Richard C Wang, Agata Smogorzewska, Titia de Lange. Cell 2004
Times Cited: 401
Times Cited: 401
Times Cited
Times Co-cited
Similarity
Mammalian telomeres end in a large duplex loop.
J D Griffith, L Comeau, S Rosenfield, R M Stansel, A Bianchi, H Moss, T de Lange. Cell 1999
J D Griffith, L Comeau, S Rosenfield, R M Stansel, A Bianchi, H Moss, T de Lange. Cell 1999
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Mammalian telomeres resemble fragile sites and require TRF1 for efficient replication.
Agnel Sfeir, Settapong T Kosiyatrakul, Dirk Hockemeyer, Sheila L MacRae, Jan Karlseder, Carl L Schildkraut, Titia de Lange. Cell 2009
Agnel Sfeir, Settapong T Kosiyatrakul, Dirk Hockemeyer, Sheila L MacRae, Jan Karlseder, Carl L Schildkraut, Titia de Lange. Cell 2009
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Super-resolution fluorescence imaging of telomeres reveals TRF2-dependent T-loop formation.
Ylli Doksani, John Y Wu, Titia de Lange, Xiaowei Zhuang. Cell 2013
Ylli Doksani, John Y Wu, Titia de Lange, Xiaowei Zhuang. Cell 2013
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Shelterin: the protein complex that shapes and safeguards human telomeres.
Titia de Lange. Genes Dev 2005
Titia de Lange. Genes Dev 2005
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Telomeric DNA in ALT cells is characterized by free telomeric circles and heterogeneous t-loops.
Anthony J Cesare, Jack D Griffith. Mol Cell Biol 2004
Anthony J Cesare, Jack D Griffith. Mol Cell Biol 2004
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DNA damage foci at dysfunctional telomeres.
Hiroyuki Takai, Agata Smogorzewska, Titia de Lange. Curr Biol 2003
Hiroyuki Takai, Agata Smogorzewska, Titia de Lange. Curr Biol 2003
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RTEL1 dismantles T loops and counteracts telomeric G4-DNA to maintain telomere integrity.
Jean-Baptiste Vannier, Visnja Pavicic-Kaltenbrunner, Mark I R Petalcorin, Hao Ding, Simon J Boulton. Cell 2012
Jean-Baptiste Vannier, Visnja Pavicic-Kaltenbrunner, Mark I R Petalcorin, Hao Ding, Simon J Boulton. Cell 2012
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TRF2 protects human telomeres from end-to-end fusions.
B van Steensel, A Smogorzewska, T de Lange. Cell 1998
B van Steensel, A Smogorzewska, T de Lange. Cell 1998
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Control of telomere length by a trimming mechanism that involves generation of t-circles.
Hilda A Pickett, Anthony J Cesare, Rebecca L Johnston, Axel A Neumann, Roger R Reddel. EMBO J 2009
Hilda A Pickett, Anthony J Cesare, Rebecca L Johnston, Axel A Neumann, Roger R Reddel. EMBO J 2009
25
DNA C-circles are specific and quantifiable markers of alternative-lengthening-of-telomeres activity.
Jeremy D Henson, Ying Cao, Lily I Huschtscha, Andy C Chang, Amy Y M Au, Hilda A Pickett, Roger R Reddel. Nat Biotechnol 2009
Jeremy D Henson, Ying Cao, Lily I Huschtscha, Andy C Chang, Amy Y M Au, Hilda A Pickett, Roger R Reddel. Nat Biotechnol 2009
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Alternative lengthening of telomeres: models, mechanisms and implications.
Anthony J Cesare, Roger R Reddel. Nat Rev Genet 2010
Anthony J Cesare, Roger R Reddel. Nat Rev Genet 2010
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Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1.
Eros Lazzerini Denchi, Titia de Lange. Nature 2007
Eros Lazzerini Denchi, Titia de Lange. Nature 2007
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Telomere maintenance by recombination in human cells.
M A Dunham, A A Neumann, C L Fasching, R R Reddel. Nat Genet 2000
M A Dunham, A A Neumann, C L Fasching, R R Reddel. Nat Genet 2000
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Telomerase-negative immortalized human cells contain a novel type of promyelocytic leukemia (PML) body.
T R Yeager, A A Neumann, A Englezou, L I Huschtscha, J R Noble, R R Reddel. Cancer Res 1999
T R Yeager, A A Neumann, A Englezou, L I Huschtscha, J R Noble, R R Reddel. Cancer Res 1999
21
DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion.
Giulia B Celli, Titia de Lange. Nat Cell Biol 2005
Giulia B Celli, Titia de Lange. Nat Cell Biol 2005
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Telomeric 3' overhangs derive from resection by Exo1 and Apollo and fill-in by POT1b-associated CST.
Peng Wu, Hiroyuki Takai, Titia de Lange. Cell 2012
Peng Wu, Hiroyuki Takai, Titia de Lange. Cell 2012
21
Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor-derived cell lines.
T M Bryan, A Englezou, L Dalla-Pozza, M A Dunham, R R Reddel. Nat Med 1997
T M Bryan, A Englezou, L Dalla-Pozza, M A Dunham, R R Reddel. Nat Med 1997
20
Pot1, the putative telomere end-binding protein in fission yeast and humans.
P Baumann, T R Cech. Science 2001
P Baumann, T R Cech. Science 2001
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Telomeres shorten during ageing of human fibroblasts.
C B Harley, A B Futcher, C W Greider. Nature 1990
C B Harley, A B Futcher, C W Greider. Nature 1990
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Rapid induction of alternative lengthening of telomeres by depletion of the histone chaperone ASF1.
Roderick J O'Sullivan, Nausica Arnoult, Daniel H Lackner, Liana Oganesian, Candy Haggblom, Armelle Corpet, Genevieve Almouzni, Jan Karlseder. Nat Struct Mol Biol 2014
Roderick J O'Sullivan, Nausica Arnoult, Daniel H Lackner, Liana Oganesian, Candy Haggblom, Armelle Corpet, Genevieve Almouzni, Jan Karlseder. Nat Struct Mol Biol 2014
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Telomeric repeat containing RNA and RNA surveillance factors at mammalian chromosome ends.
Claus M Azzalin, Patrick Reichenbach, Lela Khoriauli, Elena Giulotto, Joachim Lingner. Science 2007
Claus M Azzalin, Patrick Reichenbach, Lela Khoriauli, Elena Giulotto, Joachim Lingner. Science 2007
18
Loss of Rap1 induces telomere recombination in the absence of NHEJ or a DNA damage signal.
Agnel Sfeir, Shaheen Kabir, Megan van Overbeek, Giulia B Celli, Titia de Lange. Science 2010
Agnel Sfeir, Shaheen Kabir, Megan van Overbeek, Giulia B Celli, Titia de Lange. Science 2010
18
Loss of ATRX, genome instability, and an altered DNA damage response are hallmarks of the alternative lengthening of telomeres pathway.
Courtney A Lovejoy, Wendi Li, Steven Reisenweber, Supawat Thongthip, Joanne Bruno, Titia de Lange, Saurav De, John H J Petrini, Patricia A Sung, Maria Jasin,[...]. PLoS Genet 2012
Courtney A Lovejoy, Wendi Li, Steven Reisenweber, Supawat Thongthip, Joanne Bruno, Titia de Lange, Saurav De, John H J Petrini, Patricia A Sung, Maria Jasin,[...]. PLoS Genet 2012
17
Removal of shelterin reveals the telomere end-protection problem.
Agnel Sfeir, Titia de Lange. Science 2012
Agnel Sfeir, Titia de Lange. Science 2012
17
T-loop assembly in vitro involves binding of TRF2 near the 3' telomeric overhang.
R M Stansel, T de Lange, J D Griffith. EMBO J 2001
R M Stansel, T de Lange, J D Griffith. EMBO J 2001
17
Identification of human Rap1: implications for telomere evolution.
B Li, S Oestreich, T de Lange. Cell 2000
B Li, S Oestreich, T de Lange. Cell 2000
16
Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2.
D Broccoli, A Smogorzewska, L Chong, T de Lange. Nat Genet 1997
D Broccoli, A Smogorzewska, L Chong, T de Lange. Nat Genet 1997
16
TRF2 recruits RTEL1 to telomeres in S phase to promote t-loop unwinding.
Grzegorz Sarek, Jean-Baptiste Vannier, Stephanie Panier, John H J Petrini, Simon J Boulton. Mol Cell 2015
Grzegorz Sarek, Jean-Baptiste Vannier, Stephanie Panier, John H J Petrini, Simon J Boulton. Mol Cell 2015
16
Identification of a specific telomere terminal transferase activity in Tetrahymena extracts.
C W Greider, E H Blackburn. Cell 1985
C W Greider, E H Blackburn. Cell 1985
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Telomere protection by TPP1/POT1 requires tethering to TIN2.
Kaori K Takai, Tatsuya Kibe, Jill R Donigian, David Frescas, Titia de Lange. Mol Cell 2011
Kaori K Takai, Tatsuya Kibe, Jill R Donigian, David Frescas, Titia de Lange. Mol Cell 2011
15
TRF2 promotes, remodels and protects telomeric Holliday junctions.
Anaïs Poulet, Rémi Buisson, Cendrine Faivre-Moskalenko, Mélanie Koelblen, Simon Amiard, Fabien Montel, Santiago Cuesta-Lopez, Olivier Bornet, Françoise Guerlesquin, Thomas Godet,[...]. EMBO J 2009
Anaïs Poulet, Rémi Buisson, Cendrine Faivre-Moskalenko, Mélanie Koelblen, Simon Amiard, Fabien Montel, Santiago Cuesta-Lopez, Olivier Bornet, Françoise Guerlesquin, Thomas Godet,[...]. EMBO J 2009
18
A DNA damage checkpoint response in telomere-initiated senescence.
Fabrizio d'Adda di Fagagna, Philip M Reaper, Lorena Clay-Farrace, Heike Fiegler, Philippa Carr, Thomas Von Zglinicki, Gabriele Saretzki, Nigel P Carter, Stephen P Jackson. Nature 2003
Fabrizio d'Adda di Fagagna, Philip M Reaper, Lorena Clay-Farrace, Heike Fiegler, Philippa Carr, Thomas Von Zglinicki, Gabriele Saretzki, Nigel P Carter, Stephen P Jackson. Nature 2003
15
Telomere elongation in immortal human cells without detectable telomerase activity.
T M Bryan, A Englezou, J Gupta, S Bacchetti, R R Reddel. EMBO J 1995
T M Bryan, A Englezou, J Gupta, S Bacchetti, R R Reddel. EMBO J 1995
15
A topological mechanism for TRF2-enhanced strand invasion.
Simon Amiard, Michel Doudeau, Sébastien Pinte, Anaïs Poulet, Christelle Lenain, Cendrine Faivre-Moskalenko, Dimitar Angelov, Nele Hug, Alessandro Vindigni, Philippe Bouvet,[...]. Nat Struct Mol Biol 2007
Simon Amiard, Michel Doudeau, Sébastien Pinte, Anaïs Poulet, Christelle Lenain, Cendrine Faivre-Moskalenko, Dimitar Angelov, Nele Hug, Alessandro Vindigni, Philippe Bouvet,[...]. Nat Struct Mol Biol 2007
14
TERRA RNA binding to TRF2 facilitates heterochromatin formation and ORC recruitment at telomeres.
Zhong Deng, Julie Norseen, Andreas Wiedmer, Harold Riethman, Paul M Lieberman. Mol Cell 2009
Zhong Deng, Julie Norseen, Andreas Wiedmer, Harold Riethman, Paul M Lieberman. Mol Cell 2009
14
Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in mice.
Paula Martínez, Maria Thanasoula, Purificación Muñoz, Chunyan Liao, Agueda Tejera, Carolyn McNees, Juana M Flores, Oscar Fernández-Capetillo, Madalena Tarsounas, Maria A Blasco. Genes Dev 2009
Paula Martínez, Maria Thanasoula, Purificación Muñoz, Chunyan Liao, Agueda Tejera, Carolyn McNees, Juana M Flores, Oscar Fernández-Capetillo, Madalena Tarsounas, Maria A Blasco. Genes Dev 2009
14
The basic domain of TRF2 directs binding to DNA junctions irrespective of the presence of TTAGGG repeats.
Nicole Fouché, Anthony J Cesare, Smaranda Willcox, Sezgin Ozgür, Sarah A Compton, Jack D Griffith. J Biol Chem 2006
Nicole Fouché, Anthony J Cesare, Smaranda Willcox, Sezgin Ozgür, Sarah A Compton, Jack D Griffith. J Biol Chem 2006
18
A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins.
Yong Chen, Yuting Yang, Megan van Overbeek, Jill R Donigian, Paul Baciu, Titia de Lange, Ming Lei. Science 2008
Yong Chen, Yuting Yang, Megan van Overbeek, Jill R Donigian, Paul Baciu, Titia de Lange, Ming Lei. Science 2008
14
The basic N-terminal domain of TRF2 limits recombination endonuclease action at human telomeres.
Adélaïde Saint-Léger, Melanie Koelblen, Livia Civitelli, Amadou Bah, Nadir Djerbi, Marie-Josèphe Giraud-Panis, Arturo Londoño-Vallejo, Fiorentina Ascenzioni, Eric Gilson. Cell Cycle 2014
Adélaïde Saint-Léger, Melanie Koelblen, Livia Civitelli, Amadou Bah, Nadir Djerbi, Marie-Josèphe Giraud-Panis, Arturo Londoño-Vallejo, Fiorentina Ascenzioni, Eric Gilson. Cell Cycle 2014
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A two-step mechanism for TRF2-mediated chromosome-end protection.
Keiji Okamoto, Cristina Bartocci, Iliana Ouzounov, Jolene K Diedrich, John R Yates, Eros Lazzerini Denchi. Nature 2013
Keiji Okamoto, Cristina Bartocci, Iliana Ouzounov, Jolene K Diedrich, John R Yates, Eros Lazzerini Denchi. Nature 2013
14
Altered telomeres in tumors with ATRX and DAXX mutations.
Christopher M Heaphy, Roeland F de Wilde, Yuchen Jiao, Alison P Klein, Barish H Edil, Chanjuan Shi, Chetan Bettegowda, Fausto J Rodriguez, Charles G Eberhart, Sachidanand Hebbar,[...]. Science 2011
Christopher M Heaphy, Roeland F de Wilde, Yuchen Jiao, Alison P Klein, Barish H Edil, Chanjuan Shi, Chetan Bettegowda, Fausto J Rodriguez, Charles G Eberhart, Sachidanand Hebbar,[...]. Science 2011
14
Specific association of human telomerase activity with immortal cells and cancer.
N W Kim, M A Piatyszek, K R Prowse, C B Harley, M D West, P L Ho, G M Coviello, W E Wright, S L Weinrich, J W Shay. Science 1994
N W Kim, M A Piatyszek, K R Prowse, C B Harley, M D West, P L Ho, G M Coviello, W E Wright, S L Weinrich, J W Shay. Science 1994
14
TRF2 and apollo cooperate with topoisomerase 2alpha to protect human telomeres from replicative damage.
Jing Ye, Christelle Lenain, Serge Bauwens, Angela Rizzo, Adelaïde Saint-Léger, Anaïs Poulet, Delphine Benarroch, Frédérique Magdinier, Julia Morere, Simon Amiard,[...]. Cell 2010
Jing Ye, Christelle Lenain, Serge Bauwens, Angela Rizzo, Adelaïde Saint-Léger, Anaïs Poulet, Delphine Benarroch, Frédérique Magdinier, Julia Morere, Simon Amiard,[...]. Cell 2010
13
POT1 as a terminal transducer of TRF1 telomere length control.
Diego Loayza, Titia De Lange. Nature 2003
Diego Loayza, Titia De Lange. Nature 2003
13
Apollo contributes to G overhang maintenance and protects leading-end telomeres.
Peng Wu, Megan van Overbeek, Sean Rooney, Titia de Lange. Mol Cell 2010
Peng Wu, Megan van Overbeek, Sean Rooney, Titia de Lange. Mol Cell 2010
13
Xrcc3 and Nbs1 are required for the production of extrachromosomal telomeric circles in human alternative lengthening of telomere cells.
Sarah A Compton, Jun-Hyuk Choi, Anthony J Cesare, Sezgin Ozgür, Jack D Griffith. Cancer Res 2007
Sarah A Compton, Jun-Hyuk Choi, Anthony J Cesare, Sezgin Ozgür, Jack D Griffith. Cancer Res 2007
22
Unusual telomeric DNAs in human telomerase-negative immortalized cells.
Akira Nabetani, Fuyuki Ishikawa. Mol Cell Biol 2009
Akira Nabetani, Fuyuki Ishikawa. Mol Cell Biol 2009
16
p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2.
J Karlseder, D Broccoli, Y Dai, S Hardy, T de Lange. Science 1999
J Karlseder, D Broccoli, Y Dai, S Hardy, T de Lange. Science 1999
13
Spontaneous occurrence of telomeric DNA damage response in the absence of chromosome fusions.
Anthony J Cesare, Zeenia Kaul, Scott B Cohen, Christine E Napier, Hilda A Pickett, Axel A Neumann, Roger R Reddel. Nat Struct Mol Biol 2009
Anthony J Cesare, Zeenia Kaul, Scott B Cohen, Christine E Napier, Hilda A Pickett, Axel A Neumann, Roger R Reddel. Nat Struct Mol Biol 2009
13
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