A citation-based method for searching scientific literature

Alexander Zimprich, Saskia Biskup, Petra Leitner, Peter Lichtner, Matthew Farrer, Sarah Lincoln, Jennifer Kachergus, Mary Hulihan, Ryan J Uitti, Donald B Calne, A Jon Stoessl, Ronald F Pfeiffer, Nadja Patenge, Iria Carballo Carbajal, Peter Vieregge, Friedrich Asmus, Bertram Müller-Myhsok, Dennis W Dickson, Thomas Meitinger, Tim M Strom, Zbigniew K Wszolek, Thomas Gasser. Neuron 2004
Times Cited: 1920







List of co-cited articles
1568 articles co-cited >1



Times Cited
  Times     Co-cited
Similarity


Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease.
Coro Paisán-Ruíz, Shushant Jain, E Whitney Evans, William P Gilks, Javier Simón, Marcel van der Brug, Adolfo López de Munain, Silvia Aparicio, Angel Martínez Gil, Naheed Khan,[...]. Neuron 2004
54

Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases.
Martin Steger, Francesca Tonelli, Genta Ito, Paul Davies, Matthias Trost, Melanie Vetter, Stefanie Wachter, Esben Lorentzen, Graham Duddy, Stephen Wilson,[...]. Elife 2016
431
34

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease.
M H Polymeropoulos, C Lavedan, E Leroy, S E Ide, A Dehejia, A Dutra, B Pike, H Root, J Rubenstein, R Boyer,[...]. Science 1997
31

Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study.
Daniel G Healy, Mario Falchi, Sean S O'Sullivan, Vincenzo Bonifati, Alexandra Durr, Susan Bressman, Alexis Brice, Jan Aasly, Cyrus P Zabetian, Stefano Goldwurm,[...]. Lancet Neurol 2008
909
26

Genome-wide association study reveals genetic risk underlying Parkinson's disease.
Javier Simón-Sánchez, Claudia Schulte, Jose M Bras, Manu Sharma, J Raphael Gibbs, Daniela Berg, Coro Paisan-Ruiz, Peter Lichtner, Sonja W Scholz, Dena G Hernandez,[...]. Nat Genet 2009
23

Staging of brain pathology related to sporadic Parkinson's disease.
Heiko Braak, Kelly Del Tredici, Udo Rüb, Rob A I de Vos, Ernst N H Jansen Steur, Eva Braak. Neurobiol Aging 2003
20

LRRK2 activation in idiopathic Parkinson's disease.
Roberto Di Maio, Eric K Hoffman, Emily M Rocha, Matthew T Keeney, Laurie H Sanders, Briana R De Miranda, Alevtina Zharikov, Amber Van Laar, Antonia F Stepan, Thomas A Lanz,[...]. Sci Transl Med 2018
152
19

Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity.
Andrew B West, Darren J Moore, Saskia Biskup, Artem Bugayenko, Wanli W Smith, Christopher A Ross, Valina L Dawson, Ted M Dawson. Proc Natl Acad Sci U S A 2005
820
19

Functional variants in the LRRK2 gene confer shared effects on risk for Crohn's disease and Parkinson's disease.
Ken Y Hui, Heriberto Fernandez-Hernandez, Jianzhong Hu, Adam Schaffner, Nathan Pankratz, Nai-Yun Hsu, Ling-Shiang Chuang, Shai Carmi, Nicole Villaverde, Xianting Li,[...]. Sci Transl Med 2018
128
18

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism.
T Kitada, S Asakawa, N Hattori, H Matsumine, Y Yamamura, S Minoshima, M Yokochi, Y Mizuno, N Shimizu. Nature 1998
18

Identification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: a meta-analysis of genome-wide association studies.
Mike A Nalls, Cornelis Blauwendraat, Costanza L Vallerga, Karl Heilbron, Sara Bandres-Ciga, Diana Chang, Manuela Tan, Demis A Kia, Alastair J Noyce, Angli Xue,[...]. Lancet Neurol 2019
333
18

Ser1292 autophosphorylation is an indicator of LRRK2 kinase activity and contributes to the cellular effects of PD mutations.
Zejuan Sheng, Shuo Zhang, Daisy Bustos, Tracy Kleinheinz, Claire E Le Pichon, Sara L Dominguez, Hilda O Solanoy, Jason Drummond, Xiaolin Zhang, Xiao Ding,[...]. Sci Transl Med 2012
211
18

Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis.
Martin Steger, Federico Diez, Herschel S Dhekne, Pawel Lis, Raja S Nirujogi, Ozge Karayel, Francesca Tonelli, Terina N Martinez, Esben Lorentzen, Suzanne R Pfeffer,[...]. Elife 2017
161
17

Hereditary early-onset Parkinson's disease caused by mutations in PINK1.
Enza Maria Valente, Patrick M Abou-Sleiman, Viviana Caputo, Miratul M K Muqit, Kirsten Harvey, Suzana Gispert, Zeeshan Ali, Domenico Del Turco, Anna Rita Bentivoglio, Daniel G Healy,[...]. Science 2004
17

Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease.
Mike A Nalls, Nathan Pankratz, Christina M Lill, Chuong B Do, Dena G Hernandez, Mohamad Saad, Anita L DeStefano, Eleanna Kara, Jose Bras, Manu Sharma,[...]. Nat Genet 2014
17

alpha-Synuclein locus triplication causes Parkinson's disease.
A B Singleton, M Farrer, J Johnson, A Singleton, S Hague, J Kachergus, M Hulihan, T Peuralinna, A Dutra, R Nussbaum,[...]. Science 2003
17

Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease.
Wataru Satake, Yuko Nakabayashi, Ikuko Mizuta, Yushi Hirota, Chiyomi Ito, Michiaki Kubo, Takahisa Kawaguchi, Tatsuhiko Tsunoda, Masahiko Watanabe, Atsushi Takeda,[...]. Nat Genet 2009
929
17

Kinase activity is required for the toxic effects of mutant LRRK2/dardarin.
Elisa Greggio, Shushant Jain, Ann Kingsbury, Rina Bandopadhyay, Patrick Lewis, Alice Kaganovich, Marcel P van der Brug, Alexandra Beilina, Jeff Blackinton, Kelly Jean Thomas,[...]. Neurobiol Dis 2006
537
17

A mutation in VPS35, encoding a subunit of the retromer complex, causes late-onset Parkinson disease.
Alexander Zimprich, Anna Benet-Pagès, Walter Struhal, Elisabeth Graf, Sebastian H Eck, Marc N Offman, Dietrich Haubenberger, Sabine Spielberger, Eva C Schulte, Peter Lichtner,[...]. Am J Hum Genet 2011
530
16

Alpha-synuclein in Lewy bodies.
M G Spillantini, M L Schmidt, V M Lee, J Q Trojanowski, R Jakes, M Goedert. Nature 1997
16

The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia.
Juan J Zarranz, Javier Alegre, Juan C Gómez-Esteban, Elena Lezcano, Raquel Ros, Israel Ampuero, Lídice Vidal, Janet Hoenicka, Olga Rodriguez, Begoña Atarés,[...]. Ann Neurol 2004
15

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease.
R Krüger, W Kuhn, T Müller, D Woitalla, M Graeber, S Kösel, H Przuntek, J T Epplen, L Schöls, O Riess. Nat Genet 1998
15

A meta-analysis of genome-wide association studies identifies 17 new Parkinson's disease risk loci.
Diana Chang, Mike A Nalls, Ingileif B Hallgrímsdóttir, Julie Hunkapiller, Marcel van der Brug, Fang Cai, Geoffrey A Kerchner, Gai Ayalon, Baris Bingol, Morgan Sheng,[...]. Nat Genet 2017
480
15

LRRK2 phosphorylates membrane-bound Rabs and is activated by GTP-bound Rab7L1 to promote recruitment to the trans-Golgi network.
Zhiyong Liu, Nicole Bryant, Ravindran Kumaran, Alexandra Beilina, Asa Abeliovich, Mark R Cookson, Andrew B West. Hum Mol Genet 2018
109
14

LRRK2 and its substrate Rab GTPases are sequentially targeted onto stressed lysosomes and maintain their homeostasis.
Tomoya Eguchi, Tomoki Kuwahara, Maria Sakurai, Tadayuki Komori, Tetta Fujimoto, Genta Ito, Shin-Ichiro Yoshimura, Akihiro Harada, Mitsunori Fukuda, Masato Koike,[...]. Proc Natl Acad Sci U S A 2018
89
15

A new locus for Parkinson's disease (PARK8) maps to chromosome 12p11.2-q13.1.
Manabu Funayama, Kazuko Hasegawa, Hisayuki Kowa, Masaaki Saito, Shoji Tsuji, Fumiya Obata. Ann Neurol 2002
412
14

LRRK2 in Parkinson disease: challenges of clinical trials.
Eduardo Tolosa, Miquel Vila, Christine Klein, Olivier Rascol. Nat Rev Neurol 2020
81
17

Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease.
Alexandria Beilina, Iakov N Rudenko, Alice Kaganovich, Laura Civiero, Hien Chau, Suneil K Kalia, Lorraine V Kalia, Evy Lobbestael, Ruth Chia, Kelechi Ndukwe,[...]. Proc Natl Acad Sci U S A 2014
239
13

Rab29 activation of the Parkinson's disease-associated LRRK2 kinase.
Elena Purlyte, Herschel S Dhekne, Adil R Sarhan, Rachel Gomez, Pawel Lis, Melanie Wightman, Terina N Martinez, Francesca Tonelli, Suzanne R Pfeffer, Dario R Alessi. EMBO J 2018
115
13

The effect of LRRK2 loss-of-function variants in humans.
Nicola Whiffin, Irina M Armean, Aaron Kleinman, Jamie L Marshall, Eric V Minikel, Julia K Goodrich, Nicholas M Quaife, Joanne B Cole, Qingbo Wang, Konrad J Karczewski,[...]. Nat Med 2020
35
37

alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies.
M G Spillantini, R A Crowther, R Jakes, M Hasegawa, M Goedert. Proc Natl Acad Sci U S A 1998
12

LRRK2 protein levels are determined by kinase function and are crucial for kidney and lung homeostasis in mice.
Martin C Herzig, Carine Kolly, Elke Persohn, Diethilde Theil, Tatjana Schweizer, Thomas Hafner, Christine Stemmelen, Thomas J Troxler, Peter Schmid, Simone Danner,[...]. Hum Mol Genet 2011
224
12

Association of LRRK2 exonic variants with susceptibility to Parkinson's disease: a case-control study.
Owen A Ross, Alexandra I Soto-Ortolaza, Michael G Heckman, Jan O Aasly, Nadine Abahuni, Grazia Annesi, Justin A Bacon, Soraya Bardien, Maria Bozi, Alexis Brice,[...]. Lancet Neurol 2011
218
12

Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism.
Vincenzo Bonifati, Patrizia Rizzu, Marijke J van Baren, Onno Schaap, Guido J Breedveld, Elmar Krieger, Marieke C J Dekker, Ferdinando Squitieri, Pablo Ibanez, Marijke Joosse,[...]. Science 2003
12

14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization.
R Jeremy Nichols, Nicolas Dzamko, Nicholas A Morrice, David G Campbell, Maria Deak, Alban Ordureau, Thomas Macartney, Youren Tong, Jie Shen, Alan R Prescott,[...]. Biochem J 2010
253
11

Lewy pathology in Parkinson's disease consists of crowded organelles and lipid membranes.
Sarah H Shahmoradian, Amanda J Lewis, Christel Genoud, Jürgen Hench, Tim E Moors, Paula P Navarro, Daniel Castaño-Díez, Gabriel Schweighauser, Alexandra Graff-Meyer, Kenneth N Goldie,[...]. Nat Neurosci 2019
203
11

VPS35 mutations in Parkinson disease.
Carles Vilariño-Güell, Christian Wider, Owen A Ross, Justus C Dachsel, Jennifer M Kachergus, Sarah J Lincoln, Alexandra I Soto-Ortolaza, Stephanie A Cobb, Greggory J Wilhoite, Justin A Bacon,[...]. Am J Hum Genet 2011
519
11

Alpha-synuclein locus duplication as a cause of familial Parkinson's disease.
Marie-Christine Chartier-Harlin, Jennifer Kachergus, Christophe Roumier, Vincent Mouroux, Xavier Douay, Sarah Lincoln, Clotilde Levecque, Lydie Larvor, Joris Andrieux, Mary Hulihan,[...]. Lancet 2004
11

MLi-2, a Potent, Selective, and Centrally Active Compound for Exploring the Therapeutic Potential and Safety of LRRK2 Kinase Inhibition.
Matthew J Fell, Christian Mirescu, Kallol Basu, Boonlert Cheewatrakoolpong, Duane E DeMong, J Michael Ellis, Lynn A Hyde, Yinghui Lin, Carrie G Markgraf, Hong Mei,[...]. J Pharmacol Exp Ther 2015
122
11

Functional Impairment in Miro Degradation and Mitophagy Is a Shared Feature in Familial and Sporadic Parkinson's Disease.
Chung-Han Hsieh, Atossa Shaltouki, Ashley E Gonzalez, Alexandre Bettencourt da Cruz, Lena F Burbulla, Erica St Lawrence, Birgitt Schüle, Dimitri Krainc, Theo D Palmer, Xinnan Wang. Cell Stem Cell 2016
215
11

LRRK2 Biology from structure to dysfunction: research progresses, but the themes remain the same.
Daniel C Berwick, George R Heaton, Sonia Azeggagh, Kirsten Harvey. Mol Neurodegener 2019
40
27

Structure of LRRK2 in Parkinson's disease and model for microtubule interaction.
C K Deniston, J Salogiannis, S Mathea, D M Snead, I Lahiri, M Matyszewski, O Donosa, R Watanabe, J Böhning, A K Shiau,[...]. Nature 2020
30
36

The In Situ Structure of Parkinson's Disease-Linked LRRK2.
Reika Watanabe, Robert Buschauer, Jan Böhning, Martina Audagnotto, Keren Lasker, Tsan-Wen Lu, Daniela Boassa, Susan Taylor, Elizabeth Villa. Cell 2020
27
40

Cellular processes associated with LRRK2 function and dysfunction.
Rebecca Wallings, Claudia Manzoni, Rina Bandopadhyay. FEBS J 2015
89
11

The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease.
Zhihua Liu, Jinwoo Lee, Scott Krummey, Wei Lu, Huaibin Cai, Michael J Lenardo. Nat Immunol 2011
238
10

Multicenter analysis of glucocerebrosidase mutations in Parkinson's disease.
E Sidransky, M A Nalls, J O Aasly, J Aharon-Peretz, G Annesi, E R Barbosa, A Bar-Shira, D Berg, J Bras, A Brice,[...]. N Engl J Med 2009
10


The Parkinson's disease VPS35[D620N] mutation enhances LRRK2-mediated Rab protein phosphorylation in mouse and human.
Rafeeq Mir, Francesca Tonelli, Pawel Lis, Thomas Macartney, Nicole K Polinski, Terina N Martinez, Meng-Yun Chou, Andrew J M Howden, Theresa König, Christoph Hotzy,[...]. Biochem J 2018
73
13

Effect of selective LRRK2 kinase inhibition on nonhuman primate lung.
Reina N Fuji, Michael Flagella, Miriam Baca, Marco A S Baptista, Jens Brodbeck, Bryan K Chan, Brian K Fiske, Lee Honigberg, Adrian M Jubb, Paula Katavolos,[...]. Sci Transl Med 2015
154
10

LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity.
Mahaboobi Jaleel, R Jeremy Nichols, Maria Deak, David G Campbell, Frank Gillardon, Axel Knebel, Dario R Alessi. Biochem J 2007
382
10


Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.