded proteins.
J A Johnston, C L Ward, R R Kopito. J Cell Biol 1998
12

Huntingtin Inclusions Trigger Cellular Quiescence, Deactivate Apoptosis, and Lead to Delayed Necrosis.
Yasmin M Ramdzan, Mikhail M Trubetskov, Angelique R Ormsby, Estella A Newcombe, Xiaojing Sui, Mark J Tobin, Marie N Bongiovanni, Sally L Gras, Grant Dewson, Jason M L Miller,[...]. Cell Rep 2017
54
20

Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy.
Brinda Ravikumar, Rainer Duden, David C Rubinsztein. Hum Mol Genet 2002
729
11

Identifying polyglutamine protein species in situ that best predict neurodegeneration.
Jason Miller, Montserrat Arrasate, Elizabeth Brooks, Clare Peters Libeu, Justin Legleiter, Danny Hatters, Jessica Curtis, Kenneth Cheung, Preethi Krishnan, Siddhartha Mitra,[...]. Nat Chem Biol 2011
122
11

Cytoplasmic protein aggregates interfere with nucleocytoplasmic transport of protein and RNA.
Andreas C Woerner, Frédéric Frottin, Daniel Hornburg, Li R Feng, Felix Meissner, Maria Patra, Jörg Tatzelt, Matthias Mann, Konstanze F Winklhofer, F Ulrich Hartl,[...]. Science 2016
213
10

Huntingtin-encoded polyglutamine expansions form amyloid-like protein aggregates in vitro and in vivo.
E Scherzinger, R Lurz, M Turmaine, L Mangiarini, B Hollenbach, R Hasenbank, G P Bates, S W Davies, H Lehrach, E E Wanker. Cell 1997
858
10

Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice.
L Mangiarini, K Sathasivam, M Seller, B Cozens, A Harper, C Hetherington, M Lawton, Y Trottier, H Lehrach, S W Davies,[...]. Cell 1996
10

Sustained therapeutic reversal of Huntington's disease by transient repression of huntingtin synthesis.
Holly B Kordasiewicz, Lisa M Stanek, Edward V Wancewicz, Curt Mazur, Melissa M McAlonis, Kimberly A Pytel, Jonathan W Artates, Andreas Weiss, Seng H Cheng, Lamya S Shihabuddin,[...]. Neuron 2012
414
10

Huntingtin functions as a scaffold for selective macroautophagy.
Yan-Ning Rui, Zhen Xu, Bindi Patel, Zhihua Chen, Dongsheng Chen, Antonio Tito, Gabriela David, Yamin Sun, Erin F Stimming, Hugo J Bellen,[...]. Nat Cell Biol 2015
208
10

Aggresomes protect cells by enhancing the degradation of toxic polyglutamine-containing protein.
J Paul Taylor, Fumiaki Tanaka, Jon Robitschek, C Miguel Sandoval, Addis Taye, Silva Markovic-Plese, Kenneth H Fischbeck. Hum Mol Genet 2003
298
10

Adapting proteostasis for disease intervention.
William E Balch, Richard I Morimoto, Andrew Dillin, Jeffery W Kelly. Science 2008
9

Spatiotemporal Proteomic Profiling of Huntington's Disease Inclusions Reveals Widespread Loss of Protein Function.
Fabian Hosp, Sara Gutiérrez-Ángel, Martin H Schaefer, Jürgen Cox, Felix Meissner, Mark S Hipp, F-Ulrich Hartl, Rüdiger Klein, Irina Dudanova, Matthias Mann. Cell Rep 2017
47
19

Huntingtin spheroids and protofibrils as precursors in polyglutamine fibrilization.
Michelle A Poirier, Huilin Li, Jed Macosko, Shuowei Cai, Mario Amzel, Christopher A Ross. J Biol Chem 2002
247
9

Loss of autophagy in the central nervous system causes neurodegeneration in mice.
Masaaki Komatsu, Satoshi Waguri, Tomoki Chiba, Shigeo Murata, Jun-ichi Iwata, Isei Tanida, Takashi Ueno, Masato Koike, Yasuo Uchiyama, Eiki Kominami,[...]. Nature 2006
9

Proteostasis impairment in protein-misfolding and -aggregation diseases.
Mark S Hipp, Sae-Hun Park, F Ulrich Hartl. Trends Cell Biol 2014
323
8

Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis.
Manuela Neumann, Deepak M Sampathu, Linda K Kwong, Adam C Truax, Matthew C Micsenyi, Thomas T Chou, Jennifer Bruce, Theresa Schuck, Murray Grossman, Christopher M Clark,[...]. Science 2006
8

Cellular strategies for controlling protein aggregation.
Jens Tyedmers, Axel Mogk, Bernd Bukau. Nat Rev Mol Cell Biol 2010
513
8

Spatial sequestration of misfolded proteins by a dynamic chaperone pathway enhances cellular fitness during stress.
Stéphanie Escusa-Toret, Willianne I M Vonk, Judith Frydman. Nat Cell Biol 2013
183
8

Protein aggregation and neurodegenerative disease.
Christopher A Ross, Michelle A Poirier. Nat Med 2004
8

Potential function for the Huntingtin protein as a scaffold for selective autophagy.
Joseph Ochaba, Tamás Lukacsovich, George Csikos, Shuqiu Zheng, Julia Margulis, Lisa Salazar, Kai Mao, Alice L Lau, Sylvia Y Yeung, Sandrine Humbert,[...]. Proc Natl Acad Sci U S A 2014
140
8

Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease.
Marta Martinez-Vicente, Zsolt Talloczy, Esther Wong, Guomei Tang, Hiroshi Koga, Susmita Kaushik, Rosa de Vries, Esperanza Arias, Spike Harris, David Sulzer,[...]. Nat Neurosci 2010
492
8

Widespread Proteome Remodeling and Aggregation in Aging C. elegans.
Dirk M Walther, Prasad Kasturi, Min Zheng, Stefan Pinkert, Giulia Vecchi, Prajwal Ciryam, Richard I Morimoto, Christopher M Dobson, Michele Vendruscolo, Matthias Mann,[...]. Cell 2015
264
8

In vivo aspects of protein folding and quality control.
David Balchin, Manajit Hayer-Hartl, F Ulrich Hartl. Science 2016
498
8

mHTT Seeding Activity: A Marker of Disease Progression and Neurotoxicity in Models of Huntington's Disease.
Anne Ast, Alexander Buntru, Franziska Schindler, Regine Hasenkopf, Aline Schulz, Lydia Brusendorf, Konrad Klockmeier, Gerlinde Grelle, Benjamin McMahon, Hannah Niederlechner,[...]. Mol Cell 2018
22
36

Huntington disease.
Gillian P Bates, Ray Dorsey, James F Gusella, Michael R Hayden, Chris Kay, Blair R Leavitt, Martha Nance, Christopher A Ross, Rachael I Scahill, Ronald Wetzel,[...]. Nat Rev Dis Primers 2015
473
8

Targeting Huntingtin Expression in Patients with Huntington's Disease.
Sarah J Tabrizi, Blair R Leavitt, G Bernhard Landwehrmeyer, Edward J Wild, Carsten Saft, Roger A Barker, Nick F Blair, David Craufurd, Josef Priller, Hugh Rickards,[...]. N Engl J Med 2019
195
8

Soluble polyglutamine oligomers formed prior to inclusion body formation are cytotoxic.
Toshiaki Takahashi, Shinya Kikuchi, Shinichi Katada, Yoshitaka Nagai, Masatoyo Nishizawa, Osamu Onodera. Hum Mol Genet 2008
153
8

PolyQ proteins interfere with nuclear degradation of cytosolic proteins by sequestering the Sis1p chaperone.
Sae-Hun Park, Yury Kukushkin, Rajat Gupta, Taotao Chen, Ayano Konagai, Mark S Hipp, Manajit Hayer-Hartl, F Ulrich Hartl. Cell 2013
218
7

Protein misfolding, functional amyloid, and human disease.
Fabrizio Chiti, Christopher M Dobson. Annu Rev Biochem 2006
7


The amyloid state and its association with protein misfolding diseases.
Tuomas P J Knowles, Michele Vendruscolo, Christopher M Dobson. Nat Rev Mol Cell Biol 2014
7

Huntington disease: natural history, biomarkers and prospects for therapeutics.
Christopher A Ross, Elizabeth H Aylward, Edward J Wild, Douglas R Langbehn, Jeffrey D Long, John H Warner, Rachael I Scahill, Blair R Leavitt, Julie C Stout, Jane S Paulsen,[...]. Nat Rev Neurol 2014
475
7

Nuclear and neuropil aggregates in Huntington's disease: relationship to neuropathology.
C A Gutekunst, S H Li, H Yi, J S Mulroy, S Kuemmerle, R Jones, D Rye, R J Ferrante, S M Hersch, X J Li. J Neurosci 1999
501
7


Trinucleotide repeat disorders.
Harry T Orr, Huda Y Zoghbi. Annu Rev Neurosci 2007
919
7

Polyglutamine disruption of the huntingtin exon 1 N terminus triggers a complex aggregation mechanism.
Ashwani K Thakur, Murali Jayaraman, Rakesh Mishra, Monika Thakur, Veronique M Chellgren, In-Ja L Byeon, Dalaver H Anjum, Ravindra Kodali, Trevor P Creamer, James F Conway,[...]. Nat Struct Mol Biol 2009
288
7

Serines 13 and 16 are critical determinants of full-length human mutant huntingtin induced disease pathogenesis in HD mice.
Xiaofeng Gu, Erin R Greiner, Rakesh Mishra, Ravindra Kodali, Alex Osmand, Steven Finkbeiner, Joan S Steffan, Leslie Michels Thompson, Ronald Wetzel, X William Yang. Neuron 2009
201
7


Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.